Gene

KWMTBOMO10702

Annotation

hypothetical_protein_KGM_03840_[Danaus_plexippus]

Location

Bomo_Chr18(+):892100-893524      View in EpiBrowser

Full name

Dopamine D2-like receptor      

Location in the cell

PlasmaMembrane   Reliability : 3.958

CDS

ATGACTCATCAGCCAAAAAATGTTTCAAACGTGAACACAGCTATGTTAAACACCACGGCTCCGTATGACCACGTTGTATATAACGCCTTGACTTACATACATCCATCAAAAAGACCACCAGATTTCAACGCGTCTCTCGTCCAGACACCAAAATCGAAGGACGATAATCTGACCAATGAAACAGGCGGGGATTTTTTGAGACTAGTCGAAGACTTCAGTGATTATTTTTACGGGAATTCAAGTCACGACCTATTCAATGAACGTAATGCAACACTAAATGTTTTGAACGATATAAGTGAGTACACAAATTGCAGTTTCAATGGTACGTTCAATGTGTCCTGTTTCGGGAAACAAAACGACGAACCAGAATACAATCTGTGGGCCTTATTACTGTTGATATTCCCTTTTTTTACGTTGTTCGGTAATGTGCTGGTTATCATGAGTGTAGTCAAAGAAAGGACATTGCAGACTGTTACGAATTATTTCATCGTGAGCTTGGCGGTCGCGGACCTTCTCGTCGCGGTCGTCGTTATGCCGTTTGGAGTTTATTATTTGGTGAGTTTTTATTTTATTCTATTTATCTGTTTCCGTATCTGTACCGACAGTTAA

Protein

MTHQPKNVSNVNTAMLNTTAPYDHVVYNALTYIHPSKRPPDFNASLVQTPKSKDDNLTNETGGDFLRLVEDFSDYFYGNSSHDLFNERNATLNVLNDISEYTNCSFNGTFNVSCFGKQNDEPEYNLWALLLLIFPFFTLFGNVLVIMSVVKERTLQTVTNYFIVSLAVADLLVAVVVMPFGVYYLVSFYFILFICFRICTDS

Description

Receptor for dopamine. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase.

Similarity

Belongs to the G-protein coupled receptor 1 family.

Keywords

Alternative splicing   Cell membrane   Complete proteome   Disulfide bond   G-protein coupled receptor   Glycoprotein   Membrane   Receptor   Reference proteome   Transducer   Transmembrane   Transmembrane helix  

Feature

chain  Dopamine D2-like receptor
splice variant  In isoform B.

Uniprot

A0A0K0QWN5   A0A2W1BG48   A0A2H1VTU2   A0A194PDA9   A0A0L7LDZ1   A0A1B0CAE3   + More
A0A1B0FK81   A0A182MMZ2   A0A0L0BTW0   A0A182QQY6   A0A182IW26   A0A139WJF6   Q8IS44-5   Q8IS44-2   Q8IS44-6   Q8IS44   Q8IS44-3   A0A0R1EAQ9   A0A0R1EBE0   A0A1B3P5V0   B4PYY5   A0A212FHQ4   B3NWF1   A0A0Q5TEU2   A0A0Q5T436   A0A0Q5TIW7   A0A0R1EB29   B4I7D7   K7JAM3   A0A232EZB4   B3MQK3   D1ZZA0  

Pubmed

26179416    28756777    26354079    26227816    26108605    18362917    + More
19820115    10731132    12537572    12391323    17994087    17550304    22118469    20075255    28648823    18054377    18025266    18316733    20068045    21843505    23604020   

EMBL

KP784319    AKR18180.1    KZ150165    PZC72654.1    ODYU01004411    SOQ44255.1    + More
KQ459606    KPI90993.1    JTDY01001537    KOB73620.1    AJWK01003701    AJWK01003702    AJWK01003703    AJWK01003704    CCAG010008096    AXCM01000147    JRES01001467    KNC22659.1    AXCN02000234    KQ971338    KYB27915.1    AY150862    AY150863    AY150864    AE014298    BT015236    AAN15955.1    CM000162    KRK06540.1    KRK06543.1    KU712058    AOG12988.1    EDX02063.1    AGBW02008468    OWR53273.1    CH954180    EDV46771.2    KQS30117.1    KQS30115.1    KQS30116.1    KRK06541.1    KRK06542.1    CH480823    EDW56235.1    AAZX01002686    AAZX01002687    AAZX01005132    AAZX01005492    AAZX01005518    AAZX01010816    AAZX01011767    AAZX01011906    AAZX01013726    AAZX01025392    NNAY01001505    OXU23764.1    CH902621    EDV44629.2    BK005862    DAA64499.1   

Proteomes

UP000053268    UP000037510    UP000092461    UP000092444    UP000075883    UP000037069    + More
UP000075886    UP000075880    UP000007266    UP000000803    UP000002282    UP000007151    UP000008711    UP000001292    UP000002358    UP000215335    UP000007801   

PRIDE

Q8IS44   

Pfam

PF00001   7tm_1

Interpro

IPR017452   GPCR_Rhodpsn_7TM        + More
IPR000276   GPCR_Rhodpsn       

ProteinModelPortal

A0A0K0QWN5   A0A2W1BG48   A0A2H1VTU2   A0A194PDA9   A0A0L7LDZ1   A0A1B0CAE3   + More
A0A1B0FK81   A0A182MMZ2   A0A0L0BTW0   A0A182QQY6   A0A182IW26   A0A139WJF6   Q8IS44-5   Q8IS44-2   Q8IS44-6   Q8IS44   Q8IS44-3   A0A0R1EAQ9   A0A0R1EBE0   A0A1B3P5V0   B4PYY5   A0A212FHQ4   B3NWF1   A0A0Q5TEU2   A0A0Q5T436   A0A0Q5TIW7   A0A0R1EB29   B4I7D7   K7JAM3   A0A232EZB4   B3MQK3   D1ZZA0  

PDB

3PBL     E-value=0.00472779,     Score=90

KEGG

809258    K03883 NADH-ubiquinone oxidoreductase chain 5 [EC:7.1.1.2] | (RefSeq) ND5; NADH dehydrogenase subuni

PATHWAY

00190    Oxidative phosphorylation - Bombyx mori (domestic silkworm)
01100    Metabolic pathways - Bombyx mori (domestic silkworm)

GO

GO:0016021   GO:0004930   GO:0071880   GO:0005887   GO:0007188   GO:0004935   GO:0007212   GO:0005886   GO:0001591   GO:0008227   GO:0007615   GO:0007186   GO:0009055   GO:0051536   GO:0016491   GO:0046872   GO:0051537   GO:0003824  

Subcellular location

Cell membrane  

Length:

202

Number of predicted TMHs:

2

Exp number of AAs in TMHs:

51.31779

Exp number, first 60 AAs:

0.1903

Total prob of N-in:

0.75257

inside

1  -  126

TMhelix

127  -  149

outside

150  -  170

TMhelix

171  -  193

inside

194  -  202

 

 

Pi

217.764078

Theta

178.015249

Tajima's D

0.753219

CLR

0.350868

CSRT

0.587370631468427

Interpretation

Uncertain