Gene

KWMTBOMO10635  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA003933

Annotation

PREDICTED:_uncharacterized_protein_LOC101746000_isoform_X1_[Bombyx_mori]

Location

Bomo_Chr17(-):16650354-16678685      View in EpiBrowser

Full name

Fatty acyl-CoA reductase      

Location in the cell

Cytoplasmic   Reliability : 2.389

CDS

ATGGCTTCAGATACTTCAACTGTTGTTGAACTCTACATTTATGATCTGACACATGGGGTGGCTTCCTTATTGGCACCTACTATCATTGGCCGCGACGTGGAAGGCATATGGCACACAGCCATCGTGGCGTACGACAGGGAGTTCTTCTACGGGGCCAATGGCATCACCAGTTGCACTCCGGGCACCACGCAGCTGGGCCCGCCGCACCGCGTGCAGCGTCTGGGGGAGACCTTTGTGCCATTCGCAGTGTTCGTAGAATATCTGCAGGGACTAGCCGGATCCACTTATTTACCGTCGCAGTACAACCTGCTGGAGCACAACTGCAACCACTTCTCGGACGAGGTGGCGGAGTTCCTGTGCGACGCGCGCGTGCCCAAGGACATCCTGCAGCAGCCCGAGGAGTTGCTGGCGCCGCAGCAGCGCGACGTGCTGCACGCGCTGCTGGCCGACCTGCTGCCGCGCTCCGGGGACGCGCCGCAGAGCCTGTACTCGAGCGGGGCGCGGGCGGCGCGCCAGGACAGCCCCGACTACCTCACGCTCAACAGCCAGATAGAGCAGGCCAGGATACAATCTCAAGAGCTGGAACAACGCCGCAGTACGCTCGCGGAGAAGCTGGCGCGGAAGGAACGGAAGAAGCAGAAGAAGAGGAAGAAACAAATCCGGGAGAGGGGGGAAGCCGATGGAGAGGAGATAGATTCCGACATGGCAGAAGCAGTAGAAGTTCCACTAGCTCATGAAGAATTGTCTCGCGCTGGACCCAGCTCGGAGGCCCTAGAGCTGGAGGCAGATGAAAGGAGACAGGAGGAACAACGCAAGAGGGAGAGAGAGCCGCCGATTGTGTTTAGAGATATAGACCCGATAGCGGAGTTCGAGAAGTTGGCGGACGCTCTGGAAGGCGTGGAGATGTCAGCCGAGGAGCGGCAGAGCCTGGACGAGCTGCAGCAGTACCTGGTGCAGGGGGAGGGGAGCTGGGTGCTGGGGGACGATTTCTTGGAGTTCATGGGCGGGCTGCTGGGGGCGGAGCGCGAGGCGGTGCGCGCGGCGGCGGGCGGGTGCCTGGCGGCGGCGGCGCTGCGGGACGACGTGGCGCTGCTGCTGCACCAGGACCGGCGCCAGCACGCGCTGCTGCAGCACGCGCACCGCATCGACGCGCTCTCGCTGCCCGACCAGCGCGCCATCGCCACCTTCCTGTGCAACCTGTTCGAGCACGTGTCGTCCTCGGAGTGGCTGCTGTACATCAGCGAGTGGGAGGCGGGCGGCCAGCAGCTGTCCAACATCAGGGTCACCACCAAGGTGTGCGTGCACGCGGTGCTGAGCGAGGACGCGGCGCTGCGCGCGGTGGGCACGGCGCTCATGCACAACATCTCCACCAAGGAGCGCTTCATGGTGGGCAGGGCGCTCCGGGAGCTGCTGCCCAAGCGCGCCAAGTCCAAGGTACTGACAGTAACACAACAGCTTGATGTCGTTTTACTAACCATCGCAAATCATTTGTCGGCCCGAGTGTTCGATGAGGTGTGCGTGGAGCTGGCGATGGCGCTGCTGCAGGTGCTGTCGTGCGCGCCGGCCGAGGAGGACCTGTACCGCGCGTGCGGCGCCCTGGCCCGCCTGGCCGCGCGCTGCGCCGACGTGCCGCCGCTGGTGGCGCTGGTGGGCCCGCACCCCGCCGCCTTCAGAGGCACGAGTCCCCGCGTCGACGAACAAATAGATCTGATCGTGAAGTACATCAAGTAG

Protein

MASDTSTVVELYIYDLTHGVASLLAPTIIGRDVEGIWHTAIVAYDREFFYGANGITSCTPGTTQLGPPHRVQRLGETFVPFAVFVEYLQGLAGSTYLPSQYNLLEHNCNHFSDEVAEFLCDARVPKDILQQPEELLAPQQRDVLHALLADLLPRSGDAPQSLYSSGARAARQDSPDYLTLNSQIEQARIQSQELEQRRSTLAEKLARKERKKQKKRKKQIRERGEADGEEIDSDMAEAVEVPLAHEELSRAGPSSEALELEADERRQEEQRKREREPPIVFRDIDPIAEFEKLADALEGVEMSAEERQSLDELQQYLVQGEGSWVLGDDFLEFMGGLLGAEREAVRAAAGGCLAAAALRDDVALLLHQDRRQHALLQHAHRIDALSLPDQRAIATFLCNLFEHVSSSEWLLYISEWEAGGQQLSNIRVTTKVCVHAVLSEDAALRAVGTALMHNISTKERFMVGRALRELLPKRAKSKVLTVTQQLDVVLLTIANHLSARVFDEVCVELAMALLQVLSCAPAEEDLYRACGALARLAARCADVPPLVALVGPHPAAFRGTSPRVDEQIDLIVKYIK

Description

Catalyzes the reduction of fatty acyl-CoA to fatty alcohols.

Catalytic Activity

a long-chain fatty acyl-CoA + 2 H(+) + 2 NADPH = a long-chain primary fatty alcohol + CoA + 2 NADP(+)

Similarity

Belongs to the fatty acyl-CoA reductase family.

Uniprot

A0A3S2TEX5   A0A212F921   A0A2W1BR70   A0A3L8DQH1   A0A2A3E1I6   A0A1L8E5S5   + More
A0A182GVB6   A0A1B0D6L9   E2ALF6   A0A336LVT3   A0A088ABN7   V5GPH0   A0A0M8ZWZ0   A0A232F1T8   Q16I44   A0A194R563   A0A0L7QWF5   A0A026VYD5   E9ICT4   N6STU0   A0A1Y1KMR9   A0A158NL42   A0A1B6CL26   U5ES88   A0A1Q3FYY8   A0A1Q3FZ19   A0A151X8D1   A0A1B6C7X8   A0A195CYI6   A0A1B6HXM6   K7IX00   A0A151IRX6   A0A1B6EE06   A0A0P4YLT7   A0A1B6ECD8   A0A0P5G587   A0A0P5BB81   A0A0P5P367   A0A0P5DJ23   A0A1B6IBC1   A0A0P5QC26   A0A195F558   A0A0P5EN05   E9GVF2   A0A0P5HNA1   A0A0N7ZMY9   A0A0P5RSL6   A0A0P4YVG0   A0A0P5DXM3   A0A1B6IA04   A0A1B6II04   A0A0P5S9D0   A0A0P4ZIM3   A0A0P5IHZ4   A0A0P5MSC1   A0A0P6EPA6   A0A0P5E362   A0A0P5RTZ3   A0A0P4YPW9   A0A0P5B189   A0A0N8C1X8   D6WVG7   A0A0P5ETC3   A0A0P5XQP8   A0A0P5ZRD4   A0A0P5ST23   A0A0P4WTK1   A0A0P5TSC7   A0A0P5HA01   A0A0P5NL77   V9IF97   A0A0P5KCQ8   A0A0P5U1J5   A0A0P5NLB5   A0A0P5WWE9   A0A0P5H5S6   A0A0P6GFJ6   A0A0P5NS44   F4WXE4   A0A0P4WY52   A0A0P5ELF1   A0A154P5U0   A0A139WDU8   A0A0P6CVL1   A0A0N8AVC8   A0A0P5ZIQ2   A0A0P5KQC8   A0A0P5DHG5   A0A0P5ESQ0   A0A0P5ZGZ7   A0A1J1HWI9   A0A0P5EM40   A0A0P5SQY8   A0A0P5ZRB5   A0A0P5HMP7   A0A0P5SC46  

EC Number

1.2.1.84

Pubmed

22118469    28756777    30249741    26483478    20798317    28648823    + More
17510324    26354079    24508170    21282665    23537049    28004739    21347285    20075255    21292972    18362917    19820115    21719571   

EMBL

RSAL01000214    RVE44150.1    AGBW02009651    OWR50246.1    KZ149989    PZC75637.1    + More
QOIP01000005    RLU22502.1    KZ288452    PBC25560.1    GFDF01000021    JAV14063.1    JXUM01090719    JXUM01090720    JXUM01090721    JXUM01090722    KQ563860    KXJ73154.1    AJVK01012082    AJVK01012083    AJVK01012084    GL440607    EFN65714.1    UFQT01000234    SSX22162.1    GALX01002457    JAB66009.1    KQ435812    KOX72805.1    NNAY01001284    OXU24493.1    CH478110    EAT33931.1    KQ460779    KPJ12380.1    KQ414716    KOC62896.1    KK107570    EZA48777.1    GL762354    EFZ21637.1    APGK01056613    APGK01056614    APGK01056615    KB741277    KB631611    ENN71084.1    ERL84655.1    GEZM01083907    JAV60955.1    ADTU01002138    GEDC01023129    JAS14169.1    GANO01003355    JAB56516.1    GFDL01002274    JAV32771.1    GFDL01002275    JAV32770.1    KQ982431    KYQ56538.1    GEDC01027879    JAS09419.1    KQ977110    KYN05701.1    GECU01028311    JAS79395.1    AAZX01000597    AAZX01007293    KQ981102    KYN09475.1    GEDC01001178    JAS36120.1    GDIP01225480    JAI97921.1    GEDC01001692    JAS35606.1    GDIP01150887    GDIQ01246098    GDIQ01096236    GDIQ01068655    JAJ72515.1    JAK05627.1    GDIP01191223    JAJ32179.1    GDIQ01140729    JAL10997.1    GDIP01156696    JAJ66706.1    GECU01023498    JAS84208.1    GDIQ01122837    JAL28889.1    KQ981805    KYN35593.1    GDIQ01267750    JAJ83974.1    GL732568    EFX76406.1    GDIQ01230942    JAK20783.1    GDIP01229625    JAI93776.1    GDIQ01097898    JAL53828.1    GDIP01223074    JAJ00328.1    GDIP01154134    JAJ69268.1    GECU01023959    GECU01021776    JAS83747.1    JAS85930.1    GECU01021173    JAS86533.1    GDIP01142750    JAL60964.1    GDIP01225477    JAI97924.1    GDIQ01216103    JAK35622.1    GDIQ01151921    JAK99804.1    GDIQ01061007    GDIQ01061006    JAN33731.1    GDIP01152287    JAJ71115.1    GDIQ01268690    GDIQ01246097    GDIQ01246096    GDIQ01176848    GDIQ01096232    GDIP01135690    GDIP01106790    JAL55494.1    JAL68024.1    GDIP01225478    JAI97923.1    GDIP01191221    JAJ32181.1    GDIQ01122835    JAL28891.1    KQ971357    EFA08564.2    GDIQ01267748    GDIQ01267747    JAJ83976.1    GDIP01081051    JAM22664.1    GDIP01039354    JAM64361.1    GDIP01135691    GDIQ01065759    JAL68023.1    JAN28978.1    GDIP01251766    JAI71635.1    GDIP01122684    JAL81030.1    GDIQ01230941    JAK20784.1    GDIQ01140728    JAL10998.1    JR040125    JR040126    AEY58988.1    AEY58989.1    GDIQ01192505    JAK59220.1    GDIP01121032    JAL82682.1    GDIQ01140730    JAL10996.1    GDIP01081052    JAM22663.1    GDIQ01230940    JAK20785.1    GDIQ01033917    JAN60820.1    GDIQ01138582    JAL13144.1    GL888424    EGI61110.1    GDIP01251767    JAI71634.1    GDIQ01267749    JAJ83975.1    KQ434823    KZC07237.1    KYB26148.1    GDIQ01089635    JAN05102.1    GDIQ01239235    JAK12490.1    GDIP01042994    JAM60721.1    GDIQ01206462    JAK45263.1    GDIP01161838    JAJ61564.1    GDIP01155690    JAJ67712.1    GDIP01043852    JAM59863.1    CVRI01000028    CRK92432.1    GDIQ01267456    JAJ84268.1    GDIP01141693    JAL62021.1    GDIP01040260    JAM63455.1    GDIQ01224796    JAK26929.1    GDIP01141694    JAL62020.1   

Proteomes

UP000283053    UP000007151    UP000279307    UP000242457    UP000069940    UP000249989    + More
UP000092462    UP000000311    UP000005203    UP000053105    UP000215335    UP000008820    UP000053240    UP000053825    UP000053097    UP000019118    UP000030742    UP000005205    UP000075809    UP000078542    UP000002358    UP000078492    UP000078541    UP000000305    UP000007266    UP000007755    UP000076502    UP000183832   

Pfam

PF05903   Peptidase_C97        + More
PF00916   Sulfate_transp
PF01740   STAS
PF07993   NAD_binding_4
PF03015   Sterile

Interpro

IPR008580   PPPDE_dom        + More
IPR042266   PPPDE_sf       
IPR016024   ARM-type_fold       
IPR001902   SLC26A/SulP_fam       
IPR018045   S04_transporter_CS       
IPR002645   STAS_dom       
IPR011547   SLC26A/SulP_dom       
IPR036513   STAS_dom_sf       
IPR013535   PUL_dom       
IPR033640   FAR_C       
IPR036291   NAD(P)-bd_dom_sf       
IPR013120   Male_sterile_NAD-bd       
IPR026055   FAR       

SUPFAM

SSF48371   SSF48371        + More
SSF52091   SSF52091       
SSF51735   SSF51735       

Gene 3D

3.90.1720.30     3.30.750.24    

CDD

cd09071  FAR_C

ProteinModelPortal

A0A3S2TEX5   A0A212F921   A0A2W1BR70   A0A3L8DQH1   A0A2A3E1I6   A0A1L8E5S5   + More
A0A182GVB6   A0A1B0D6L9   E2ALF6   A0A336LVT3   A0A088ABN7   V5GPH0   A0A0M8ZWZ0   A0A232F1T8   Q16I44   A0A194R563   A0A0L7QWF5   A0A026VYD5   E9ICT4   N6STU0   A0A1Y1KMR9   A0A158NL42   A0A1B6CL26   U5ES88   A0A1Q3FYY8   A0A1Q3FZ19   A0A151X8D1   A0A1B6C7X8   A0A195CYI6   A0A1B6HXM6   K7IX00   A0A151IRX6   A0A1B6EE06   A0A0P4YLT7   A0A1B6ECD8   A0A0P5G587   A0A0P5BB81   A0A0P5P367   A0A0P5DJ23   A0A1B6IBC1   A0A0P5QC26   A0A195F558   A0A0P5EN05   E9GVF2   A0A0P5HNA1   A0A0N7ZMY9   A0A0P5RSL6   A0A0P4YVG0   A0A0P5DXM3   A0A1B6IA04   A0A1B6II04   A0A0P5S9D0   A0A0P4ZIM3   A0A0P5IHZ4   A0A0P5MSC1   A0A0P6EPA6   A0A0P5E362   A0A0P5RTZ3   A0A0P4YPW9   A0A0P5B189   A0A0N8C1X8   D6WVG7   A0A0P5ETC3   A0A0P5XQP8   A0A0P5ZRD4   A0A0P5ST23   A0A0P4WTK1   A0A0P5TSC7   A0A0P5HA01   A0A0P5NL77   V9IF97   A0A0P5KCQ8   A0A0P5U1J5   A0A0P5NLB5   A0A0P5WWE9   A0A0P5H5S6   A0A0P6GFJ6   A0A0P5NS44   F4WXE4   A0A0P4WY52   A0A0P5ELF1   A0A154P5U0   A0A139WDU8   A0A0P6CVL1   A0A0N8AVC8   A0A0P5ZIQ2   A0A0P5KQC8   A0A0P5DHG5   A0A0P5ESQ0   A0A0P5ZGZ7   A0A1J1HWI9   A0A0P5EM40   A0A0P5SQY8   A0A0P5ZRB5   A0A0P5HMP7   A0A0P5SC46  

PDB

2WP7     E-value=2.43285e-32,     Score=349

KEGG

101746000    K22762 desumoylating isopeptidase 1 [EC:3.4.-.-] | (RefSeq) uncharacterized LOC101746000

GO

GO:0016021   GO:0008271   GO:0102965   GO:0006629  

PANTHER

PTHR12378   PTHR11814   PTHR11011  

Length:

576

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

1.21331

Exp number, first 60 AAs:

1.13761

Total prob of N-in:

0.05614

outside

1  -  576

 

 

Pi

243.433533

Theta

176.271492

Tajima's D

-0.947399

CLR

12.043354

CSRT

0.149492525373731

Interpretation

Uncertain