Gene

KWMTBOMO10704

Pre Gene Modal

BGIBMGA008272

Annotation

PREDICTED:_dopamine_D2-like_receptor_[Amyelois_transitella]

Location

Bomo_Chr18(+):1034900-1045305      View in EpiBrowser

Full name

Dopamine D2-like receptor      

Location in the cell

PlasmaMembrane   Reliability : 2.046

CDS

ATGTTGTCACGTGTGACTTCAATTGTTCCGATCAACGACCGAGTTTTCGCGACTTCTTTATCGAAACATTTACGAGTATATGTTTACATAGCATCTGGTGAGGTACACGGTTCGTGGGGTCTTCCAGCCTTCGTGTGTGACGTGTACATAGCAATGGACGTAACCTCGTCCACTTCTAGCATATTCAATTTAGTCGCTATATCCATTGATAGGTACATCGCCGTCACTCAACCAATAAAATACGCAAAGCATAAAAACAACAGGCGAGTCTGGTTCACTATAGTTCTGGTCTGGCTGATATCTGCTGCTATTGGTGCTCCAATCGTCTTAGGCCTCAACGACACGCCCGACAGGAACTTTGACGAGTGCCTGTTCAATAGCCAGAACTATATCATCTATTCATCAATGGGATCGTTCTATATACCGTGCATCATGATGATGTTCCTCTATTACAATATTTTTAAGGCACTAAGAATACGAGCAAAGAAACAAAGGGCGGCCAAGAAGCCACCAGTTTCTGGTGACCCAGCAGCCGGTGCGTCCGCAGCTGTGGTCATAGAAAATGTTGCCCAAACTAGAAGGCTGGCGGAAACAGCGCTTCACGATGACAGAGCTACGAATACTGGGTCTGGGAGTAACGAGGAAGACCATGAGGACAGTTACGACAAACGATCAGCAGATCTCGAGGCAGACGCAGACGAATGTCACGTGATACCAAATGACAAGTCTACGGAATTCATGTTGGCGACAGTTGCGGAAGAGTCCATTATTACCCCAAAAAACCACAGCAAAAACCGCATGCCGGATCCGAATGGCAACAACGACTCGGGGAATGCGCCTTCGAACCTCGAAGACACGATCAGAGAGCACGTCTCTCCACCTGGTTCACCTGGCATGAAAGACGCTACAGTCTTGAAGAATATGGGCTGTGATGGTATCAAATGGAAGAAAAACGGAAAGACTGCGAAATTGACTGATTCTAGAAACGTTTCCCTCGCCATACGTTCGGAGGAAGACTTGGAAGCCAGCACCTTGGACCTCCATGATGGCGCAACGTCTAAAAAAGAGCGCAAAGCCAGCGCTGCGACAGCACGCTTCACGATTTACAAAGCGAATAAAGCCAGTAAGAAGAAACGCGAAAAATCCTCTGCCAAAAAAGAAAGAAAGGCCACCAAAACTTTGGCCATAGTTTTAGGAGTTTTCCTCTTTTGCTGGGCTCCGTTCTTCACGTACTCCGTCCTTGGAGCTATCTGCGATAAGTTCGATCTCCCTTTCTCCCCTGGAGTGACGGTCTTCATTCTGACAACGTGGCTCGGGTACATCAACTCGTTCCTCAACCCGGTCATCTACACGATCTTCAACCCGGAATTCAGGAAGGCTTTCAGGAAGATCCTGCATTGCGGCACCTAG

Protein

MLSRVTSIVPINDRVFATSLSKHLRVYVYIASGEVHGSWGLPAFVCDVYIAMDVTSSTSSIFNLVAISIDRYIAVTQPIKYAKHKNNRRVWFTIVLVWLISAAIGAPIVLGLNDTPDRNFDECLFNSQNYIIYSSMGSFYIPCIMMMFLYYNIFKALRIRAKKQRAAKKPPVSGDPAAGASAAVVIENVAQTRRLAETALHDDRATNTGSGSNEEDHEDSYDKRSADLEADADECHVIPNDKSTEFMLATVAEESIITPKNHSKNRMPDPNGNNDSGNAPSNLEDTIREHVSPPGSPGMKDATVLKNMGCDGIKWKKNGKTAKLTDSRNVSLAIRSEEDLEASTLDLHDGATSKKERKASAATARFTIYKANKASKKKREKSSAKKERKATKTLAIVLGVFLFCWAPFFTYSVLGAICDKFDLPFSPGVTVFILTTWLGYINSFLNPVIYTIFNPEFRKAFRKILHCGT

Description

Receptor for dopamine. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase.

Similarity

Belongs to the G-protein coupled receptor 1 family.

Keywords

Alternative splicing   Cell membrane   Complete proteome   Disulfide bond   G-protein coupled receptor   Glycoprotein   Membrane   Receptor   Reference proteome   Transducer   Transmembrane   Transmembrane helix  

Feature

chain  Dopamine D2-like receptor
splice variant  In isoform B.

Uniprot

H9JFH5   A0A2D1QSG0   A0A0K0QWN5   A0A2W1BMS8   A0A3S2LY29   A0A0N1IH03   + More
A0A194PIS7   A0A2H1V676   A0A0L7LB25   A0A2D1QSC3   A0A2P8Z7W0   M4GWU0   D1ZZA0   Q7QA35   F5HLP6   A0A1B0BGM8   A0A1J1IIS0   A0A2W1BHI5   A0A1J1IHH0   A0A2J7PGC7   A0A1A9WVF9   B4N1M8   Q8IS44-4   A0A0Q9WMR4   B4L4R3   A0A0Q9WMR1   A0A0L0BTW0   A0A0Q5TIW7   B3NWF1   B4PYY5   E0VLC9   A0A0R1EB29   A0A0M4EXI5   B4M2E9   A0A1I8PCW6   B4JMH2   A0A2S2PWR8   A0A0N1IPR0   Q29GV2   B4GV08   A0A212FHQ4   A0A1W4UDE8   A0A0R3P0F3   A0A0R3P0S7   A0A2S2NBT0   A0A1W4USE0   A0A1W4UDX1   Q8IS44-5   Q8IS44-6   A0A3B0J9C7   Q8IS44   A0A2H8TPN4   A0A0Q9WYJ8   A0A0Q5TEU2   A0A0Q5T436   A0A0R1EAQ9   A0A0R1EBE0   F5HLP5   A0A0H4ADE4   A0A1W4UQM0   A0A154P477   A0A1I8NBH5   E2C2Y3   A0A1I8PD55   A0A0R3P0L5   A0A0R3P0T9   A0A2A3ESA7   A0A0Q9WRL4   A0A182F9I3   A0A3L8DJL8   A0A182Y8W6   S4VNA9   A0A194PCI3   A0A182MT40   A0A182RT33   A0A182W3C3   Q56JK9   A0A182HYJ9   A0A182NSH9   A0A182JDV9   A0A0R3P0H7   Q8IS44-2   A0A087ZUQ7   A0A158N9R8   B0X7F1   H9JFH6   A0A026WM41   A0A195E267   A0A195B8C3   A0A195CMY7   F4WB54   K7JAM3   A0A182QXL3   E1ZXP4   A0A0L7RAJ6   A0A151WUT5   A0A1B3P972   A0A1B0CAE3   Q09HM5  

Pubmed

19121390    28754962    26179416    28756777    26354079    26227816    + More
29403074    18054377    18025266    18316733    20068045    21843505    23604020    12364791    14747013    17210077    17994087    10731132    12537572    12391323    26108605    17550304    20566863    15632085    22118469    25315136    20798317    30249741    25244985    15944083    21347285    24508170    21719571    20075255    17134931   

EMBL

BABH01034998    BABH01034999    KY092434    ATP13229.1    KP784319    AKR18180.1    + More
KZ150135    PZC72993.1    RSAL01000123    RVE46651.1    KQ460326    KPJ15690.1    KQ459606    KPI90995.1    ODYU01000883    SOQ36317.1    JTDY01001871    KOB72672.1    KY092435    ATP13230.1    PYGN01000157    PSN52577.1    JN859085    AFH53996.1    BK005862    DAA64499.1    AAAB01008898    EAA09118.4    EGK97178.1    JXJN01013906    CVRI01000052    CRK99666.1    KZ150045    PZC74512.1    CRK99667.1    NEVH01025635    PNF15381.1    CH963925    EDW78267.2    AY150862    AY150863    AY150864    AE014298    BT015236    AAN15955.1    CH933810    KRF94097.1    EDW07541.2    KRF94098.1    JRES01001467    KNC22659.1    CH954180    KQS30116.1    EDV46771.2    CM000162    EDX02063.1    DS235271    EEB14185.1    KRK06541.1    KRK06542.1    CP012528    ALC48467.1    CH940651    EDW65853.2    CH916371    EDV91915.1    GGMS01000708    MBY69911.1    KPJ15688.1    CH379064    EAL32007.2    CH479192    EDW26545.1    AGBW02008468    OWR53273.1    KRT06763.1    KRT06761.1    GGMR01002021    MBY14640.1    OUUW01000003    SPP78515.1    GFXV01004311    MBW16116.1    KRF94096.1    KQS30117.1    KQS30115.1    KRK06540.1    KRK06543.1    EGK97179.1    KP789372    AKN44277.1    KQ434804    KZC06028.1    GL452255    EFN77687.1    KRT06762.1    KRT06764.1    KZ288193    PBC34096.1    KRF98842.1    QOIP01000007    RLU20048.1    KC814692    AGO81727.1    KPI90991.1    AXCM01000165    AY921573    AAX62923.1    KRT06760.1    ADTU01009243    ADTU01009244    ADTU01009245    ADTU01009246    ADTU01009247    ADTU01009248    ADTU01009249    ADTU01009250    ADTU01009251    ADTU01009252    DS232449    EDS41903.1    BABH01035027    BABH01035028    BABH01035029    KK107152    EZA57112.1    KQ979776    KYN19166.1    KQ976556    KYM80783.1    KQ977532    KYN02106.1    GL888057    EGI68561.1    AAZX01002686    AAZX01002687    AAZX01005132    AAZX01005492    AAZX01005518    AAZX01010816    AAZX01011767    AAZX01011906    AAZX01013726    AAZX01025392    AXCN02000234    GL435087    EFN74016.1    KQ414618    KOC67869.1    KQ982723    KYQ51613.1    KU710378    AOG14374.1    AJWK01003701    AJWK01003702    AJWK01003703    AJWK01003704    DQ900655    ABI64137.1   

Proteomes

UP000005204    UP000283053    UP000053240    UP000053268    UP000037510    UP000245037    + More
UP000007062    UP000092460    UP000183832    UP000235965    UP000091820    UP000007798    UP000000803    UP000009192    UP000037069    UP000008711    UP000002282    UP000009046    UP000092553    UP000008792    UP000095300    UP000001070    UP000001819    UP000008744    UP000007151    UP000192221    UP000268350    UP000076502    UP000095301    UP000008237    UP000242457    UP000069272    UP000279307    UP000076408    UP000075883    UP000075900    UP000075920    UP000075884    UP000075880    UP000005203    UP000005205    UP000002320    UP000053097    UP000078492    UP000078540    UP000078542    UP000007755    UP000002358    UP000075886    UP000000311    UP000053825    UP000075809    UP000092461   

PRIDE

H9JFH5    Q8IS44    H9JFH6   

Pfam

PF00001   7tm_1

Interpro

IPR017452   GPCR_Rhodpsn_7TM        + More
IPR001671   Melcrt_ACTH_rcpt       
IPR000276   GPCR_Rhodpsn       
IPR000929   Dopamine_rcpt       

ProteinModelPortal

H9JFH5   A0A2D1QSG0   A0A0K0QWN5   A0A2W1BMS8   A0A3S2LY29   A0A0N1IH03   + More
A0A194PIS7   A0A2H1V676   A0A0L7LB25   A0A2D1QSC3   A0A2P8Z7W0   M4GWU0   D1ZZA0   Q7QA35   F5HLP6   A0A1B0BGM8   A0A1J1IIS0   A0A2W1BHI5   A0A1J1IHH0   A0A2J7PGC7   A0A1A9WVF9   B4N1M8   Q8IS44-4   A0A0Q9WMR4   B4L4R3   A0A0Q9WMR1   A0A0L0BTW0   A0A0Q5TIW7   B3NWF1   B4PYY5   E0VLC9   A0A0R1EB29   A0A0M4EXI5   B4M2E9   A0A1I8PCW6   B4JMH2   A0A2S2PWR8   A0A0N1IPR0   Q29GV2   B4GV08   A0A212FHQ4   A0A1W4UDE8   A0A0R3P0F3   A0A0R3P0S7   A0A2S2NBT0   A0A1W4USE0   A0A1W4UDX1   Q8IS44-5   Q8IS44-6   A0A3B0J9C7   Q8IS44   A0A2H8TPN4   A0A0Q9WYJ8   A0A0Q5TEU2   A0A0Q5T436   A0A0R1EAQ9   A0A0R1EBE0   F5HLP5   A0A0H4ADE4   A0A1W4UQM0   A0A154P477   A0A1I8NBH5   E2C2Y3   A0A1I8PD55   A0A0R3P0L5   A0A0R3P0T9   A0A2A3ESA7   A0A0Q9WRL4   A0A182F9I3   A0A3L8DJL8   A0A182Y8W6   S4VNA9   A0A194PCI3   A0A182MT40   A0A182RT33   A0A182W3C3   Q56JK9   A0A182HYJ9   A0A182NSH9   A0A182JDV9   A0A0R3P0H7   Q8IS44-2   A0A087ZUQ7   A0A158N9R8   B0X7F1   H9JFH6   A0A026WM41   A0A195E267   A0A195B8C3   A0A195CMY7   F4WB54   K7JAM3   A0A182QXL3   E1ZXP4   A0A0L7RAJ6   A0A151WUT5   A0A1B3P972   A0A1B0CAE3   Q09HM5  

PDB

5WIV     E-value=7.38051e-27,     Score=300

KEGG

101738739    K04145 dopamine receptor D2 | (RefSeq) dopamine D2-like receptor

PATHWAY

04080    Neuroactive ligand-receptor interaction - Bombyx mori (domestic silkworm)

GO

GO:0004977   GO:0016021   GO:0004930   GO:0007188   GO:0071880   GO:0004935   GO:0005887   GO:0001591   GO:0007615   GO:0007212   GO:0008227   GO:0007186   GO:0005886   GO:0004715   GO:0051536   GO:0016491   GO:0046872   GO:0051537   GO:0003824  

Subcellular location

Cell membrane  

Length:

469

Number of predicted TMHs:

4

Exp number of AAs in TMHs:

101.47016

Exp number, first 60 AAs:

6.67598

Total prob of N-in:

0.61568

inside

1  -  89

TMhelix

90  -  112

outside

113  -  131

TMhelix

132  -  154

inside

155  -  393

TMhelix

394  -  416

outside

417  -  430

TMhelix

431  -  453

inside

454  -  469

 

 

Pi

20.097473

Theta

163.750869

Tajima's D

0.149638

CLR

0.341461

CSRT

0.410929453527324

Interpretation

Uncertain