Gene

KWMTBOMO10516

Pre Gene Modal

BGIBMGA007125

Annotation

innexin_4_[Bombyx_mori]

Location

Bomo_Chr17(+):13168487-13170829      View in EpiBrowser

Full name

Innexin       + More
Innexin inx2      

Alternative Name

Gap junction protein prp33
Pas-related protein 33
G-Inx2

Location in the cell

PlasmaMembrane   Reliability : 4.335

CDS

ATGATTGATCTTTTTATGCCTTTTCGTTCATTTTTGAAATTTGAGAATGTATGTACTGATAATAATATTTTTCGAATGCATTACAAGCTCACAGTCATAATATTATTGGTGTTTACACTTCTTGTGACTTCAAAGCAGTTTTTCGGAGAGCCCATACATTGTATGAGCGGCAATGATAAAGGCAATGATAAGGACGCCGTGAACAGTTATTGTTGGATATATGGAACATACACGCTGAAGAGCCAGCTTTTAGGTGTTGAAGGCAGGCACATGGCATATGTAGGAGTAGGACCGGCTAAGTCCGACGATGATGAGCAGATCAAACACACTTACTACCAGTGGGTGTGTTTTGTACTACTTGGTCAAGCCACCATGTTTTATGCTCCTCGATACCTGTGGAAAATGTGGGAAGGAGGCAGGCTGAAGGCACTGGCAGCTGATCTTAGCAGTCCAATGGTTTCGAAGGATTGGTCAGAGTTCAGGCGCAAGGAACTTGTCTCATATTTTAATTACACAAATATGTATACTCATAATATGTATGCCCTGCGTTATGCATTTTGTGAGTTACTGAACCTTGTAAATGTGGTTGGTCAAATATTTATTCTGGACTTGTTCCTTGGTGGTTCATTCCGTAACTATGGTGCTGCAGTTGCAGCTTTTACGCACACCCCACGCATACCTAACGATTTTACCAACTTCACCTCTGTCAACCCCATGGATGAATTTTTTCCCAAACTCACTAAATGCTGGTTAAGAAACTATGGACCTTCAGGCTCTCTTGAATTAAAGGATCGATTGTGTGTACTACCTTTAAATATTGTTAATGAAAAGATATTTGTTATCCTTTGGTTCTGGCTTATTATATTAACGGCTTTTTCGATACTAGCAGTAGTTTTTCGTTTTCTCTTGCTTATATTATATCCACTGCGGACAGTAATGATACGTGGACAAATACGCTATGTTAAAAGAAGTGTTGTCTCACGTATTGTAAAGAGATTTGGTTTTGGGGACTGGTTTATTCTCCACTTATTGGGTAAGAACATGAATCCAATAATTTTTAAGGATTTAGTACTTGAATTGGCCAAAGAAATAGAACATAATGCTATAATGGTATAA

Protein

MIDLFMPFRSFLKFENVCTDNNIFRMHYKLTVIILLVFTLLVTSKQFFGEPIHCMSGNDKGNDKDAVNSYCWIYGTYTLKSQLLGVEGRHMAYVGVGPAKSDDDEQIKHTYYQWVCFVLLGQATMFYAPRYLWKMWEGGRLKALAADLSSPMVSKDWSEFRRKELVSYFNYTNMYTHNMYALRYAFCELLNLVNVVGQIFILDLFLGGSFRNYGAAVAAFTHTPRIPNDFTNFTSVNPMDEFFPKLTKCWLRNYGPSGSLELKDRLCVLPLNIVNEKIFVILWFWLIILTAFSILAVVFRFLLLILYPLRTVMIRGQIRYVKRSVVSRIVKRFGFGDWFILHLLGKNMNPIIFKDLVLELAKEIEHNAIMV

Description

Structural component of the gap junctions.
Structural components of the gap junctions. Involved in gap junctional communication between germline and somatic cells which is essential for normal oogenesis. In embryonic epidermis, required for epithelial morphogenesis. Required for keyhole formation during early stages of proventriculus development in response to wg signaling. In follicle cells, promotes the formation of egg chambers in part through regulation of shg and baz at the boundary between germ cells and follicle cells. In inner germarial sheath cells, required for survival of early germ cells and for cyst formation.

Subunit

Monomer and heterooligomer with ogre or Inx3 (via cytoplasmic C-terminal region). Interacts (via cytoplasmic loop) with shg (via cytoplasmic region). Interacts with arm.

Similarity

Belongs to the pannexin family.

Keywords

Cell junction   Cell membrane   Complete proteome   Cytoplasm   Developmental protein   Differentiation   Gap junction   Ion channel   Ion transport   Membrane   Oogenesis   Reference proteome   Transmembrane   Transmembrane helix   Transport  

Feature

chain  Innexin

Uniprot

Q5XLD8   A2TEZ1   A0A2H1VAA9   A0A2A4K6C4   S4P161   H9JC80   + More
A0A2A4K4P2   A0A0N1PHR1   A0A194PK59   E2BKJ4   A0A151WZW3   A0A151I4W9   F4WK32   A0A195DJR1   A0A3L8DU44   A0A195FL04   E1ZVA0   A0A026X0B1   A0A034VKH4   A0A0A9VUC1   A0A0K8VKP7   A0A1B6CKW9   A0A2J7PHC1   A0A182JZM3   A0A182VWE0   A0A195C9G7   A0A1A9XRV8   A0A1B0AP71   A2TEZ0   Q6SA04   A0A1B0G4W2   A0A1A9UUN2   A0A1A9ZE59   A0A182YB92   A0A182NA24   A0A194PPJ2   A0A0N0PCR1   W8B342   W8AZ10   V5GVY7   A0A1B0DD12   A0A182M026   A0A2P8YZB7   A0A0A1XMB6   E1JJF3   Q9V427   Q6XZI1   B3NXY3   Q6PYX4   A0A182R506   A0A1L8E3F2   A0A067R1S3   T1PEY5   A0A1B0CVA1   B4Q160   B4M9W2   Q9XYN1   A0A1I8P411   C0KLS6   A0A182QM11   A0A0L0BUG1   K9RY87   K9S0V4   A0A2A4K0K9   A0A2R7WYH0   A0A1A9WPK2   A0A1B6L2T6   B4IHI6   A0A084W2Z8   A0A158NU57   B3MQ11   U5EUV3   A0A3S2LJH0   B4NEG0   A0A3B0K691   A0A0P6IZ10   A0A182SMM5   A0A226EJI1   B4JMT1   A0A1B6IFW0   A0A212EYK5   A0A182GB47   A0A1W4WZU8   A0A1W4V8D0   D6X4J0   T1E2R6   A0A1E1WFT8   A0A1B6GUR0   Q29GY8   A0A224XSQ0   A0A069DSD1   Q16FA2   S4PA74   T1DI93   A0A0M5J2R8   A0A1J1I1G9   J3JY90   E1ZXE9   B4L565  

Pubmed

17950307    23622113    19121390    26354079    20798317    21719571    + More
30249741    24508170    25348373    25401762    26823975    25244985    24495485    29403074    25830018    10731132    12537568    12537572    12537573    12537574    16110336    17569856    17569867    26109357    26109356    10352230    10888681    12537569    11956317    11960713    15047872    16436513    19038051    22001874    17994087    18057021    28433752    24845553    25315136    17550304    10079517    26108605    24438588    21347285    22118469    26483478    18362917    19820115    24330624    15632085    26334808    17510324    25585357    22516182   

EMBL

AY754727    AAV28707.1    EF197892    ABM88791.1    ODYU01001480    SOQ37731.1    + More
NWSH01000131    PCG79222.1    GAIX01009046    JAA83514.1    BABH01015047    BABH01015048    BABH01015049    PCG79221.1    KQ460711    KPJ12677.1    KQ459603    KPI93114.1    GL448810    EFN83781.1    KQ982638    KYQ53297.1    KQ976445    KYM86057.1    GL888193    EGI65404.1    KQ980794    KYN13057.1    QOIP01000004    RLU23891.1    KQ981522    KYN40674.1    GL434491    EFN74876.1    KK107046    EZA61697.1    GAKP01016340    JAC42612.1    GBHO01044300    GBHO01030105    GBRD01012033    GDHC01002278    JAF99303.1    JAG13499.1    JAG53791.1    JAQ16351.1    GDHF01015923    GDHF01012857    JAI36391.1    JAI39457.1    GEDC01023218    GEDC01018802    JAS14080.1    JAS18496.1    NEVH01025142    PNF15718.1    KQ978143    KYM96758.1    JXJN01001234    EF197891    ABM88790.1    BABH01003247    AY461704    AAR97567.2    CCAG010000780    KQ459596    KPI95361.1    KQ460497    KPJ14319.1    GAMC01015097    JAB91458.1    GAMC01015098    JAB91457.1    GALX01004058    JAB64408.1    AJVK01014295    AXCM01003927    PYGN01000272    PSN49595.1    GBXI01002190    JAD12102.1    AE014298    ACZ95220.1    AF137269    AF172257    AY060368    AY196138    ODYU01003264    AAP40732.1    SOQ41789.1    CH954180    EDV47434.1    AY570724    AAS77384.1    GFDF01000920    JAV13164.1    KK853092    KDR11527.1    KA646715    AFP61344.1    AJWK01030336    CM000162    EDX02415.1    CH940655    EDW66021.1    AF115854    FJ619503    ACN41954.1    AXCN02001524    JRES01001325    KNC23628.1    KC018471    AFY62975.1    KC018473    AFY62977.1    NWSH01000281    PCG77801.1    KK855997    PTY24583.1    GEBQ01022017    JAT17960.1    CH480839    EDW49337.1    ATLV01019742    KE525279    KFB44592.1    ADTU01026241    CH902621    EDV44437.1    GANO01001288    JAB58583.1    RSAL01000001    RVE55224.1    CH964239    EDW82129.1    OUUW01000016    SPP88803.1    GDIQ01002289    JAN92448.1    LNIX01000003    OXA57277.1    CH916371    EDV92024.1    GECU01021896    JAS85810.1    AGBW02011483    OWR46576.1    JXUM01157673    KQ572819    KXJ67988.1    KQ971380    EEZ97563.1    GALA01001055    JAA93797.1    GDQN01005226    JAT85828.1    GECZ01003608    JAS66161.1    CH379064    EAL31971.1    GFTR01005427    JAW10999.1    GBGD01001916    JAC86973.1    KJ736824    CH478475    AIF75096.1    EAT32915.1    GAIX01003374    JAA89186.1    GALA01001056    JAA93796.1    CP012528    ALC48311.1    CVRI01000024    CRK92217.1    BT128214    AEE63175.1    GL435038    EFN74126.1    CH933811    EDW06324.1   

Proteomes

UP000218220    UP000005204    UP000053240    UP000053268    UP000008237    UP000075809    + More
UP000078540    UP000007755    UP000078492    UP000279307    UP000078541    UP000000311    UP000053097    UP000235965    UP000075881    UP000075920    UP000078542    UP000092443    UP000092460    UP000092444    UP000078200    UP000092445    UP000076408    UP000075884    UP000092462    UP000075883    UP000245037    UP000000803    UP000008711    UP000075900    UP000027135    UP000095301    UP000092461    UP000002282    UP000008792    UP000095300    UP000075886    UP000037069    UP000091820    UP000001292    UP000030765    UP000005205    UP000007801    UP000283053    UP000007798    UP000268350    UP000075901    UP000198287    UP000001070    UP000007151    UP000069940    UP000249989    UP000192223    UP000192221    UP000007266    UP000001819    UP000008820    UP000092553    UP000183832    UP000009192   

PRIDE

Q5XLD8    A2TEZ1    H9JC80    Q6SA04    E1JJF3    Q9V427    + More
Q6PYX4   

Pfam

PF00876   Innexin        + More
PF01565   FAD_binding_4
PF02913   FAD-oxidase_C

Interpro

IPR000990   Innexin        + More
IPR016169   FAD-bd_PCMH_sub2       
IPR036318   FAD-bd_PCMH-like_sf       
IPR016167   FAD-bd_PCMH_sub1       
IPR004113   FAD-linked_oxidase_C       
IPR025650   Alkyl-DHAP_Synthase       
IPR016166   FAD-bd_PCMH       
IPR016164   FAD-linked_Oxase-like_C       
IPR016171   Vanillyl_alc_oxidase_C-sub2       
IPR006094   Oxid_FAD_bind_N       
IPR023123   Tubulin_C       
IPR008280   Tub_FtsZ_C       

SUPFAM

SSF56176   SSF56176        + More
SSF55103   SSF55103       
SSF55307   SSF55307       

Gene 3D

1.10.45.10     3.30.43.10     3.30.465.10     1.10.287.600    

ProteinModelPortal

Q5XLD8   A2TEZ1   A0A2H1VAA9   A0A2A4K6C4   S4P161   H9JC80   + More
A0A2A4K4P2   A0A0N1PHR1   A0A194PK59   E2BKJ4   A0A151WZW3   A0A151I4W9   F4WK32   A0A195DJR1   A0A3L8DU44   A0A195FL04   E1ZVA0   A0A026X0B1   A0A034VKH4   A0A0A9VUC1   A0A0K8VKP7   A0A1B6CKW9   A0A2J7PHC1   A0A182JZM3   A0A182VWE0   A0A195C9G7   A0A1A9XRV8   A0A1B0AP71   A2TEZ0   Q6SA04   A0A1B0G4W2   A0A1A9UUN2   A0A1A9ZE59   A0A182YB92   A0A182NA24   A0A194PPJ2   A0A0N0PCR1   W8B342   W8AZ10   V5GVY7   A0A1B0DD12   A0A182M026   A0A2P8YZB7   A0A0A1XMB6   E1JJF3   Q9V427   Q6XZI1   B3NXY3   Q6PYX4   A0A182R506   A0A1L8E3F2   A0A067R1S3   T1PEY5   A0A1B0CVA1   B4Q160   B4M9W2   Q9XYN1   A0A1I8P411   C0KLS6   A0A182QM11   A0A0L0BUG1   K9RY87   K9S0V4   A0A2A4K0K9   A0A2R7WYH0   A0A1A9WPK2   A0A1B6L2T6   B4IHI6   A0A084W2Z8   A0A158NU57   B3MQ11   U5EUV3   A0A3S2LJH0   B4NEG0   A0A3B0K691   A0A0P6IZ10   A0A182SMM5   A0A226EJI1   B4JMT1   A0A1B6IFW0   A0A212EYK5   A0A182GB47   A0A1W4WZU8   A0A1W4V8D0   D6X4J0   T1E2R6   A0A1E1WFT8   A0A1B6GUR0   Q29GY8   A0A224XSQ0   A0A069DSD1   Q16FA2   S4PA74   T1DI93   A0A0M5J2R8   A0A1J1I1G9   J3JY90   E1ZXE9   B4L565  

PDB

5H1R     E-value=6.49742e-11,     Score=162

KEGG

692656    K22037 innexin | (RefSeq) Inx4; innexin 4

GO

GO:0005921   GO:0006811   GO:0005886   GO:0016021   GO:0016491   GO:0008610   GO:0071949   GO:0008609   GO:0005243   GO:0016324   GO:0005737   GO:0007293   GO:0007154   GO:0016331   GO:0007440   GO:0007283   GO:0010496   GO:0016328   GO:0016323   GO:0030727   GO:0016327   GO:0036098   GO:0003824   GO:0016614   GO:0005852   GO:0006413   GO:0031369   GO:0005515   GO:0046872  

PANTHER

PTHR11893   PTHR46568  

Subcellular location

Cell membrane  
Cell junction  
Gap junction  
Cytoplasm  
Apical cell membrane  
Apicolateral cell membrane  
Basolateral cell membrane  
Lateral cell membrane  

Length:

371

Number of predicted TMHs:

4

Exp number of AAs in TMHs:

93.5126400000001

Exp number, first 60 AAs:

21.07015

Total prob of N-in:

0.96080

POSSIBLE N-term signal

sequence

inside

1  -  20

TMhelix

21  -  43

outside

44  -  110

TMhelix

111  -  133

inside

134  -  179

TMhelix

180  -  202

outside

203  -  280

TMhelix

281  -  303

inside

304  -  371

 

 

Pi

232.798146

Theta

200.751791

Tajima's D

0.281875

CLR

2.105894

CSRT

0.452477376131193

Interpretation

Uncertain