Gene

KWMTBOMO10746  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA008405

Annotation

ecdysteroid-regulated_16_kDa_protein_precursor_[Bombyx_mori]

Location

Bomo_Chr18(-):2287942-2297420      View in EpiBrowser

Full name

Ecdysteroid-regulated 16 kDa protein       + More
NPC intracellular cholesterol transporter 2 homolog a      

Alternative Name

Niemann Pick type C2 protein homolog

Location in the cell

Extracellular   Reliability : 2.396

CDS

ATGTTGTTTTTCATCACTGCGGCGGTGCTCTTGGCCAGTGCTGAGGCTAAATTCTTCAAGGATTGCGGGTCCAAACTAGCGACAGTCCACAACGTGACGGTGAGCGGATGCGAAGAGTCGTCCAGTCATTGTATACTGAAGAGAAACACAGACGCCACGATCGGCCTGCAGTTTACACCACTGCACAACATCGATCGCATAAATACAGAAGTTCACGGGGTCATCATGAACATCCCGATACCGTTCCCCCTGCCGGAGTCTGACGCGTGCAAGGACAACGGGCTGACCTGCCCCCTCAAGGAGGGAACCCTGGCGGATTATAAAGCAACACTGCCTATCCTGAAGTCTTATCCTAAGGTGACAGTGGAAGTAAAGTGGGAGCTCCAAAGTGAACATGGCGACTTAGTTTGCGTTCTTATAAACGCTAAACTGGTCTAA

Protein

MLFFITAAVLLASAEAKFFKDCGSKLATVHNVTVSGCEESSSHCILKRNTDATIGLQFTPLHNIDRINTEVHGVIMNIPIPFPLPESDACKDNGLTCPLKEGTLADYKATLPILKSYPKVTVEVKWELQSEHGDLVCVLINAKLV

Description

Functions redundantly with Npc2b in regulating sterol homeostasis and ecdysteroid biosynthesis, probably by controlling the availability of sterol substrate.

Similarity

Belongs to the NPC2 family.

Keywords

Disulfide bond   Glycoprotein   Secreted   Signal   Complete proteome   Lipid biosynthesis   Lipid metabolism   Reference proteome   Steroid biosynthesis  

Feature

chain  Ecdysteroid-regulated 16 kDa protein

Uniprot

Q2F605   A0A0N1I601   I4DJK0   A0A2A4JQ29   A0A2H1VE72   A0A212ENK2   + More
Q25481   A0A346M703   A0A3G1T1M5   A0A1W4WIQ1   A0A1L8EFU4   S4P6N1   A0A1B0CIZ5   A0A1Y1LLU3   E9G6P7   B4Q7L1   D2A0E4   A0A1W4V1G3   A0A1I8PDR9   A0A1L8DYJ4   A0A1L8E2Z2   B4NW31   A0A084WI66   K7IM48   B3MJE0   A0A1I8M1L2   A0A182IJI4   A0A182FT82   B3N8Z9   U4TW37   A0A2M4C231   Q9VQ62   A0A2M4C1Q3   A0A0K8VUX6   A0A162QG06   A0A182NPT8   J3JU13   A0A2M4A3K2   W5J537   A0A034UZ71   A0A0C9Q191   A0A0P5FBV5   A0A0A1XK49   A0A182VKL7   A0A182X7V4   A0A182LZD1   A0A1S4HCZ8   A0A182HHV7   A0A1Q3FJU3   A0A182R2B1   A0A2A3EQW7   W8BKI7   A0A0L0CL09   A0A182QJC3   Q29LN3   B4G804   B4LVI0   A0A023EH77   A0A182WCX0   A0A087ZVK5   A0A182PLY6   A0A182YCF5   B4N1E7   A0A182KTH9   A0A1W7R8D3   A0A3B0JF70   B4KIY2   A0A023EH86   B0WBV3   B4JZA0   A0A0M4E369   U5EUS6   B4KKW4   E9IRH9   A0A1A9WA19   A0A0N8CH98   A0A1B0G482   A0A067RFZ4   A0A2J7PEF0   A0A232ED99   V9IJV5   Q174K0   A0A1J1J2J9   A0A219T7U5   A0A1A9VDL7   A0A1A9ZLD8   A0A1A9Y618   A0A154PRA9   A0A1B0BTY1   A0A336L530   A0A0N5DYI0   A0A1V9X7V1   A0A0V0XZT4   A0A2L2YEB4   A0A0P4W5I0   A0A1D2MLM9   A0A336MUM4   A0A369RZZ6   B3RMY9   A0A346TI37  

Pubmed

19121390    26354079    22651552    22118469    23622113    28004739    + More
21292972    17994087    22936249    18362917    19820115    17550304    24438588    20075255    25315136    23537049    10731132    12537572    12537569    17804599    22516182    20920257    23761445    25348373    25830018    12364791    24495485    26108605    15632085    24945155    25244985    20966253    21282665    24845553    28648823    17510324    28327890    26561354    27289101    30042472    18719581    30154418   

EMBL

BABH01001544    DQ311267    MF405489    ABD36212.1    AWL83212.1    KQ460940    + More
KPJ10655.1    AK401468    KQ459606    BAM18090.1    KPI90959.1    NWSH01000928    PCG73510.1    ODYU01001827    SOQ38564.1    AGBW02013630    OWR43085.1    U31456    MG020560    AXQ06575.1    MG992446    AXY94884.1    GFDG01001228    JAV17571.1    GAIX01006776    JAA85784.1    AJWK01013919    GEZM01054169    JAV73808.1    GL732533    EFX84782.1    CM000361    CM002910    EDX03391.1    KMY87559.1    KQ971338    EFA02897.1    GFDF01002588    JAV11496.1    GFDF01001080    JAV13004.1    CM000157    EDW87311.1    ATLV01023918    KE525347    KFB49910.1    CH902620    EDV31350.1    CH954177    EDV57399.1    KB631647    ERL84997.1    GGFJ01010183    MBW59324.1    AE014134    AY118810    BT001844    GGFJ01010109    MBW59250.1    GDHF01009622    JAI42692.1    LRGB01000337    KZS19660.1    APGK01007838    APGK01052149    BT126724    KB741210    KB737476    AEE61686.1    ENN72835.1    ENN83012.1    GGFK01001897    MBW35218.1    ADMH02002103    ETN59081.1    GAKP01022676    JAC36276.1    GBYB01007673    JAG77440.1    GDIQ01257729    JAJ93995.1    GBXI01002916    JAD11376.1    AXCM01009472    AAAB01008986    APCN01002448    GFDL01007198    JAV27847.1    KZ288193    PBC34128.1    GAMC01016496    JAB90059.1    JRES01000256    KNC32912.1    AXCN02001675    CH379060    EAL34012.1    CH479180    EDW29368.1    CH940649    EDW64374.1    GAPW01005368    JAC08230.1    CH963920    EDW78084.1    GEHC01000262    JAV47383.1    OUUW01000004    SPP79323.1    CH933807    EDW13495.1    GAPW01005367    JAC08231.1    DS231882    EDS42883.1    CH916379    EDV94209.1    CP012523    ALC38008.1    GANO01002191    JAB57680.1    EDW11694.1    GL765144    EFZ16828.1    GDIP01131863    JAL71851.1    CCAG010013953    KK852498    KDR22662.1    NEVH01026098    PNF14713.1    NNAY01007404    OXU16317.1    JR048812    AEY60771.1    CH477409    EAT41505.1    CVRI01000065    CRL05670.1    KU342585    ANT46052.1    KQ435007    KZC13650.1    JXJN01020411    UFQS01002006    UFQT01002006    SSX12948.1    SSX32390.1    MNPL01020339    OQR69614.1    JYDU01000086    KRX93590.1    IAAA01024750    LAA06474.1    GDRN01088442    JAI60854.1    LJIJ01000923    ODM93754.1    UFQT01001835    SSX31947.1    NOWV01000119    RDD39861.1    DS985242    EDV27931.1    MH510335    AXU25120.1   

Proteomes

UP000005204    UP000053240    UP000053268    UP000218220    UP000007151    UP000192223    + More
UP000092461    UP000000305    UP000000304    UP000007266    UP000192221    UP000095300    UP000002282    UP000030765    UP000002358    UP000007801    UP000095301    UP000075880    UP000069272    UP000008711    UP000030742    UP000000803    UP000076858    UP000075884    UP000019118    UP000000673    UP000075903    UP000076407    UP000075883    UP000075840    UP000075900    UP000242457    UP000037069    UP000075886    UP000001819    UP000008744    UP000008792    UP000075920    UP000005203    UP000075885    UP000076408    UP000007798    UP000075882    UP000268350    UP000009192    UP000002320    UP000001070    UP000092553    UP000091820    UP000092444    UP000027135    UP000235965    UP000215335    UP000008820    UP000183832    UP000078200    UP000092445    UP000092443    UP000076502    UP000092460    UP000046395    UP000192247    UP000054815    UP000094527    UP000253843    UP000009022   

PRIDE

Q2F605    Q9VQ62   

Pfam

PF02221   E1_DerP2_DerF2

Interpro

IPR014756   Ig_E-set        + More
IPR003172   ML_dom       
IPR033916   ML_Npc2-like       
IPR039670   NPC2-like       

SUPFAM

SSF81296   SSF81296       

CDD

cd00916  Npc2_like

ProteinModelPortal

Q2F605   A0A0N1I601   I4DJK0   A0A2A4JQ29   A0A2H1VE72   A0A212ENK2   + More
Q25481   A0A346M703   A0A3G1T1M5   A0A1W4WIQ1   A0A1L8EFU4   S4P6N1   A0A1B0CIZ5   A0A1Y1LLU3   E9G6P7   B4Q7L1   D2A0E4   A0A1W4V1G3   A0A1I8PDR9   A0A1L8DYJ4   A0A1L8E2Z2   B4NW31   A0A084WI66   K7IM48   B3MJE0   A0A1I8M1L2   A0A182IJI4   A0A182FT82   B3N8Z9   U4TW37   A0A2M4C231   Q9VQ62   A0A2M4C1Q3   A0A0K8VUX6   A0A162QG06   A0A182NPT8   J3JU13   A0A2M4A3K2   W5J537   A0A034UZ71   A0A0C9Q191   A0A0P5FBV5   A0A0A1XK49   A0A182VKL7   A0A182X7V4   A0A182LZD1   A0A1S4HCZ8   A0A182HHV7   A0A1Q3FJU3   A0A182R2B1   A0A2A3EQW7   W8BKI7   A0A0L0CL09   A0A182QJC3   Q29LN3   B4G804   B4LVI0   A0A023EH77   A0A182WCX0   A0A087ZVK5   A0A182PLY6   A0A182YCF5   B4N1E7   A0A182KTH9   A0A1W7R8D3   A0A3B0JF70   B4KIY2   A0A023EH86   B0WBV3   B4JZA0   A0A0M4E369   U5EUS6   B4KKW4   E9IRH9   A0A1A9WA19   A0A0N8CH98   A0A1B0G482   A0A067RFZ4   A0A2J7PEF0   A0A232ED99   V9IJV5   Q174K0   A0A1J1J2J9   A0A219T7U5   A0A1A9VDL7   A0A1A9ZLD8   A0A1A9Y618   A0A154PRA9   A0A1B0BTY1   A0A336L530   A0A0N5DYI0   A0A1V9X7V1   A0A0V0XZT4   A0A2L2YEB4   A0A0P4W5I0   A0A1D2MLM9   A0A336MUM4   A0A369RZZ6   B3RMY9   A0A346TI37  

PDB

3WEB     E-value=8.3451e-20,     Score=232

KEGG

100101154    K13443 Niemann-Pick C2 protein | (RefSeq) ecdysteroid-regulated 16 kDa protein precursor

PATHWAY

04142    Lysosome - Bombyx mori (domestic silkworm)

GO

GO:0005623   GO:0032367   GO:0005576   GO:0015918   GO:0032934   GO:0005615   GO:0001530   GO:0070891   GO:0061057   GO:0055092   GO:0008039   GO:0042834   GO:0030882   GO:0045456   GO:0016021   GO:0005549   GO:0007608   GO:0016020   GO:0005515   GO:0016491   GO:0046872   GO:0051537   GO:0003824  

PANTHER

PTHR11306  

Subcellular location

Secreted  

SignalP

Position:   1 - 16,         Likelihood:  0.997412

 

 

Length:

145

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.00918

Exp number, first 60 AAs:

0.00918

Total prob of N-in:

0.02671

outside

1  -  145

 

 

Pi

202.355711

Theta

169.856725

Tajima's D

-1.228888

CLR

27.826322

CSRT

0.102494875256237

Interpretation

Uncertain