Gene

KWMTBOMO10471  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA007103

Annotation

PREDICTED:_hydroxyacylglutathione_hydrolase?_mitochondrial_[Amyelois_transitella]

Location

Bomo_Chr17(+):11988967-11991781      View in EpiBrowser

Full name

Hydroxyacylglutathione hydrolase, mitochondrial      

Alternative Name

Glyoxalase II

Location in the cell

Cytoplasmic   Reliability : 1.79 Mitochondrial   Reliability : 1.171

CDS

ATGCTTGCCAGATTCGTAAATTCGTTGCCGTCTGGCCTTTCTCAGCGAATAACTAAACTTTATTTTCGAGCGTTAATTCGCAATCAAAGGGAAGCTCACAGTTCCCAAGAGGACCACCAGTATAAAAACATGGATGTAAAAATCCTGCCAGCACTCCAGGACAACTACATGTACTTGATTGTAGACAAGGCAACAAAGGAAGCTGCTATTGTTGATCCTGTGGAACCTAAAACAGTTTTAAAAGCTGTTGAAGAACAGGGTGTAAATTTGACTACTGTTCTAACTACTCATCATCATTGGGATCATGCTGGTGGAAATGAAGATCTCATCAAAGAACGTCCAGGTTTAATAGTTTATGGAGGTGACGACAGGATCGGAGCCCTCACAAAAAAAGTTGAGCACAATACAAAGTTTAAAATCGGTAACCTGAATGTACAGTGTCTTTTTACACCCTGTCATACAACTGGGCATATATGTTATTTCGTAACTGCTCCAGAAGAAGGTAACGATTCAGTTGTCTTCACCGGGGATACACTCTTCTTAGGCGGATGTGGCAGGTTCTTTGAAGGCACGGCAGATCAAATGTACAAAGCATTAACAATTCTGAGCAGCCTGCCTGACCACACTAAAGTGTTTTGTGGCCATGAGTACACTTTGCAGAATTTAAAATTTGCTGCTCACGTAGAACCTACTAATGAGAATGTCAAAGCCAAAATTAGCTGGTCACAAGACAGGCGAAACCAGGGAAAGCCCACAGTGCCTTCTACGATAGGTGAAGAGAAATTATACAATCCATTCATGAGGGTCACTGAGTTGGCAGTTCAGAATCACACTGGAAAAAATGATCCGATTGATACTATGAAAGCAATACGGCTAGAAAAAGATACATTTAAGTAA

Protein

MLARFVNSLPSGLSQRITKLYFRALIRNQREAHSSQEDHQYKNMDVKILPALQDNYMYLIVDKATKEAAIVDPVEPKTVLKAVEEQGVNLTTVLTTHHHWDHAGGNEDLIKERPGLIVYGGDDRIGALTKKVEHNTKFKIGNLNVQCLFTPCHTTGHICYFVTAPEEGNDSVVFTGDTLFLGGCGRFFEGTADQMYKALTILSSLPDHTKVFCGHEYTLQNLKFAAHVEPTNENVKAKISWSQDRRNQGKPTVPSTIGEEKLYNPFMRVTELAVQNHTGKNDPIDTMKAIRLEKDTFK

Catalytic Activity

an S-(2-hydroxyacyl)glutathione + H2O = a 2-hydroxy carboxylate + glutathione + H(+)

Cofactor

Zn(2+)

Similarity

Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family.

Keywords

Alternative initiation   Complete proteome   Cytoplasm   Hydrolase   Metal-binding   Mitochondrion   Reference proteome   Transit peptide   Zinc  

Feature

chain  Hydroxyacylglutathione hydrolase, mitochondrial
splice variant  In isoform 2.

Uniprot

H9JC58   A0A2H1VKF1   A0A194PIE0   A0A3S2TPH1   A0A194QU42   A0A0L7KTT1   + More
A0A212EU16   A0A1Y1KF96   U5EWA1   A0A0K8VG60   A0A1W4WES5   A0A1B0GQQ2   A0A034VW14   A0A2D0PKS8   A0A0Q5U6L6   A0A1L8E5L7   A0A0R1E220   A0A0R1DYW1   A0A1B0CMM5   A0A1L8E690   Q9VPB3   A0A0J9RZ08   A0A164VJZ3   A0A3B1J3L9   A0A0P5JSK2   W8BK64   A0A1W4VPK6   A0A2D0PJ76   A0A0P5BVG3   A0A0P5BN58   A0A3B0JTX2   A0A0K8V7S7   A0A034VWX5   B3M9T4   A0A0P6ELQ7   A0A336KHQ4   B4PEP9   B4PEQ3   A0A034VUA7   A0A067QLS0   A0A1W5AAM5   B4IAF8   B3NIR9   A0A2J7QWP1   W8B4Z3   Q29D97   B4H7S8   A0A0R1DYV5   A0A0R1E3Q9   A0A3N0YB26   W8B4Y8   A0A0Q5U5L3   B4QJ72   A0A3B0J590   E4NKL2   A0A0L0CJX2   H1UUD4   Q8IPU3   A0A0P8YAA8   A0A1W4VNY3   A0A3B0J4M4   A0A0J9S0B4   A0A3B4D6Y5   Q9I7P8   A0A0A1XBP0   B4LG24   A0A2G9RKQ9   A0A1W4VN87   A0A146W0Q7   A0A2G9RIW4   A0A3Q2DMT0   A0A1I8M8A2   A0A1I8M8A6   A0A2I4CRA1   A0A0P8ZUX5   A0A2I4CR95   A0A3Q2R2L5   Q6P963   B4KYH1   Q6P963-2   A0A146ZYG5   A0A3P8ZMP6   A0A0R3P8V0   A0A0P5L153   E9FXP0   A0A0R3P926   E2AFQ9   A0A0R3P9A8   A0A0R3P7J9   A0A0R3P7B8   A0A384A314   H3A1W6   B4J3N2   H9GB33   A0A2Y9SRW5   A0A087XUC6   A0A3B3VNI6   A0A091H006   A0A3B3XPU8   A0A341CLG0  

EC Number

3.1.2.6

Pubmed

19121390    26354079    26227816    22118469    28004739    25348373    + More
17994087    17550304    10731132    12537568    12537572    12537573    12537574    16110336    17569856    17569867    26109357    26109356    22936249    25329095    24495485    24845553    15632085    18057021    26108605    25830018    25315136    15520368    25069045    21292972    20798317    9215903    21881562   

EMBL

BABH01014932    ODYU01002794    SOQ40734.1    KQ459603    KPI93082.1    RSAL01000031    + More
RVE51619.1    KQ461137    KPJ08834.1    JTDY01005929    KOB66471.1    AGBW02012517    OWR44951.1    GEZM01085157    JAV60172.1    GANO01003044    JAB56827.1    GDHF01014779    GDHF01006523    JAI37535.1    JAI45791.1    AJVK01007773    GAKP01012907    JAC46045.1    CH954178    KQS44329.1    GFDF01000034    JAV14050.1    CM000159    KRK02243.1    KRK02246.1    AJWK01018979    GFDF01000042    JAV14042.1    AE014296    AY061337    AAF51642.2    AAL28885.1    CM002912    KMZ00864.1    LRGB01001361    KZS12396.1    GDIQ01210616    GDIQ01199423    GDIQ01131149    JAK52302.1    GAMC01012909    JAB93646.1    GDIP01179352    JAJ44050.1    GDIP01182198    JAJ41204.1    OUUW01000002    SPP76806.1    GDHF01017327    GDHF01010245    JAI34987.1    JAI42069.1    GAKP01012909    JAC46043.1    CH902618    EDV40125.1    GDIQ01060770    JAN33967.1    UFQS01000439    UFQT01000439    SSX03969.1    SSX24334.1    EDW95123.1    EDW95127.1    GAKP01012908    JAC46044.1    KK853278    KDR09065.1    CH480826    EDW44271.1    EDV52565.1    NEVH01009422    PNF33002.1    GAMC01012908    JAB93647.1    CH379070    EAL30517.2    CH479219    EDW34718.1    KRK02247.1    KRK02248.1    KRK02244.1    KRK02245.1    RJVU01049122    ROL42958.1    GAMC01012913    JAB93642.1    KQS44327.1    KQS44328.1    KQS44330.1    CM000363    EDX11289.1    KMZ00862.1    SPP76805.1    BT125809    ADR71718.1    JRES01000303    KNC32512.1    BT133018    AEX91655.1    AAN12145.1    KPU78382.1    SPP76804.1    KMZ00863.1    KMZ00865.1    AAG22178.1    GBXI01005926    JAD08366.1    CH940647    EDW70423.1    KV938947    PIO27831.1    GCES01063089    JAR23234.1    PIO27832.1    KPU78380.1    KPU78381.1    AY398356    BC060913    BC066607    CH933809    EDW18782.1    GCES01015306    JAR71017.1    KRT09023.1    GDIQ01184077    GDIQ01184076    JAK67649.1    GL732526    EFX88128.1    KRT09021.1    GL439124    EFN67738.1    KRT09024.1    KRT09022.1    KRT09020.1    AFYH01138636    CH916366    EDV97263.1    AAWZ02022495    AYCK01006933    KL519562    KFO89151.1   

Proteomes

UP000005204    UP000053268    UP000283053    UP000053240    UP000037510    UP000007151    + More
UP000192223    UP000092462    UP000221080    UP000008711    UP000002282    UP000092461    UP000000803    UP000076858    UP000018467    UP000192221    UP000268350    UP000007801    UP000027135    UP000192224    UP000001292    UP000235965    UP000001819    UP000008744    UP000000304    UP000037069    UP000261440    UP000008792    UP000265020    UP000095301    UP000192220    UP000265000    UP000000437    UP000009192    UP000265140    UP000000305    UP000000311    UP000261681    UP000008672    UP000001070    UP000001646    UP000028760    UP000261500    UP000261480    UP000252040   

PRIDE

H9JC58    Q9VPB3    E4NKL2    H1UUD4    Q8IPU3    Q9I7P8    + More
Q6P963   

Pfam

PF00753   Lactamase_B        + More
PF16123   HAGH_C

Interpro

IPR001279   Metallo-B-lactamas        + More
IPR017782   Hydroxyacylglutathione_Hdrlase       
IPR036866   RibonucZ/Hydroxyglut_hydro       
IPR035680   Clx_II_MBL       
IPR032282   HAGH_C       

SUPFAM

SSF56281   SSF56281       

Gene 3D

3.60.15.10    

CDD

cd07723  hydroxyacylglutathione_hydrola

ProteinModelPortal

H9JC58   A0A2H1VKF1   A0A194PIE0   A0A3S2TPH1   A0A194QU42   A0A0L7KTT1   + More
A0A212EU16   A0A1Y1KF96   U5EWA1   A0A0K8VG60   A0A1W4WES5   A0A1B0GQQ2   A0A034VW14   A0A2D0PKS8   A0A0Q5U6L6   A0A1L8E5L7   A0A0R1E220   A0A0R1DYW1   A0A1B0CMM5   A0A1L8E690   Q9VPB3   A0A0J9RZ08   A0A164VJZ3   A0A3B1J3L9   A0A0P5JSK2   W8BK64   A0A1W4VPK6   A0A2D0PJ76   A0A0P5BVG3   A0A0P5BN58   A0A3B0JTX2   A0A0K8V7S7   A0A034VWX5   B3M9T4   A0A0P6ELQ7   A0A336KHQ4   B4PEP9   B4PEQ3   A0A034VUA7   A0A067QLS0   A0A1W5AAM5   B4IAF8   B3NIR9   A0A2J7QWP1   W8B4Z3   Q29D97   B4H7S8   A0A0R1DYV5   A0A0R1E3Q9   A0A3N0YB26   W8B4Y8   A0A0Q5U5L3   B4QJ72   A0A3B0J590   E4NKL2   A0A0L0CJX2   H1UUD4   Q8IPU3   A0A0P8YAA8   A0A1W4VNY3   A0A3B0J4M4   A0A0J9S0B4   A0A3B4D6Y5   Q9I7P8   A0A0A1XBP0   B4LG24   A0A2G9RKQ9   A0A1W4VN87   A0A146W0Q7   A0A2G9RIW4   A0A3Q2DMT0   A0A1I8M8A2   A0A1I8M8A6   A0A2I4CRA1   A0A0P8ZUX5   A0A2I4CR95   A0A3Q2R2L5   Q6P963   B4KYH1   Q6P963-2   A0A146ZYG5   A0A3P8ZMP6   A0A0R3P8V0   A0A0P5L153   E9FXP0   A0A0R3P926   E2AFQ9   A0A0R3P9A8   A0A0R3P7J9   A0A0R3P7B8   A0A384A314   H3A1W6   B4J3N2   H9GB33   A0A2Y9SRW5   A0A087XUC6   A0A3B3VNI6   A0A091H006   A0A3B3XPU8   A0A341CLG0  

PDB

1QH5     E-value=6.17979e-87,     Score=816

KEGG

101735625    K01069 hydroxyacylglutathione hydrolase [EC:3.1.2.6] | (RefSeq) hydroxyacylglutathione hydrolase, mi

PATHWAY

00620    Pyruvate metabolism - Bombyx mori (domestic silkworm)
01100    Metabolic pathways - Bombyx mori (domestic silkworm)

GO

GO:0004416   GO:0019243   GO:0001666   GO:0016787   GO:0005759   GO:0046872   GO:0006750   GO:0008237   GO:0005245   GO:0005891   GO:0004674   GO:0006418   GO:0003723   GO:0003824  

Subcellular location

Mitochondrion matrix  
Cytoplasm  

Length:

298

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.00418

Exp number, first 60 AAs:

0.00018

Total prob of N-in:

0.00866

outside

1  -  298

 

 

Pi

80.475526

Theta

135.967428

Tajima's D

-1.235203

CLR

1192.172437

CSRT

0.0993950302484876

Interpretation

Uncertain