Gene

KWMTBOMO10558  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA007144

Annotation

PREDICTED:_3-hydroxyisobutyrate_dehydrogenase_isoform_X1_[Bombyx_mori]

Location

Bomo_Chr17(+):13988588-14000787      View in EpiBrowser

Full name

3-hydroxyisobutyrate dehydrogenase      

Location in the cell

Mitochondrial   Reliability : 2.507

CDS

ATGGCCGCGCGCACCATATTAAGCACTCAGTGTTTGTACACAGCCGCCAGACGGGCGTATAGTTCTAACACCGACAAGAATGTGGCTTTCCTCGGCCTCGGAAACATGGGAGGGTTCATGGCTGCGAACTTGGTTAAAAAGGGTTTCACAGTTCGCGGCTACGATCCTTCCAAAGATGCACTGAACGCAGCGGCCAAGAACGGAGTGACGCCAGCCAACTCCATTGCTGCAGCCGTTGATGGAGTCGACGTGGTCGTTTCCATATTGACCAGCAATAAAGTCGTGCTCGACGTGTACCTGGGCAAAGATGGCGTTGTGGCTCATGCGAAAAAAGGATCGCTTCTGATCGATTCGAGTACAATAGATCCGAATGTTCCCAAACAGATCTTCCCTATAGCCCTAGAGAAAGGGCTGGGATTCACAGATGCACCTGTATCTGGAGGAGTCATGGGTGCTCAGAACGCTACCCTGGCCTTCATGGCCGGAGGTCGTAAAGAAGACTTCGAAAGGTCCCTTCCTCTCCTCAAAGTGATGGGAGCTAAGCAGTTCCACTGCGGACAGATCGGCTCAGGACAGGTGGCTAAACTGACCAATAACATGTTGATGGGCATCACCGGAATGGCTACAGCTGAGTGCATGAACATGGGCATTAAAATGGGACTCGAACCGAAGGTTCTGTTGGACGTGCTGAACAACTCATCGGCTCGCTCCTGGTCGACCGAGGTGTACTGTCCAGTCCCCGGACTGGTGCCCACCGCTCCGTCGAGTAGAAATTACGATGGCGGCTTCAAAAACGAACTTATGGTTAAGGACTTAGAATTAGCCAGTGGCATGGCGTTGGGTATTCGTTCGCCGATCCCATTGGGCGCTGTCGCAACTCAGCTCTACCGCATCGTGCAGTCCAGGGGCTACGGCCAGAAAGACTTCTCGTTCGTCTTCCAGCTACTGAAAGAAGAAAACAAAAATTAG

Protein

MAARTILSTQCLYTAARRAYSSNTDKNVAFLGLGNMGGFMAANLVKKGFTVRGYDPSKDALNAAAKNGVTPANSIAAAVDGVDVVVSILTSNKVVLDVYLGKDGVVAHAKKGSLLIDSSTIDPNVPKQIFPIALEKGLGFTDAPVSGGVMGAQNATLAFMAGGRKEDFERSLPLLKVMGAKQFHCGQIGSGQVAKLTNNMLMGITGMATAECMNMGIKMGLEPKVLLDVLNNSSARSWSTEVYCPVPGLVPTAPSSRNYDGGFKNELMVKDLELASGMALGIRSPIPLGAVATQLYRIVQSRGYGQKDFSFVFQLLKEENKN

Catalytic Activity

3-hydroxy-2-methylpropanoate + NAD(+) = 2-methyl-3-oxopropanoate + H(+) + NADH

Similarity

Belongs to the HIBADH-related family.

Uniprot

H9JC99   B3GQU6   A0A2H1V253   A0A194RJP5   A0A2A4K6B3   A0A194PJC7   + More
S4P4G9   I4DR58   A0A212F4X2   A0A232F4U2   E2BKV7   A0A026WLY7   A0A151X333   A0A1A9V4T6   A0A151I2H3   A0A1A9XAS1   A0A1A9ZX23   A0A0P5CP75   A0A0N8A5N0   A0A158NSB4   A0A0P5T8P1   A0A0P5BK54   A0A1B0G2W9   W8B751   D3TQ47   A0A0P5HKP8   A0A369RZ39   A0A1L8E147   A0A0A1X062   A0A1A9WNV5   A0A195ERZ3   A0A0P5HR85   A0A034VRZ1   E9GCN3   A0A0K8WJS2   A0A2A3EI45   A0A0K8VJQ9   A0A2P2HY37   A0A1S3JB31   A0A146P678   A0A1L8E1I8   V5I8T8   A0A1W7RFT5   A0A0F7Z8R5   T1DKE8   A0A098LZM6   A0A0S7HGG7   A0A3P9MXD6   T1DN42   A0A0B6YUP5   A0A3B4T5Q7   A0A315WD32   A0A2M3Z1E6   A0A3B5R058   A0A3Q2XI03   A0A2M4ABV3   A0A3B4XQP0   E2A2W8   A0A1U7S972   A0A3B5QWB3   H2UQQ7   A0A3Q3LQE4   A0A3Q1HD37   A0A3B4GAF1   A0A3Q3IBG0   A0A3Q3M485   A0A3P8NKB1   A0A3P9C8X0   A8DSV9   A0A151MR22   A0A2M4BTZ9   A0A2D0RUI2   L8HDI8   A0A2M3Z1N8   A0A3Q2E582   A0A0S7HE98   A0A182LJB1   A0A3B3XSR0   A0A3B3DSE3   A0A3P9I6H8   A0A2M3Z1J6   A0A3Q3VSV9   W5J8L6   C3Y133   A0A3P9K560   A0A182PHH0   A0A182FEI1   A0A0F8ADE7   A0A3Q3JGK6   Q1KKZ7   A0A3S2P847   A0A1B6GZS7   A0A3P8V030   A0A3B5KQ40   H2LTU1   A0A3P9IJU4   A0A182VGD6   A0A2M4BTL5   A0A3P9L0W1  

EC Number

1.1.1.31

Pubmed

19121390    26354079    23622113    22651552    22118469    28648823    + More
20798317    24508170    21347285    24495485    20353571    30042472    25830018    25348373    21292972    26383154    26358130    23758969    25727380    29703783    23542700    21551351    25186727    17845724    22293439    23375108    20966253    29451363    17554307    20920257    23761445    18563158    25835551    16636282    24487278   

EMBL

BABH01015134    EU719652    ACD92999.1    ODYU01000337    SOQ34911.1    KQ460124    + More
KPJ17659.1    NWSH01000133    PCG79210.1    KQ459603    KPI93143.1    GAIX01005969    JAA86591.1    AK404956    BAM20398.1    AGBW02010289    OWR48798.1    NNAY01000942    OXU25801.1    GL448826    EFN83706.1    KK107171    EZA56099.1    KQ982562    KYQ54835.1    KQ976543    KYM81008.1    GDIP01183447    JAJ39955.1    GDIP01180097    JAJ43305.1    ADTU01024780    GDIP01217791    GDIP01213050    GDIQ01241264    GDIQ01208968    GDIQ01154185    GDIQ01138344    GDIP01131661    GDIP01094509    JAK10461.1    JAL72053.1    GDIP01183448    JAJ39954.1    CCAG010015288    GAMC01013642    GAMC01013641    JAB92913.1    EZ423549    ADD19825.1    GDIQ01231713    GDIQ01121050    JAK20012.1    NOWV01000116    RDD39948.1    GFDF01001718    JAV12366.1    GBXI01010127    JAD04165.1    KQ981993    KYN30998.1    GDIQ01229461    JAK22264.1    GAKP01014065    JAC44887.1    GL732539    EFX82586.1    GDHF01027621    GDHF01022291    GDHF01012221    GDHF01004573    GDHF01001020    JAI24693.1    JAI30023.1    JAI40093.1    JAI47741.1    JAI51294.1    KZ288253    PBC30942.1    GDHF01013190    JAI39124.1    IACF01000960    LAB66694.1    GCES01147306    GCES01146523    JAQ39016.1    GFDF01001719    JAV12365.1    GALX01004110    JAB64356.1    GDAY02001414    JAV50013.1    GBEX01001987    JAI12573.1    GAAZ01001418    GBKC01002103    GBKD01001263    JAA96525.1    JAG43967.1    JAG46355.1    GBSI01001072    JAC95424.1    GBYX01442853    JAO38541.1    GAMD01003205    JAA98385.1    HACG01012962    CEK59827.1    NHOQ01000034    PWA33647.1    GGFM01001560    MBW22311.1    GGFK01004767    MBW38088.1    GL436229    EFN72210.1    EF594311    ABS70747.1    AKHW03005461    KYO26850.1    GGFJ01007280    MBW56421.1    KB007857    ELR23250.1    GGFM01001672    MBW22423.1    GBYX01442852    JAO38542.1    GGFM01001639    MBW22390.1    ADMH02002097    ETN59220.1    GG666480    EEN65573.1    KQ042840    KKF09948.1    DQ481664    ABF22397.1    CM012447    RVE66853.1    GECZ01001847    JAS67922.1    GGFJ01007276    MBW56417.1   

Proteomes

UP000005204    UP000053240    UP000218220    UP000053268    UP000007151    UP000215335    + More
UP000008237    UP000053097    UP000075809    UP000078200    UP000078540    UP000092443    UP000092445    UP000005205    UP000092444    UP000253843    UP000091820    UP000078541    UP000000305    UP000242457    UP000085678    UP000265000    UP000242638    UP000261420    UP000002852    UP000264820    UP000261360    UP000000311    UP000189705    UP000005226    UP000261640    UP000265040    UP000261460    UP000261600    UP000265100    UP000265160    UP000264840    UP000050525    UP000221080    UP000011083    UP000265020    UP000075882    UP000261480    UP000261560    UP000265200    UP000261620    UP000000673    UP000001554    UP000265180    UP000075885    UP000069272    UP000265120    UP000001038    UP000075903   

PRIDE

H9JC99    B3GQU6   

Pfam

PF03446   NAD_binding_2        + More
PF14833   NAD_binding_11

Interpro

IPR029154   NADP-bd        + More
IPR002204   3-OH-isobutyrate_DH-rel_CS       
IPR013328   6PGD_dom2       
IPR015815   HIBADH-related       
IPR006115   6PGDH_NADP-bd       
IPR011548   HIBADH       
IPR008927   6-PGluconate_DH-like_C_sf       
IPR036291   NAD(P)-bd_dom_sf       

SUPFAM

SSF51735   SSF51735        + More
SSF48179   SSF48179       

Gene 3D

1.10.1040.10    

ProteinModelPortal

H9JC99   B3GQU6   A0A2H1V253   A0A194RJP5   A0A2A4K6B3   A0A194PJC7   + More
S4P4G9   I4DR58   A0A212F4X2   A0A232F4U2   E2BKV7   A0A026WLY7   A0A151X333   A0A1A9V4T6   A0A151I2H3   A0A1A9XAS1   A0A1A9ZX23   A0A0P5CP75   A0A0N8A5N0   A0A158NSB4   A0A0P5T8P1   A0A0P5BK54   A0A1B0G2W9   W8B751   D3TQ47   A0A0P5HKP8   A0A369RZ39   A0A1L8E147   A0A0A1X062   A0A1A9WNV5   A0A195ERZ3   A0A0P5HR85   A0A034VRZ1   E9GCN3   A0A0K8WJS2   A0A2A3EI45   A0A0K8VJQ9   A0A2P2HY37   A0A1S3JB31   A0A146P678   A0A1L8E1I8   V5I8T8   A0A1W7RFT5   A0A0F7Z8R5   T1DKE8   A0A098LZM6   A0A0S7HGG7   A0A3P9MXD6   T1DN42   A0A0B6YUP5   A0A3B4T5Q7   A0A315WD32   A0A2M3Z1E6   A0A3B5R058   A0A3Q2XI03   A0A2M4ABV3   A0A3B4XQP0   E2A2W8   A0A1U7S972   A0A3B5QWB3   H2UQQ7   A0A3Q3LQE4   A0A3Q1HD37   A0A3B4GAF1   A0A3Q3IBG0   A0A3Q3M485   A0A3P8NKB1   A0A3P9C8X0   A8DSV9   A0A151MR22   A0A2M4BTZ9   A0A2D0RUI2   L8HDI8   A0A2M3Z1N8   A0A3Q2E582   A0A0S7HE98   A0A182LJB1   A0A3B3XSR0   A0A3B3DSE3   A0A3P9I6H8   A0A2M3Z1J6   A0A3Q3VSV9   W5J8L6   C3Y133   A0A3P9K560   A0A182PHH0   A0A182FEI1   A0A0F8ADE7   A0A3Q3JGK6   Q1KKZ7   A0A3S2P847   A0A1B6GZS7   A0A3P8V030   A0A3B5KQ40   H2LTU1   A0A3P9IJU4   A0A182VGD6   A0A2M4BTL5   A0A3P9L0W1  

PDB

2I9P     E-value=3.8415e-65,     Score=629

KEGG

100174823    K00020 3-hydroxyisobutyrate dehydrogenase [EC:1.1.1.31] K23146 3-hydroxypropionate dehydrogenase [EC

PATHWAY

00280    Valine, leucine and isoleucine degradation - Bombyx mori (domestic silkworm)
00410    beta-Alanine metabolism - Bombyx mori (domestic silkworm)
00640    Propanoate metabolism - Bombyx mori (domestic silkworm)
01100    Metabolic pathways - Bombyx mori (domestic silkworm)
01200    Carbon metabolism - Bombyx mori (domestic silkworm)

GO

GO:0051287   GO:0006574   GO:0008442   GO:0050661   GO:0005739   GO:0016491   GO:0004616   GO:0006284   GO:0003906   GO:0005634   GO:0006285   GO:0019104   GO:0003824   GO:0055114  

Length:

322

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

7.40525

Exp number, first 60 AAs:

7.15559

Total prob of N-in:

0.40494

outside

1  -  322

 

 

Pi

245.552836

Theta

149.197322

Tajima's D

1.748495

CLR

0.348776

CSRT

0.84050797460127

Interpretation

Uncertain