Gene

KWMTBOMO10597

Pre Gene Modal

BGIBMGA003909

Annotation

PREDICTED:_deoxynucleoside_kinase-like_isoform_X1_[Papilio_polytes]

Location

Bomo_Chr17(-):14967958-14970966      View in EpiBrowser

Full name

Deoxynucleoside kinase      

Alternative Name

Deoxyribonucleoside kinase
Multispecific deoxynucleoside kinase

Location in the cell

Nuclear   Reliability : 2.774

CDS

ATGAACACTATTAGCAAGACAGCTCGTATCGTACGCAAAAGACCTTTTAGAGTGTCAATTGAAGGAAACATAGGATCTGGAAAATCAACATGTATAAAATTCTTCAACAAGTTTCATAATGTTGAACACCATACTGAGCCTCTACATGAATGGAGAGATGTTAGTGGCCACAACTTACTTAGCCTAATGTACAGTGATCAGAAGAAATGGATCTTTACATTCCAGCACTATGTACATCTGAGTCGGCTTAAAATTCAAACAAGCCATCCTTGTAATTCTAATATAACAGTTAAAATGTTTGAAAGATCAGTTCAAAACAGTAGATATTGTTTTGTCGAGAATGCTAGAAGGCAAAACTTTTTAGAGGACCCTGAATATCAAACATTATTAGCTTGGTATGACTACACTGAGAAGTGCCTCGATACTAGCCTAGACCTAATTGTATACTTGAAGACATCGCCACAAGTAGTGTGGGAGCGTGTAATGAGACGAGGCAGAGCTGAAGAATCTGAAGTTCCTTTAGAATACTTACAACAGGTTCACGACTCTTATGAGTCATGGTTGAATTCCGAAGTTGGCTGTGAAGTTCTGACGATAGACGCTGATAGACCTCTAGATCTAGTCAAAGAAGACTTAGATCGATACACATACAAAATACTGGGTGGAAATCATACAAATTAA

Protein

MNTISKTARIVRKRPFRVSIEGNIGSGKSTCIKFFNKFHNVEHHTEPLHEWRDVSGHNLLSLMYSDQKKWIFTFQHYVHLSRLKIQTSHPCNSNITVKMFERSVQNSRYCFVENARRQNFLEDPEYQTLLAWYDYTEKCLDTSLDLIVYLKTSPQVVWERVMRRGRAEESEVPLEYLQQVHDSYESWLNSEVGCEVLTIDADRPLDLVKEDLDRYTYKILGGNHTN

Description

Deoxyribonucleoside kinase that has a broad specificity phosphorylating thymidine, 2'-deoxyriboadenosine, 2'-deoxyribocytidine and 2'-deoxyriboguanosine. Specificity is higher for pyrimidine nucleosides. Several anti-viral and anti-cancer nucleoside analogs are also efficiently phosphorylated.

Catalytic Activity

a 2'-deoxyribonucleoside + ATP = a 2'-deoxyribonucleoside 5'-phosphate + ADP + H(+)

Biophysicochemical Properties

0.9 uM for thymidine
1 uM for deoxycytidine
109 uM for deoxyadenosine
654 uM for deoxyguanosine

Subunit

Monomer.

Similarity

Belongs to the DCK/DGK family.

Keywords

3D-structure   ATP-binding   Complete proteome   DNA synthesis   Kinase   Nucleotide-binding   Phosphoprotein   Reference proteome   Transferase  

Feature

chain  Deoxynucleoside kinase

Uniprot

H9J322   A0A2A4ITE5   A0A2H1VC47   S4PFE5   A0A212EL64   A0A1E1W7J3   + More
A0A2Z5U7S6   A0A3S2LQK8   A0A194PIL6   D6WVH3   A0A1Y1N2X5   A0A0T6B011   E0VRZ9   A0A1B6CFZ0   A0A1B6LK22   C4WUU6   A0A1B6EMJ0   A0A2S2R2U8   A0A1B6HCD5   A0A2H8TMN3   A0A0P5Z716   E9GT29   A0A0P6AJ77   A0A0P6C935   A0A0N8BE23   A0A3R7QGM9   A0A2J7QN86   A0A067QVF5   A0A0P5KNG9   B3MSS5   A0A2P2I8W1   A0A0P5KPE6   A0A0P4YTY2   Q540Z9   Q9XZT6   A0A1D2NEM5   B4QTW8   B4IME5   A0A0P4W058   A0A3B0KC97   A0A3B0K3U4   A0A3B0K976   A0A0P4VV16   A0A0P4W3N5   B3P388   A0A0P6CQQ9   E2BVS6   B4PMQ1   A0A195EZI7   A0A1W4UN77   A0A2P8YKW4   B4N8I2   A0A151WJF6   A0A034WFX4   A0A3R7PNS3   A0A034WL34   A0A195EGL4   A0A151IAQ9   A0A1A9WMC8   A0A195B780   A0A158NT48   A0A212ERF0   F4WG76   B4JV40   A0A0K8U7P9   A0A1I8M992   A0A0K8V759   A0A1I8M996   S4PCU4   A0A139WLL6   Q298E1   A0A0R3NM75   A0A0P5J011   B4G3N4   A0A1A9W713   A0A151N750   E9G7L8   A0A194QV82   E9IN12   A0A1I8PES5   A0A2A4J006   A0A2H1V7L8   A0A2A4IZE2   H9IZN6   Q9BKL3   A0A0P6CW53   A0A194Q3Z2   A0A0P6AB70   A0A0P4WIK3   A0A1B0AGW7   W8C7H4   R7TZV8   A0A0P5FVB2   W8BZ45   A0A3Q0H4J1   A0A1W4X2M2  

EC Number

2.7.1.145

Pubmed

19121390    23622113    22118469    26354079    18362917    19820115    + More
28004739    20566863    21292972    24845553    17994087    10731132    12537568    12537572    12537573    12537574    16110336    17569856    17569867    26109357    26109356    10446143    10692477    9461577    17372656    18327897    12741827    16008571    18384378    27289101    20798317    17550304    29403074    25348373    21347285    21719571    25315136    15632085    22293439    21282665    24495485    23254933   

EMBL

BABH01037666    NWSH01008167    PCG62668.1    ODYU01001747    SOQ38371.1    GAIX01004047    + More
JAA88513.1    AGBW02014131    OWR42222.1    GDQN01008094    JAT82960.1    AP017481    BBB06731.1    RSAL01000439    RVE41703.1    KQ459603    KPI93162.1    KQ971357    EFA08299.2    GEZM01014102    JAV92199.1    LJIG01016424    KRT80642.1    DS235639    EEB16155.1    GEDC01024892    GEDC01022487    JAS12406.1    JAS14811.1    GEBQ01015925    JAT24052.1    ABLF02022763    ABLF02022764    ABLF02048558    AK341227    BAH71666.1    GECZ01030619    JAS39150.1    GGMS01015116    MBY84319.1    GECU01035434    JAS72272.1    GFXV01003611    MBW15416.1    GDIQ01254152    GDIP01049473    GDIQ01054927    JAJ97572.1    JAM54242.1    GL732563    EFX77346.1    GDIP01041974    JAM61741.1    GDIP01011272    JAM92443.1    GDIQ01186875    JAK64850.1    QCYY01002886    ROT66787.1    NEVH01013198    PNF30046.1    KK852971    KDR13090.1    GDIQ01182831    JAK68894.1    CH902623    EDV30315.2    IACF01004751    LAB70340.1    GDIQ01181522    JAK70203.1    GDIP01223747    JAI99654.1    AY102689    AE014297    AAM27518.1    AGB96102.1    AF045610    AF185268    Y18048    LJIJ01000069    ODN03555.1    CM000364    EDX12391.1    CH480980    EDW45841.1    GDRN01094801    JAI59667.1    OUUW01000007    SPP82631.1    SPP82630.1    SPP82629.1    GDRN01094800    JAI59668.1    GDRN01094799    JAI59669.1    CH954181    EDV48540.1    GDIQ01088512    JAN06225.1    GL450957    EFN80204.1    CM000160    EDW95971.2    KQ981897    KYN33715.1    PYGN01000524    PSN44844.1    CH964232    EDW81433.2    KQ983039    KYQ47947.1    GAKP01004466    JAC54486.1    QCYY01001460    ROT77900.1    GAKP01004464    JAC54488.1    KQ978957    KYN27029.1    KQ978192    KYM96528.1    KQ976579    KYM80054.1    ADTU01025539    AGBW02013039    OWR44057.1    GL888128    EGI66843.1    CH916374    EDV91360.1    GDHF01029701    GDHF01012326    GDHF01001672    JAI22613.1    JAI39988.1    JAI50642.1    GDHF01017721    JAI34593.1    GAIX01003966    JAA88594.1    KQ971319    KYB28840.1    CM000070    EAL28014.2    KRT00381.1    GDIQ01207356    JAK44369.1    CH479179    EDW24355.1    AKHW03003905    KYO32653.1    GL732534    EFX84624.1    KQ461103    KPJ09443.1    GL764272    EFZ18039.1    NWSH01004519    PCG65008.1    ODYU01001093    SOQ36843.1    PCG65009.1    BABH01014537    BABH01014538    AF226281    AAK28318.1    GDIP01187454    GDIQ01086713    GDIQ01086712    LRGB01002076    JAJ35948.1    JAN08025.1    KZS09325.1    KQ459465    KPJ00262.1    GDIP01032066    JAM71649.1    GDRN01056404    JAI65828.1    GAMC01008001    JAB98554.1    AMQN01011293    KB308811    ELT96475.1    GDIP01143109    JAJ80293.1    GAMC01007999    JAB98556.1   

Proteomes

UP000005204    UP000218220    UP000007151    UP000283053    UP000053268    UP000007266    + More
UP000009046    UP000007819    UP000000305    UP000283509    UP000235965    UP000027135    UP000007801    UP000000803    UP000094527    UP000000304    UP000001292    UP000268350    UP000008711    UP000008237    UP000002282    UP000078541    UP000192221    UP000245037    UP000007798    UP000075809    UP000078492    UP000078542    UP000091820    UP000078540    UP000005205    UP000007755    UP000001070    UP000095301    UP000001819    UP000008744    UP000050525    UP000053240    UP000095300    UP000076858    UP000092445    UP000014760    UP000189705    UP000192223   

PRIDE

H9J322    Q540Z9    Q9XZT6    H9IZN6    Q9BKL3   

Pfam

PF01712   dNK

Interpro

IPR002624   DCK/DGK        + More
IPR027417   P-loop_NTPase       
IPR031314   DNK_dom       

SUPFAM

SSF52540   SSF52540       

CDD

cd01673  dNK

ProteinModelPortal

H9J322   A0A2A4ITE5   A0A2H1VC47   S4PFE5   A0A212EL64   A0A1E1W7J3   + More
A0A2Z5U7S6   A0A3S2LQK8   A0A194PIL6   D6WVH3   A0A1Y1N2X5   A0A0T6B011   E0VRZ9   A0A1B6CFZ0   A0A1B6LK22   C4WUU6   A0A1B6EMJ0   A0A2S2R2U8   A0A1B6HCD5   A0A2H8TMN3   A0A0P5Z716   E9GT29   A0A0P6AJ77   A0A0P6C935   A0A0N8BE23   A0A3R7QGM9   A0A2J7QN86   A0A067QVF5   A0A0P5KNG9   B3MSS5   A0A2P2I8W1   A0A0P5KPE6   A0A0P4YTY2   Q540Z9   Q9XZT6   A0A1D2NEM5   B4QTW8   B4IME5   A0A0P4W058   A0A3B0KC97   A0A3B0K3U4   A0A3B0K976   A0A0P4VV16   A0A0P4W3N5   B3P388   A0A0P6CQQ9   E2BVS6   B4PMQ1   A0A195EZI7   A0A1W4UN77   A0A2P8YKW4   B4N8I2   A0A151WJF6   A0A034WFX4   A0A3R7PNS3   A0A034WL34   A0A195EGL4   A0A151IAQ9   A0A1A9WMC8   A0A195B780   A0A158NT48   A0A212ERF0   F4WG76   B4JV40   A0A0K8U7P9   A0A1I8M992   A0A0K8V759   A0A1I8M996   S4PCU4   A0A139WLL6   Q298E1   A0A0R3NM75   A0A0P5J011   B4G3N4   A0A1A9W713   A0A151N750   E9G7L8   A0A194QV82   E9IN12   A0A1I8PES5   A0A2A4J006   A0A2H1V7L8   A0A2A4IZE2   H9IZN6   Q9BKL3   A0A0P6CW53   A0A194Q3Z2   A0A0P6AB70   A0A0P4WIK3   A0A1B0AGW7   W8C7H4   R7TZV8   A0A0P5FVB2   W8BZ45   A0A3Q0H4J1   A0A1W4X2M2  

PDB

2VP0     E-value=1.0523e-46,     Score=468

KEGG

101741300    K05961 deoxynucleoside kinase [EC:2.7.1.145] | (RefSeq) deoxynucleoside kinase-like

GO

GO:0019206   GO:0005524   GO:0019136   GO:0005739   GO:0005737   GO:0016301   GO:0006165   GO:0004797   GO:0046939   GO:0006230   GO:0071897   GO:0016310   GO:0006139   GO:0008270   GO:0000166   GO:0003906   GO:0005634   GO:0006285   GO:0019104   GO:0003824  

Length:

226

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.00031

Exp number, first 60 AAs:

0.00016

Total prob of N-in:

0.27945

outside

1  -  226

 

 

Pi

48.369155

Theta

70.114178

Tajima's D

-1.065402

CLR

4.767359

CSRT

0.127843607819609

Interpretation

Uncertain