Gene

KWMTBOMO10489  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA007111

Annotation

PREDICTED:_dihydropyrimidine_dehydrogenase_[NADP(+)]_[Papilio_machaon]

Location

Bomo_Chr17(+):12443707-12465424      View in EpiBrowser

Full name

Dihydropyrimidine dehydrogenase [NADP(+)]      

Alternative Name

Dihydrothymine dehydrogenase
Dihydrouracil dehydrogenase

Location in the cell

Cytoplasmic   Reliability : 2.461

CDS

ATGGCGAAGCTACTAAGTAAAGAGCTGCCCGACATCGAGAATCTCCTGAAGTTAAATCCTACAGTGAAGCCTTACACCAATTTGGTTCCATCGGCCCAAACCAAGAAGATTAAGCAACATTGGAAAAGAAATGCTGATAGAAAATGTACTACATGTCCAACCCTGAACAAGAATTTCGACGATATCAAACACACGACGCTGTCAGAACGTGGAGCTTTACGGGAGGCGGCACGATGTCTCAAGTGTGCTGACGCGCCGTGTCAGAAGTCGTGTCCCACGCAGATCGATGTCAAAAGCTTCATCACTAGCATCGCCAATAAGAATTACTATGGAGCAGCGAAGGCCATTTTATCAGACAATCCCCTCGGTTTGACTTGCGGCATGGTCTGCCCCACCAGCGATTTATGCGTCGGGGGATGCAACCTTCACGCCACTGAAGAAGGAGCTATCAATATTGGAGGACTTCAACATTTCGCTGTTGACATATTCATGAAGATGGGCATCCCCCAAACTTTAGACCCCAATACGAAACCGCTACCAAAAGGAGGGGACCATAAAATCGCTTTGATCGGCGGAGGACCGGCCAGTATCAGCTGTGCCTGCTTCCTGGCTAGGTTGGGTTACAAGGACATCACGGTGTACGAGAAGGAAAAGTATCTCGGGGGCTTAAGTTCTTCAGAAATCCCTCAATACCGACTTCCATACGAAGTGGTACAATACGAAGTTGATCTCGTTAAAAACCTCGGAGTGAAATTTGAGACCGGAAGAATGCTGTCTACAAATGACATCACTTTGAATAATCTCCTTGAAGACCACGCAGCAGTATTCCTCGGGATCGGATTACCGGAACCCAAAAGCGTTCCCATATTCAAAGGCCTTACGCAAGAAATGGGTTTCTACACTAGCAAGGATTTCTTGCCTCTAGTATCTAGAGGCAGTAAGAAAGGAATGTGTGCCTGCAAGCCACCACTACCAGAGCTGTACGGTAACGTCGTAGTGCTGGGAGCTGGCGACACGGCGTTCGACTGTGCCACATCTGCTTTACGTTGCGGAGCTAGAAGGGTCTATGTCGTGTTTAGAAAAGGATTCAGCAATATAAGAGCTGTGCCCGAAGAAGTCGATTTGGCTAAAGACGAAAAATGTGAATTCGTACCATTCATGTCTCCGCAAGAAGTAATTGTCAAAGACGGAAAGATAATTGGTTTAAAGATGTGCCGCACGGAACAATTAGAAGACGGCGAATGGATCGAAGATCACGATCAAATCATGCAATTAAAAGCAAATTTCATCATTTCGGCATTCGGTTCTGGTCTTTATGATAATGATGTTATACAAGCGATGTTTGGTGTGAAGTTCAACCGTTGGGGACTACCAGAAGTAGAAGACTCCAGCATGCAAAGCGTCTCAGAACCCCGCGTGTTCATAGGCGGGGATCTGGCTGGAGTGGCCGAGACAACTGTTGAATCTGTCAACGATGGCAAAACGGCGGCTTGGTACATGCACTGCTACTTGCAGGGCCTTCCGTTCGACTCGCCGGTAGAACTCCCAAAATTCCATTGTCCTATTGACGACGTGGACCTTTCAGTCGAAGTGTGCGGGATCAAGTTCGAGAACCCGTTCGGCCTGGCCAGCGCTCCCCCCACTACCAGCTCGGCAATGATACGCAGAGCTTTCCAACAGGGATGGGGGTTTGCGGTGACTAAGACCTTTGGACTAGACAAGGATATAGTAACGAATGTCTCACCTCGGATCGTACGCGGCGTCACCTCTGGCGAGAACTACGGTCCAGGTCAAGGATCATTCCTGAACATTGAACTTATATCCGAGAAATGTGAAGCGTATTGGTGCCAGAGCATTAAAGAATTGAAGAAAGATTTCCCTAATAAAGTGGTGATAGCGTCGATAATGTGTTCGTACAATGAAGATGACTGGACGGAATTAGCACGGAAAGCAGAGGCCGCGGGCTCAGACGCTTTGGAACTCAATCTATCTTGCCCACACGGAATGGGAGAATCTGGCATGGGACTTGCCTGTGGACAGGATCCGGTGTTAGTGAAAGGGATTTCTCAGTGGGTACGCAAAGCCATCAAGATTCCGTTCTTTGTGAAATTAACACCAAATATTACGGACATTGTCAGTATCGCTGTGGCTGCTTATGAAGGTGGTGCGAACGGTGTTTCTGCCATAAACACAGTATCGGGATTAATGTCGGTTAAAGCGGACGCAACACCTTGGCCTGCCGTCGGTAAACAAAAACGCACAACTTACGGCGGCGTATCGGGGAACGCGACTCGTCCAATCGGATTGCGGGCAGTCTCTGCGGTCGGAAATAAATTACCGGGATTCCCAATACTGGGCATCGGAGGTATCGACTCTGCTGATTCGGCACTACAGTTCATCTTGTGTGGTGCACCGGTCGTACAGATTTGCAGTGCAGTGCAAAATCAAGATTTCACAGTGGTCGAAGATTACATAACAGGACTTAAAGCTCTTTTGTATCTACGTTCTCGTGGTCTAGACGGATGGACGGGACAATCGCCACCTACTTTTAAGCACCAGAAAGGAAAACCCGTACAAACAATTCGTGACGAAAATGGAAAGGTACTGACACACTTCGGTATTTACAACAAAAAACGCGAACAGATTCTCCATCAAAATAGATTAAAATTAGGTTTACTGGACGACGACTGTGTTGTTGACAATCGTTCGACCAATGGCAGTACATACGGCCTTAGCGCAGTACCAAGAATCAGCGACGTATTGGGTCAAGCTCTGCCTAAAGTGGGGGCGTACAAGCACCTGGATAATAAACTCCAAGTCGTCGCGCTCATTGATGATGATATGTGTATCAATTGCGGAAAATGCTACATGGCGTGTGCAGACTCTGGGTACCAAGCGATAGAATTCGATTCTGACACCCATCTTCCACATGTGACCGATGATTGCACTGGTTGTACTCTATGTTTGTCTGTGTGCCCAATTATCGACTGTATATCAATGGTCCCGAAGAAAATTCCTCACGTCATCAAAAGGGGTTTAGGCTATGAAATTCATCCGATTTCACCTCTAGACGGAATTTGTCAATAA

Protein

MAKLLSKELPDIENLLKLNPTVKPYTNLVPSAQTKKIKQHWKRNADRKCTTCPTLNKNFDDIKHTTLSERGALREAARCLKCADAPCQKSCPTQIDVKSFITSIANKNYYGAAKAILSDNPLGLTCGMVCPTSDLCVGGCNLHATEEGAINIGGLQHFAVDIFMKMGIPQTLDPNTKPLPKGGDHKIALIGGGPASISCACFLARLGYKDITVYEKEKYLGGLSSSEIPQYRLPYEVVQYEVDLVKNLGVKFETGRMLSTNDITLNNLLEDHAAVFLGIGLPEPKSVPIFKGLTQEMGFYTSKDFLPLVSRGSKKGMCACKPPLPELYGNVVVLGAGDTAFDCATSALRCGARRVYVVFRKGFSNIRAVPEEVDLAKDEKCEFVPFMSPQEVIVKDGKIIGLKMCRTEQLEDGEWIEDHDQIMQLKANFIISAFGSGLYDNDVIQAMFGVKFNRWGLPEVEDSSMQSVSEPRVFIGGDLAGVAETTVESVNDGKTAAWYMHCYLQGLPFDSPVELPKFHCPIDDVDLSVEVCGIKFENPFGLASAPPTTSSAMIRRAFQQGWGFAVTKTFGLDKDIVTNVSPRIVRGVTSGENYGPGQGSFLNIELISEKCEAYWCQSIKELKKDFPNKVVIASIMCSYNEDDWTELARKAEAAGSDALELNLSCPHGMGESGMGLACGQDPVLVKGISQWVRKAIKIPFFVKLTPNITDIVSIAVAAYEGGANGVSAINTVSGLMSVKADATPWPAVGKQKRTTYGGVSGNATRPIGLRAVSAVGNKLPGFPILGIGGIDSADSALQFILCGAPVVQICSAVQNQDFTVVEDYITGLKALLYLRSRGLDGWTGQSPPTFKHQKGKPVQTIRDENGKVLTHFGIYNKKREQILHQNRLKLGLLDDDCVVDNRSTNGSTYGLSAVPRISDVLGQALPKVGAYKHLDNKLQVVALIDDDMCINCGKCYMACADSGYQAIEFDSDTHLPHVTDDCTGCTLCLSVCPIIDCISMVPKKIPHVIKRGLGYEIHPISPLDGICQ

Description

Involved in pyrimidine base degradation. Catalyzes the reduction of uracil and thymine.

Catalytic Activity

5,6-dihydrouracil + NADP(+) = H(+) + NADPH + uracil

Cofactor

FAD
FMN
[4Fe-4S] cluster

Similarity

Belongs to the dihydropyrimidine dehydrogenase family.
Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.

Uniprot

H9JC66   A0A3S2NXM8   A0A194PI46   A0A212FC04   A0A2H1VIP2   A0A1Q3FZ17   + More
Q16H04   A0A084WPZ4   A0A182H1J5   T1PFN8   A0A1I8MVU6   A0A1L8EDB8   A0A182NV38   A0A182PI33   A0A336LVY6   A0A1L8EDI8   A0A1L8EDA8   A0A182GPU5   A0A336LTE6   A0A1L8EDN8   Q16TK6   Q7QHY0   A0A182V481   A0A182F9Y4   A0A1B0CRF4   A0A182W4X2   A0A182Q9D4   W5JJZ0   A0A2M4A1W2   A0A2M4A1V9   A0A182INX8   A0A1I8P398   A0A2M4CXX5   A0A182RP99   A0A2M4CXU1   A0A0L0CL49   A0A182K9R1   A0A088AHJ1   A0A232FBC0   K7IQT0   A0A182Y4Z6   A0A182MGV8   D6WGA9   A0A2A3E9Z3   A0A0J7KJ55   A0A2J7Q6D9   A0A0L7RIP2   A0A158NQD2   A0A0M4ETL3   A0A1J1IPD5   A0A2M4CYP9   A0A151K347   B4L397   A0A154PS15   B4M3S4   E0VSW7   A0A026WQC3   V5GTH2   A0A194QTJ2   B4R6V3   Q9W374   A0A1A9WDB6   B4JXK7   Q4TWT4   B3NUF8   B4PZV8   A0A1W4UR08   A0A151WGG2   A0A1B0BMY1   A0A1A9Z8M1   A0A1A9XY87   A0A131YH29   A0A0N0BIN2   B4NDZ2   A0A1S3JSU0   A0A2R5LF66   V4AGP9   A0A3Q3N1Q1   A0A1D2ND40   A0A3B0K2Q8   A0A3Q3A8J4   W5MNR9   F4WAA0   B3MZM3   A0A3Q2ED11   A0A0C9R2D8   A0A3B1J9M6   W5UJH6   A0A1L8GMQ4   A0A0R3NZ50   A0A1A9VDB9   A0A0R3P3X8   A0A3B4UKG7   A0A0F8AJ29   Q29IG0   A0A195B607   C3YCJ1   A0A1B6HTQ3   A0A1B0FAA5   A0A1E1XGE5  

EC Number

1.3.1.2

Pubmed

19121390    26354079    22118469    17510324    24438588    26483478    + More
25315136    12364791    14747013    17210077    20920257    23761445    26108605    28648823    20075255    25244985    18362917    19820115    21347285    17994087    20566863    24508170    30249741    10731132    12537568    12537572    12537573    12537574    16110336    17569856    17569867    26109357    26109356    16361227    17550304    26830274    23254933    27289101    21719571    25329095    23127152    27762356    15632085    25835551    18563158    28503490   

EMBL

BABH01014971    RSAL01000031    RVE51612.1    KQ459603    KPI93091.1    AGBW02009256    + More
OWR51247.1    ODYU01002780    SOQ40693.1    GFDL01002333    JAV32712.1    CH478218    EAT33526.1    ATLV01025144    KE525369    KFB52288.1    JXUM01104641    KQ564902    KXJ71601.1    KA646718    AFP61347.1    GFDG01002081    JAV16718.1    UFQT01000180    SSX21211.1    GFDG01002083    JAV16716.1    GFDG01002082    JAV16717.1    JXUM01001854    KQ560129    KXJ84289.1    SSX21210.1    GFDG01002080    JAV16719.1    CH477646    EAT37844.1    AAAB01008811    EAA04946.2    AJWK01024713    AXCN02002673    ADMH02001298    ETN63099.1    GGFK01001475    MBW34796.1    GGFK01001452    MBW34773.1    GGFL01005989    MBW70167.1    GGFL01005972    MBW70150.1    JRES01000336    KNC32184.1    NNAY01000475    OXU28124.1    AXCM01001371    KQ971329    EFA01139.2    KZ288310    PBC28593.1    LBMM01006614    KMQ90458.1    NEVH01017533    PNF24144.1    KQ414583    KOC70730.1    ADTU01023017    ADTU01023018    ADTU01023019    ADTU01023020    ADTU01023021    ADTU01023022    ADTU01023023    CP012528    ALC48926.1    CVRI01000057    CRL02099.1    GGFL01006217    MBW70395.1    LKEY01022044    KYN50550.1    CH933810    EDW07025.1    KQ435119    KZC14706.1    CH940651    EDW65449.1    DS235758    EEB16473.1    KK107128    QOIP01000006    EZA58247.1    RLU22087.1    GALX01004928    JAB63538.1    KQ461137    KPJ08843.1    CM000366    EDX17483.1    AE014298    AF545061    BT032682    AAN09247.1    AAN64918.1    ACD81696.1    CH916376    EDV95106.1    DQ027826    AAY44826.1    CH954180    EDV46281.1    CM000162    EDX02164.1    KQ983176    KYQ46914.1    JXJN01009852    JXJN01017100    GEDV01009963    JAP78594.1    KQ435727    KOX77918.1    CH964239    EDW81961.1    GGLE01004047    MBY08173.1    KB202050    ESO92596.1    LJIJ01000085    ODN03162.1    OUUW01000015    SPP88565.1    AHAT01016124    GL888045    EGI68891.1    CH902635    EDV33824.1    GBYB01002160    JAG71927.1    JT415858    AHH41840.1    CM004472    OCT85138.1    CH379063    KRT06244.1    KRT06245.1    KQ041766    KKF22937.1    EAL32693.2    KQ976595    KYM79614.1    GG666501    EEN62028.1    GECU01029654    JAS78052.1    CCAG010017192    GFAC01000856    JAT98332.1   

Proteomes

UP000005204    UP000283053    UP000053268    UP000007151    UP000008820    UP000030765    + More
UP000069940    UP000249989    UP000095301    UP000075884    UP000075885    UP000007062    UP000075903    UP000069272    UP000092461    UP000075920    UP000075886    UP000000673    UP000075880    UP000095300    UP000075900    UP000037069    UP000075881    UP000005203    UP000215335    UP000002358    UP000076408    UP000075883    UP000007266    UP000242457    UP000036403    UP000235965    UP000053825    UP000005205    UP000092553    UP000183832    UP000078492    UP000009192    UP000076502    UP000008792    UP000009046    UP000053097    UP000279307    UP000053240    UP000000304    UP000000803    UP000091820    UP000001070    UP000008711    UP000002282    UP000192221    UP000075809    UP000092460    UP000092445    UP000092443    UP000053105    UP000007798    UP000085678    UP000030746    UP000261660    UP000094527    UP000268350    UP000264800    UP000018468    UP000007755    UP000007801    UP000265020    UP000018467    UP000221080    UP000186698    UP000001819    UP000078200    UP000261420    UP000078540    UP000001554    UP000092444   

PRIDE

H9JC66    Q4TWT4    B3MZM3   

Pfam

PF01180   DHO_dh        + More
PF14691   Fer4_20
PF07992   Pyr_redox_2
PF00083   Sugar_tr
PF01266   DAO
PF08669   GCV_T_C
PF16350   FAO_M
PF01571   GCV_T
PF11835   RRM_8

Interpro

IPR005720   Dihydroorotate_DH        + More
IPR009051   Helical_ferredxn       
IPR001295   Dihydroorotate_DH_CS       
IPR023753   FAD/NAD-binding_dom       
IPR017896   4Fe4S_Fe-S-bd       
IPR017900   4Fe4S_Fe_S_CS       
IPR036188   FAD/NAD-bd_sf       
IPR028261   DPD_II       
IPR013785   Aldolase_TIM       
IPR005828   MFS_sugar_transport-like       
IPR036259   MFS_trans_sf       
IPR005829   Sugar_transporter_CS       
IPR020846   MFS_dom       
IPR003663   Sugar/inositol_transpt       
IPR013977   GCV_T_C       
IPR006076   FAD-dep_OxRdtase       
IPR029043   GcvT/YgfZ_C       
IPR032503   FAO_M       
IPR006222   GCV_T_N       
IPR027266   TrmE/GcvT_dom1       
IPR035979   RBD_domain_sf       
IPR006536   HnRNP-L/PTB       
IPR000504   RRM_dom       
IPR021790   PTBP1_RRM       
IPR035002   PTBP2_RRM1       
IPR012677   Nucleotide-bd_a/b_plait_sf       
IPR034798   PTBP1/2/3_RRM2       

SUPFAM

SSF46548   SSF46548        + More
SSF103473   SSF103473       
SSF51905   SSF51905       
SSF101790   SSF101790       
SSF54928   SSF54928       

Gene 3D

1.10.1060.10     3.20.20.70     3.50.50.60     3.30.1360.120     3.30.70.330    

CDD

cd06174  MFS
cd12778  RRM1_PTBP2
cd12693  RRM2_PTBP1_like

ProteinModelPortal

H9JC66   A0A3S2NXM8   A0A194PI46   A0A212FC04   A0A2H1VIP2   A0A1Q3FZ17   + More
Q16H04   A0A084WPZ4   A0A182H1J5   T1PFN8   A0A1I8MVU6   A0A1L8EDB8   A0A182NV38   A0A182PI33   A0A336LVY6   A0A1L8EDI8   A0A1L8EDA8   A0A182GPU5   A0A336LTE6   A0A1L8EDN8   Q16TK6   Q7QHY0   A0A182V481   A0A182F9Y4   A0A1B0CRF4   A0A182W4X2   A0A182Q9D4   W5JJZ0   A0A2M4A1W2   A0A2M4A1V9   A0A182INX8   A0A1I8P398   A0A2M4CXX5   A0A182RP99   A0A2M4CXU1   A0A0L0CL49   A0A182K9R1   A0A088AHJ1   A0A232FBC0   K7IQT0   A0A182Y4Z6   A0A182MGV8   D6WGA9   A0A2A3E9Z3   A0A0J7KJ55   A0A2J7Q6D9   A0A0L7RIP2   A0A158NQD2   A0A0M4ETL3   A0A1J1IPD5   A0A2M4CYP9   A0A151K347   B4L397   A0A154PS15   B4M3S4   E0VSW7   A0A026WQC3   V5GTH2   A0A194QTJ2   B4R6V3   Q9W374   A0A1A9WDB6   B4JXK7   Q4TWT4   B3NUF8   B4PZV8   A0A1W4UR08   A0A151WGG2   A0A1B0BMY1   A0A1A9Z8M1   A0A1A9XY87   A0A131YH29   A0A0N0BIN2   B4NDZ2   A0A1S3JSU0   A0A2R5LF66   V4AGP9   A0A3Q3N1Q1   A0A1D2ND40   A0A3B0K2Q8   A0A3Q3A8J4   W5MNR9   F4WAA0   B3MZM3   A0A3Q2ED11   A0A0C9R2D8   A0A3B1J9M6   W5UJH6   A0A1L8GMQ4   A0A0R3NZ50   A0A1A9VDB9   A0A0R3P3X8   A0A3B4UKG7   A0A0F8AJ29   Q29IG0   A0A195B607   C3YCJ1   A0A1B6HTQ3   A0A1B0FAA5   A0A1E1XGE5  

PDB

1H7W     E-value=0,     Score=3570

KEGG

101737414    K00207 dihydropyrimidine dehydrogenase (NADP+) [EC:1.3.1.2] | (RefSeq) dihydropyrimidine dehydrogena

PATHWAY

00240    Pyrimidine metabolism - Bombyx mori (domestic silkworm)
00410    beta-Alanine metabolism - Bombyx mori (domestic silkworm)
00770    Pantothenate and CoA biosynthesis - Bombyx mori (domestic silkworm)
00983    Drug metabolism - other enzymes - Bombyx mori (domestic silkworm)
01100    Metabolic pathways - Bombyx mori (domestic silkworm)

GO

GO:0017113   GO:0019483   GO:0004152   GO:0051539   GO:0005737   GO:0006207   GO:0005829   GO:0002058   GO:0051536   GO:0006210   GO:0006212   GO:0050661   GO:0016627   GO:0022857   GO:0016021   GO:0004159   GO:0042803   GO:0003954   GO:0006397   GO:0005634   GO:0003723   GO:0003824   GO:0016491   GO:0046872   GO:0055114  

Length:

1028

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.01795

Exp number, first 60 AAs:

0

Total prob of N-in:

0.00047

outside

1  -  1028

 

 

Pi

159.95117

Theta

146.672338

Tajima's D

0.001686

CLR

1.132893

CSRT

0.371681415929204

Interpretation

Uncertain