Pre Gene Modal
BGIBMGA007112
Annotation
PREDICTED:_DNA-directed_RNA_polymerase_III_subunit_RPC5_[Bombyx_mori]
Full name
DNA-directed RNA polymerase III subunit RPC5
Alternative Name
Sex-lethal interactor homolog
Location in the cell
Nuclear Reliability : 4.186
Sequence
CDS
ATGGATGACGACGATCCCGTAGTGCAAGAGATACCAGTTTATCTATCGAGGACCTTAGCCAAGAATCTGTACATATATCAGTATCCAGCAAGGCCCGCAAATAGGGACTGGAGTGATGTGCAGATCGTGAATGCTGCTCTTAAGCCTAAAAACCAAGTTGTAAGGCTGGAAGTTGGCCTAGACACGAACAGTGATAAGTTCTGTTCTTCCGTTGCTGAACAGATAGCAATAAACACTGATGGACATCAGGAATCTTCATGGCATGTAAAAGAGAAAGATAAATCATTTTATTTCAAAAATAGAATGATGGATAAAATAGTGTATGAGAGCAGCCGACCAACAGTTGACACTCGACACTATGCTGTGGCGATATTAGAGGATAAAGAACTACACTGTACTCCTTTACAAGGTATAATACAAATGAGGCCGTCATACACATATCATGATAAGCAAGATAAACGTAAACAAGAAAAGAGCAAGGCTGATGATCCTGAAGAGGAAGAGAATGAACCTGAACCACAACAGGTGACCGTAAAATTTGCTCGTCAAGAAACAGATGTGGCTAAGAAAGCACGAGAGAAATCTTACGAAACTATAACTCAACGTGTGACTGCAGAGCCTTGGTATGATGCGTTTTGGGTGAATCCAAATACTGATCAAGCTGAATTGGAACGCCTAAAACTGTTCAGTCAAACTACACTTGATGGCTCAGCCCTAAGTTTGAACGCTCATGAATATATCCGGAATCTCGTACCACCACCGCCTGAAGATGAGGCGGATATAGTTCCCACCAAACGGCCTTCAGTTGTAGAGCAAATTAAGAATTTACTTCTAAATGCTAAGTTGATGACATTGAGTGACGTCCGGTCGCTCGTCCGCACGGAGAGTGGCAGCGCCGTGAGTGAGAGCGCCGCAGTGAGCGCGCTGTCCAGCGTGGCGTGCTGCGTGCGCGGCGTGTGGGCGGCGCGCTCCGCCGACCTGTACCCGCGCGCCGGGCCCGCGCCCCCCGCGCTGCTGATAGCCGCCAGGGACCACATATTGTACCTCTTCACTCAGAACACGTACATCGACCGTCGGAAGGTGACCGCGGCTGTACGCCTGCCGCCCTTAGACGTATTGGAAATAATACGTTCAGTCGCCAAATACAATCCCCGGTACGGCTGGGAGCTGCTCATACCGCCCGACGTGGAGTTCGAGAGGAAATACCCTGACGTGATTCAAAGGCAGAACCTGGCTTGGGAGGCGAAGCAGAGGCAGTTCACCGAAACGTTGATGGGCGAAAATGTACCTAAACGTCAGAGGAAGAAGTCCCAAAGGGATTCGGTGAGCTCGGACACGATGCTCAGCCCGAAGCCCCGGTGTAATAGTGTTAGTGAGGAAGACAGTGAGCGAAAGAGACACAAGAACAAATCCGCTACCGGTAGCGGGAAAAGGACGCGCAATGTCAGTTCGGGCAGTGTTACGGAAGGGACGTGA
Protein
MDDDDPVVQEIPVYLSRTLAKNLYIYQYPARPANRDWSDVQIVNAALKPKNQVVRLEVGLDTNSDKFCSSVAEQIAINTDGHQESSWHVKEKDKSFYFKNRMMDKIVYESSRPTVDTRHYAVAILEDKELHCTPLQGIIQMRPSYTYHDKQDKRKQEKSKADDPEEEENEPEPQQVTVKFARQETDVAKKAREKSYETITQRVTAEPWYDAFWVNPNTDQAELERLKLFSQTTLDGSALSLNAHEYIRNLVPPPPEDEADIVPTKRPSVVEQIKNLLLNAKLMTLSDVRSLVRTESGSAVSESAAVSALSSVACCVRGVWAARSADLYPRAGPAPPALLIAARDHILYLFTQNTYIDRRKVTAAVRLPPLDVLEIIRSVAKYNPRYGWELLIPPDVEFERKYPDVIQRQNLAWEAKQRQFTETLMGENVPKRQRKKSQRDSVSSDTMLSPKPRCNSVSEEDSERKRHKNKSATGSGKRTRNVSSGSVTEGT
Summary
Description
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific periphjeric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. Essential for efficient transcription from both the type 2 VAI and type 3 U6 RNA polymerase III promoters. Plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts induce type I interferon and NF- Kappa-B through the RIG-I pathway (By similarity).
Subunit
Component of the RNA polymerase III (Pol III) complex consisting of 17 subunits. Interacts with RPC4 (By similarity).
Keywords
Alternative splicing
Antiviral defense
Complete proteome
DNA-directed RNA polymerase
Immunity
Innate immunity
Isopeptide bond
Nucleus
Phosphoprotein
Reference proteome
Transcription
Ubl conjugation
Feature
chain DNA-directed RNA polymerase III subunit RPC5
splice variant In isoform 2.
splice variant In isoform 2.
Uniprot
H9JC67
A0A2H1VIS8
A0A3S2M545
A0A194PJ77
A0A212FBY7
A0A194QZ23
+ More
A0A2J7PK07 A0A154P2P4 A0A088AC64 A0A0L7RET3 A0A1B0DLU8 A0A310SPP0 A0A2A3EN96 A0A1L8DHA5 U5EU45 A0A0C9Q5H0 B4N3V2 D3TPM4 A0A1B0B708 A0A1B0A8Q9 A0A1Q3EXZ3 A0A1A9UJV9 A0A1I8P3U1 A0A1B0FI91 A0A0L0BYW1 A0A1I8N103 B0XH13 K7J786 B4QJM1 Q9VP85 Q9U778 A0A1W4VA13 B0WK04 B3NIV1 A0A182GS90 Q16PB1 W8BN55 B4PE80 A0A232F9Z9 B3M6U7 B4KWK4 Q2M162 A0A3B0J988 U6D0Y9 A0A2M4AQ09 A0A0A1X2M2 A0A1B6DQ29 A0A1A9YB08 B4IAJ1 G9KHT3 A0A2M4APW8 A0A2M4APV9 W5JIB4 A0A034WHD0 A0A3N0Y096 B4LEC6 A0A1A9W1P9 W5U7M1 A0A210R4Y7 B4IYW9 A0A384CKQ6 J9P814 A0A3Q7XWC0 A0A384CKP0 A0A3L7HUG2 A0A3Q7Y3P6 Q9CZT4 Q3UJW8 D3ZP45 A0A3Q7WE82 M3YZD9 E1JI58 A0A2U9CN15 A0A337SG83 A0A2Y9LKD4 A0A2U3VU41 A0A2U3VU85 A0A2U3XH95 Q3TWE8 A0A3B1JTT4 A0A3Q7MVL9 A0A3Q7MVK2 H0RNI5 A0A2I2V2B4 A0A2Y9LA89 G1LA81 A0A2U3XHA0 A0A3Q7MTL2 A0A2U3VUC8 A0A2Y9GZ53 Q5BI58 A0A2Y9GXH8 A0A2Y9GT91 A0A3P9B4L8 A0A3Q2VCP4
A0A2J7PK07 A0A154P2P4 A0A088AC64 A0A0L7RET3 A0A1B0DLU8 A0A310SPP0 A0A2A3EN96 A0A1L8DHA5 U5EU45 A0A0C9Q5H0 B4N3V2 D3TPM4 A0A1B0B708 A0A1B0A8Q9 A0A1Q3EXZ3 A0A1A9UJV9 A0A1I8P3U1 A0A1B0FI91 A0A0L0BYW1 A0A1I8N103 B0XH13 K7J786 B4QJM1 Q9VP85 Q9U778 A0A1W4VA13 B0WK04 B3NIV1 A0A182GS90 Q16PB1 W8BN55 B4PE80 A0A232F9Z9 B3M6U7 B4KWK4 Q2M162 A0A3B0J988 U6D0Y9 A0A2M4AQ09 A0A0A1X2M2 A0A1B6DQ29 A0A1A9YB08 B4IAJ1 G9KHT3 A0A2M4APW8 A0A2M4APV9 W5JIB4 A0A034WHD0 A0A3N0Y096 B4LEC6 A0A1A9W1P9 W5U7M1 A0A210R4Y7 B4IYW9 A0A384CKQ6 J9P814 A0A3Q7XWC0 A0A384CKP0 A0A3L7HUG2 A0A3Q7Y3P6 Q9CZT4 Q3UJW8 D3ZP45 A0A3Q7WE82 M3YZD9 E1JI58 A0A2U9CN15 A0A337SG83 A0A2Y9LKD4 A0A2U3VU41 A0A2U3VU85 A0A2U3XH95 Q3TWE8 A0A3B1JTT4 A0A3Q7MVL9 A0A3Q7MVK2 H0RNI5 A0A2I2V2B4 A0A2Y9LA89 G1LA81 A0A2U3XHA0 A0A3Q7MTL2 A0A2U3VUC8 A0A2Y9GZ53 Q5BI58 A0A2Y9GXH8 A0A2Y9GT91 A0A3P9B4L8 A0A3Q2VCP4
Pubmed
19121390
26354079
22118469
17994087
20353571
26108605
+ More
25315136 20075255 22936249 10731132 12537568 12537572 12537573 12537574 16110336 17569856 17569867 26109357 26109356 10521666 26483478 17510324 24495485 17550304 28648823 15632085 25830018 23236062 20920257 23761445 25348373 23127152 28812685 24813606 16341006 29704459 16141072 15489334 17242355 21183079 10349636 11042159 11076861 11217851 12466851 16141073 15057822 15632090 22673903 17975172 25329095 20010809 25186727
25315136 20075255 22936249 10731132 12537568 12537572 12537573 12537574 16110336 17569856 17569867 26109357 26109356 10521666 26483478 17510324 24495485 17550304 28648823 15632085 25830018 23236062 20920257 23761445 25348373 23127152 28812685 24813606 16341006 29704459 16141072 15489334 17242355 21183079 10349636 11042159 11076861 11217851 12466851 16141073 15057822 15632090 22673903 17975172 25329095 20010809 25186727
EMBL
BABH01014971
BABH01014972
ODYU01002780
SOQ40696.1
RSAL01000031
RVE51610.1
+ More
KQ459603 KPI93093.1 AGBW02009256 OWR51245.1 KQ461137 KPJ08846.1 NEVH01024942 PNF16672.1 KQ434796 KZC05614.1 KQ414608 KOC69472.1 AJVK01016560 KQ760512 OAD60047.1 KZ288210 PBC32964.1 GFDF01008344 JAV05740.1 GANO01004043 JAB55828.1 GBYB01000806 GBYB01004865 GBYB01009292 GBYB01009293 JAG70573.1 JAG74632.1 JAG79059.1 JAG79060.1 CH964095 EDW79307.1 EZ423376 ADD19652.1 JXJN01009336 GFDL01014872 JAV20173.1 CCAG010019168 JRES01001238 KNC24424.1 DS233085 EDS27981.1 CM000363 CM002912 EDX11321.1 KMZ00918.1 AE014296 BT126277 AAF51670.1 AEB39638.1 AF151390 AAF02535.1 DS231966 EDS29548.1 CH954178 EDV52597.1 JXUM01016843 KQ560467 KXJ82267.1 CH477789 EAT36190.1 GAMC01004080 JAC02476.1 CM000159 EDW95093.2 KRK02228.1 NNAY01000636 OXU27268.1 CH902618 EDV39783.1 CH933809 EDW19633.1 CH379069 EAL30713.2 OUUW01000002 SPP76903.1 HAAF01004795 CCP76620.1 GGFK01009501 MBW42822.1 GBXI01008965 JAD05327.1 GEDC01009520 JAS27778.1 CH480826 EDW44304.1 JP015860 AES04458.1 GGFK01009514 MBW42835.1 GGFK01009500 MBW42821.1 ADMH02001091 ETN64132.1 GAKP01005250 JAC53702.1 RJVU01055667 ROK76661.1 CH940647 EDW70102.1 JT407336 AHH37953.1 NEDP02000408 OWF55981.1 CH916366 EDV97677.1 AAEX03004457 RAZU01000142 RLQ69567.1 AK005034 AK012184 BC037637 AK146279 BAE27037.1 AC116250 CH473956 EDM17598.1 AEYP01099119 AEYP01099120 AEYP01099121 AEYP01099122 AEYP01099123 ACZ94757.2 CP026260 AWP17948.1 AANG04001668 AK159723 BAE35318.1 BT132907 AEV66557.1 ACTA01067991 ACTA01075991 BT021366 AAX33514.1
KQ459603 KPI93093.1 AGBW02009256 OWR51245.1 KQ461137 KPJ08846.1 NEVH01024942 PNF16672.1 KQ434796 KZC05614.1 KQ414608 KOC69472.1 AJVK01016560 KQ760512 OAD60047.1 KZ288210 PBC32964.1 GFDF01008344 JAV05740.1 GANO01004043 JAB55828.1 GBYB01000806 GBYB01004865 GBYB01009292 GBYB01009293 JAG70573.1 JAG74632.1 JAG79059.1 JAG79060.1 CH964095 EDW79307.1 EZ423376 ADD19652.1 JXJN01009336 GFDL01014872 JAV20173.1 CCAG010019168 JRES01001238 KNC24424.1 DS233085 EDS27981.1 CM000363 CM002912 EDX11321.1 KMZ00918.1 AE014296 BT126277 AAF51670.1 AEB39638.1 AF151390 AAF02535.1 DS231966 EDS29548.1 CH954178 EDV52597.1 JXUM01016843 KQ560467 KXJ82267.1 CH477789 EAT36190.1 GAMC01004080 JAC02476.1 CM000159 EDW95093.2 KRK02228.1 NNAY01000636 OXU27268.1 CH902618 EDV39783.1 CH933809 EDW19633.1 CH379069 EAL30713.2 OUUW01000002 SPP76903.1 HAAF01004795 CCP76620.1 GGFK01009501 MBW42822.1 GBXI01008965 JAD05327.1 GEDC01009520 JAS27778.1 CH480826 EDW44304.1 JP015860 AES04458.1 GGFK01009514 MBW42835.1 GGFK01009500 MBW42821.1 ADMH02001091 ETN64132.1 GAKP01005250 JAC53702.1 RJVU01055667 ROK76661.1 CH940647 EDW70102.1 JT407336 AHH37953.1 NEDP02000408 OWF55981.1 CH916366 EDV97677.1 AAEX03004457 RAZU01000142 RLQ69567.1 AK005034 AK012184 BC037637 AK146279 BAE27037.1 AC116250 CH473956 EDM17598.1 AEYP01099119 AEYP01099120 AEYP01099121 AEYP01099122 AEYP01099123 ACZ94757.2 CP026260 AWP17948.1 AANG04001668 AK159723 BAE35318.1 BT132907 AEV66557.1 ACTA01067991 ACTA01075991 BT021366 AAX33514.1
Proteomes
UP000005204
UP000283053
UP000053268
UP000007151
UP000053240
UP000235965
+ More
UP000076502 UP000005203 UP000053825 UP000092462 UP000242457 UP000007798 UP000092460 UP000092445 UP000078200 UP000095300 UP000092444 UP000037069 UP000095301 UP000002320 UP000002358 UP000000304 UP000000803 UP000192221 UP000008711 UP000069940 UP000249989 UP000008820 UP000002282 UP000215335 UP000007801 UP000009192 UP000001819 UP000268350 UP000092443 UP000001292 UP000000673 UP000008792 UP000091820 UP000221080 UP000242188 UP000001070 UP000261680 UP000291021 UP000002254 UP000286642 UP000273346 UP000000589 UP000002494 UP000000715 UP000246464 UP000011712 UP000248482 UP000245340 UP000245341 UP000018467 UP000286641 UP000008912 UP000248481 UP000265160 UP000264840
UP000076502 UP000005203 UP000053825 UP000092462 UP000242457 UP000007798 UP000092460 UP000092445 UP000078200 UP000095300 UP000092444 UP000037069 UP000095301 UP000002320 UP000002358 UP000000304 UP000000803 UP000192221 UP000008711 UP000069940 UP000249989 UP000008820 UP000002282 UP000215335 UP000007801 UP000009192 UP000001819 UP000268350 UP000092443 UP000001292 UP000000673 UP000008792 UP000091820 UP000221080 UP000242188 UP000001070 UP000261680 UP000291021 UP000002254 UP000286642 UP000273346 UP000000589 UP000002494 UP000000715 UP000246464 UP000011712 UP000248482 UP000245340 UP000245341 UP000018467 UP000286641 UP000008912 UP000248481 UP000265160 UP000264840
ProteinModelPortal
H9JC67
A0A2H1VIS8
A0A3S2M545
A0A194PJ77
A0A212FBY7
A0A194QZ23
+ More
A0A2J7PK07 A0A154P2P4 A0A088AC64 A0A0L7RET3 A0A1B0DLU8 A0A310SPP0 A0A2A3EN96 A0A1L8DHA5 U5EU45 A0A0C9Q5H0 B4N3V2 D3TPM4 A0A1B0B708 A0A1B0A8Q9 A0A1Q3EXZ3 A0A1A9UJV9 A0A1I8P3U1 A0A1B0FI91 A0A0L0BYW1 A0A1I8N103 B0XH13 K7J786 B4QJM1 Q9VP85 Q9U778 A0A1W4VA13 B0WK04 B3NIV1 A0A182GS90 Q16PB1 W8BN55 B4PE80 A0A232F9Z9 B3M6U7 B4KWK4 Q2M162 A0A3B0J988 U6D0Y9 A0A2M4AQ09 A0A0A1X2M2 A0A1B6DQ29 A0A1A9YB08 B4IAJ1 G9KHT3 A0A2M4APW8 A0A2M4APV9 W5JIB4 A0A034WHD0 A0A3N0Y096 B4LEC6 A0A1A9W1P9 W5U7M1 A0A210R4Y7 B4IYW9 A0A384CKQ6 J9P814 A0A3Q7XWC0 A0A384CKP0 A0A3L7HUG2 A0A3Q7Y3P6 Q9CZT4 Q3UJW8 D3ZP45 A0A3Q7WE82 M3YZD9 E1JI58 A0A2U9CN15 A0A337SG83 A0A2Y9LKD4 A0A2U3VU41 A0A2U3VU85 A0A2U3XH95 Q3TWE8 A0A3B1JTT4 A0A3Q7MVL9 A0A3Q7MVK2 H0RNI5 A0A2I2V2B4 A0A2Y9LA89 G1LA81 A0A2U3XHA0 A0A3Q7MTL2 A0A2U3VUC8 A0A2Y9GZ53 Q5BI58 A0A2Y9GXH8 A0A2Y9GT91 A0A3P9B4L8 A0A3Q2VCP4
A0A2J7PK07 A0A154P2P4 A0A088AC64 A0A0L7RET3 A0A1B0DLU8 A0A310SPP0 A0A2A3EN96 A0A1L8DHA5 U5EU45 A0A0C9Q5H0 B4N3V2 D3TPM4 A0A1B0B708 A0A1B0A8Q9 A0A1Q3EXZ3 A0A1A9UJV9 A0A1I8P3U1 A0A1B0FI91 A0A0L0BYW1 A0A1I8N103 B0XH13 K7J786 B4QJM1 Q9VP85 Q9U778 A0A1W4VA13 B0WK04 B3NIV1 A0A182GS90 Q16PB1 W8BN55 B4PE80 A0A232F9Z9 B3M6U7 B4KWK4 Q2M162 A0A3B0J988 U6D0Y9 A0A2M4AQ09 A0A0A1X2M2 A0A1B6DQ29 A0A1A9YB08 B4IAJ1 G9KHT3 A0A2M4APW8 A0A2M4APV9 W5JIB4 A0A034WHD0 A0A3N0Y096 B4LEC6 A0A1A9W1P9 W5U7M1 A0A210R4Y7 B4IYW9 A0A384CKQ6 J9P814 A0A3Q7XWC0 A0A384CKP0 A0A3L7HUG2 A0A3Q7Y3P6 Q9CZT4 Q3UJW8 D3ZP45 A0A3Q7WE82 M3YZD9 E1JI58 A0A2U9CN15 A0A337SG83 A0A2Y9LKD4 A0A2U3VU41 A0A2U3VU85 A0A2U3XH95 Q3TWE8 A0A3B1JTT4 A0A3Q7MVL9 A0A3Q7MVK2 H0RNI5 A0A2I2V2B4 A0A2Y9LA89 G1LA81 A0A2U3XHA0 A0A3Q7MTL2 A0A2U3VUC8 A0A2Y9GZ53 Q5BI58 A0A2Y9GXH8 A0A2Y9GT91 A0A3P9B4L8 A0A3Q2VCP4
Ontologies
GO
PANTHER
Topology
Subcellular location
Nucleus
Length:
491
Number of predicted TMHs:
0
Exp number of AAs in TMHs:
0.01638
Exp number, first 60 AAs:
0.00459
Total prob of N-in:
0.00252
outside
1 - 491
Population Genetic Test Statistics
Pi
220.670035
Theta
177.34539
Tajima's D
-1.605166
CLR
277.227175
CSRT
0.0454477276136193
Interpretation
Uncertain
