Gene

KWMTBOMO10588

Pre Gene Modal

BGIBMGA003916

Annotation

PREDICTED:_hexosaminidase_D-like_[Papilio_xuthus]

Location

Bomo_Chr17(-):14817238-14825636      View in EpiBrowser

Full name

Hexosaminidase D      

Alternative Name

Beta-N-acetylhexosaminidase
Beta-hexosaminidase D
Hexosaminidase domain-containing protein
N-acetyl-beta-galactosaminidase

Location in the cell

Cytoplasmic   Reliability : 2.038

CDS

ATGCATAGAATAGTACATTTCGATTTGAAAGGAGCCCCATTAAAAGTTCAATATTTGGAACAGGTTATTATCCAAATTAAATCATGGGGAGCGACTGGTGTATTGTTCGAGTGGGAAGACACCTTCCCATATACTGGAGACTTGCAGATCGTTGGGAGCATAGCCAATGCTGGAGGAGATGGTCTTTACAGTATAGAGGAAACCAGACATCTCCTTGATTTTGCCAACCAAAATGGATTAGTTCCTATTCAGTTAGTTCAAACTATAGGGCACCTGGAATTTGTCTTAAAACATCCAGCATTTAGGAACTACCGAGAGACACAACGGTCACCAGCAGTTCTCTGTCCTAGCCAACCCCAATCTTTACAAATTGTGAAGGCTATGGTCAACCAGGCTTTAGATTTGCAACCAGATGCAAAATATTTTCATATTGGGGCTGATGAGGTATGGCATACAGGCGTATGTCGTGAATGTCAAGAGAGAGCGGCAAGGAGTGAGTACAGATTGTCTTCCCTATTTTTGGAGCACATACAACAATTAGTCTTATTCATTAAGCAGAAAAGACCAGAATTGACGGTTCTGATGTGGGATGACATGCTAAGGACGATACGTCTTGATACATTGTTGGCATACAAACTAGGTGAACTTGTGGAGCCCGTCATCTGGAATTACAGTGCAATGGAGTACTTTCAAATAGAGTCAGACTTGTGGAGTAATTATAAAAAATTGTTTCCAAAAGTCTGGGCTGGGTCTGCCTTCAAAGGAGCTAATGGCAGTTGTCAGATGTTATCCCCGGTGTGTCGCTACGTGAGCAACCATGAGGCCTGGAGGCGCGAGTTCAAGAAGTGTGGACCTAATATTAACTTCGCTGGAGTCATCCTGACTGGCTGGTCCAGATACGACCATTACGCTACGCTGTGCGAACTGTTGCCGGTGTCATTGCCAAGTCTGTCGAGCTGTCTGAAAGTGTTGGCCAAGAGTGACGATTCTCAGGAGGTGGGGTCGAGCGACGTATTGCCGACCGCGCAGTGGGCTGGCGAGCAGCTCGCGCGCTGCGTGCACTCCCTCGCCATCCTGCGGGAGAGAGCCTTCTCCTTCGTGCACGGAGAGCACGTGACGACCTGGATGAACCCGTGGCAGCTGGAGAGGAACTACACGAATCCGGCACACCTGGAAACTATAGCCCGGGACGCGGGAGTATTGCAGTCAGAGCTGAGTTCGTTGCAAGCGAACCTGGAGGTTCAATTGCCGAAGTTGACCGGCCCCAGGAGCACCGAGGAGTGGTTGGCCACGAACGTGACGCCGGCTCTGCGTCAAGTGGCCGACCTGCACCGCGTGGCCCACGAGAGGCTGAACGCGGCCGCCGGGATCTCGCCCCTACGAACACATAACGATGGATGA

Protein

MHRIVHFDLKGAPLKVQYLEQVIIQIKSWGATGVLFEWEDTFPYTGDLQIVGSIANAGGDGLYSIEETRHLLDFANQNGLVPIQLVQTIGHLEFVLKHPAFRNYRETQRSPAVLCPSQPQSLQIVKAMVNQALDLQPDAKYFHIGADEVWHTGVCRECQERAARSEYRLSSLFLEHIQQLVLFIKQKRPELTVLMWDDMLRTIRLDTLLAYKLGELVEPVIWNYSAMEYFQIESDLWSNYKKLFPKVWAGSAFKGANGSCQMLSPVCRYVSNHEAWRREFKKCGPNINFAGVILTGWSRYDHYATLCELLPVSLPSLSSCLKVLAKSDDSQEVGSSDVLPTAQWAGEQLARCVHSLAILRERAFSFVHGEHVTTWMNPWQLERNYTNPAHLETIARDAGVLQSELSSLQANLEVQLPKLTGPRSTEEWLATNVTPALRQVADLHRVAHERLNAAAGISPLRTHNDG

Description

Has hexosaminidase activity. Responsible for the cleavage of the monosaccharides N-acetylglucosamine (GlcNAc) and N-acetylgalactosamine (GalNAc) from cellular substrates. Has a preference for galactosaminide over glucosaminide substrates (PubMed:27149221).

Catalytic Activity

Hydrolysis of terminal non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides.

Biophysicochemical Properties

0.0721 mM for 4-nitrophenyl N-acetylgalactosamine (PNP-GalNAc)
0.607 mM for 4-nitrophenyl-N-acetylglucosamine (PNP-GlcNAc)
0.172 mM for 3-fluoro-4-nitrophenyl-N-acetylgalactosamine (3F4NP-GalNAc)
0.852 mM for 3-fluoro-4-nitrophenyl-N-acetylglucosamine (3F4NP-GlcNAc)

Subunit

Homodimer; disulfide-linked.

Similarity

Belongs to the peptidase C19 family.
Belongs to the glycosyl hydrolase 20 family.

Keywords

Alternative splicing   Complete proteome   Cytoplasm   Disulfide bond   Glycosidase   Hydrolase   Nucleus   Polymorphism   Reference proteome  

Feature

chain  Hexosaminidase D
splice variant  In isoform 2.
sequence variant  In dbSNP:rs4789773.

Uniprot

H9J329   A0A3S2L0D8   A0A2A4ITM8   A0A194PJD8   A0A212EL57   K7IYF2   + More
A0A2J7Q3Q1   A0A0L7REW7   A0A2A3E9G6   A0A0M8ZZP4   A0A088AMI8   E2BHH0   A0A067R0D7   A0A195CCQ3   A0A154P1M2   A0A026X0D9   A0A1B6MCN2   E2APY8   F4W885   A0A195DVJ5   A0A158NSQ5   A0A069DUB3   D6WYJ2   A0A310SGR5   A0A023EYS0   A0A1W4XGX1   A0A151X0E5   A0A1B6HZU4   A0A151HYJ7   A0A0V0G8J1   A0A0P4VTM3   T1HCW0   A0A1Y1MH70   A0A2P8Z2J8   A0A146KRY0   A0A0C5C9L0   A0A195EXN2   A0A1B6EYK3   T1J1S1   V3ZXT4   A0A210Q7V1   V5GYD2   A0A3S0ZCW9   A0A0C5CUF2   A0A1S3JE28   A0A3R7PX99   E0VEV0   A0A1B6ENS6   A0A2C9LG55   A0A2C9LFZ9   A0A0A9WZV3   A0A1B6LZF5   A0A224YZU4   A0A131XU34   A0A0A9X4K8   A0A0L8FNC7   A0A131YQM9   A0A1E1X8S4   C3Z7M8   V5HVB9   D6X2G1   A0A1B6CXU7   A0A2R5L624   R7TS87   A0A023F1A2   A0A0P4W6X7   A0A1B6EDX3   A0A1D2M6Q5   T1HKU8   A0A1D2M6L2   E9IYJ6   K7IR30   A0A195CXF3   A0A0K2TF20   A0A0P4W3B6   A0A0L7RBP0   A0A026VT35   A0A151JBD2   A0A3L8DDL5   A0A151WW14   Q8WVB3   A0A195FXL0   A0A232EXT9   A0A154PIG2   A0A195B199   E2CAA1   A0A158P0P9   A0A2P2I5C7   A0A2J7PI68   E9HPI8  

EC Number

3.2.1.52

Pubmed

19121390    26354079    22118469    20075255    20798317    24845553    + More
24508170    30249741    21719571    21347285    26334808    18362917    19820115    25474469    27129103    28004739    29403074    26823975    25224926    23254933    28812685    20566863    15562597    25401762    28797301    29652888    26830274    28503490    18563158    25765539    27289101    21282665    19040401    16625196    15489334    14702039    23099419    27149221    28648823    21292972   

EMBL

BABH01037648    BABH01037649    RSAL01000304    RVE42715.1    NWSH01007033    PCG63125.1    + More
KQ459603    KPI93153.1    AGBW02014130    OWR42230.1    NEVH01019065    PNF23214.1    KQ414608    KOC69373.1    KZ288313    PBC28360.1    KQ435791    KOX74395.1    GL448301    EFN84823.1    KK853134    KDR10871.1    KQ978023    KYM98001.1    KQ434796    KZC05722.1    KK107046    QOIP01000004    EZA61732.1    RLU24207.1    GEBQ01014567    GEBQ01006299    JAT25410.1    JAT33678.1    GL441643    EFN64505.1    GL887898    EGI69580.1    KQ980322    KYN16584.1    ADTU01025107    GBGD01001349    JAC87540.1    KQ971362    EFA08995.1    KQ767621    OAD53379.1    GBBI01004389    JAC14323.1    KQ982624    KYQ53691.1    GECU01027520    GECU01020208    GECU01008586    GECU01006451    JAS80186.1    JAS87498.1    JAS99120.1    JAT01256.1    KQ976723    KYM76671.1    GECL01001891    JAP04233.1    GDKW01000625    JAI55970.1    ACPB03000247    GEZM01036481    JAV82657.1    PYGN01000224    PSN50719.1    GDHC01019376    JAP99252.1    KM217128    AJO25053.1    KQ981948    KYN32639.1    GECZ01027026    GECZ01007686    JAS42743.1    JAS62083.1    JH431789    KB203251    ESO85796.1    NEDP02004686    OWF44769.1    GALX01003053    JAB65413.1    RQTK01000693    RUS76014.1    KM217127    AJO25052.1    QCYY01000245    ROT85581.1    DS235099    EEB11906.1    GECZ01030181    JAS39588.1    GBHO01031566    JAG12038.1    GEBQ01010963    JAT29014.1    GFPF01008358    MAA19504.1    GEFM01005257    GEGO01006382    JAP70539.1    JAR89022.1    GBHO01031569    JAG12035.1    KQ428717    KOF65930.1    GEDV01007659    JAP80898.1    GFAC01003501    JAT95687.1    GG666591    EEN51383.1    GANP01001989    JAB82479.1    KQ971372    EFA10268.1    GEDC01019225    JAS18073.1    GGLE01000774    MBY04900.1    AMQN01011291    KB308811    ELT96467.1    GBBI01003921    JAC14791.1    GDRN01068357    JAI64203.1    GEDC01001162    JAS36136.1    LJIJ01003398    ODM88604.1    ACPB03022066    ACPB03022067    ODM88603.1    GL767018    EFZ14358.1    KQ977141    KYN05336.1    HACA01007258    CDW24619.1    GDRN01092534    JAI60095.1    KQ414617    KOC68279.1    KK108837    EZA46621.1    KQ979203    KYN22265.1    QOIP01000010    RLU17989.1    KQ982691    KYQ52028.1    FM204887    AC132938    CH471099    BC018205    BC035561    AK074405    KQ981200    KYN45047.1    NNAY01001695    OXU23201.1    KQ434899    KZC10980.1    KQ976667    KYM78263.1    GL453952    EFN75150.1    ADTU01005711    IACF01003474    LAB69090.1    NEVH01025129    PNF16023.1    GL732707    EFX66336.1   

Proteomes

UP000005204    UP000283053    UP000218220    UP000053268    UP000007151    UP000002358    + More
UP000235965    UP000053825    UP000242457    UP000053105    UP000005203    UP000008237    UP000027135    UP000078542    UP000076502    UP000053097    UP000279307    UP000000311    UP000007755    UP000078492    UP000005205    UP000007266    UP000192223    UP000075809    UP000078540    UP000015103    UP000245037    UP000078541    UP000030746    UP000242188    UP000271974    UP000085678    UP000283509    UP000009046    UP000076420    UP000053454    UP000001554    UP000014760    UP000094527    UP000005640    UP000215335    UP000000305   

PRIDE

H9J329    Q8WVB3   

Pfam

PF00728   Glyco_hydro_20        + More
PF00443   UCH
PF03259   Robl_LC7

Interpro

IPR038901   HEXDC-like        + More
IPR015883   Glyco_hydro_20_cat       
IPR017853   Glycoside_hydrolase_SF       
IPR001394   Peptidase_C19_UCH       
IPR028889   USP_dom       
IPR018200   USP_CS       
IPR038765   Papain-like_cys_pep_sf       
IPR004942   Roadblock/LAMTOR2_dom       

SUPFAM

SSF51445   SSF51445        + More
SSF54001   SSF54001       

ProteinModelPortal

H9J329   A0A3S2L0D8   A0A2A4ITM8   A0A194PJD8   A0A212EL57   K7IYF2   + More
A0A2J7Q3Q1   A0A0L7REW7   A0A2A3E9G6   A0A0M8ZZP4   A0A088AMI8   E2BHH0   A0A067R0D7   A0A195CCQ3   A0A154P1M2   A0A026X0D9   A0A1B6MCN2   E2APY8   F4W885   A0A195DVJ5   A0A158NSQ5   A0A069DUB3   D6WYJ2   A0A310SGR5   A0A023EYS0   A0A1W4XGX1   A0A151X0E5   A0A1B6HZU4   A0A151HYJ7   A0A0V0G8J1   A0A0P4VTM3   T1HCW0   A0A1Y1MH70   A0A2P8Z2J8   A0A146KRY0   A0A0C5C9L0   A0A195EXN2   A0A1B6EYK3   T1J1S1   V3ZXT4   A0A210Q7V1   V5GYD2   A0A3S0ZCW9   A0A0C5CUF2   A0A1S3JE28   A0A3R7PX99   E0VEV0   A0A1B6ENS6   A0A2C9LG55   A0A2C9LFZ9   A0A0A9WZV3   A0A1B6LZF5   A0A224YZU4   A0A131XU34   A0A0A9X4K8   A0A0L8FNC7   A0A131YQM9   A0A1E1X8S4   C3Z7M8   V5HVB9   D6X2G1   A0A1B6CXU7   A0A2R5L624   R7TS87   A0A023F1A2   A0A0P4W6X7   A0A1B6EDX3   A0A1D2M6Q5   T1HKU8   A0A1D2M6L2   E9IYJ6   K7IR30   A0A195CXF3   A0A0K2TF20   A0A0P4W3B6   A0A0L7RBP0   A0A026VT35   A0A151JBD2   A0A3L8DDL5   A0A151WW14   Q8WVB3   A0A195FXL0   A0A232EXT9   A0A154PIG2   A0A195B199   E2CAA1   A0A158P0P9   A0A2P2I5C7   A0A2J7PI68   E9HPI8  

PDB

6EZS     E-value=3.62394e-05,     Score=113

KEGG

101742100    K14459 hexosaminidase [EC:3.2.1.52] | (RefSeq) hexosaminidase D-like

PATHWAY

00511    Other glycan degradation - Bombyx mori (domestic silkworm)
01100    Metabolic pathways - Bombyx mori (domestic silkworm)

GO

GO:0005975   GO:0015929   GO:0016021   GO:0016579   GO:0036459   GO:0006511   GO:0004553   GO:0102148   GO:0004563   GO:1903561   GO:0005634   GO:0005737   GO:0051287   GO:0008442   GO:0006284   GO:0003906   GO:0006285   GO:0019104   GO:0003824  

PANTHER

PTHR21040  

Subcellular location

Cytoplasm  
Nucleus  
Extracellular vesicle  

Length:

466

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.00520999999999999

Exp number, first 60 AAs:

0.000740000000000001

Total prob of N-in:

0.00374

outside

1  -  466

 

 

Pi

223.807706

Theta

156.776779

Tajima's D

1.661226

CLR

0.12805

CSRT

0.818009099545023

Interpretation

Uncertain