Gene

KWMTBOMO10568

Pre Gene Modal

BGIBMGA014032

Annotation

reverse_transcriptase_[Danaus_plexippus]

Location

Bomo_Chr17(+):14338578-14383194      View in EpiBrowser

Full name

L-dopachrome tautomerase yellow-f       + More
L-dopachrome tautomerase yellow-f2      
Major royal jelly protein 5      
Major royal jelly protein 1      
Major royal jelly protein 4      

Alternative Name

Bee-milk protein
56-kDa protein 4
Apalbumin 1
Apisin subunit MRJP1
Royalactin
Royal jelly protein RJP57-2

Location in the cell

Nuclear   Reliability : 2.139

CDS

ATGAACGACTCGGATTACGAATACAAAGAAGGGACGTTTCATTTTCAGGACGTGGCCTTAGAGGAACATGAAAAGTTTCTAATAAGACAAAACTTGATTCCCTATGATTTTATTTATGATGTTCCTCAAACAACGATAAGCATCCCTAGAACTCGACCTGGAATACCATTTACTGTCAACTTTATTGATAACTTTCTTCATGAAAAAGAGCCAATGCTAAGACCATTTCCTAATTCAAAGGAAGGTAAAGAATTTACATCGGTTTTTAACATGTTTGAAGATGGTTGTGATAGGCTTTGGTTTGTTGATACAGGATACCTCGATATCCCAGGTGTACGAAAGCAAGTACAACCAGCATCATTGCTACTTTACAATAGTCTTCCAAAACCAAATTTTCAGTTCAGGAAAGATATCAACAGTGCTTTACTCCATAACGGTATCACTAGTGGACTCCGATCTTTATCAGTTGATTTTATATTACCGTGCGCCGAGTCTTACGTATACATTACTGACGACACTACCCGCGACCTCATTGTATTCTCGCTTCAGGACTTGCGTTTTACCAAAATCAGCCGCGCAAGTAATACGGCTGATTCTTGGAAATTTGTTGTACCACGATTTGAAATACAATTCAGGCTAGAAGTTGAAAAATATAGAAAAAGGCCAAACGAAACATACGAACACTATGTCGATTTTTTAAATTCTACAAATCAACTGTATGATCCAAAAAGTGATTCAAGACCTCGTGATACATTTAACAGCACCTACTATCCAAATTATGAAGGGATGATTTATACGAGAAATTTTGAAGGAAACATTTTGTTATTCACGAATTGGAATCGTAACAAGCTTTACTGTTGGAATATGGATACTCCGTATGAAGAAGAAAACGTTGATGTGCTCTCGAGAATCGGTGAGACTAAATATAGATTTTCAGCTTTAGATGCGGTTGGTAGCGTTTTGCACGGACTAATGCAAAGAACTTTAAAGAGCACGTCGTCAAAGTTCAATGAAGACGAAAACAATTTTTGGCTTTTCTCAACGAACCTTGATAAGCTGCTGGAAGGATCAAAATGCTCCAAAACTTATGATGCTAAACGTAACTTTACATATGAGCATGGTTGGAAACTGTTTAGTTACGATATTGATGGAGTAAAATACACGAATGACTCGGATTACGAAAACAACGAAGAGTCGTTGGGCTCTCAGGGCCTGGACTTAGAGGAACATGACAAGTTTCTAATAAGACAAAATTTGATACCCTATGATATTAAGGAAGATGTAGTGCGAACAACAATAAGTATCCCTAGAACTCGACCTGGAATTCCATATACAGTAAACTTTATTAGTAATCTGGATGATAAGGAGCTAATGCTAAGACCATTTCCTAATTCAAAGGAAGGTAAAGAATTAGTATCGGTTTTTAACATGTTTCAAGACAGCTGTTCTAGACTTTGGTTTGTTGATACAGGATACCTCGATATCCCAGGTGTACGAAAGCAAGTAAAACCAGCATCATTGTTACTTTACCTTAGTTTTTCAACAGCAGATCTGCAGTTTAGGAAAGATATTGACAGTGCTTTACTCCATAACGGTATCACTAGTGGACTCCGATCTCTATCGGTTGATTTTATATTCCCGTGCGCCGAGTCATACGTATACATTACTGACGACACTACCCGCGACCTCATTGTCTTCTCGCTTCAGGACATGCGTTTTACGAAAATCAGCCGCGCAAGTAATACGGCTGATTCTTGGAAATTTATTGTGCCACAGTTTGAAACACAATACAGGCTAGAAGTTGAAAAATATAGAAAAAGGCCGAATGAAACATACGAACACTATGTGGATTTTTTAAATTCTACAAATCAACTGTATGATCCAAGCAGTGATTCAAGACCTCGTGATACATTTAACAACACCTACTATCCAAATTATGAAGGGATGATCTATACGAGAACTTATGAAGGTAATATTTTGTTATTCACGAATTGGAATCGTAACAAGCTTTACTGTTGGAATATGGATACTCCATATGAAGAAGAAAATGTTGATTTGCTCACGACAATCGATGAGACTAAATATAGATTTTCAGCTTTAGATGCGTCGGGTAGCGTTTTACACGGACTAATACAAAGAACTTTAAATAATACGTCGTCAAAGTTCAATGAAGACGAAAACAATTTTTGGCTTTTCTCAAAGATCATTAAGGAGCTGCTGGAGGGATCAAAATGCTCAGAGAGCAACCAGTGCACGGATTACCTGACGCGGAGAACGGAGAGTCAATCATTATTATTTATCAAAAAAATATCACCGAAATACGTAACCGATACCGTCGTTAGAAAGTTTGAAAAAATATGGAAGAGGGTACCTCCCGCTCCGCGGGGGAGAATCCCTCCGTGCGGTCGAGCGATCGGCCGCACGCTGCCCCACCGTTTCTGGGGGGGCACACACTGTCACGCAGAAGGGGGCGACAGCACGGGTCGCGTAAGGGACAGGGTCCCCACCGTGCGCCTCGAGCGCTGCGAGAGCCTTATCTCGCTCTACTCGGCGCGGAGCTCCGCGAGGGGCGACGCGTCCAGTGGGCGGGAGACACCGGCGCTGTTCACCGACACTCGACAGCGGACTCGGCGGAAGCGGAAGTCGGCCCGACGGCCGGCGTCCTCCGCTCCGTCTGACTCGTCCGAGGGTGAGCCTGCCAGCGCCAAATATATGGCGTTGGCGGAAGGGCCGGCGGCTGCTGCGGCGCCGCCCGCCACAGATTGTGACGCAGTCTCTTCTCGCGGACTGGCTGCTGCCTCCTCGGCGCAGTCCAGGGCCGCCTGCTGTGAGGCAAGAGGAAAAGCGGAAACCGGAGAGGTCGCGCGTTTGGAGCGCTGCCTGGCCGGGGTGGGTCCCTCTGACCCCTTCCGAGCATTCGAGGTGGTTGGGAAATTGGTTTCCGCAGTCGTGGCAACATCCGGCGGTGGACTCAAGGGTGACTGCGTGCGGGCCTTAAAATCCGGAGCGGCCACCCTAGAAGAACGTCTGAGGGAAGTGGTAGACCGCACCACAACGACGGAGACGGCGGGCTTGCGGCAGGAAGTGGCCCTGCAGCACGCCCGCCTCGAGCAACTCTCGAACGAGAATGGCAAACTTCGGGCGGAGAATGGGCAGCTGCGAGTGGACATGGCCGAGTTGAGGACCATGGTTGCCGACCTCATCGAGCGGCAACGCAGCTCGGCCCCTGCCCCTCCTCCGCCCGAAGCGGAAGGCCTCAGTGAGGTGGACGAGTTGAGGCGGCAGCTCCTCATACAGGAGGCGCGCAGCTCCAAGGTGGAGCGCGCGAGACCGCCCCTCGCTCACGAGGCTAACGGAACCCCGGCCAACATGGACGAGGCCTGGACGACGGTGGTGCGGCGAGGGCCCAAAAAGGTTGCGGCGCCTGTCGCGCCGCGCCCCAAGCCCGCCCCTACGGCCGCCGCTCCCCGCCAAGAGGGTCGAGCGGAGCCTAGGGGCCGAACTGGACGAAGGAGGCCGCGCGCCCCGCGGTCGGCTGCAGTAGTCGTGGAGCTGCTGCCGGCCGCCAAAGAACGGGGCATCACGTACCACGACGTGATGACTCAGGCGCGCGGCGGCGTAAATGTGGACGCCCTCGGCGTGGAGGGTGGCCTGAAGGTCCGGCAGACGGCCAACGGGGCCCGCCTGGTAGAATGCCCCGGCGCGAATTCCAGCGCCGCGGCAGAAAAACTGGCGGTCCGTCTGCGGGAAATCTTGCCGGACCCCGAGGTGGTGCGCATCGCGCGGCCCGTAAAAATGGCGGAAGTGAAGATTACGGGCCTCGACGAGTGCGCCACGAAGGAGGAGGTCGCCGCGGCCATCGCGTCGCAGGGCAACTGCGCCCTCGCCGACGTCAAAGTCGGGGAGCTCCGGGCGACGTACTCCGGAACCCGGACGGCGTGGGCGCGTTGCCCGGTAGCAACGGCGAACCTCCTGGCCACCCCTCCACAGGGTCGGCCTTCGGACAGCCCAGGATGGCTGCGCGTGGGCTGGGTAGTGGCCCACGTGCAACTGCAGGAGAGCAGGCCGTGGCGTTGTCTTCGGTGCTTCGGCACCGGCCACGGCCTCGCCAAGTGCCCCTCGACAGTGGACCGCAGCGACCTGTGCTTCCGCTGCGGCCAACCGGGGCACAAGGCAGCCTCCTGCACCGCAGCCGCGCCGCACTGTGTCTTGTGCGACGCGGCTAAAAGGAAGGCCGACCACCGGGCCGGGGGCCCGGCGTGCAAGTCCGCCCCTCCTCTACAAAAACGAGGAGGGGCGGAAAGAAAAAGAAGCCGGCTGCAAAAAGGGCAGCCGGATCTCCTCGTCCACACCATGGCGGAGTGGTCAATCGATGTTGCTGTCGCCGCGGAGCCGTATTTCGTCCCCACCGACCAGGACTGCTGGATCGGGGACGTCGACGGCTCAGTGGCCATTATATTACGACAGTCCGCGGCGTTACCCCCCTTGGATATGGTGGCCAGGGGACCCGGGTACGTCGCGGCTAGGATCGACGGGACCGTCGTGATCGGGGCGTACTTTTCTCCGAATAGGAGCCTCGCCGAGTTCGAGCGGTTTCTGGGCGGGCTCGAGGCGCTTTTACACCGCCTCGGGTCCCGCCCTGTCATCGTCGCGGGGGACCTCAATGCCAAGTGTACGGCTTGGGGTTCCCCCCGCACGGATTCGCGAGGCGGGGCCCTTTCGGAGTGGGCGATCGCGACCGGCCTCTGTCTCCTAAACAGAGGCACGGTCGCGACTTGCGTGCGGTGGAACGGGGAATCTCACGTGGACGTGACGTTCGCGTCCCCGTCCGCCGTGCGCCGCACCCGCGGCTGGCGCGTACTCGAGGGGGCGGAGACGCTCTCGGACCACAGATACGTCCGATTCGAGCTCTCCGCCTCCTCCTTGTCGTCGTCGTCAGCCGTGGGCGCCCGCGGCGAGGAGGAGCTCCCGCAAGGTGCGCCCCGTTCGTTCCCCAGGTGGGCCTTGAAACGGATGAACAAGGAGTTGCTGATGGAGGCGGCCGCTGTTGCTGCGTGGGCGCCAAAACCCGCGCGACTCGCGGACGTGGATGCGGAGGTCGACTGGTTCCGGGGCACCATGGCAAACATTTGTGATGCCGCCATGCCCCGGGTCGGCCCCCGAGCACCACGTGGGGGTGCGTTCTGGTGGTCGCCCGAGATCGCAAGACTCCGCGAGGAGTGCGTGAGGGCGCGCCGCCGGAGCGCACGCCACCGCCGCCGCCGTCGTCGCGACGCTGCGTTCGCGGAGACGGCGGCCCAGCTGCACGCTGACTGTCGTCAAAAGCAGACGGCGCTGCAGCTGGCCATCGGCGAGGCCAAGAAGCAGAGCATGAAGACTCTCCTGGAGTCGCTCGACGAAGATCCCTGGGGGCGCCCATACAAGATGGTTCGCAGGAAACTGCAGCCGTGGGCGCTCCCGATGGACGCCACGTGGGGCACGCCTCCGCGTCGCCCCAGCGTTCCCGCTGCCGAGGAGCCCCCTCCCCCTATCACGGGGGCGGAGATCCATGCGGCCGTGTCCAGAATGAGAGCGAAGGACGCGGCCCCCGGCCCTGACGGCGTTCACGGCCGGGTCTGGAGCTTGGCCTTCGAGGCCCTAGGGGACCGGCTCGGGGGGCTTTTCGAAGCGTGCCTCGAGTCGGGACGGTTCCCGTCGAAATGGAAGACGGGCAGACTGGTCCTTCTGCGGAAGGACGGGCGCCCCGCGGACTCACCCGCGGGCTATCGCCCCATCGTGTTGCTGGACGAAGCGGGCAAGATGCTCGAGAGGATCGTCGCGGCCCGCATCGTCCGGCACCTGACCGAGACGGGTCCCGATCTTTCGGCGGAACAATACGGCTTCAGAGAGGGCCGCTCGACGATAGACGCAATTCTGCGCGTGCGTGCCCTCTCCGACGAAGCCGTATCCCGGGGCGGGGTGGCGATGGCGTTATCCTTAGATGTAAGGAACGCCTTCAACACCCTGCCCTGGTCGGTGATCGCGGGGGCGCTGGAGTATCACGGCGTCCCCGCATACCTCCGCCGACTGATCGGCTCCTACCTCGAGGGCAGGTCGATCCAGTGCATCGGACACGGTGGGGCGATGTACCGCTTCCCCGTCGAGCGCGGTGTTCCGCAGGGGTCTGTCCTGGGCCCCCTGCTGTGGAACATCGGCTACGACTGGGTCCTGCGGGGCGTCATTCGGGGTCCCCTCCCCGGGCTGAGCGTAATATGTTACGCCGACGACACGTTGGTCGTGGCTCCGGGGAGGGACTACCGGGAGTCTGCCCGTCTGGCGTGCGCAGGCGTGGCACACGTCGTCACAAGGATCCGACGGCTGGGACTCGAGGTGGCGCTCGACAAAACCCAGGCCCTGTTGTTTCACGGGCCGGGACGAGCGCCGCCTCTGGGTGCCCACCTCGTGATCGGAGGCGTCCGCGTCGGGGTCGGGGTGACCGGTCTTCGGTACCTCGGCCTTGAACTGGATGGTCGGTGGAACTTCCGCGCTCACTTTGCGAAGTTAGGCCCTCGACTGATGGCGACGGCCGGCTCTTTGAGCCGGCTGCTTCCAAACGTCGGGGGTCCCGATCAGGTGGCGCGCCGCCTCTACATGGGGGTGGTGCGGTCGATGGCACTATACGGCGCGCCCGTATGGTGCCACGCCCTGACCCGCCAGAACGTCGCCGCGCTGCGACGTCCGCAGCGCGCGATCGCGGTCAGGGCGATCCGAGGATACCGCACCGTCTCCTTCGAGGCGGCGTGCTTGCTCGCCGGGGCGCCACCCTGGGACCTGGAGGCGGAGGCGCTCGCTGCCGATTACCGGTGGCGTAGCGACCTCCGCTCTAGGGGGGAAGGGCGCCCCAGCGAAGGTGTAGTTCGAGCGCGGAGGCTCCACTCTCGGCGGTCCGTGCTGGAGGCGTGGTCTCGCCGCTTGGCGGATCCGTCGGCCGGCCTCCGAACCGTCGAGGCGGTCCGCCCGGTTCTCGCGGACTGGGTGGGCCGCGACCGCGGATGCCTCACCTTCCGGCTAACGCAGATGCTTACCGGCCATGGTTGTTTCGGCCGGTACTTGCACAAGATAGCCGGAAGGGAACCGACGGCGCAGTGCCACCACTGCGCGGACCGCGACGAGGAAGACACAGCGGAACACACATTGGCGCGTTGCTCTGGATTTGACGAGCAACGCGCCGCCCTCGTCGCGGTCATAGGAGAAGACCTCTCGCTGCCGCGCGTCGTGGCTACGATGCTCGGCAGCGACGCGTCCTGGAAGGCGATGCTCGACTTCTGCGAGTCCACCATCTCGCAGAAGGAGGCGGCGGAGCGAGAGAGGGAGAGCTCTTCCCTTTCCGCACCGATCCGTCGCCGTCGAGCCGGGGGCCGGAGGCGGGAATACGCCCCATTCTACAATGATAACGGACTCGCGCGGCAACGCGATCAAATTTTCGAATTCCTCCGCGACAATCTTGTAGATATTTTGTTAGTGCAGGCGACCTGCCTGAAGCCCTCGCGTCGTGACCCAAAAGTCGCGAATTACGTCATGGTTAGGAATGACAGACTCACCGCCTCCAAAGGCGGGACTGCTATTTACTATAGGCGGGCCCTGCACGTTGTCCCTCTCGATACTCCCTCGCTCTCACATATCAAGGCGTCAGTGTGCCGTATCTCGCTGACGGGACACCAGCCGATCGTCATCGCATCCGTATATCTCCCCCCGGACAAGCCCCTCCTGAGCAGTGACATCGAGTCACTGTTCGGCATGGGAAACTCTGTCATCCTGGCAGGCGATTTAAATTGCCACCACACTAGGTGGAACTGCCATCGTACAAATGTTAACGGTAGGCGTCTCGACGCGTTTATAGACGACCTCACCTTTGAAGTAGTCGGTCCCCCAACTTCAACATGTTATCCGTATAACATCGCGCTCCGTCCGAGCACTATAAACCTGGCACTGCTTAGGAACGTAACTCTGCGCTTGCGTTCCATCGAAGCACTGTCAGAGCTCGACTCAGACCACCGACCTGTCGTTATGCAGCTCGGTCGCCCTCACAACCCAGTCACTGTTACGAGGACCATGGTGGATTGGAATAAGCTAAGCACGTGCTTAGCCGAAGCCGCTCCACCAATCCTCCCTTACGGCCCGGATTCGAATCTATCCCCCGAGGACACCGTCGAGTCCATAAACATCATTACCGATCACATCTCTTCCGCGATCATTAGATCTTCAAAAGAAGTCAATGTGGAGGACAGCTTCCACCGCATCAGACTGTCCCCCGATCTTAGGAATCTCTTAAGAGTTAGGAACGCGGCAATCCGGGCCTACGATCGTCTTCCCACGCATTCAAACCGGATTTGGATGCGTCGTCTACAACGCGAAGTCCACTCCCGCCTAAGCGACGCGCGTAACGATAATTGGCATAGTTATTTAGAACAACTCGCGCCCTCCCACCAAGCATACTGGCGACTAGCTAGGACTCTCAAATCCGAAACTACCGCTACTATGCCTCCCCTCGTACGCCCTTCAGGCCAACCACCGGCATTCGATGACGATGACAAGGCTGAGCTGCTGGCCGATGTACTGCAAGAGCAGTGCACCACCAGCACTCAATACGCGGACCCCGAACACACCGAAAATTATTATCATATCGGCTGTGTTCTTCCTGCAAATAAGGATTGGACGCCGGACTCTGAATTTAAGTCTACATGGATATGTCTTAATTGTGCGACTAAATCACGTACTGTTAATGATGAAACTCCTGTCCGTGGCAATGTGAGGCCTCGAGCACCTGATACATCCAATGTTACGATGAGACCGTTGCGTGCTGGATCCAGGGAACGTGAGGGACCTGAATTACAGGTTGTCCCTTTAGAACAGGTCAGGAGTATAGTGCGCGCGGAAGTCCAGGAAGCTGTTGCTTGTTTCAGGGACACTATTCTTGAACTCAAGAGTGAAATCTCAACTCTTCGTGATAGTGTCTCCTTCATTAGTGACAAGTATGAAGCCATATCGAAAAGATTTCTTGAGTTTAACGACCATCTGAAAATTATTCCAACACTCAAAAACGAGCTCAGTATACTGGATTCAAGAATGCAATCCATTGATTCTCAATTCAACTTAAAAGAGCAGTGGAGCAGGAGATCTAATATAGAAATTCTGGGTATCCCCGAAAGGAAAGGCGAAAATCTAATAGAATTGGTCTCGAAAATTGCCGAGAGGGCGGGTTTTGCCTTGAATCCTCAGATAGACATCGATTTTGTTACAAGGGTTGCGCCGATGGACAGAAGCAGTAGCAGATCAAAGCCAGTTATTCTTAGATTTGTATCCCGGTATAGGAAGGATAACATGTTGGCTAAATTGCGGAGGTTGAAGGAATTGAAATCTTCTGATATTGGATTCCCACATGATTCATCTAGGCTTTATTTTAATGACCACCTCACGAAAAACAATAAACTTTTGTTAAAAAACGTAAAAAAATTAGCCAAGGAAAAATTTTACAAATACGTGTGGTTTGAAGATGAAGTTGGTTTTTTTGAGGATATTTCTGACACAATTATTACTAATCCGGGTGACGAATTTTTGTGCGTCAGCGATTTCAATATAAGGAATGCTTCTTGGGAGCTGATCGGTGTTGGTGGACCTTCTAGACTCTTGAATGGTGATCGAACCAAAAGATTCGTTTATCGTACCATCAAACGATACAATGAAGACTCTAGTGTAGATGACAGTTCAAGAAGTGGTCGCCCTCGGTCTGTTAGGACTCCAGCAGTGATAAAAGCTGTGAAGGCGCGAATTCAAAGAAATCCCAAACGTAAGCAGAAACTGTTGGCCCTTCAGATGGGGTTAAGCAGAACCACGGTGAATAGGGTGTTGAATGAAGACTTAGGGCTTCGGGCATATCGAAGAAAAACAGGACATCGTTTGAATGCTCGTCTAATGGACCTGAGACTGAAGAGATGCCGCGCTTTGTTGAAGCGCTCTAAGGAAGCTTCCCAATTAGTCGACAGAGTGCAACGTGGGCACTATCCGACTTCAGTGATAGTTTGGTGGGGTATTAGCTATGAAGAAGTGGCTGAGCCATACTTTTGTGTAAAAGGTATCAAAACATCGGCACAAGTGGATCAAGATACCATTCTTGAGAAGGTAATGAAGCCTCTCAACAACACCATGTTCAATAATCAAGAATGGTCCTTCCAGCAAGACTCGGCGCCAGGTCATAAAGCTCGGTCTACGCAGTCTTGGTTGGAAACGAACGTTTCGGACTTCATCAGAGCTGAAGACTGGCCGTCGTCTAGTCCCGATCTTAATCCGCTGGATTATGATTTATGGTCAGTTTTAGAGAGTACAGCTTGCTCTAAACACCATGATGATTTGGAGTCCCTAAAACAATCCGTACGATTGGCAGTGAAAAAATTTCCCATGGAAAGAGTGCGTGCTTCTATTGATAACTGGCCTCAACGTTTAAAGGACTGTATTGCAGCCAATGGAGACCACTTCGAATAA

Protein

MNDSDYEYKEGTFHFQDVALEEHEKFLIRQNLIPYDFIYDVPQTTISIPRTRPGIPFTVNFIDNFLHEKEPMLRPFPNSKEGKEFTSVFNMFEDGCDRLWFVDTGYLDIPGVRKQVQPASLLLYNSLPKPNFQFRKDINSALLHNGITSGLRSLSVDFILPCAESYVYITDDTTRDLIVFSLQDLRFTKISRASNTADSWKFVVPRFEIQFRLEVEKYRKRPNETYEHYVDFLNSTNQLYDPKSDSRPRDTFNSTYYPNYEGMIYTRNFEGNILLFTNWNRNKLYCWNMDTPYEEENVDVLSRIGETKYRFSALDAVGSVLHGLMQRTLKSTSSKFNEDENNFWLFSTNLDKLLEGSKCSKTYDAKRNFTYEHGWKLFSYDIDGVKYTNDSDYENNEESLGSQGLDLEEHDKFLIRQNLIPYDIKEDVVRTTISIPRTRPGIPYTVNFISNLDDKELMLRPFPNSKEGKELVSVFNMFQDSCSRLWFVDTGYLDIPGVRKQVKPASLLLYLSFSTADLQFRKDIDSALLHNGITSGLRSLSVDFIFPCAESYVYITDDTTRDLIVFSLQDMRFTKISRASNTADSWKFIVPQFETQYRLEVEKYRKRPNETYEHYVDFLNSTNQLYDPSSDSRPRDTFNNTYYPNYEGMIYTRTYEGNILLFTNWNRNKLYCWNMDTPYEEENVDLLTTIDETKYRFSALDASGSVLHGLIQRTLNNTSSKFNEDENNFWLFSKIIKELLEGSKCSESNQCTDYLTRRTESQSLLFIKKISPKYVTDTVVRKFEKIWKRVPPAPRGRIPPCGRAIGRTLPHRFWGGTHCHAEGGDSTGRVRDRVPTVRLERCESLISLYSARSSARGDASSGRETPALFTDTRQRTRRKRKSARRPASSAPSDSSEGEPASAKYMALAEGPAAAAAPPATDCDAVSSRGLAAASSAQSRAACCEARGKAETGEVARLERCLAGVGPSDPFRAFEVVGKLVSAVVATSGGGLKGDCVRALKSGAATLEERLREVVDRTTTTETAGLRQEVALQHARLEQLSNENGKLRAENGQLRVDMAELRTMVADLIERQRSSAPAPPPPEAEGLSEVDELRRQLLIQEARSSKVERARPPLAHEANGTPANMDEAWTTVVRRGPKKVAAPVAPRPKPAPTAAAPRQEGRAEPRGRTGRRRPRAPRSAAVVVELLPAAKERGITYHDVMTQARGGVNVDALGVEGGLKVRQTANGARLVECPGANSSAAAEKLAVRLREILPDPEVVRIARPVKMAEVKITGLDECATKEEVAAAIASQGNCALADVKVGELRATYSGTRTAWARCPVATANLLATPPQGRPSDSPGWLRVGWVVAHVQLQESRPWRCLRCFGTGHGLAKCPSTVDRSDLCFRCGQPGHKAASCTAAAPHCVLCDAAKRKADHRAGGPACKSAPPLQKRGGAERKRSRLQKGQPDLLVHTMAEWSIDVAVAAEPYFVPTDQDCWIGDVDGSVAIILRQSAALPPLDMVARGPGYVAARIDGTVVIGAYFSPNRSLAEFERFLGGLEALLHRLGSRPVIVAGDLNAKCTAWGSPRTDSRGGALSEWAIATGLCLLNRGTVATCVRWNGESHVDVTFASPSAVRRTRGWRVLEGAETLSDHRYVRFELSASSLSSSSAVGARGEEELPQGAPRSFPRWALKRMNKELLMEAAAVAAWAPKPARLADVDAEVDWFRGTMANICDAAMPRVGPRAPRGGAFWWSPEIARLREECVRARRRSARHRRRRRRDAAFAETAAQLHADCRQKQTALQLAIGEAKKQSMKTLLESLDEDPWGRPYKMVRRKLQPWALPMDATWGTPPRRPSVPAAEEPPPPITGAEIHAAVSRMRAKDAAPGPDGVHGRVWSLAFEALGDRLGGLFEACLESGRFPSKWKTGRLVLLRKDGRPADSPAGYRPIVLLDEAGKMLERIVAARIVRHLTETGPDLSAEQYGFREGRSTIDAILRVRALSDEAVSRGGVAMALSLDVRNAFNTLPWSVIAGALEYHGVPAYLRRLIGSYLEGRSIQCIGHGGAMYRFPVERGVPQGSVLGPLLWNIGYDWVLRGVIRGPLPGLSVICYADDTLVVAPGRDYRESARLACAGVAHVVTRIRRLGLEVALDKTQALLFHGPGRAPPLGAHLVIGGVRVGVGVTGLRYLGLELDGRWNFRAHFAKLGPRLMATAGSLSRLLPNVGGPDQVARRLYMGVVRSMALYGAPVWCHALTRQNVAALRRPQRAIAVRAIRGYRTVSFEAACLLAGAPPWDLEAEALAADYRWRSDLRSRGEGRPSEGVVRARRLHSRRSVLEAWSRRLADPSAGLRTVEAVRPVLADWVGRDRGCLTFRLTQMLTGHGCFGRYLHKIAGREPTAQCHHCADRDEEDTAEHTLARCSGFDEQRAALVAVIGEDLSLPRVVATMLGSDASWKAMLDFCESTISQKEAAERERESSSLSAPIRRRRAGGRRREYAPFYNDNGLARQRDQIFEFLRDNLVDILLVQATCLKPSRRDPKVANYVMVRNDRLTASKGGTAIYYRRALHVVPLDTPSLSHIKASVCRISLTGHQPIVIASVYLPPDKPLLSSDIESLFGMGNSVILAGDLNCHHTRWNCHRTNVNGRRLDAFIDDLTFEVVGPPTSTCYPYNIALRPSTINLALLRNVTLRLRSIEALSELDSDHRPVVMQLGRPHNPVTVTRTMVDWNKLSTCLAEAAPPILPYGPDSNLSPEDTVESINIITDHISSAIIRSSKEVNVEDSFHRIRLSPDLRNLLRVRNAAIRAYDRLPTHSNRIWMRRLQREVHSRLSDARNDNWHSYLEQLAPSHQAYWRLARTLKSETTATMPPLVRPSGQPPAFDDDDKAELLADVLQEQCTTSTQYADPEHTENYYHIGCVLPANKDWTPDSEFKSTWICLNCATKSRTVNDETPVRGNVRPRAPDTSNVTMRPLRAGSREREGPELQVVPLEQVRSIVRAEVQEAVACFRDTILELKSEISTLRDSVSFISDKYEAISKRFLEFNDHLKIIPTLKNELSILDSRMQSIDSQFNLKEQWSRRSNIEILGIPERKGENLIELVSKIAERAGFALNPQIDIDFVTRVAPMDRSSSRSKPVILRFVSRYRKDNMLAKLRRLKELKSSDIGFPHDSSRLYFNDHLTKNNKLLLKNVKKLAKEKFYKYVWFEDEVGFFEDISDTIITNPGDEFLCVSDFNIRNASWELIGVGGPSRLLNGDRTKRFVYRTIKRYNEDSSVDDSSRSGRPRSVRTPAVIKAVKARIQRNPKRKQKLLALQMGLSRTTVNRVLNEDLGLRAYRRKTGHRLNARLMDLRLKRCRALLKRSKEASQLVDRVQRGHYPTSVIVWWGISYEEVAEPYFCVKGIKTSAQVDQDTILEKVMKPLNNTMFNNQEWSFQQDSAPGHKARSTQSWLETNVSDFIRAEDWPSSSPDLNPLDYDLWSVLESTACSKHHDDLESLKQSVRLAVKKFPMERVRASIDNWPQRLKDCIAANGDHFE

Description

Tautomerization of L-dopachrome with decarboxylation to give 5,6-dihydroxyindole (DHI). Also catalyzes the tautomerization of the methyl ester of L-dopachrome and dopamine chrome. May play a role in melanization reactions during late pupal and adult stages. May play a role in melanization reactions during larval and early pupal stages.
Tautomerization of L-dopachrome with decarboxylation to give 5,6-dihydroxyindole (DHI). Also catalyzes the tautomerization of the methyl ester of L-dopachrome and dopamine chrome. May play a role in melanization reactions during late pupal and adult stages.
Major royal jelly protein 1: induces the differentiation of honeybee larvae into queens through an Egfr-mediated signaling pathway. Promotes body size increase by activating p70 S6 kinase, stimulates ovary development by augmenting the titer of vitellogenin (Vg) and juvenile hormone, and reduces developmental time by increasing the activity of mitogen-activated protein kinase and inducing the 20-hydroxyecdysone protein (20E). Most abundant protein found in the royal jelly which is the food of the queen honey bee larva. The royal jelly determines the development of the young larvae and is responsible for the high reproductive ability of the honeybee queen.
Jellein-1: has antibacterial activity against the Gram-positive bacteria S.aureus ATCC 6535, S.saprophyticus and B.subtilis CCT2471, and the Gram-negative bacteria E.coli CCT1371, E.cloacae ATCC 23355, K.pneumoniae ATCC 13883 and P.aeruginosa ATCC 27853, and antifungal activity against C.albicans. Lack cytolytic activity and does not induce rat peritoneal mast cell degranulation.
Jellein-2: has antibacterial activity against the Gram-positive bacteria S.aureus ATCC 6535, S.saprophyticus and B.subtilis CCT2471, and the Gram-negative bacteria E.coli CCT1371, E.cloacae ATCC 23355, K.pneumoniae ATCC 13883 and P.aeruginosa ATCC 27853, and antifungal activity against C.albicans. Lack cytolytic activity and does not induce rat peritoneal mast cell degranulation.
Jellein-4: lacks antibacterial and antifungal activity. Lacks cytolytic activity and does not induce rat peritoneal mast cell degranulation.

Catalytic Activity

L-dopachrome = 5,6-dihydroxyindole-2-carboxylate

Biophysicochemical Properties

0.33 mM for L-dopachrome
0.29 mM for dopamine chrome
0.11 mM for L-dopachrome
0.31 mM for dopamine chrome

Subunit

Is present in royal jelly in different forms: monomer (55 kDa), oligomeric subunit (ca. 420 kDa), and water-insoluble aggregates in sediment after interaction with fatty acids (Ref.7). Interacts with apisimin to form the heterooligomer apisin (350 kDa) (PubMed:27721892).

Miscellaneous

Exhibits a growth factor-like action on primary-cultured rat hepatocytes by stimulating DNA synthesis and protecting cells from apoptosis induced by serum deprivation. Also activates mitogen-activated protein kinase, as well as protein kinase B, a key regulator of cell survival (PubMed:16290177).
Degraded proportionally to the period of storage, and is completely lost during storage at 40 degrees Celsius for 30 days.

Similarity

Belongs to the major royal jelly protein family.

Keywords

Alternative initiation   Complete proteome   Glycoprotein   Isomerase   Melanin biosynthesis   Reference proteome   Secreted   Signal   Repeat   3D-structure   Amidation   Antibiotic   Antimicrobial   Developmental protein   Direct protein sequencing   Fungicide  

Feature

chain  L-dopachrome tautomerase yellow-f
splice variant  In isoform 2.
peptide  Jellein-2

Uniprot

Q9VG09.1   Q9VG08.2   O97432.1   O18330.1   Q17061.1  

EC Number

5.3.3.12

Pubmed

10731132    12537572    12164780    12537569    10441680    9395329    + More
9791542    12559578    11302159    15203237    16290177    21516106    27721892   

EMBL

AE014297    BT003613    AAO39616.1    AY060728    AAL28276.1    AF004842    + More
D79207    AF000633    AF388203    GQ160518    Z26319   

Proteomes

UP000000803    UP000005203   

PRIDE

Q9VG09    Q9VG08    O97432    O18330    Q17061   

Pfam

PF03022   MRJP

Interpro

IPR011042   6-blade_b-propeller_TolB-like        + More
IPR017996   Royal_jelly/protein_yellow       

Gene 3D

2.120.10.30    

ProteinModelPortal

Q9VG09.1   Q9VG08.2   O97432.1   O18330.1   Q17061.1  

PDB

5YYL     E-value=1.34725e-13,     Score=194

KEGG

101737492    K22203 dopachrome tautomerase [EC:5.3.3.12] | (RefSeq) yellow-14, yellow-16; major royal jelly prote

PATHWAY

00350    Tyrosine metabolism - Bombyx mori (domestic silkworm)
01100    Metabolic pathways - Bombyx mori (domestic silkworm)

GO

GO:0006583   GO:0048066   GO:0004167   GO:0042435   GO:0005576   GO:0050830   GO:0050832   GO:0031640   GO:0048650   GO:0050829   GO:0003676   GO:0008270   GO:0051287   GO:0008442   GO:0006284   GO:0003906   GO:0005634   GO:0006285   GO:0019104   GO:0003824  

PANTHER

PTHR10009  

Subcellular location

Secreted  

Length:

3505

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.0665299999999998

Exp number, first 60 AAs:

0.00051

Total prob of N-in:

0.00024

outside

1  -  3505

 

 

Pi

18.824283

Theta

177.280433

Tajima's D

-1.630911

CLR

1.318635

CSRT

0.0456977151142443

Interpretation

Uncertain