Gene

KWMTBOMO10511

Pre Gene Modal

BGIBMGA006985

Annotation

E3_ubiquitin-protein_ligase_RING1_[Bombyx_mori]

Location

Bomo_Chr17(-):13033432-13037246      View in EpiBrowser

Full name

E3 ubiquitin-protein ligase RING2-A      

Alternative Name

RING finger protein 1B-A
RING finger protein 2-A
RING-type E3 ubiquitin transferase RING2-A

Location in the cell

Nuclear   Reliability : 4.808

CDS

ATGTCTTCAACAGAGCCTTCGCAAAATAAAACATGGGAGCTATCCCTTTACGAGTTACACCGTACTCCACAAGAAGTGATCACAGACGCGACGGAAATAGCGGTCTCCCCACGAAGTCTTCACAGCGAGCTGATGTGCCCAATCTGTTTGGATATGCTCAAAAAGACAATGACTACAAAAGAATGCCTCCATAGATTCTGCAACGACTGTATTATAACCGCTTTGAGATCGGGCAACAAAGAGTGTCCGACTTGTAGAAAGAAATTAGTGTCCAAACGTTCTCTTCGACCGGACCCCAACTTTGACCTGCTCATATCCAAGATATATCCCAGTAGGGACGAATACGAGGCTCACCAAGAACTGGTTCTGGCTAAACTAAGCATGTCCCATTCACAAGCTTCTCTCGTCAATTCTATAACCGAAGGCATAAAGTTACAGTCACAGAACAGACCTCAAAGATCAAGAAAGAACCACGACGAGAGTAGCAATGCGTCTAATTCCAATGGTAATGTAGAAACAGCTCAAAATGGTAGTAATTCTGCCACTCCCAAAGATGGAACTTCTTCAAGCGGGAATCCTGCACAATCCGGTCAGTCAACATCGAATCCTGCTTCTGTGAGAAGTACACCATCTCCAGTCCCGTCGAATGTTTCATCAGTATCCAAAAACACAAGTACAACTAAAAGGGCCAAATCGGTATTGACTTCAGAGAGAAGTGAAGAAAGTGAATCTAGTGATGGAAGAACAGAAGGAGAGAACTCGATGGACACGGAAGGAGAAGGGGAGCCCCTAAACCCCAATGAGATAGAGCTAGTCTTCAAACCCCACCCTACAGAGATGACTGGGGACAATCAACTTATGAGAGCTCTTTGTGACAATTCTGTGAGATATCTAAAGACAACACCCAATGCTTCTGTCGATCATCTAAGCAACACCTTCGCCTGGACAGTTTGTGCTGTTGGCTGGCTCACAGACCCTTCGTCAGATTATCGATAA

Protein

MSSTEPSQNKTWELSLYELHRTPQEVITDATEIAVSPRSLHSELMCPICLDMLKKTMTTKECLHRFCNDCIITALRSGNKECPTCRKKLVSKRSLRPDPNFDLLISKIYPSRDEYEAHQELVLAKLSMSHSQASLVNSITEGIKLQSQNRPQRSRKNHDESSNASNSNGNVETAQNGSNSATPKDGTSSSGNPAQSGQSTSNPASVRSTPSPVPSNVSSVSKNTSTTKRAKSVLTSERSEESESSDGRTEGENSMDTEGEGEPLNPNEIELVFKPHPTEMTGDNQLMRALCDNSVRYLKTTPNASVDHLSNTFAWTVCAVGWLTDPSSDYR

Description

E3 ubiquitin-protein ligase that mediates monoubiquitination of 'Lys-119' of histone H2A (H2AK119Ub), thereby playing a central role in histone code and gene regulation. H2AK119Ub gives a specific tag for epigenetic transcriptional repression. Essential component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones, rendering chromatin heritably changed in its expressibility.

Catalytic Activity

S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.

Subunit

Component of chromatin-associated Polycomb (PcG) complexes. Component of a PRC1-like complex. Component of some MLL1/MLL complex (By similarity).

Keywords

Chromosome   Metal-binding   Nucleus   Repressor   Transcription   Transcription regulation   Transferase   Ubl conjugation pathway   Zinc   Zinc-finger  

Feature

chain  E3 ubiquitin-protein ligase RING2-A

Uniprot

H9JBU0   E5RWX6   A0A0N0PC08   A0A194PK54   A0A1E1W6A1   A0A2H1VGA3   + More
A0A212F5A8   A0A2A4JQR0   A0A0L7KMG3   A0A3S2LBG6   A0A0L7LMW3   E2BLF1   A0A151J6F1   A0A088AR91   A0A026W8P6   E9IKH9   F4WUC4   A0A151I502   A0A195C9E7   E2ANG8   A0A3L8DKN3   A0A0J7KFC6   K7IYL6   A0A0L7RCN9   A0A2A3EBY3   A0A195FL50   A0A158NTY5   A0A232FFR0   D7GXI1   A0A1L7N281   A0A0C9R528   Q16MR9   A0A1B6M0Y1   A0A1B0D2L4   A0A1B6IB90   A0A146M3B0   A0A2S2R5U9   A0A1A9WBZ9   A0A1A9VJ31   D3TP98   A0A1A9Z7A9   A0A224XSC4   A0A023FAH4   J9K0P7   A0A1A9YPA2   A0A1B0BV01   A0A0V0GD64   A0A1B0FP57   J9K346   A0A1B0CP72   J3JTL5   R4FM35   A0A0R3NFC3   N6UGJ3   A0A2R7WM18   E0VVL7   A0A0P6I3U2   A0A3B0JEA5   A0A336M8A3   A0A293MUX8   V9L088   C3ZPC6   A0A1L8F8A8   A4IGP4   F6SMP4   Q66J69  

EC Number

2.3.2.27

Pubmed

19121390    22485166    26354079    22118469    26227816    20798317    + More
24508170    21282665    21719571    30249741    20075255    21347285    28648823    18362917    19820115    27956627    17510324    26823975    20353571    25474469    22516182    15632085    17994087    23537049    20566863    24402279    18563158    27762356    20431018   

EMBL

BABH01015035    AB607836    BAJ54070.1    KQ460711    KPJ12673.1    KQ459603    + More
KPI93109.1    GDQN01008673    JAT82381.1    ODYU01002382    SOQ39811.1    AGBW02010224    OWR48889.1    NWSH01000822    PCG74038.1    JTDY01009081    KOB64124.1    RSAL01000054    RVE50009.1    JTDY01000561    KOB76674.1    GL449017    EFN83503.1    KQ979854    KYN18803.1    KK107390    EZA51399.1    GL763991    EFZ18908.1    GL888355    EGI62232.1    KQ976445    KYM86097.1    KQ978143    KYM96791.1    GL441216    EFN65017.1    QOIP01000007    RLU20753.1    LBMM01008135    KMQ89118.1    KQ414615    KOC68516.1    KZ288289    PBC29245.1    KQ981522    KYN40714.1    ADTU01026204    ADTU01026205    NNAY01000295    OXU29393.1    GG694140    EFA13676.1    LC100103    BAW19568.1    GBYB01011419    JAG81186.1    CH477851    EAT35639.1    GEBQ01010399    JAT29578.1    AJVK01022940    GECU01023502    JAS84204.1    GDHC01004884    JAQ13745.1    GGMS01016186    MBY85389.1    EZ423250    ADD19526.1    GFTR01005547    JAW10879.1    GBBI01000703    JAC18009.1    ABLF02021898    JXJN01020982    GECL01000326    JAP05798.1    CCAG010023117    CCAG010023118    ABLF02034556    AJWK01021496    BT126572    AEE61536.1    ACPB03005784    GAHY01001879    JAA75631.1    CM000070    KRS99741.1    APGK01036257    KB740937    ENN77772.1    KK854883    PTY19465.1    DS235812    EEB17423.1    GDIQ01009738    JAN84999.1    OUUW01000005    SPP80714.1    UFQT01000675    SSX26435.1    GFWV01019915    MAA44643.1    JW872492    AFP05010.1    GG666656    EEN45623.1    CM004480    OCT67819.1    BC135191    AAI35192.1    AAMC01083630    BC081039   

Proteomes

UP000005204    UP000053240    UP000053268    UP000007151    UP000218220    UP000037510    + More
UP000283053    UP000008237    UP000078492    UP000005203    UP000053097    UP000007755    UP000078540    UP000078542    UP000000311    UP000279307    UP000036403    UP000002358    UP000053825    UP000242457    UP000078541    UP000005205    UP000215335    UP000007266    UP000008820    UP000092462    UP000091820    UP000078200    UP000092445    UP000007819    UP000092443    UP000092460    UP000092444    UP000092461    UP000015103    UP000001819    UP000019118    UP000009046    UP000268350    UP000001554    UP000186698    UP000008143   

PRIDE

H9JBU0    E5RWX6    Q66J69   

Pfam

PF16207   RAWUL        + More
PF05485   THAP

Interpro

IPR001841   Znf_RING        + More
IPR017907   Znf_RING_CS       
IPR032443   RAWUL       
IPR013083   Znf_RING/FYVE/PHD       
IPR006612   THAP_Znf       
IPR038441   THAP_Znf_sf       
IPR037937   RING2       

Gene 3D

3.30.40.10     3.30.40.180    

ProteinModelPortal

H9JBU0   E5RWX6   A0A0N0PC08   A0A194PK54   A0A1E1W6A1   A0A2H1VGA3   + More
A0A212F5A8   A0A2A4JQR0   A0A0L7KMG3   A0A3S2LBG6   A0A0L7LMW3   E2BLF1   A0A151J6F1   A0A088AR91   A0A026W8P6   E9IKH9   F4WUC4   A0A151I502   A0A195C9E7   E2ANG8   A0A3L8DKN3   A0A0J7KFC6   K7IYL6   A0A0L7RCN9   A0A2A3EBY3   A0A195FL50   A0A158NTY5   A0A232FFR0   D7GXI1   A0A1L7N281   A0A0C9R528   Q16MR9   A0A1B6M0Y1   A0A1B0D2L4   A0A1B6IB90   A0A146M3B0   A0A2S2R5U9   A0A1A9WBZ9   A0A1A9VJ31   D3TP98   A0A1A9Z7A9   A0A224XSC4   A0A023FAH4   J9K0P7   A0A1A9YPA2   A0A1B0BV01   A0A0V0GD64   A0A1B0FP57   J9K346   A0A1B0CP72   J3JTL5   R4FM35   A0A0R3NFC3   N6UGJ3   A0A2R7WM18   E0VVL7   A0A0P6I3U2   A0A3B0JEA5   A0A336M8A3   A0A293MUX8   V9L088   C3ZPC6   A0A1L8F8A8   A4IGP4   F6SMP4   Q66J69  

PDB

2CKL     E-value=3.18923e-61,     Score=595

KEGG

100529121    K10695 E3 ubiquitin-protein ligase RNF1/2 [EC:2.3.2.27] | (RefSeq) SCE; E3 ubiquitin-protein ligase

GO

GO:0035102   GO:0016874   GO:0003677   GO:0016740   GO:0000122   GO:0036353   GO:0031519   GO:0071339   GO:0046872   GO:0005694   GO:0005515   GO:0008270   GO:0005840   GO:0006412   GO:0005852   GO:0006413   GO:0031369   GO:0003824  

PANTHER

PTHR46076:SF4  

Subcellular location

Nucleus  
Chromosome  

Length:

331

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.02788

Exp number, first 60 AAs:

0

Total prob of N-in:

0.03385

outside

1  -  331

 

 

Pi

180.658348

Theta

169.409328

Tajima's D

0.261497

CLR

0.674562

CSRT

0.448927553622319

Interpretation

Uncertain