SGID Silkworm Genome Informatics Database
Gene
KWMTBOMO10508  Validated by peptides from experiments
Pre Gene Modal
BGIBMGA007121
Annotation
PREDICTED:_probable_aconitate_hydratase?_mitochondrial_[Papilio_xuthus]
Location
Bomo_Chr17(+):12999157-13023622      View in EpiBrowser
Full name
Aconitate hydratase, mitochondrial      
Location in the cell
Mitochondrial   Reliability : 3.767
 

Sequence

CDS
ATGGCGCACTGTATGAGAGTTTTGCATGGCCAGGGTAGCAGGACAAGGGTGGTACTCTCTGAAATCCAACAAAGATGTTTCAGCGTATCTCCATTGACCGCCGCCGCGGCCCAGGTGGCGATGTCCAAGTTCGACAAGGTACCCTTGCCTTACGAAAAGTTGACGAAGAATTTAGAGGTGGTTAAGAAGAGGCTAGGGAGAGAATTGACCTTGTCTGAGAAAATCCTATATTCTCACTTGGATGACCCCAAAGGACAGGAAATTGAACGCGGCGCAAGTTATCTCCGCCTGCGTCCCGACCGTGTGGCCATGCAAGACGCCACTGCACAAATGGCAATGTTACAATTTATCTCTTCCGGCCTTCCCCGTGTAGCTGTACCGTCCACCATTCATTGTGATCACTTGATCGAAGCCCAAGTCGGAGGCGAGAAGGATTTGGCCAGGGCTAAGGACCTCAACAAAGAAGTATACAAGTTTTTAGAGACTGCCGGAGCTAAATATGGAGTCGGTTTCTGGAAGCCCGGCTCTGGTATTATCCATCAGATCATTCTGGAGAACTATGCGTTCCCTGGTCTACTCATGATCGGCACAGACTCCCACACACCTAATGGAGGTGGCCTTGGTGGATTGTGTATTGGTGTCGGTGGTGCTGATGCTGTGGACGTAATGGCCAACATCCCGTGGGAGCTGAAGTGTCCTAAAGTTATCGGCGTCAAATTGACCGGTAAACTCACCGGCTGGACGAGTCCGAAAGATGTGATCTTGAAGGTGGCCGGCATCCTGACTGTGAAGGGAGGTACCGGCGCCATCGTGGAGTACCACGGACCCGGGGTGGACCACATCTCGTGTACAGGCATGGCGACAATCTGCAACATGGGAGCTGAGATCGGTGCTACCACTAGCGTGTTCCCGTACAACTCCCGCATGGAAGCCTACCTTAAGTCGACCGGGCGCCACGACATCGCCGCCACCGCCAACTCCTACAAGCACCTGCTCACGCCCGACAACAAGGCACCCTATGACCAGTTGATCGAGATCGACCTGTCCACGCTGGAGCCCCACGTGAACGGGCCCTTCACTCCGGACCTCGCCAACCCTATCTCGAAGCTCGGCGAAGCGGCCAAGAAGAACGACTGGCCGGTGGACATCCGCGTCGGCCTCATCGGGTCCTGCACCAACTCCTCCTACGAAGACATGGGCAGGTGCGCCAGCATCGTCAAAGAGGCGATCAGTCACGGCCTGAAGTCTAAGATTCCGTTCAACGTGACCCCCGGGTCGGAGCAGGTCCGTGCCACCATCGAGAGGGACGGCATCGCCAAGACCCTCAGGGACTTCGGAGGCACCGTGCTGGCGAACGCGTGCGGCCCGTGCATCGGCCAGTGGGACCGCAAGGACGTGAAGAAGGGGGAGAAGAACACGATCGTGACGTCATACAACCGCAACTTCACCGGCAGGAACGACGCCAACCCCGCCACGCACTGCTTCGTCACCAGCCCCGAGCTCGTCACGGCGCTGTCCATCGCGGGCCGGCTTGACTTCAACCCGCTGAAGGACGAACTGACTGGCGCTGATGGAAAGAAATTCAAGTTGTCAGATCCGTTTGCCGACGAGCTCCCCTCCAAGGGCTTCGACCCCGGACAGGACACGTACGAGCACCCGCCCGCCGACGGATCCAAAGTGAAAGTTGACGTCTCACCGACATCCGACCGCCTTCAACTCCTCGAGCCGTTCGACAAGTGGGACGGCAAAGACCTCACCGACCTCACGATCCTGATCAAGGTGAAGGGGAAGTGCACCACCGACCACATCTCGGCGGCTGGACCCTGGCTGAAGTACAGAGGCCATCTCGACAACATCTCCAATAACATGTTTATTACGGCAACGAACGCAGAGAACGGCGAGCTGAACAAAGTCCGCAACCAGGTGACGGGCGAGTACGGGCCGGTGCCCGCCACGGCGCGCGCGTACAAGGCGGCCGGCGTGCGCTGGTGCGTCGTCGGCGACGAGAACTACGGCGAGGGCTCGTCCCGCGAGCACGCCGCGCTCGAGCCGCGACACCTCGGCGGCCGCGCCATCATCGTCAAGTCGTTCGCTAGAATCCACGAGACCAACTTGAAGAAACAAGGTATGCTGCCCCTCACGTTCGCCAACGCCGCTGACTACGACAAGATCAAGCCTGACGATAAAATCTCACTCCTTGGACTGAACAGCCTCGCTCCCGGCAAGCCAGTGGACTGCGAAATTAAGCACAAAGACGGCAGCACCGACCGCATCAAGCTCAACCATTCGTTGAACGACCAACAGATCAACTGGTTCAAGGCCGGCTCGGCGCTCAACAGAATGAAGGAAATCGCTTCCGGAAAGTGA
Protein
MAHCMRVLHGQGSRTRVVLSEIQQRCFSVSPLTAAAAQVAMSKFDKVPLPYEKLTKNLEVVKKRLGRELTLSEKILYSHLDDPKGQEIERGASYLRLRPDRVAMQDATAQMAMLQFISSGLPRVAVPSTIHCDHLIEAQVGGEKDLARAKDLNKEVYKFLETAGAKYGVGFWKPGSGIIHQIILENYAFPGLLMIGTDSHTPNGGGLGGLCIGVGGADAVDVMANIPWELKCPKVIGVKLTGKLTGWTSPKDVILKVAGILTVKGGTGAIVEYHGPGVDHISCTGMATICNMGAEIGATTSVFPYNSRMEAYLKSTGRHDIAATANSYKHLLTPDNKAPYDQLIEIDLSTLEPHVNGPFTPDLANPISKLGEAAKKNDWPVDIRVGLIGSCTNSSYEDMGRCASIVKEAISHGLKSKIPFNVTPGSEQVRATIERDGIAKTLRDFGGTVLANACGPCIGQWDRKDVKKGEKNTIVTSYNRNFTGRNDANPATHCFVTSPELVTALSIAGRLDFNPLKDELTGADGKKFKLSDPFADELPSKGFDPGQDTYEHPPADGSKVKVDVSPTSDRLQLLEPFDKWDGKDLTDLTILIKVKGKCTTDHISAAGPWLKYRGHLDNISNNMFITATNAENGELNKVRNQVTGEYGPVPATARAYKAAGVRWCVVGDENYGEGSSREHAALEPRHLGGRAIIVKSFARIHETNLKKQGMLPLTFANAADYDKIKPDDKISLLGLNSLAPGKPVDCEIKHKDGSTDRIKLNHSLNDQQINWFKAGSALNRMKEIASGK

Summary

Cofactor
[4Fe-4S] cluster
Similarity
Belongs to the aconitase/IPM isomerase family.
Feature
chain  Aconitate hydratase, mitochondrial
Uniprot
A0A194PI65   A0A3S2TMC5   Q86GF8   A0A2A4JQI9   D6WWL1   A0A1Y1KNE0   + More
A0A2J7RRZ9   J3JWT3   A0A067R825   A0A1W4X0G9   A0A0T6B6I7   K7IMY0   A0A232FK46   A0A0C9QFK7   A0A2A3EDI2   V9IHT5   A0A087ZXK3   A0A0J7NRU4   Q16KR4   A0A336K422   A0A023EW32   A0A1B6DJW1   A0A182GM09   A0A158NLP6   A0A151IU55   A0A3L8DIS0   Q17EL3   F4X2U7   A0A1B6H3E8   A0A182QJC6   A0A151WK30   A0A195BLF6   A0A182NLL1   A0A1J1I2U2   A0A026X5E9   A0A3Q0IZI1   A0A182H7F2   A0A182MK76   A0A182YPN0   A0A0M8ZWK8   E2A4Y0   A0A182W9X3   R4WKE5   A0A182JQG1   E2BSG2   A0A182IEM3   A0A182P0J0   A0A182UN50   A0A182L2B6   A0A182WTG5   A0A1S4GWF2   A0A182R397   T1DN98   A0A2M3ZZX0   A0A182TV65   A0A2H8TNH1   A0A1Q3G4U8   A0A0C5QDN7   A0A182F685   A0A2M3YXT4   A0A154P379   A0A2M4BEF5   A0A2M3YXT6   A0A2M4BEF8   A0A023EXU2   A0A2M4CW41   T1DHZ4   A0A084W3X9   Q7Q3F6   A0A182IXZ9   A0A2M4CUU9   A0A0A9X6E8   A0A023EXR0   U5EU23   T1PD24   A0A1I8N262   J9KAT0   A0A2M3YXV2   A0A0L7QQW8   A0A195FV98   A0A1L8EDF9   A0A151IAM2   A0A069DWY8   W5JMI4   A0A310S9H3   A0A0A1XE57   A0A1B0CX01   A0A1I8NML7   W8B5J2   A0A2P2HXE8   R4G408   A0A1L8DH08   A0A1L8DH00   A0A0P4VIL1   A0A0L0CD74   A0A034W2U8   Q29NT1   B4GJJ6   A0A023GLX2   E9GUX6  
EC Number
4.2.1.-
Pubmed
26354079    18362917    19820115    28004739    22516182    23537049    + More
24845553    20075255    28648823    17510324    24945155    26483478    21347285    30249741    21719571    24508170    25244985    20798317    23691247    20966253    12364791    25702953    24330624    24438588    25401762    26823975    25315136    26334808    20920257    23761445    25830018    24495485    27129103    26108605    25348373    15632085    17994087    21292972   
EMBL
KQ459603    KPI93106.1    RSAL01000054    RVE50012.1    AB105050    BAC65324.1    + More
NWSH01000822    PCG74036.1    KQ971361    EFA08121.1    GEZM01083906    JAV60956.1    NEVH01000597    PNF43609.1    APGK01058660    BT127701    KB741291    KB631579    AEE62663.1    ENN70544.1    ERL84416.1    KK852872    KDR14559.1    LJIG01009490    KRT82976.1    NNAY01000130    OXU30697.1    GBYB01013263    JAG83030.1    KZ288288    PBC29352.1    JR048497    AEY60683.1    LBMM01002199    KMQ95155.1    CH477941    EAT34906.1    UFQS01000048    UFQT01000048    SSW98592.1    SSX18978.1    GAPW01000256    JAC13342.1    GEDC01011312    JAS25986.1    JXUM01073449    KQ562775    KXJ75145.1    ADTU01019627    KQ980968    KYN10979.1    QOIP01000007    RLU20340.1    CH477280    EAT44980.1    GL888591    EGI59293.1    GECZ01000560    JAS69209.1    AXCN02000614    KQ983020    KYQ48222.1    KQ976450    KYM85637.1    CVRI01000038    CRK93908.1    KK107019    EZA62649.1    JXUM01116117    JXUM01116118    JXUM01116119    JXUM01116120    AXCM01007919    KQ435834    KOX71536.1    GL436756    EFN71522.1    AK418050    BAN21265.1    GL450233    EFN81350.1    APCN01005209    AAAB01008964    GAMD01003080    JAA98510.1    GGFK01000793    MBW34114.1    GFXV01003377    MBW15182.1    GFDL01000213    JAV34832.1    KM609494    AJQ30118.1    GGFM01000328    MBW21079.1    KQ434796    KZC05590.1    GGFJ01002284    MBW51425.1    GGFM01000326    MBW21077.1    GGFJ01002283    MBW51424.1    GAPW01000254    JAC13344.1    GGFL01004880    MBW69058.1    GALA01001246    JAA93606.1    ATLV01020201    KE525295    KFB44923.1    EAA12184.4    GGFL01004881    MBW69059.1    GBHO01028388    GBRD01017760    GDHC01017684    JAG15216.1    JAG48067.1    JAQ00945.1    GAPW01000309    JAC13289.1    GANO01001669    JAB58202.1    KA646574    AFP61203.1    ABLF02022040    GGFM01000348    MBW21099.1    KQ414784    KOC61025.1    KQ981219    KYN44388.1    GFDG01002134    JAV16665.1    KQ978186    KYM96557.1    GBGD01000548    JAC88341.1    ADMH02000676    ETN65346.1    KQ768478    OAD53151.1    GBXI01005076    JAD09216.1    AJWK01033078    AJWK01033079    AJWK01033080    AJWK01033081    AJWK01033082    AJWK01033083    AJWK01033084    GAMC01014172    GAMC01014170    JAB92383.1    IACF01000700    LAB66458.1    ACPB03000177    GAHY01001755    JAA75755.1    GFDF01008351    JAV05733.1    GFDF01008352    JAV05732.1    GDKW01002818    JAI53777.1    JRES01000668    KNC29409.1    GAKP01010854    JAC48098.1    CH379058    EAL34563.2    CH479184    EDW36812.1    GBBM01000516    JAC34902.1    GL732567    EFX76569.1   
Proteomes
UP000053268    UP000283053    UP000218220    UP000007266    UP000235965    UP000019118    + More
UP000030742    UP000027135    UP000192223    UP000002358    UP000215335    UP000242457    UP000005203    UP000036403    UP000008820    UP000069940    UP000249989    UP000005205    UP000078492    UP000279307    UP000007755    UP000075886    UP000075809    UP000078540    UP000075884    UP000183832    UP000053097    UP000079169    UP000075883    UP000076408    UP000053105    UP000000311    UP000075920    UP000075881    UP000008237    UP000075840    UP000075885    UP000075903    UP000075882    UP000076407    UP000075900    UP000075902    UP000069272    UP000076502    UP000030765    UP000007062    UP000075880    UP000095301    UP000007819    UP000053825    UP000078541    UP000078542    UP000000673    UP000092461    UP000095300    UP000015103    UP000037069    UP000001819    UP000008744    UP000000305   
PRIDE
A0A087ZXK3   
Pfam
PF00330   Aconitase        + More
PF00694   Aconitase_C
PF04438   zf-HIT
Interpro
IPR036008   Aconitase_4Fe-4S_dom        + More
IPR018136   Aconitase_4Fe-4S_BS       
IPR000573   AconitaseA/IPMdHydase_ssu_swvl       
IPR015932   Aconitase_dom2       
IPR006248   Aconitase_mito-like       
IPR001030   Acoase/IPM_deHydtase_lsu_aba       
IPR015928   Aconitase/3IPM_dehydase_swvl       
IPR015931   Acnase/IPM_dHydase_lsu_aba_1/3       
IPR007529   Znf_HIT       
SUPFAM
SSF53732   SSF53732       
Gene 3D
3.20.19.10     3.30.499.10     3.40.1060.10    
ProteinModelPortal
A0A194PI65   A0A3S2TMC5   Q86GF8   A0A2A4JQI9   D6WWL1   A0A1Y1KNE0   + More
A0A2J7RRZ9   J3JWT3   A0A067R825   A0A1W4X0G9   A0A0T6B6I7   K7IMY0   A0A232FK46   A0A0C9QFK7   A0A2A3EDI2   V9IHT5   A0A087ZXK3   A0A0J7NRU4   Q16KR4   A0A336K422   A0A023EW32   A0A1B6DJW1   A0A182GM09   A0A158NLP6   A0A151IU55   A0A3L8DIS0   Q17EL3   F4X2U7   A0A1B6H3E8   A0A182QJC6   A0A151WK30   A0A195BLF6   A0A182NLL1   A0A1J1I2U2   A0A026X5E9   A0A3Q0IZI1   A0A182H7F2   A0A182MK76   A0A182YPN0   A0A0M8ZWK8   E2A4Y0   A0A182W9X3   R4WKE5   A0A182JQG1   E2BSG2   A0A182IEM3   A0A182P0J0   A0A182UN50   A0A182L2B6   A0A182WTG5   A0A1S4GWF2   A0A182R397   T1DN98   A0A2M3ZZX0   A0A182TV65   A0A2H8TNH1   A0A1Q3G4U8   A0A0C5QDN7   A0A182F685   A0A2M3YXT4   A0A154P379   A0A2M4BEF5   A0A2M3YXT6   A0A2M4BEF8   A0A023EXU2   A0A2M4CW41   T1DHZ4   A0A084W3X9   Q7Q3F6   A0A182IXZ9   A0A2M4CUU9   A0A0A9X6E8   A0A023EXR0   U5EU23   T1PD24   A0A1I8N262   J9KAT0   A0A2M3YXV2   A0A0L7QQW8   A0A195FV98   A0A1L8EDF9   A0A151IAM2   A0A069DWY8   W5JMI4   A0A310S9H3   A0A0A1XE57   A0A1B0CX01   A0A1I8NML7   W8B5J2   A0A2P2HXE8   R4G408   A0A1L8DH08   A0A1L8DH00   A0A0P4VIL1   A0A0L0CD74   A0A034W2U8   Q29NT1   B4GJJ6   A0A023GLX2   E9GUX6  
PDB
1AMJ     E-value=0,     Score=3083

Ontologies

KEGG
101738186    K01681 aconitate hydratase [EC:4.2.1.3] | (RefSeq) probable aconitate hydratase, mitochondrial
PATHWAY
00020    Citrate cycle (TCA cycle) - Bombyx mori (domestic silkworm)
00630    Glyoxylate and dicarboxylate metabolism - Bombyx mori (domestic silkworm)
01100    Metabolic pathways - Bombyx mori (domestic silkworm)
01200    Carbon metabolism - Bombyx mori (domestic silkworm)
01210    2-Oxocarboxylic acid metabolism - Bombyx mori (domestic silkworm)
01230    Biosynthesis of amino acids - Bombyx mori (domestic silkworm)
GO
GO:0046872   GO:0005739   GO:0003994   GO:0051539   GO:0006099   GO:0016829   GO:0005829   GO:0008152   GO:0005852   GO:0006413   GO:0031369   GO:0005515   GO:0003824  

Topology

Subcellular location
Mitochondrion  
Length:
788
Number of predicted TMHs:
0
Exp number of AAs in TMHs:
0.03267
Exp number, first 60 AAs:
0.00707
Total prob of N-in:
0.00163
outside
1  -  788
 
 

Population Genetic Test Statistics

Pi
235.168141
Theta
162.808271
Tajima's D
1.359197
CLR
0.349329
CSRT
0.752662366881656
Interpretation
Uncertain
Peptides ×
Source Sequence Identity Evalue
28556443 NDANPATHCFVTSPELVTALSIAGR 100.00 6e-11
28556443 LQLLEPFDK 100.00 6e-11
28556443 TGGLDVLALNEEDVTK 100.00 6e-11
28556443 NVTPGSEQVR 100.00 2e-10
28556443 GHLDNISNNMFITATNAENGELNK 100.00 2e-10
28556443 GFDPGQDTYEHPPADGSK 100.00 2e-10
28556443 WLEDNQDAESEEYKK 100.00 2e-10
26822097 MEAYIK 95.24 4e-10
26280517 DFFAAIK 95.24 4e-10
28467696 DFGGTVIANACGPCIGQWDR 95.24 4e-10
28556443 VKVDVSPTSDR 100.00 6e-10
28556443 VAGILTVK 100.00 8e-09
28556443 QGMLPLTFANAADYDK 100.00 8e-09
28556443 FDKVPLPYEK 100.00 2e-08
26280517 VAQDFNIEASK 95.24 4e-08
28467696 VAVPQPYEVVK 95.24 4e-08
28556443 IPFNVTPGSEQVR 100.00 8e-07
26822097 IQIIEPFDKWDGK 100.00 1e-06
26280517 GEDHCGIESSIVTGEPFIDEH 100.00 1e-06
25044914 GFDPFMNIVIDESVEECKDGQR 100.00 1e-06
28467696 GFDIVDYIDTWK 100.00 1e-06
28556443 FDKVPLPYEK 100.00 1e-06
28556443 VAGILTVK 100.00 1e-06
28556443 NTIVTSYNR 100.00 7e-06
28556443 VAMQDATAQMAMLQFISSGLPR 100.00 7e-06
26822097 CTTDHISAAGPWIK 100.00 2e-05
26280517 VYNIDVEVIGK 100.00 2e-05
25044914 WCNMAK 100.00 2e-05
28467696 WCTTNINEQTK 100.00 2e-05
28556443 VGLIGSCTNSSYEDMGR 100.00 2e-05
28556443 QGMLPLTFANAADYDK 100.00 8e-05
28556443 NTIVTSYNR 100.00 8e-05
28556443 NQVTGEYGPVPATAR 100.00 8e-05
28556443 LDFNPLKDELTGADGK 100.00 9e-05
28556443 LDFNPLKDELTGADGK 100.00 1e-04
28556443 LDFNPLKDELTGADGKK 100.00 1e-04
28556443 KNDWPVDIR 100.00 3e-04
28556443 ISLLGLNSLAPGKPVDCEIK 100.00 3e-04
26822097 VGIIGSCTNSSYEDMGR 100.00 9e-04
26280517 NQEPGGQYAPGNQNIMQR 100.00 9e-04
25044914 NQVNDFEIDTDITVVEPWSISK 100.00 9e-04
27102218 SSYKPIDSK 100.00 9e-04
28467696 NQVGAPMPGTVITIK 100.00 9e-04
28556443 LQLLEPFDKWDGK 100.00 9e-04
28556443 LSDPFADELPSK 100.00 9e-04
26822097 NDWPVDIR 100.00 0.001
26280517 SIVNNFEDAR 100.00 0.001
25044914 SKIPADFVVK 100.00 0.001
28467696 SKIESIVGDIIR 100.00 0.001
28556443 LQLLEPFDKWDGK 100.00 0.001
28556443 LQLLEPFDK 100.00 0.001
28556443 WCVVGDENYGEGSSR 100.00 0.001
26280517 STGAGSGGMWR 100.00 0.002
28467696 STGPASPPPHQPPR 100.00 0.002
26822097 NTIVTSYNR 100.00 0.010
26280517 INVSYPATGCQK 100.00 0.010
25044914 IPFEQQTVIR 100.00 0.010
28467696 IPFNMESTFVR 100.00 0.010
28556443 IPFNVTPGSEQVR 100.00 0.010
28556443 HDIAATANSYK 100.00 0.010
28556443 HDIAATANSYK 100.00 0.010
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