Gene

KWMTBOMO10711

Pre Gene Modal

BGIBMGA008273

Annotation

PREDICTED:_dopamine_D2-like_receptor_isoform_X2_[Papilio_polytes]

Location

Bomo_Chr18(+):1310505-1324570      View in EpiBrowser

Full name

Dopamine D2-like receptor      

Location in the cell

Mitochondrial   Reliability : 1.172 Nuclear   Reliability : 1.415 PlasmaMembrane   Reliability : 1.783

CDS

ATGATGTTCCTGTATTATAATATTTTCAAGGCTATAAGACAAAGAGCAAAAAAACAGAGGGTAGCGAAGAAGACCTCTGCCGCAATCGGGTCAGCGCTCTCCAGCGGCACTGCAGCTGTAGTCATTGAGAACATGGCGCAAACTCAAAGGCTGACTGAAGCATTACAAGACGATAGACCGACTAACACCGCTTCGGGAAGCAACGATGAAGTGGACGACGAGGAAGACAAAACGGAAATGGGGCCGTATGCCGAGGAACTGGTCAACACGAGGTCGGCGCGGTTCATGTTGGCAGCTGTCGTCGAAGAAACCGGCCTAATAATGGCAAACCTCGCGTCACCGATTCCAATGGTGGACCCGAACACAAATAATGATTCGGGATACGCTCCATCTAACATCGACGGAGAAACCAAAGAGCATACGCCACCAGCTTCTCCCACGCACAAGGATGGCAAGAAGATTCAGGAGGATCAAACTAAGAAACCTGAACTAAGCATTGTTTGCAGAAAGAAACTGAGCCGCCTCAGCAATAGCTCCTTGATCTCGACGCCGCGGAGGCGGTTTAGGAGCGCAGCTTCGGCTGCAAGATTTACAATCTTCAGGGCGAACAGAGCAGGGAAGCTAAGAGCCAAATCATTCGCCAAGAAAGAGAAGAAGGCAACGCAAACTTTAGCTATTGTTTTAGGAGTCTTCTTATTCTGCTGGGCACCATTCTTCACGTGCTCCGTCCTGGACGCTCTCTGTACGAAATTCGATCTCCCTTTCTCCCCTGGAGTGACTGTCTTCATTCTGACAACGTGGCTCGGGTACATCAACTCGTTCCTCAACCCGGTCATCTACACGATCTTCAACCCGGAATTCAGGAAGGCTTTCAGGAAGATCCTGCATTGCACCACCTAG

Protein

MMFLYYNIFKAIRQRAKKQRVAKKTSAAIGSALSSGTAAVVIENMAQTQRLTEALQDDRPTNTASGSNDEVDDEEDKTEMGPYAEELVNTRSARFMLAAVVEETGLIMANLASPIPMVDPNTNNDSGYAPSNIDGETKEHTPPASPTHKDGKKIQEDQTKKPELSIVCRKKLSRLSNSSLISTPRRRFRSAASAARFTIFRANRAGKLRAKSFAKKEKKATQTLAIVLGVFLFCWAPFFTCSVLDALCTKFDLPFSPGVTVFILTTWLGYINSFLNPVIYTIFNPEFRKAFRKILHCTT

Description

Receptor for dopamine. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase.

Similarity

Belongs to the G-protein coupled receptor 1 family.

Keywords

Alternative splicing   Cell membrane   Complete proteome   Disulfide bond   G-protein coupled receptor   Glycoprotein   Membrane   Receptor   Reference proteome   Transducer   Transmembrane   Transmembrane helix  

Feature

chain  Dopamine D2-like receptor
splice variant  In isoform B.

Uniprot

H9JFH6   A0A2D1QSC3   A0A2W1BHI5   A0A194PCI3   A0A212FHQ4   A0A0N1IPR0   + More
A0A2W1BMS8   A0A2D1QSG0   H9JFH5   A0A212FAQ5   A0A3S2LY29   A0A0K0QWN5   A0A0N1IH03   A0A0L7LB25   A0A2A4J4N3   A0A194PIS7   A0A182NSH9   A0A182QXL3   A0A182RT33   A0A182W3C3   A0A1B0BGM8   A0A182HYJ9   A0A182Y8W6   Q7QA35   A0A182MT40   A0A1J1IHH0   A0A182XFA6   F5HLP6   A0A182F9I3   A0A182KZN5   A0A0Q9WMR4   D1ZZA0   A0A182JDV9   B4L4R3   B0X7F1   A0A067QHK1   A0A0Q9WMR1   A0A1A9WVF9   A0A2J7PGC7   B4M2E9   M4GWU0   Q29GV2   B4GV08   A0A1J1IIS0   A0A2P8Z7W0   B4JMH2   A0A0L0BTW0   A0A0Q9WYJ8   A0A0M4EXI5   E0VLC9   A0A1I8PCW6   F5HLP5   A0A1W4UDE8   A0A0Q9WRL4   A0A1I8NBH5   A0A1W4UQM0   A0A1I8PD55   A0A1B0CAE3   E2C2Y3   A0A2A3ESA7   A0A139WJ45   Q56JK9   S4VNA9   A0A154P477   A0A0H4ADE4   A0A0R3P0H7   Q8IS44-2  

Pubmed

19121390    28754962    28756777    26354079    22118469    26179416    + More
26227816    25244985    12364791    14747013    17210077    20966253    17994087    18054377    18025266    18316733    20068045    21843505    23604020    24845553    15632085    29403074    26108605    20566863    25315136    20798317    18362917    19820115    15944083    10731132    12537572    12391323   

EMBL

BABH01035027    BABH01035028    BABH01035029    KY092435    ATP13230.1    KZ150045    + More
PZC74512.1    KQ459606    KPI90991.1    AGBW02008468    OWR53273.1    KQ460326    KPJ15688.1    KZ150135    PZC72993.1    KY092434    ATP13229.1    BABH01034998    BABH01034999    AGBW02009434    OWR50824.1    RSAL01000123    RVE46651.1    KP784319    AKR18180.1    KPJ15690.1    JTDY01001871    KOB72672.1    NWSH01003411    PCG66352.1    KPI90995.1    AXCN02000234    JXJN01013906    AAAB01008898    EAA09118.4    AXCM01000165    CVRI01000052    CRK99667.1    EGK97178.1    CH933810    KRF94097.1    BK005862    DAA64499.1    EDW07541.2    DS232449    EDS41903.1    KK853374    KDR08065.1    KRF94098.1    NEVH01025635    PNF15381.1    CH940651    EDW65853.2    JN859085    AFH53996.1    CH379064    EAL32007.2    CH479192    EDW26545.1    CRK99666.1    PYGN01000157    PSN52577.1    CH916371    EDV91915.1    JRES01001467    KNC22659.1    KRF94096.1    CP012528    ALC48467.1    DS235271    EEB14185.1    EGK97179.1    CH963925    KRF98842.1    AJWK01003701    AJWK01003702    AJWK01003703    AJWK01003704    GL452255    EFN77687.1    KZ288193    PBC34096.1    KQ971338    KYB27914.1    AY921573    AAX62923.1    KC814692    AGO81727.1    KQ434804    KZC06028.1    KP789372    AKN44277.1    KRT06760.1    AY150862    AY150863    AY150864    AE014298    BT015236    AAN15955.1   

Proteomes

UP000005204    UP000053268    UP000007151    UP000053240    UP000283053    UP000037510    + More
UP000218220    UP000075884    UP000075886    UP000075900    UP000075920    UP000092460    UP000076408    UP000007062    UP000075883    UP000183832    UP000076407    UP000069272    UP000075882    UP000009192    UP000075880    UP000002320    UP000027135    UP000091820    UP000235965    UP000008792    UP000001819    UP000008744    UP000245037    UP000001070    UP000037069    UP000092553    UP000009046    UP000095300    UP000192221    UP000007798    UP000095301    UP000092461    UP000008237    UP000242457    UP000007266    UP000076502    UP000000803   

PRIDE

H9JFH6    H9JFH5    Q8IS44   

Pfam

PF00001   7tm_1

Interpro

IPR000276   GPCR_Rhodpsn        + More
IPR017452   GPCR_Rhodpsn_7TM       
IPR001671   Melcrt_ACTH_rcpt       
IPR000929   Dopamine_rcpt       

ProteinModelPortal

H9JFH6   A0A2D1QSC3   A0A2W1BHI5   A0A194PCI3   A0A212FHQ4   A0A0N1IPR0   + More
A0A2W1BMS8   A0A2D1QSG0   H9JFH5   A0A212FAQ5   A0A3S2LY29   A0A0K0QWN5   A0A0N1IH03   A0A0L7LB25   A0A2A4J4N3   A0A194PIS7   A0A182NSH9   A0A182QXL3   A0A182RT33   A0A182W3C3   A0A1B0BGM8   A0A182HYJ9   A0A182Y8W6   Q7QA35   A0A182MT40   A0A1J1IHH0   A0A182XFA6   F5HLP6   A0A182F9I3   A0A182KZN5   A0A0Q9WMR4   D1ZZA0   A0A182JDV9   B4L4R3   B0X7F1   A0A067QHK1   A0A0Q9WMR1   A0A1A9WVF9   A0A2J7PGC7   B4M2E9   M4GWU0   Q29GV2   B4GV08   A0A1J1IIS0   A0A2P8Z7W0   B4JMH2   A0A0L0BTW0   A0A0Q9WYJ8   A0A0M4EXI5   E0VLC9   A0A1I8PCW6   F5HLP5   A0A1W4UDE8   A0A0Q9WRL4   A0A1I8NBH5   A0A1W4UQM0   A0A1I8PD55   A0A1B0CAE3   E2C2Y3   A0A2A3ESA7   A0A139WJ45   Q56JK9   S4VNA9   A0A154P477   A0A0H4ADE4   A0A0R3P0H7   Q8IS44-2  

PDB

3PBL     E-value=2.14037e-21,     Score=251

KEGG

101739021    K04145 dopamine receptor D2 | (RefSeq) dopamine D2-like receptor

PATHWAY

04080    Neuroactive ligand-receptor interaction - Bombyx mori (domestic silkworm)

GO

GO:0004977   GO:0016021   GO:0004930   GO:0007188   GO:0071880   GO:0004935   GO:0005887   GO:0001591   GO:0007615   GO:0004715   GO:0007212   GO:0005886   GO:0007186   GO:0008227   GO:0051536   GO:0016491   GO:0046872   GO:0051537   GO:0003824  

Subcellular location

Cell membrane  

Length:

299

Number of predicted TMHs:

2

Exp number of AAs in TMHs:

46.84904

Exp number, first 60 AAs:

1.21746

Total prob of N-in:

0.93573

inside

1  -  223

TMhelix

224  -  246

outside

247  -  260

TMhelix

261  -  283

inside

284  -  299

 

 

Pi

26.626494

Theta

163.124266

Tajima's D

2.056341

CLR

0.152771

CSRT

0.892805359732013

Interpretation

Uncertain