Gene

KWMTBOMO10722

Pre Gene Modal

BGIBMGA008283

Annotation

1-phosphatidylinositol-4?5-bisphosphate_phosphodiesterase_beta-4_[Bombyx_mori]

Location

Bomo_Chr18(+):1496329-1591846      View in EpiBrowser

Full name

Phosphoinositide phospholipase C       + More
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase      

Location in the cell

Nuclear   Reliability : 3.474

CDS

ATGACCAAGAAATTTGAATTCAACTGGCAGATACCAGTCCCCGAGCCGCTGTTGCAGGGCGCAGTCTTCGACAGATGGACGGAAGAGAAGGACAATACAGAGTTTGAACAAAATTGCTTATTCAAGGTCGACGAATATGGCTTCTTCATCTACTGGAAGAGTGATGGAAAGGACGGTGACGTGATAGAATTGTGTCAAGTAAGCGACGTCAGATCCGGAGGTGTTCCCAAGGACTCCAAGCTCAACTCGAATCTGGTGAACAAACACGGGGACACGTTGGAAGACAAATCGCTAACCATATGCAGTGGAACTGACTATATTAACATCAACTACCAACACGTGGTGTGTCCTGACGCCGCCACAGCGAAGATATGGTTGCAAGCTTTAAGGAAGATAACTCACAACGTGAAAGCCAACAACGTTTGTCCGATGACATGCCTCAAGAAACACTGGATGCGCCTCTGTTTCCTGACCGACCCTCGGGGCAAAGTTCCCGTCAAGGTGGTGGCCAGGACATTTGCTTCTGGTAAAACTGAGAAGCTGGTCTACCAGTGCCTGTCCGAACTGGGTCTGCCGTCAGGGAAGAATGACGTCATGGAAAAAGAAGCCTTCACGTTTGACAAGTTTTACGCTCTGTATCATAAGATTTGCCCGAGAAACGATATTGAAGAGTTGTTTCGTTCTATAACTCAAGGCAAATCCGATCGCATCAATTTGGACCAGTTCGTGAACTTCCTGAATGAGAAGCAACGTGATCCTCGACTCAACGAGATCCTGTACCCGCTGTACGATGAGAAGAGAGCAGCTGAGATCATCACGACTTATGAACAGAATGAGGAAGCCAAAAATGCCAAATGCTTGACAAAAGACGGTCTGATCCGCTACTTGATGTCGGACGAGAATGCTCCTGTGTTCCTCGACCGTCTCGACAACTATATGGACATGGACCAGCCACTCGCTCACTACTACATCAACTCATCGCACAACACGTACCTAAGCGGACGACAGTTCGGAGGGAAAAGCTCCGTGGAGATGTACCGACAGGTCTTGTTGGCTGGTTGCCGATGCGTAGAGCTAGACTGTTGGGATGGCAAAGGCGAGGATGAAGAGCCAATCATAACGCACGGCATGGCAATGTGCACTGACATACTGTTCAAAGATGTCATATACGCCCTGAGGGATACCGCCTTCGTGACTTCAGACTACCCAGTCATCCTATCATTTGAGAACCACTGTTGCAAGGCCCAGCAATACAAGCTGGCCAAATACTGTGACGAGATCTTGGGTGATTTGCTGCTTAAGGAACCGCTGCCTGATCATCCGTTGGACCCAGGAGTGCCATTACCTCCGCCTTCAGCCCTCAAACGCAAGATCATGATTAAGAACAAACGTCTAAAGCCAGAAGTTGAGAAGCAAGAATTAGAGCTGTTCCGTCAAGGACAGTTTGTCATCGAAGAAGAAGAGAAAGAAGATGCTTCTGCAGTCGCCATTCTGGATAAAAAGCCTGAAGAGATCGTAGCCGAAGCAGCATCGGCTGGCGATGACGCACCTCCTCCCGTTGCGTACACAGGATCTACAACCAACGTTCATCCATGGCTCTCGTCCATGGTCAACTACGCGCAGCCCATCAAGTTCCAAGGCTTCGAAGAGGCAGATAAGCGCAACATTTACCACAACATGTCCTCGTTCGCTGAGACGACCGGCATGAACTACCTAAAGAGCCAAGCCATCGACTTCGTGAATTACAACAAGCGACAGATGTCCCGTATTTATCCTAAAGGAACCCGTGCTGACTCCTCTAATTACATGCCTCAGGTATTCTGGAACGCCGGATGTCAAATGGTGTCCCTAAACTTCCAAACGTCAGACTTGCCAATGCAACTGAACCAAGGCAAGTTCGAGTACAACGGGAACTGCGGATACCTGTTGAAGCCGGACTTCATGCGGCGCGCGGACCGTAGCTTCGATCCTTTTGCCGACGCGCCAGTCGATGGCGTCATCGCGGCTCAGTGCAGTGTCCAGGTCATAGCTGGTCAGTTTCTGTCAGACAAGAAGATCGGGACCTACGTTGAAGTGGATATGTACGGTCTACCGTCAGACACGATCCGCAAGGAATTCCGCACGAGAATGGTGCCTGCGAACGGATTGAACCCAGTTTACAACGAGGAGCCTTTCTTGTTTAGGAAGGTCGTGCTTCCTGACCTAGCCGTCCTCCGTTTCGGTGTTTACGACGAGAACGGCAAGCTCCTGGGCCAGAGGATCCTGCCGCTGGACGGGCTCCAAGCCGGCTACAGGCACATCTCGCTCAGGACCGAAGCAAACTTCCCTATGTCACTGCCCATGTTGTTCTGCAACATCGAACTCAAGATTTACGTCCCGGACGGTTTTGCTGATTTCATGGACGCTCTCTCAGACCCGCGTGCGTTCAAGAAACGTTCCGAAGACATGCAGCAGATGGGCATTGAAGCTGGTGGACCTGAAAAAAGAGTGCAGCTCGAAGAGAAGAAAGAAGAGCCTCCCATCGTCTTCGAACCTATAACAGTGGAGTCCTTGCGCCAAGAGAAGGGCTTCCTAAAGACCGGCAGGAAACAGCAGAAAGACCTGGACGCAATGAGGAAGCGACATGCCAAAGAGAAGATGGCATTGCAAAAGCAACAATGCACTGCACTTGAGAAGATGATAAAGGGAAAGAACAAAGAGCAGTTGAGCACTGATCCGGCCTTCCGCAAGATGGTCAACGAACAGTCGACGGCGTGGAGTGAGCTGGTAGCCAAGCACCGAGTGGAAGAGTGGACCAACACCAGGAACCGCCTCAACGAACAACGGGAACTGCTGAAGAAAATGATGGAGCAGACACAACAGGCTCAAGTCAAACGCCTCGAAGCCAAGCATGAGAGGGAGCTGAAAGAGATGAACGCTCGTCAGGCCAGGATCAGTATGGAGACCAGCAAAGAGGTCGCCAACGACAAAACTTTGAAGACCAAACAAGAAAAAGATAGACGACTCAGGGAGAAAAAACAAAACAACACAAAGAAGTTTATGGACGAAAGACTGAGTCACACTAAGAAACAAAACCGCGAGAAGGATAACTTGAAGGCGACACACGAGAAACAGATGGAAGAGCTGTCAAAAGATGTTGATAATCTAATCGAGATGTACAAGATGGAGGAATCCGAATTCGACATGGCGAGTAAAACGGAATTTTTTGCATGA

Protein

MTKKFEFNWQIPVPEPLLQGAVFDRWTEEKDNTEFEQNCLFKVDEYGFFIYWKSDGKDGDVIELCQVSDVRSGGVPKDSKLNSNLVNKHGDTLEDKSLTICSGTDYININYQHVVCPDAATAKIWLQALRKITHNVKANNVCPMTCLKKHWMRLCFLTDPRGKVPVKVVARTFASGKTEKLVYQCLSELGLPSGKNDVMEKEAFTFDKFYALYHKICPRNDIEELFRSITQGKSDRINLDQFVNFLNEKQRDPRLNEILYPLYDEKRAAEIITTYEQNEEAKNAKCLTKDGLIRYLMSDENAPVFLDRLDNYMDMDQPLAHYYINSSHNTYLSGRQFGGKSSVEMYRQVLLAGCRCVELDCWDGKGEDEEPIITHGMAMCTDILFKDVIYALRDTAFVTSDYPVILSFENHCCKAQQYKLAKYCDEILGDLLLKEPLPDHPLDPGVPLPPPSALKRKIMIKNKRLKPEVEKQELELFRQGQFVIEEEEKEDASAVAILDKKPEEIVAEAASAGDDAPPPVAYTGSTTNVHPWLSSMVNYAQPIKFQGFEEADKRNIYHNMSSFAETTGMNYLKSQAIDFVNYNKRQMSRIYPKGTRADSSNYMPQVFWNAGCQMVSLNFQTSDLPMQLNQGKFEYNGNCGYLLKPDFMRRADRSFDPFADAPVDGVIAAQCSVQVIAGQFLSDKKIGTYVEVDMYGLPSDTIRKEFRTRMVPANGLNPVYNEEPFLFRKVVLPDLAVLRFGVYDENGKLLGQRILPLDGLQAGYRHISLRTEANFPMSLPMLFCNIELKIYVPDGFADFMDALSDPRAFKKRSEDMQQMGIEAGGPEKRVQLEEKKEEPPIVFEPITVESLRQEKGFLKTGRKQQKDLDAMRKRHAKEKMALQKQQCTALEKMIKGKNKEQLSTDPAFRKMVNEQSTAWSELVAKHRVEEWTNTRNRLNEQRELLKKMMEQTQQAQVKRLEAKHERELKEMNARQARISMETSKEVANDKTLKTKQEKDRRLREKKQNNTKKFMDERLSHTKKQNREKDNLKATHEKQMEELSKDVDNLIEMYKMEESEFDMASKTEFFA

Description

The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes.

Catalytic Activity

a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = 1D-myo-inositol 1,4,5-trisphosphate + a 1,2-diacyl-sn-glycerol + H(+)

Uniprot

D2XZ02   A0A2A4JWE6   A0A2A4JVF6   A0A194PCP3   H9JFI6   Q7PYH0   + More
A0A182VNI1   A0A084VS34   F5HMB9   A0A182PQW5   A0A182VR14   A0A182KM04   A0A182XBI3   A0A1S4FMB2   A0A182N609   A0A2M4CUG2   Q16W09   A0A2M4CVQ8   A0A2M4BAQ9   A0A2M4BBD3   A0A2M4A0I6   A0A2M3YY48   A0A1J1IP73   A0A1Q3FK53   B0WMG5   A0A1Q3FK57   A0A1B6DJU1   Q16W08   A0A1J1INZ6   A0A1W4X675   A0A1B6KIL1   A0A1Q3FKE1   A0A1Q3FK21   A0A182I0C2   A0A182QEK9   A0A1B0FV00   A0A1Q3FK46   A0A1W4XGM2   A0A1Y1KMR3   A0A182RXL5   A0A146L2V9   A0A1L8DM97   A0A2S2R2M7   A0A069DXN9   J9JSK8   A0A336LPI1   T1DDZ4   A0A336LNY5   A0A067R077   A0A139WJG1   A0A0P4VV51   A0A087ZUQ9   A0A0C9RGN3   T1IDF7   E1ZXP6   A0A3L8DJH6   A0A026WM75   A0A158N9R9   A0A0C9RU63   K7J3P9   E2C2Y5   A0A232EY40   A0A0N0U5N7   A0A151WUV0   A0A195E2Q1   A0A195B975   F4WB52   A0A195CN17   A0A195FDW9   N6T0Q4   A0A182IY33   A0A0L7RAF6   A0A154P2H4   A0A0P5ZL22   A0A0P5ZEJ2   A0A2A4JVG4   A0A2A4JW55   E9GYJ7   A0A2H1VS64   A0A0P6GU81   A0A0N8ADA8   A0A0P5YWD0   A0A0P5TTK8   A0A0P5D760   A0A2A3EQT6   E2BGZ2   A0A0P5QRN1   A0A0P5EPQ6   A0A0P5FQN3   A0A0P5X872   A0A0P4YC21   A0A1D2N7S0   A0A0P5UES1   A0A195BCL1   A0A195FN87   F4X6F2   A0A026WNG1   V9IJR2   A0A1B0ATB2   A0A0P5KSQ6  

EC Number

3.1.4.11

Pubmed

26354079    19121390    12364791    14747013    17210077    24438588    + More
20966253    17510324    28004739    26823975    26334808    24330624    24845553    18362917    19820115    27129103    20798317    30249741    24508170    21347285    20075255    28648823    21719571    23537049    21292972    27289101   

EMBL

GU266211    ADB25314.1    NWSH01000498    PCG76018.1    PCG76017.1    KQ459606    + More
KPI90982.1    BABH01035056    AAAB01008987    EAA00962.5    ATLV01015796    KE525036    KFB40778.1    EGK97441.1    GGFL01004741    MBW68919.1    CH477578    EAT38755.1    GGFL01004740    MBW68918.1    GGFJ01000969    MBW50110.1    GGFJ01001181    MBW50322.1    GGFK01000996    MBW34317.1    GGFM01000448    MBW21199.1    CVRI01000057    CRL01960.1    GFDL01007117    JAV27928.1    DS231997    EDS31022.1    GFDL01007086    JAV27959.1    GEDC01011373    JAS25925.1    EAT38756.1    CRL01959.1    GEBQ01028973    GEBQ01005174    JAT11004.1    JAT34803.1    GFDL01007092    JAV27953.1    GFDL01007118    JAV27927.1    APCN01002061    AXCN02000193    AJWK01006480    GFDL01007127    JAV27918.1    GEZM01078465    GEZM01078464    JAV62689.1    GDHC01015748    JAQ02881.1    GFDF01006498    JAV07586.1    GGMS01015094    MBY84297.1    GBGD01000234    JAC88655.1    ABLF02021068    ABLF02021069    UFQT01000095    SSX19715.1    GALA01001252    JAA93600.1    SSX19716.1    KK852804    KDR16250.1    KQ971338    KYB27925.1    GDKW01000674    JAI55921.1    GBYB01012262    JAG82029.1    ACPB03007313    GL435087    EFN74018.1    QOIP01000007    RLU20585.1    KK107152    EZA57110.1    ADTU01009261    GBYB01012265    JAG82032.1    GL452255    EFN77689.1    NNAY01001657    OXU23302.1    KQ435783    KOX74728.1    KQ982723    KYQ51616.1    KQ979776    KYN19164.1    KQ976556    KYM80780.1    GL888057    EGI68559.1    KQ977532    KYN02103.1    KQ981656    KYN38581.1    APGK01049409    APGK01049410    KB741152    ENN73669.1    KQ414618    KOC67867.1    KQ434804    KZC06032.1    GDIP01045795    JAM57920.1    GDIP01045794    JAM57921.1    PCG76015.1    PCG76016.1    GL732575    EFX75407.1    ODYU01003934    SOQ43302.1    GDIP01052246    GDIQ01029606    JAM51469.1    JAN65131.1    GDIP01158673    JAJ64729.1    GDIP01052245    GDIQ01030960    JAM51470.1    JAN63777.1    GDIP01123021    JAL80693.1    GDIP01162018    JAJ61384.1    KZ288193    PBC34098.1    GL448255    EFN85025.1    GDIQ01117381    JAL34345.1    GDIP01156768    JAJ66634.1    GDIQ01251328    JAK00397.1    GDIP01076021    JAM27694.1    GDIP01239219    JAI84182.1    LJIJ01000162    ODN01287.1    GDIP01114078    JAL89636.1    KQ976526    KYM81957.1    KQ981424    KYN41856.1    GL888812    EGI57992.1    KK107144    QOIP01000003    EZA57570.1    RLU24819.1    JR049188    AEY60892.1    JXJN01003232    GDIQ01180151    JAK71574.1   

Proteomes

UP000218220    UP000053268    UP000005204    UP000007062    UP000075903    UP000030765    + More
UP000075885    UP000075920    UP000075882    UP000076407    UP000075884    UP000008820    UP000183832    UP000002320    UP000192223    UP000075840    UP000075886    UP000092461    UP000075900    UP000007819    UP000027135    UP000007266    UP000005203    UP000015103    UP000000311    UP000279307    UP000053097    UP000005205    UP000002358    UP000008237    UP000215335    UP000053105    UP000075809    UP000078492    UP000078540    UP000007755    UP000078542    UP000078541    UP000019118    UP000075880    UP000053825    UP000076502    UP000000305    UP000242457    UP000094527    UP000092460   

PRIDE

D2XZ02    H9JFI6   

Pfam

PF17787   PH_14        + More
PF09279   EF-hand_like
PF00168   C2
PF00387   PI-PLC-Y
PF06631   DUF1154
PF00388   PI-PLC-X

Interpro

IPR017946   PLC-like_Pdiesterase_TIM-brl        + More
IPR035892   C2_domain_sf       
IPR037862   PLC-beta_PH       
IPR015359   PLC_EF-hand-like       
IPR000909   PLipase_C_PInositol-sp_X_dom       
IPR011992   EF-hand-dom_pair       
IPR000008   C2_dom       
IPR001192   PI-PLC_fam       
IPR009535   PLC-beta_CS       
IPR016280   PLC-beta       
IPR001711   PLipase_C_Pinositol-sp_Y       

SUPFAM

SSF47473   SSF47473        + More
SSF51695   SSF51695       

Gene 3D

2.60.40.150     3.20.20.190    

CDD

cd13361  PH_PLC_beta

ProteinModelPortal

D2XZ02   A0A2A4JWE6   A0A2A4JVF6   A0A194PCP3   H9JFI6   Q7PYH0   + More
A0A182VNI1   A0A084VS34   F5HMB9   A0A182PQW5   A0A182VR14   A0A182KM04   A0A182XBI3   A0A1S4FMB2   A0A182N609   A0A2M4CUG2   Q16W09   A0A2M4CVQ8   A0A2M4BAQ9   A0A2M4BBD3   A0A2M4A0I6   A0A2M3YY48   A0A1J1IP73   A0A1Q3FK53   B0WMG5   A0A1Q3FK57   A0A1B6DJU1   Q16W08   A0A1J1INZ6   A0A1W4X675   A0A1B6KIL1   A0A1Q3FKE1   A0A1Q3FK21   A0A182I0C2   A0A182QEK9   A0A1B0FV00   A0A1Q3FK46   A0A1W4XGM2   A0A1Y1KMR3   A0A182RXL5   A0A146L2V9   A0A1L8DM97   A0A2S2R2M7   A0A069DXN9   J9JSK8   A0A336LPI1   T1DDZ4   A0A336LNY5   A0A067R077   A0A139WJG1   A0A0P4VV51   A0A087ZUQ9   A0A0C9RGN3   T1IDF7   E1ZXP6   A0A3L8DJH6   A0A026WM75   A0A158N9R9   A0A0C9RU63   K7J3P9   E2C2Y5   A0A232EY40   A0A0N0U5N7   A0A151WUV0   A0A195E2Q1   A0A195B975   F4WB52   A0A195CN17   A0A195FDW9   N6T0Q4   A0A182IY33   A0A0L7RAF6   A0A154P2H4   A0A0P5ZL22   A0A0P5ZEJ2   A0A2A4JVG4   A0A2A4JW55   E9GYJ7   A0A2H1VS64   A0A0P6GU81   A0A0N8ADA8   A0A0P5YWD0   A0A0P5TTK8   A0A0P5D760   A0A2A3EQT6   E2BGZ2   A0A0P5QRN1   A0A0P5EPQ6   A0A0P5FQN3   A0A0P5X872   A0A0P4YC21   A0A1D2N7S0   A0A0P5UES1   A0A195BCL1   A0A195FN87   F4X6F2   A0A026WNG1   V9IJR2   A0A1B0ATB2   A0A0P5KSQ6  

PDB

3QR0     E-value=0,     Score=1770

KEGG

100329154    K05858 phosphatidylinositol phospholipase C, beta [EC:3.1.4.11] | (RefSeq) PLCb4; phospholipase C be

PATHWAY

00562    Inositol phosphate metabolism - Bombyx mori (domestic silkworm)
01100    Metabolic pathways - Bombyx mori (domestic silkworm)
04070    Phosphatidylinositol signaling system - Bombyx mori (domestic silkworm)
04310    Wnt signaling pathway - Bombyx mori (domestic silkworm)
04745    Phototransduction - fly - Bombyx mori (domestic silkworm)
04933    AGE-RAGE signaling pathway in diabetic complications - Bombyx mori (domestic silkworm)

GO

GO:0035556   GO:0016042   GO:0005509   GO:0004435   GO:0032959   GO:0007165   GO:0006629   GO:0008081   GO:0005515   GO:0016491   GO:0046872   GO:0051537   GO:0003824  

PANTHER

PTHR10336  

Length:

1070

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.000560000000000001

Exp number, first 60 AAs:

0.00016

Total prob of N-in:

0.00003

outside

1  -  1070

 

 

Pi

217.858486

Theta

171.195612

Tajima's D

1.054996

CLR

0.253795

CSRT

0.672266386680666

Interpretation

Uncertain