Gene

KWMTBOMO10515  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA007125

Annotation

PREDICTED:_alkyldihydroxyacetonephosphate_synthase_[Amyelois_transitella]

Location

Bomo_Chr17(+):13154957-13167661      View in EpiBrowser

Full name

Innexin       + More
Alkylglycerone-phosphate synthase      
Alkyldihydroxyacetonephosphate synthase      

Alternative Name

Alkylglycerone-phosphate synthase

Location in the cell

Cytoplasmic   Reliability : 1.927

CDS

ATGAACTGGCCATTTTTCCTTGGACAGATATTGTACCTTGTAAGAGCAGAGAATATGCTCTCCGACGAGGCTGCATTGTTTGTTGCTTATGTGCACGATAGTGGTCTTGATCGTCATGTAGTGTTGAAAGGGGCAGACTTGATGCGTCTCACGATGTCGCTCCATCTCTCCCTGCTCGAGGCCATGTCATCACAATACAATTTAAGACGTTCACCAAGCATCTTTTGGTGTAGTCGATACTCAATAGCAGGGAAATGCTTACCCCACCTACCGCAGTGGGCCATAGACAACTTTGGCATAGATCCAGATTCCCCGCCCAAAATTCCGGAAGCGCCAAGTAGTTTTGCAGAAAGTCGCCTGCCGGAAAACGTTAAGGATGAATTGGAGATGATCGCCGCAGTAAGCGTGGACGGCATGGATAGACTGATCAGAGCACACGGGCAGACCTTAAAGGACATAGCGAACGTCAGAAATAACAACTTTCGGAGAATACCTGACGCTGTCATATGGCCAGATTGTCATGAGCAGGTAGAAAAGATAGTCCAATGTGCGTCGCGGCACAACTTCGTGATCATTCCTTTCGGTGGGGGCACGTCGGTGTCCGGCGCGGTCACTTGCCCCGAGAACGAACCCAGGCCCATAGTCGCCCTGGACACGAGCGAAATGAATTCAATACTGTGGTTGGACAAGGAGCAGCTGCTGGCGAGAGTGCAAGCAGGAATAGTCGGTCAAGACTTAGAGCGGGAGATGCGGTCCCGTGGCTTCACCGTCGGCCACGAGCCAGACTCGTACGAGTTCTCTACCCTCGGGGGGTGGGTTGCGACAAGAGCCAGCGGCATGAAGAAGAACACATATGGGAATATAGAAGATTTAGTTGTACAGACGAAGGTGGTGACGCCGAAAGGAGTGCTCGAGAAGAGCTGTCGCGTGCCGAGGGTGTCGTGCGGTCCGGAATGGGAGCACGTCGTGATGGGCTCCGAAGGATGCTTCGGTGTCGTCACTGAGGTCGTCATCAAAATCCGTCCAGTGCCGGCCGTGACTCGCTACGGATCCCTCGTGTTCCCCGACTGGGAGTCCGGGTTCTGGTTCGAAAGGGAAGTCGCCAGGAAGAGGCTTCAACCTTCTAGTATTAGACTAATGGACAACGAACAGTTTCGTTTCGGGCAAGCACTGAAATTGGAGAACTCGTGGGGCGGAGTCCTGTTGGACGGGCTGAAGCGACTGTACATCACTAGGATCAAAGGGTTCGATCCTCTGAAGCTGTGCGTGGTCACGCTGCTCATGGAGGGCACCGAGGAGAAAGTCAGAGAACAAGAGCGAGCGCTCAACGGCATCGCGGCCCGGCACGGCGGGGTGCCGGCCGGCGCGGGGAACGGCGAGACCGGATACACGCTCACCTTCGTCATAGCCTACCTCAGGGACGTGGCGATAGAGTTCGACATAGTGGCGGAATCGTTCGAGACGTCGGTGCCCTGGGACCGCACCCTGGCTCTCTGCAGGAACGTGAAGACTCGCGTCCGGGACGAGTGTCTCGCCAGAAGTATCACCCGGTTCCTGATCTCGTGCCGCCTCACTCAAACTTACGACGCCGGCTGCTGTATTTATTTTTATTTTGGATTTTACTCGGGTGACTGTGAAAACCCTGTCGAAACGTACGAGCAAATCGAGGAAGCAGCCAGAGATGAAATATTAGCTTGCGGTGGGTCGATATCGCACCATCATGGCGTCGGAAAATTAAGAAAGAAATGGTACGCCGAGACTGTGAGCGAACCCGGCCGCCAATTACTACTGGCAGCTAAGAACGCCTTAGATCCGCAGAACATATTTGCAGTCGGCAATATGGCCTTTGACGAGCACAACACCGAACATAGCGTCAAAAGTAAACTATGA

Protein

MNWPFFLGQILYLVRAENMLSDEAALFVAYVHDSGLDRHVVLKGADLMRLTMSLHLSLLEAMSSQYNLRRSPSIFWCSRYSIAGKCLPHLPQWAIDNFGIDPDSPPKIPEAPSSFAESRLPENVKDELEMIAAVSVDGMDRLIRAHGQTLKDIANVRNNNFRRIPDAVIWPDCHEQVEKIVQCASRHNFVIIPFGGGTSVSGAVTCPENEPRPIVALDTSEMNSILWLDKEQLLARVQAGIVGQDLEREMRSRGFTVGHEPDSYEFSTLGGWVATRASGMKKNTYGNIEDLVVQTKVVTPKGVLEKSCRVPRVSCGPEWEHVVMGSEGCFGVVTEVVIKIRPVPAVTRYGSLVFPDWESGFWFEREVARKRLQPSSIRLMDNEQFRFGQALKLENSWGGVLLDGLKRLYITRIKGFDPLKLCVVTLLMEGTEEKVREQERALNGIAARHGGVPAGAGNGETGYTLTFVIAYLRDVAIEFDIVAESFETSVPWDRTLALCRNVKTRVRDECLARSITRFLISCRLTQTYDAGCCIYFYFGFYSGDCENPVETYEQIEEAARDEILACGGSISHHHGVGKLRKKWYAETVSEPGRQLLLAAKNALDPQNIFAVGNMAFDEHNTEHSVKSKL

Description

Structural component of the gap junctions.
Catalyzes the exchange of an acyl for a long-chain alkyl group and the formation of the ether bond in the biosynthesis of ether phospholipids.

Catalytic Activity

a 1-acylglycerone 3-phosphate + a long chain fatty alcohol = 1-O-alkylglycerone 3-phosphate + a long-chain fatty acid + H(+)

Cofactor

FAD

Subunit

Homodimer.

Similarity

Belongs to the pannexin family.
Belongs to the FAD-binding oxidoreductase/transferase type 4 family.

Keywords

Complete proteome   FAD   Flavoprotein   Lipid biosynthesis   Lipid metabolism   Peroxisome   Reference proteome   Transferase  

Feature

chain  Innexin

Uniprot

H9JC80   A0A2H1VA52   A0A2A4K6C2   A0A194PJ97   D6WW52   A0A1B0C9B7   + More
A0A2J7Q507   A0A182K051   A0A182Q4S0   A0A182VPM3   A0A1B6IX74   A0A182P3E9   A0A182YJQ0   A0A1B6EHV6   A0A1L8DAN0   A0A1L8DAN4   A0A034VKX9   A0A182R8H3   J3JW52   A0A1L8DAZ9   A0A2P8YUN1   A0A182SQW2   A0A0K8VS84   N6TXY9   A0A182LV29   A0A182LNJ1   A0A1B6LVZ4   A0A0M4EHA8   Q7QA93   A0A182XF27   A0A182UXZ6   A0A182HVJ5   A0A182NCQ5   W5JEK9   B3MH07   A0A182FPJ7   A0A0B4JD21   Q9V778   B3NQQ2   B4HRS2   A0A3B0JS51   B4P7R8   A0A1I8MB57   A0A1A9VZE3   A0A1B0GBE9   B4QGC0   D5SHU3   A0A1A9ZPI4   E0VIW8   A0A182TZH2   A0A0A1WK86   T1PK60   A0A1W4UM17   A0A1Y1MVA3   A0A1Y1MS72   A0A1B0B4G9   K7JA90   B4LLK6   W8BYB7   A0A1A9VJD3   A0A1B6CGH0   B4KP39   A0A182JL87   B5E051   A0A1Z5KWP2   A0A0L0CMS2   A0A336N0B4   B4GD67   A0A2A3E405   V9IGF4   A0A310SLM8   A0A336MYR2   A0A151X1B3   B4J5Y8   B4MQ03   A0A1I8P8Q1   A0A1Q3FIE7   A0A224YJ86   B0WMX1   A0A131Z8X7   A0A1D2NHA7   T1H9K7   A0A0N8ES99   A0A2R5LLX7   A0A154P064   A0A151I0V8   A0A146L266   A0A151I8K5   A0A1E1X931   A0A158NAD8   A0A026WRM0   A0A210QBG3   A0A195EW99   A0A1Y1MTG5   F4WMI0   A0A069DWA1   A0A023F3H5   A0A151LZZ3   A0A1U8DJK3   A0A1S3JUX1  

EC Number

2.5.1.26

Pubmed

19121390    26354079    18362917    19820115    25244985    25348373    + More
22516182    23537049    29403074    20966253    12364791    14747013    17210077    20920257    23761445    17994087    18057021    10731132    12537568    12537572    12537573    12537574    16110336    17569856    17569867    26109357    26109356    12537569    17550304    25315136    22936249    20566863    25830018    28004739    20075255    24495485    15632085    23185243    28528879    26108605    28797301    26830274    27289101    26999592    26823975    28503490    21347285    24508170    30249741    28812685    21719571    26334808    25474469    22293439   

EMBL

BABH01015047    BABH01015048    BABH01015049    ODYU01001480    SOQ37730.1    NWSH01000131    + More
PCG79220.1    KQ459603    KPI93113.1    KQ971361    EFA08666.1    AJWK01002156    NEVH01018372    PNF23665.1    AXCN02000334    GECU01016171    JAS91535.1    GECZ01032261    JAS37508.1    GFDF01010566    JAV03518.1    GFDF01010565    JAV03519.1    GAKP01016472    JAC42480.1    BT127470    KB631786    AEE62432.1    ERL86064.1    GFDF01010564    JAV03520.1    PYGN01000350    PSN47945.1    GDHF01010585    JAI41729.1    APGK01056813    KB741277    ENN71142.1    AXCM01000757    AXCM01000758    AXCM01000759    GEBQ01019593    GEBQ01012700    GEBQ01012139    JAT20384.1    JAT27277.1    JAT27838.1    CP012524    ALC41922.1    AAAB01008898    EAA09140.2    APCN01005786    APCN01005787    ADMH02001712    ETN61330.1    CH902619    EDV35766.1    KPU75815.1    AE013599    ADV37181.1    AY094917    CH954179    EDV55962.1    CH480816    EDW47936.1    OUUW01000001    SPP75531.1    CM000158    EDW91094.1    CCAG010013992    CM000362    CM002911    EDX07158.1    KMY93874.1    BT124894    ADG57801.1    DS235212    EEB13324.1    GBXI01015196    JAC99095.1    KA648348    AFP62977.1    GEZM01023333    JAV88460.1    GEZM01023334    JAV88459.1    JXJN01008310    AAZX01000485    CH940648    EDW60869.1    KRF79646.1    GAMC01012301    JAB94254.1    GEDC01024809    JAS12489.1    CH933808    EDW10105.1    CM000071    EDY69284.1    KRT02782.1    GFJQ02007515    JAV99454.1    JRES01000171    KNC33648.1    UFQT01002967    SSX34373.1    CH479181    EDW32562.1    KZ288419    PBC25986.1    JR041348    AEY59419.1    KQ759894    OAD62044.1    UFQS01002628    UFQT01002628    SSX14393.1    SSX33803.1    KQ982585    KYQ54192.1    CH916367    EDW00831.1    CH963849    EDW74192.1    GFDL01007708    JAV27337.1    GFPF01005879    MAA17025.1    DS232003    EDS31363.1    GEDV01001139    JAP87418.1    LJIJ01000039    ODN04640.1    ACPB03024436    ACPB03024437    GDUN01000058    JAN95861.1    GGLE01006398    MBY10524.1    KQ434782    KZC04648.1    KQ976600    KYM79485.1    GDHC01016794    JAQ01835.1    KQ978355    KYM94631.1    GFAC01003429    JAT95759.1    ADTU01010258    ADTU01010259    ADTU01010260    KK107119    QOIP01000009    EZA58662.1    RLU18282.1    NEDP02004288    OWF46074.1    KQ981954    KYN32164.1    GEZM01023335    JAV88458.1    GL888217    EGI64591.1    GBGD01000937    JAC87952.1    GBBI01002814    JAC15898.1    AKHW03006853    KYO17790.1   

Proteomes

UP000005204    UP000218220    UP000053268    UP000007266    UP000092461    UP000235965    + More
UP000075881    UP000075886    UP000075920    UP000075885    UP000076408    UP000075900    UP000030742    UP000245037    UP000075901    UP000019118    UP000075883    UP000075882    UP000092553    UP000007062    UP000076407    UP000075903    UP000075840    UP000075884    UP000000673    UP000007801    UP000069272    UP000000803    UP000008711    UP000001292    UP000268350    UP000002282    UP000095301    UP000091820    UP000092444    UP000000304    UP000092445    UP000009046    UP000075902    UP000192221    UP000092460    UP000002358    UP000008792    UP000078200    UP000009192    UP000075880    UP000001819    UP000037069    UP000008744    UP000242457    UP000075809    UP000001070    UP000007798    UP000095300    UP000002320    UP000094527    UP000015103    UP000076502    UP000078540    UP000078542    UP000005205    UP000053097    UP000279307    UP000242188    UP000078541    UP000007755    UP000050525    UP000189705    UP000085678   

PRIDE

H9JC80    Q9V778    D5SHU3   

Pfam

PF01565   FAD_binding_4        + More
PF02913   FAD-oxidase_C
PF00876   Innexin
PF00628   PHD

Interpro

IPR016169   FAD-bd_PCMH_sub2        + More
IPR036318   FAD-bd_PCMH-like_sf       
IPR016167   FAD-bd_PCMH_sub1       
IPR004113   FAD-linked_oxidase_C       
IPR025650   Alkyl-DHAP_Synthase       
IPR016166   FAD-bd_PCMH       
IPR016164   FAD-linked_Oxase-like_C       
IPR000990   Innexin       
IPR016171   Vanillyl_alc_oxidase_C-sub2       
IPR006094   Oxid_FAD_bind_N       
IPR019786   Zinc_finger_PHD-type_CS       
IPR039054   Int12_PHD       
IPR011011   Znf_FYVE_PHD       
IPR013083   Znf_RING/FYVE/PHD       
IPR001965   Znf_PHD       
IPR019787   Znf_PHD-finger       

SUPFAM

SSF56176   SSF56176        + More
SSF55103   SSF55103       
SSF57903   SSF57903       

Gene 3D

1.10.45.10     3.30.43.10     3.30.465.10     3.30.40.10    

CDD

cd15501  PHD_Int12

ProteinModelPortal

H9JC80   A0A2H1VA52   A0A2A4K6C2   A0A194PJ97   D6WW52   A0A1B0C9B7   + More
A0A2J7Q507   A0A182K051   A0A182Q4S0   A0A182VPM3   A0A1B6IX74   A0A182P3E9   A0A182YJQ0   A0A1B6EHV6   A0A1L8DAN0   A0A1L8DAN4   A0A034VKX9   A0A182R8H3   J3JW52   A0A1L8DAZ9   A0A2P8YUN1   A0A182SQW2   A0A0K8VS84   N6TXY9   A0A182LV29   A0A182LNJ1   A0A1B6LVZ4   A0A0M4EHA8   Q7QA93   A0A182XF27   A0A182UXZ6   A0A182HVJ5   A0A182NCQ5   W5JEK9   B3MH07   A0A182FPJ7   A0A0B4JD21   Q9V778   B3NQQ2   B4HRS2   A0A3B0JS51   B4P7R8   A0A1I8MB57   A0A1A9VZE3   A0A1B0GBE9   B4QGC0   D5SHU3   A0A1A9ZPI4   E0VIW8   A0A182TZH2   A0A0A1WK86   T1PK60   A0A1W4UM17   A0A1Y1MVA3   A0A1Y1MS72   A0A1B0B4G9   K7JA90   B4LLK6   W8BYB7   A0A1A9VJD3   A0A1B6CGH0   B4KP39   A0A182JL87   B5E051   A0A1Z5KWP2   A0A0L0CMS2   A0A336N0B4   B4GD67   A0A2A3E405   V9IGF4   A0A310SLM8   A0A336MYR2   A0A151X1B3   B4J5Y8   B4MQ03   A0A1I8P8Q1   A0A1Q3FIE7   A0A224YJ86   B0WMX1   A0A131Z8X7   A0A1D2NHA7   T1H9K7   A0A0N8ES99   A0A2R5LLX7   A0A154P064   A0A151I0V8   A0A146L266   A0A151I8K5   A0A1E1X931   A0A158NAD8   A0A026WRM0   A0A210QBG3   A0A195EW99   A0A1Y1MTG5   F4WMI0   A0A069DWA1   A0A023F3H5   A0A151LZZ3   A0A1U8DJK3   A0A1S3JUX1  

PDB

6GOU     E-value=2.09623e-172,     Score=1557

KEGG

101738589    K00803 alkyldihydroxyacetonephosphate synthase [EC:2.5.1.26] | (RefSeq) alkyldihydroxyacetonephospha

PATHWAY

00565    Ether lipid metabolism - Bombyx mori (domestic silkworm)
01100    Metabolic pathways - Bombyx mori (domestic silkworm)
04146    Peroxisome - Bombyx mori (domestic silkworm)

GO

GO:0016491   GO:0005921   GO:0006811   GO:0016021   GO:0008610   GO:0005886   GO:0071949   GO:0008609   GO:0005777   GO:0008611   GO:0046872   GO:0050660   GO:0003824   GO:0016614   GO:0005852   GO:0006413   GO:0031369   GO:0005515   GO:0055114  

PANTHER

PTHR46568  

Subcellular location

Cell membrane  
Cell junction  
Gap junction  
Peroxisome  

Length:

629

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.02736

Exp number, first 60 AAs:

0.00113

Total prob of N-in:

0.00020

outside

1  -  629

 

 

Pi

237.879774

Theta

172.220107

Tajima's D

0.102973

CLR

0.056973

CSRT

0.396830158492075

Interpretation

Uncertain