Gene

KWMTBOMO10571

Pre Gene Modal

BGIBMGA014026

Annotation

PREDICTED:_LOW_QUALITY_PROTEIN:_major_royal_jelly_protein_1-like_[Bombyx_mori]

Location

Bomo_Chr17(-):14436184-14447977      View in EpiBrowser

Full name

L-dopachrome tautomerase yellow-f2      

Location in the cell

PlasmaMembrane   Reliability : 3.145

CDS

ATGAACGTGCTACTCGTAATATTGTTAAGCCTACTATTCCTTTGTGGTACGATCTGCGTACATAATAAATACAAGAGGACGTATCTCTGGAAATTATTCGGCTACAACATTGACGGGGTTATATATACGAGTGATTCGGACTTTGAACACAAACGAGGCTCATTTACTTTTCAAGATGAACTGCTGGAAGATCACGAAAAATTTTTGATTCGAAAGAACTTAGTCCCGAACCACATTAGCTATGACCTCTTTCGTTCAATAATATCTATTCCTAGGACAAGGCCGGGTATACCGTTCACCCTCAATGAGATACCATATTTTAGCATATATCACAGTAATCACAGTCCTTTGCTCAAGCCTTATCCGTCGTCTAAAGAATCCAAAAACATTATATCGGTTTATGAAACCGCAATCGATGGATGTCAAAGATATTGGTTCGTTGACACAGGTTTCGTGGATATACCTGGTGTAAGAAAACAAGTCGTGCCTCCCAGCATTTATGTGTTTCAGGGCCGAATGGATTATCTTGTATATACATCTGATATAGATACTAGCGTTCTGAAAGACGGAGTATCGGCAGGTCTTAGGTCTCTGACGATCGACTACATTTTCCCTTGCCACGAAACCTTCGCGTACATTAGTGACGATAACGGTAACGCTGTCATTGCCTTTTCGTTTGAGGAAAAACGTTTCTGGAGGATCGAACGACAAATCACTGGAAGCGAAGCTTGGACTTTCCCCATACCGCAATCCATTTTACTGTACGCTGAAAACGTTATAAGATATAGAAAAAGTCCGAACGAGACATTTGTACATTATTCAGATATTTTGAAAAATACGAAGATTTCTCAACGTTCCGGCCAAGATGTGACCGTGGATCTTAGTGAAATAAATACAAATCCAAGAGGAGTTTTATACGACAGAAATTATGACGGCAACATTTTATTTTTCACGGATGAATCTCGCACTAATCTGTACTGTTGGAACATGGACACGCCGATGGATGAGGACAACATTGAACTGCTCACTGATGTTTCCAGGAACAACGACTTTTACATAAGCGTTACCGCATCGACGTCGATGAAATGTTGA

Protein

MNVLLVILLSLLFLCGTICVHNKYKRTYLWKLFGYNIDGVIYTSDSDFEHKRGSFTFQDELLEDHEKFLIRKNLVPNHISYDLFRSIISIPRTRPGIPFTLNEIPYFSIYHSNHSPLLKPYPSSKESKNIISVYETAIDGCQRYWFVDTGFVDIPGVRKQVVPPSIYVFQGRMDYLVYTSDIDTSVLKDGVSAGLRSLTIDYIFPCHETFAYISDDNGNAVIAFSFEEKRFWRIERQITGSEAWTFPIPQSILLYAENVIRYRKSPNETFVHYSDILKNTKISQRSGQDVTVDLSEINTNPRGVLYDRNYDGNILFFTDESRTNLYCWNMDTPMDEDNIELLTDVSRNNDFYISVTASTSMKC

Description

Tautomerization of L-dopachrome with decarboxylation to give 5,6-dihydroxyindole (DHI). Also catalyzes the tautomerization of the methyl ester of L-dopachrome and dopamine chrome. May play a role in melanization reactions during late pupal and adult stages.

Catalytic Activity

L-dopachrome = 5,6-dihydroxyindole-2-carboxylate

Biophysicochemical Properties

0.11 mM for L-dopachrome
0.31 mM for dopamine chrome

Similarity

Belongs to the major royal jelly protein family.

Keywords

Complete proteome   Glycoprotein   Isomerase   Melanin biosynthesis   Reference proteome   Secreted   Signal  

Feature

chain  L-dopachrome tautomerase yellow-f2

Uniprot

H9B425   Q2HZF9   H9B432   H9B426   H9B433   H9B423   + More
Q2HZG3   I4DJY5   A0A212EU30   A0A212EPC1   F1AAN7   A0A182S4V5   A0A182USS7   A0A182SYB1   A0A182M7Q4   A0A2Y9D0X6   A0A240PN96   A0A1C7CZU7   A0A182WQX0   A0A182MC35   A0A182S4V4   Q2HZG5   A0A1Y9G9K3   A0A2W1B8N9   Q7QBM1   A0A182WQW8   A0A1Y9HAK8   A0A182SGN2   A4GR70   A0A336KNV0   A0A336KJG6   B0W604   A0A182JYA1   A0A2A4JYP7   A0A084VJT5   Q0C7C7   A0A084VJT6   A0A182XVN5   A0A0L0CBQ0   A0A1Y9H2F4   A0A336MSU8   H9B422   A0A1Y9G9J0   A0A1I8NG88   A0A1I8JW18   W5JVT0   A0A194QZN2   A0A1B0C0W0   B0W603   A0A0K8W0Y6   A0A0A1X3L0   A0A0K8WCT9   A0A1Y9H2Y5   A0A0K8VHY4   W8BA62   A0A240PKJ9   A0A1A9UFP7   D3TNF5   A0A1B0GFL4   A0A1I8JW38   A0A240PK75   A0A1A9XRG8   S4PXQ8   A0NDC3   A0A1C7CZU5   A0A194QCC2   A0A1Q3FQT7   A0A3S2M202   A0A1A9ZA11   A0A0K8VHZ5   A0A240PJW5   A0A0M4EQV5   A0A182UDM8   A0A034W6M6   A0A0K8UHM5   A0A0K8VKB6   B4NHJ5   B4M3V3   W5JW46   A0A1Y9H9G8   A0A3F2YSJ6   A0A182G339   Q9VG08   B4PPG7   Q0C7C6   A0A034W5G2   A0A182UPV5   A0A182Q3X4   T1IDG7   B4K8J0  

EC Number

5.3.3.12

Pubmed

16884544    22651552    22118469    20966253    28756777    12364791    + More
14747013    17210077    24438588    17510324    25244985    26108605    25315136    20920257    23761445    26354079    25830018    24495485    20353571    23622113    25348373    17994087    26483478    10731132    12537572    12537569    12164780    17550304   

EMBL

JN977510    AFC87790.1    DQ358086    ABC96701.1    JN977517    AFC87797.1    + More
JN977511    AFC87791.1    JN977518    AFC87798.1    JN977508    AFC87788.1    DQ358082    ABC96697.1    AK401603    BAM18225.1    AGBW02012516    OWR44954.1    AGBW02013493    OWR43338.1    GU063836    ADX87356.1    AXCM01005162    APCN01002105    DQ358080    ABC96695.1    KZ150547    PZC70564.1    AAAB01008879    EAA08438.2    AXCN02000300    EF383145    ABO26383.1    UFQS01000574    UFQT01000574    SSX05055.1    SSX25417.1    SSX05054.1    SSX25416.1    DS231845    EDS35991.1    NWSH01000417    PCG76540.1    ATLV01013869    KE524905    KFB38229.1    CH477186    EAT48899.1    KFB38230.1    JRES01000641    KNC29686.1    UFQS01002523    UFQT01002523    SSX14209.1    SSX33624.1    JN977507    AFC87787.1    ADMH02000272    ETN67175.1    KQ460949    KPJ10435.1    JXJN01023775    EDS35990.1    GDHF01007573    JAI44741.1    GBXI01008585    JAD05707.1    GDHF01003649    JAI48665.1    GDHF01013800    JAI38514.1    GAMC01016596    GAMC01016594    JAB89961.1    EZ422957    ADD19233.1    CCAG010023921    GAIX01004613    JAA87947.1    EAU77002.3    KQ459185    KPJ03193.1    GFDL01005075    JAV29970.1    RSAL01000070    RVE49172.1    GDHF01013790    JAI38524.1    CP012526    ALC47451.1    GAKP01008990    JAC49962.1    GDHF01026140    JAI26174.1    GDHF01013000    JAI39314.1    CH964272    EDW83564.1    CH940652    EDW59314.1    ETN67174.1    JXUM01140694    KQ569110    KXJ68758.1    AE014297    AY060728    AAL28276.1    CM000160    EDW97173.1    EAT48900.1    GAKP01008988    JAC49964.1    AXCN02001168    ACPB03000149    CH933806    EDW14389.2   

Proteomes

UP000007151    UP000075900    UP000075903    UP000075901    UP000075883    UP000075840    + More
UP000075885    UP000075882    UP000075920    UP000069272    UP000007062    UP000075886    UP000002320    UP000075881    UP000218220    UP000030765    UP000008820    UP000076408    UP000037069    UP000075884    UP000095301    UP000076407    UP000000673    UP000053240    UP000092460    UP000075880    UP000078200    UP000092444    UP000092443    UP000053268    UP000283053    UP000092445    UP000092553    UP000075902    UP000007798    UP000008792    UP000069940    UP000249989    UP000000803    UP000002282    UP000015103    UP000009192   

PRIDE

H9B425    Q2HZF9    H9B432    H9B426    H9B433    H9B423    + More
Q2HZG3    Q2HZG5    A4GR70    H9B422    Q9VG08   

Pfam

PF03022   MRJP

Interpro

IPR011042   6-blade_b-propeller_TolB-like        + More
IPR017996   Royal_jelly/protein_yellow       
IPR018247   EF_Hand_1_Ca_BS       

Gene 3D

2.120.10.30    

ProteinModelPortal

H9B425   Q2HZF9   H9B432   H9B426   H9B433   H9B423   + More
Q2HZG3   I4DJY5   A0A212EU30   A0A212EPC1   F1AAN7   A0A182S4V5   A0A182USS7   A0A182SYB1   A0A182M7Q4   A0A2Y9D0X6   A0A240PN96   A0A1C7CZU7   A0A182WQX0   A0A182MC35   A0A182S4V4   Q2HZG5   A0A1Y9G9K3   A0A2W1B8N9   Q7QBM1   A0A182WQW8   A0A1Y9HAK8   A0A182SGN2   A4GR70   A0A336KNV0   A0A336KJG6   B0W604   A0A182JYA1   A0A2A4JYP7   A0A084VJT5   Q0C7C7   A0A084VJT6   A0A182XVN5   A0A0L0CBQ0   A0A1Y9H2F4   A0A336MSU8   H9B422   A0A1Y9G9J0   A0A1I8NG88   A0A1I8JW18   W5JVT0   A0A194QZN2   A0A1B0C0W0   B0W603   A0A0K8W0Y6   A0A0A1X3L0   A0A0K8WCT9   A0A1Y9H2Y5   A0A0K8VHY4   W8BA62   A0A240PKJ9   A0A1A9UFP7   D3TNF5   A0A1B0GFL4   A0A1I8JW38   A0A240PK75   A0A1A9XRG8   S4PXQ8   A0NDC3   A0A1C7CZU5   A0A194QCC2   A0A1Q3FQT7   A0A3S2M202   A0A1A9ZA11   A0A0K8VHZ5   A0A240PJW5   A0A0M4EQV5   A0A182UDM8   A0A034W6M6   A0A0K8UHM5   A0A0K8VKB6   B4NHJ5   B4M3V3   W5JW46   A0A1Y9H9G8   A0A3F2YSJ6   A0A182G339   Q9VG08   B4PPG7   Q0C7C6   A0A034W5G2   A0A182UPV5   A0A182Q3X4   T1IDG7   B4K8J0  

PDB

3Q6T     E-value=3.63445e-08,     Score=138

KEGG

101738170    K22203 dopachrome tautomerase [EC:5.3.3.12] | (RefSeq) major royal jelly protein 1-like

PATHWAY

00350    Tyrosine metabolism - Bombyx mori (domestic silkworm)
01100    Metabolic pathways - Bombyx mori (domestic silkworm)

GO

GO:0016853   GO:0048067   GO:0005576   GO:0042438   GO:0004167   GO:0048066   GO:0042435   GO:0006583  

PANTHER

PTHR10009  

Subcellular location

Secreted  

SignalP

Position:   1 - 19,         Likelihood:  0.769083

 

 

Length:

363

Number of predicted TMHs:

1

Exp number of AAs in TMHs:

17.0112999999999

Exp number, first 60 AAs:

16.98595

Total prob of N-in:

0.53507

POSSIBLE N-term signal

sequence

inside

1  -  1

TMhelix

2  -  24

outside

25  -  363

 

 

Pi

196.058496

Theta

196.303156

Tajima's D

1.639907

CLR

0.133452

CSRT

0.819859007049648

Interpretation

Uncertain