Gene

KWMTBOMO10502  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA007119

Annotation

PREDICTED:_adenylosuccinate_lyase_[Bombyx_mori]

Location

Bomo_Chr17(+):12895664-12901552      View in EpiBrowser

Full name

Adenylosuccinate lyase      

Alternative Name

Adenylosuccinase

Location in the cell

Cytoplasmic   Reliability : 1.656 Mitochondrial   Reliability : 1.219

CDS

ATGACCAAGATCAGTTCAACCGCAGAGCTCGGATTGGACATAAGCGCCGCTCAGATAGCCGAACTAGAAGCTGCTGTACATGACATCGACTTCCCAGCGGCTGCTGAACATGAGAAGCGGGTTCGTCACGACGTGATGGCGCATGTCCACACGCTCGGCGAGAGGTGTCCCCTCGCCGCGCCCATCATACACCTGGGAGCCACGTCGTGCTACGTCGGAGACAACACCGATTTGATAGTCCTTAAGAACGGACTCGAGCTGCTTCTGCCAAGGCTCGTCGCCGTCATCAAACAACTTGGAAGCTTCGCGAAACAGCACAAGTCTTTGCCCATCCTCGGCTTCACCCATCTTCAACCGGCGCAACTGACAACGGTCGGTAAAAGAGCATCGCTGTGGCTCAACGACTTGCTAATGGATGAACGCGCTTTGTCTCGCGCTAAAGACGACCTCCGGTTCAGGGGCGTGAAGGGTACCACGGGCACTCAGGCTTCCTTCCTCCAGCTCTTCAAAGGAGACGGTGAAAAGGTTCGCGCACTAGACAAAAGAGTTGCGGAACTGGCCGGATTTGATAAGAGATACATCGTGACCGGACAGACGTATTCCAGAAAAGTCGATTTAGAAGTTATTTCCGCATTGTCAGGCCTTGGAGCTACGGTACACAAAATGTGTTCAGACATACGTATTCTCGCCTCTCGTAAAGAGCTTGAGGAGCCTTTTGAAGTGTCCCAAATTGGTTCTAGTGCCATGCCTTACAAGAGGAACCCAATGCGTTCAGAACGTTGCTGCGCTCTAGCCCGTCATCTAATTACTTTACACGCTAACGCAGCTAATACTCATGCCGTCCAATGGTTAGAACGAACCCTAGACGACTCTGCCAATCGTCGCATTACCCTCGCCGAGGCTTTCCTTACCGCTGACGCTACTCTACTGACACTATTAAATATTTGCCAAGGCCTGGTGGTGTATCCGAAAGTGATCGCGCGTCATATCGCTCAAGAACTACCTTTCATGGCGACGGAAAATATAATAATGGCTATGGTCCAAGCGGGAGGTGACCGTCAAGTGTGCCACGAAAAGATTAGGGTGCTCTCCCATGAAGCAGGGGCTCAAGTGAAGCAACACGGCAGAGATAATGATTTGATTGAACGCGTTAAGAAAGACGGCTATTTCGCCCCAATTATATCCCAGTTGGACAAGATATTGGACGCTTCGACGTTCATTGGTAGAGCTCCAGAACAAGTGGACGAGTTTTTGGATGAAGAAGTCGATCCCATTATCGCTAAATACGCAGATTCCCTTATAAATGTTGACAAGCCAGTGGCACTAAACATTTAA

Protein

MTKISSTAELGLDISAAQIAELEAAVHDIDFPAAAEHEKRVRHDVMAHVHTLGERCPLAAPIIHLGATSCYVGDNTDLIVLKNGLELLLPRLVAVIKQLGSFAKQHKSLPILGFTHLQPAQLTTVGKRASLWLNDLLMDERALSRAKDDLRFRGVKGTTGTQASFLQLFKGDGEKVRALDKRVAELAGFDKRYIVTGQTYSRKVDLEVISALSGLGATVHKMCSDIRILASRKELEEPFEVSQIGSSAMPYKRNPMRSERCCALARHLITLHANAANTHAVQWLERTLDDSANRRITLAEAFLTADATLLTLLNICQGLVVYPKVIARHIAQELPFMATENIIMAMVQAGGDRQVCHEKIRVLSHEAGAQVKQHGRDNDLIERVKKDGYFAPIISQLDKILDASTFIGRAPEQVDEFLDEEVDPIIAKYADSLINVDKPVALNI

Catalytic Activity

(2S)-2-[5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamido]succinate = 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + fumarate
N(6)-(1,2-dicarboxyethyl)-AMP = AMP + fumarate

Similarity

Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.

Uniprot

H9JC74   A0A0N1PHN5   A0A2H1V6T9   B2DBN3   A0A212EUV7   A0A2A4JHM0   + More
A0A3S2NFU5   A0A0L7LGT3   S4PF95   A0A194PIF9   A0A182GJX8   A0A1L8DXT9   A0A023ESY0   B4PM94   A0A1Q3F8X8   J9HT71   A0A1B0CJJ2   J9HJI9   A0A3B0JLJ4   A0A182HT94   B0W6F1   Q7QBZ6   A0A182K1Z5   B4NJF6   B3P3J2   A0A182XIA7   A0A182V252   B4QWD5   A0A182PA48   A0A182U1L3   A0A1W4X215   Q9VEP6   A0A1W4VH91   A0A182IWI7   B4IBN8   A0A0M5J4C2   B4KV48   Q95SP9   B3M2B5   A0A182NA73   W5JM61   A0A182F8B9   A0A182QYL4   A0A2M4ACA5   A0A2M4BLZ9   A0A2M4BLP6   B4IYT5   A0A2M4BLM0   A0A2M3Z1C5   B4LDA2   A0A182LVZ8   A0A182YS80   A0A182W2W6   U5EUN6   A0A182RYG0   B4G4K3   Q297I4   A0A0L0CRA3   K7IMY2   T1PGQ8   A0A1I8P9R0   A0A0T6AUS5   A0A1Y1LA35   E2ASU4   A0A0K8TL45   A0A0A1X0W1   A0A084W1M2   A0A336KCM1   A0A026X3L2   W8C837   A0A0K8UL87   A0A034WS39   A0A0L7QQX1   A0A0M8ZUQ3   D6WX11   E2BFA3   A0A151IU78   A0A154P2M6   A0A151IAQ0   F4X2U5   A0A151WKK4   A0A2A3EC47   A0A158NLQ0   A0A195BLA0   A0A195FVD7   A0A232F4U8   A0A0C9PVA4   U4TSL0   A0A1A9W589   A0A1B0AWJ6   A0A3L8DIQ7   A0A0K8V1A4   A0A1A9Z7E5   D3TS08   A0A1A9Y5Y6   A0A1A9V512   E9J7N7   A0A1J1HY75   A0A087ZXK2   T1DST8  

EC Number

4.3.2.2

Pubmed

19121390    26354079    18712529    22118469    26227816    23622113    + More
26483478    24945155    17994087    17550304    17510324    12364791    14747013    17210077    10731132    12537568    12537572    12537573    12537574    16110336    17569856    17569867    26109357    26109356    20920257    23761445    25244985    15632085    26108605    20075255    25315136    28004739    20798317    26369729    25830018    24438588    24508170    24495485    25348373    18362917    19820115    21719571    21347285    28648823    23537049    30249741    20353571    21282665   

EMBL

BABH01015027    KQ460711    KPJ12664.1    ODYU01000980    SOQ36548.1    AB264718    + More
BAG30792.1    AGBW02012291    OWR45275.1    NWSH01001534    PCG70933.1    RSAL01000054    RVE50016.1    JTDY01001181    KOB74630.1    GAIX01004132    JAA88428.1    KQ459603    KPI93102.1    JXUM01013063    KQ560367    KXJ82788.1    GFDF01002823    JAV11261.1    GAPW01001183    JAC12415.1    CM000160    EDW96960.1    GFDL01011021    JAV24024.1    CH477623    EJY57843.1    AJWK01014673    CH478271    EJY58099.1    OUUW01000007    SPP83194.1    APCN01000423    DS231848    EDS36625.1    AAAB01008859    EAA07522.3    CH964272    EDW83880.1    CH954181    EDV48772.1    CM000364    EDX12626.1    AE014297    BT044196    AAF55375.1    ACH92261.1    CH480827    EDW44796.1    CP012525    ALC45211.1    CH933809    EDW19388.1    AY060661    AAL28209.1    CH902617    EDV42306.1    ADMH02000650    ETN65442.1    AXCN02000218    GGFK01005092    MBW38413.1    GGFJ01004830    MBW53971.1    GGFJ01004834    MBW53975.1    CH916366    EDV96622.1    GGFJ01004835    MBW53976.1    GGFM01001579    MBW22330.1    CH940647    EDW71009.1    AXCM01000066    GANO01002237    JAB57634.1    CH479179    EDW25174.1    CM000070    EAL28221.1    JRES01000032    KNC34766.1    KA647335    AFP61964.1    LJIG01022818    KRT78558.1    GEZM01061414    JAV70504.1    GL442359    EFN63519.1    GDAI01002539    JAI15064.1    GBXI01010029    GBXI01006344    JAD04263.1    JAD07948.1    ATLV01019388    KE525269    KFB44116.1    UFQS01000302    UFQT01000302    SSX02646.1    SSX23020.1    KK107019    EZA62653.1    GAMC01003244    JAC03312.1    GDHF01024998    GDHF01020518    JAI27316.1    JAI31796.1    GAKP01001947    JAC57005.1    KQ414784    KOC61028.1    KQ435834    KOX71530.1    KQ971361    EFA08776.1    GL447982    EFN85616.1    KQ980968    KYN10973.1    KQ434796    KZC05594.1    KQ978186    KYM96559.1    GL888591    EGI59291.1    KQ983020    KYQ48215.1    KZ288288    PBC29353.1    ADTU01019629    ADTU01019630    ADTU01019631    ADTU01019632    KQ976450    KYM85641.1    KQ981219    KYN44391.1    NNAY01000965    OXU25705.1    GBYB01005338    JAG75105.1    KB631584    ERL84499.1    JXJN01004810    QOIP01000007    RLU20335.1    GDHF01019607    GDHF01007503    JAI32707.1    JAI44811.1    CCAG010018629    EZ424210    ADD20486.1    GL768590    EFZ11155.1    CVRI01000021    CRK91486.1    GAMD01001334    JAB00257.1   

Proteomes

UP000005204    UP000053240    UP000007151    UP000218220    UP000283053    UP000037510    + More
UP000053268    UP000069940    UP000249989    UP000002282    UP000008820    UP000092461    UP000268350    UP000075840    UP000002320    UP000007062    UP000075881    UP000007798    UP000008711    UP000076407    UP000075903    UP000000304    UP000075885    UP000075902    UP000192223    UP000000803    UP000192221    UP000075880    UP000001292    UP000092553    UP000009192    UP000007801    UP000075884    UP000000673    UP000069272    UP000075886    UP000001070    UP000008792    UP000075883    UP000076408    UP000075920    UP000075900    UP000008744    UP000001819    UP000037069    UP000002358    UP000095301    UP000095300    UP000000311    UP000030765    UP000053097    UP000053825    UP000053105    UP000007266    UP000008237    UP000078492    UP000076502    UP000078542    UP000007755    UP000075809    UP000242457    UP000005205    UP000078540    UP000078541    UP000215335    UP000030742    UP000091820    UP000092460    UP000279307    UP000092445    UP000092444    UP000092443    UP000078200    UP000183832    UP000005203   

PRIDE

H9JC74    Q9VEP6    Q95SP9   

Pfam

PF00206   Lyase_1        + More
PF10397   ADSL_C
PF00076   RRM_1

Interpro

IPR022761   Fumarate_lyase_N        + More
IPR020557   Fumarate_lyase_CS       
IPR019468   AdenyloSucc_lyase_C       
IPR000362   Fumarate_lyase_fam       
IPR008948   L-Aspartase-like       
IPR004769   Pur_lyase       
IPR024083   Fumarase/histidase_N       
IPR001995   Peptidase_A2_cat       
IPR021109   Peptidase_aspartic_dom_sf       
IPR035979   RBD_domain_sf       
IPR000504   RRM_dom       
IPR012677   Nucleotide-bd_a/b_plait_sf       

SUPFAM

SSF48557   SSF48557        + More
SSF50630   SSF50630       
SSF54928   SSF54928       

Gene 3D

1.10.275.10     3.30.70.330    

ProteinModelPortal

H9JC74   A0A0N1PHN5   A0A2H1V6T9   B2DBN3   A0A212EUV7   A0A2A4JHM0   + More
A0A3S2NFU5   A0A0L7LGT3   S4PF95   A0A194PIF9   A0A182GJX8   A0A1L8DXT9   A0A023ESY0   B4PM94   A0A1Q3F8X8   J9HT71   A0A1B0CJJ2   J9HJI9   A0A3B0JLJ4   A0A182HT94   B0W6F1   Q7QBZ6   A0A182K1Z5   B4NJF6   B3P3J2   A0A182XIA7   A0A182V252   B4QWD5   A0A182PA48   A0A182U1L3   A0A1W4X215   Q9VEP6   A0A1W4VH91   A0A182IWI7   B4IBN8   A0A0M5J4C2   B4KV48   Q95SP9   B3M2B5   A0A182NA73   W5JM61   A0A182F8B9   A0A182QYL4   A0A2M4ACA5   A0A2M4BLZ9   A0A2M4BLP6   B4IYT5   A0A2M4BLM0   A0A2M3Z1C5   B4LDA2   A0A182LVZ8   A0A182YS80   A0A182W2W6   U5EUN6   A0A182RYG0   B4G4K3   Q297I4   A0A0L0CRA3   K7IMY2   T1PGQ8   A0A1I8P9R0   A0A0T6AUS5   A0A1Y1LA35   E2ASU4   A0A0K8TL45   A0A0A1X0W1   A0A084W1M2   A0A336KCM1   A0A026X3L2   W8C837   A0A0K8UL87   A0A034WS39   A0A0L7QQX1   A0A0M8ZUQ3   D6WX11   E2BFA3   A0A151IU78   A0A154P2M6   A0A151IAQ0   F4X2U5   A0A151WKK4   A0A2A3EC47   A0A158NLQ0   A0A195BLA0   A0A195FVD7   A0A232F4U8   A0A0C9PVA4   U4TSL0   A0A1A9W589   A0A1B0AWJ6   A0A3L8DIQ7   A0A0K8V1A4   A0A1A9Z7E5   D3TS08   A0A1A9Y5Y6   A0A1A9V512   E9J7N7   A0A1J1HY75   A0A087ZXK2   T1DST8  

PDB

2VD6     E-value=5.10229e-164,     Score=1483

KEGG

101737927    K01756 adenylosuccinate lyase [EC:4.3.2.2] | (RefSeq) adenylosuccinate lyase

PATHWAY

00230    Purine metabolism - Bombyx mori (domestic silkworm)
00250    Alanine, aspartate and glutamate metabolism - Bombyx mori (domestic silkworm)
01100    Metabolic pathways - Bombyx mori (domestic silkworm)

GO

GO:0006189   GO:0004018   GO:0070626   GO:0044208   GO:0004190   GO:0005829   GO:0006163   GO:0009152   GO:0003723   GO:0003824   GO:0003743   GO:0005852   GO:0006413   GO:0031369   GO:0005515   GO:0046872  

Length:

444

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.28763

Exp number, first 60 AAs:

0.00119

Total prob of N-in:

0.00754

outside

1  -  444

 

 

Pi

180.014273

Theta

160.298086

Tajima's D

1.510844

CLR

0.012015

CSRT

0.790460476976151

Interpretation

Uncertain