Gene

KWMTBOMO10439  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA007012

Annotation

PREDICTED:_extracellular_serine/threonine_protein_CG31145_[Papilio_xuthus]

Location

Bomo_Chr17(-):10962325-10996978      View in EpiBrowser

Full name

Extracellular serine/threonine protein CG31145      

Alternative Name

Golgi casein kinase
Golgi-enriched fraction casein kinase

Location in the cell

Nuclear   Reliability : 2.586

CDS

ATGCTCAACATGAAGCTAAAGGAGCGCTTAGCGCTCGCGATCAGCGCCTCCCTGATACTCTTCACTTTAATGCTTGTCGTCGATCTGCAAATGGACTATGGAATTTCCGGACACAGGGTACCCCTGCACGGCCGCGTCAGGATCGGCGACGTAGAAGATAAAGGCAGATCAGCCTACATAGAATTTCGGAAGAGATTCTTGCAGAAAAGCAACAGCAGCAATGGTTCCCGAGAATACGAACAGTCAGCCCAGGCAGAGACGAGTGGTCTTGCAACCGACGTGGAACCGAGGACGCCTGCGCCACCGGCCGATAAGTTTGACGACTTACAACAAATCCTGTTCGCTCAGCTACAGGGGTCCGCCTTCGATAATGCAGTGGTCATACCTCCGCACCGAGACCTGAATGTTTTGAGGCCCGAGAATCCGACTATTGGGGAGATGGAGGATTTAGAACTTAGTGTCAACGCATCTAATCTCGAGAAGTTTCAGCTGAAGATCGCTCAGCATGAACTATACGAGGATGGAGAGATTTTGGTCGAAGCTATTTTAAAAGATATGGCCACGCTGCCCGTGTTACACGCAGAACAAAAGGAAGGCGGAACGCAGCTCAAACTCATAATAGACTATCCAAACGGAGTTCAAGCACTCTTTAAACCAATGAGATTCGCCCGTGATGTCCAGACGTTGCCGAACCACTTCTATTTCTCGGATTACGAACGGCACAATGCTGAAATAGCAGCTTTTCATCTCGACAGGATACTCGGCTTCCGGCGGGCAATGCCGGTCGTGGGCCGCGTACTCAACATGACCACCGAGATCTATGACGTCACCGAAGGGGACATACTCAAGACATTTTTCGTGTCCCCTGCGAACAACTTCTGCTTCCACGGCAAGTGCTCGTACTACTGCGACACGGGACACGCAATATGCGGCAACCCTGACATGTTGGAGGGAAGCTTCGCCGCTTTTTTGCCGTCTTCTGATGTTGCTGAGAGGAAGGTTTGGCGTCATCCATGGAGGCGTTCATATCATAAGCGCAGGAAAGCGCAATGGGAGCTGCAGTCCGATTACTGTGATACGGTACGGACTACTCCGCCCTACGACTCTGGACGCCGACTACTCGATCTTATGGACATGTCTATATTTGATTTCCTTACTGGGAATATGGACCGACATCACTACGAAACATTCAAAATGTTCGGGAACGAGACGTTTACGCTGCACTTAGATCAAGGCAGGGCGTTTGGGAAGGCGTTCCACGATGAACTCAGTATTCTAGCACCTCTACTGCAATGCTGCGTCGTCAGGCACACCACGCTCGCCACCTTATTAAAATTCGTCAATGGCGTACCTCTATCAGGCACTCTACGCGAATCAATGAAGATAGATCCCGTGTCGCCTATACTCTGGGAGCCACACCTCCAAGCCTTAGACAGAAGGGTTGTAATAGTTCTCGACGCGATCCGTAAATGCGTCGAGAAGGCCAACAATCCGCTCCAAAACGAAATAAACGACTTCATTCGTCAATGGCGTACCTCTATCAGGCACTCTACGCGAATCAATGAAGATAGATCCCGTGTCGCCTATACTCTGGGAGCCACACCTCCAAGCCTTAGACAGAAGGGTTGTAATAGTTCTCGACGCGATCCGTAA

Protein

MLNMKLKERLALAISASLILFTLMLVVDLQMDYGISGHRVPLHGRVRIGDVEDKGRSAYIEFRKRFLQKSNSSNGSREYEQSAQAETSGLATDVEPRTPAPPADKFDDLQQILFAQLQGSAFDNAVVIPPHRDLNVLRPENPTIGEMEDLELSVNASNLEKFQLKIAQHELYEDGEILVEAILKDMATLPVLHAEQKEGGTQLKLIIDYPNGVQALFKPMRFARDVQTLPNHFYFSDYERHNAEIAAFHLDRILGFRRAMPVVGRVLNMTTEIYDVTEGDILKTFFVSPANNFCFHGKCSYYCDTGHAICGNPDMLEGSFAAFLPSSDVAERKVWRHPWRRSYHKRRKAQWELQSDYCDTVRTTPPYDSGRRLLDLMDMSIFDFLTGNMDRHHYETFKMFGNETFTLHLDQGRAFGKAFHDELSILAPLLQCCVVRHTTLATLLKFVNGVPLSGTLRESMKIDPVSPILWEPHLQALDRRVVIVLDAIRKCVEKANNPLQNEINDFIRQWRTSIRHSTRINEDRSRVAYTLGATPPSLRQKGCNSSRRDP

Description

Golgi serine/threonine protein kinase that phosphorylates secretory pathway proteins within Ser-x-Glu/pSer motifs.

Catalytic Activity

ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]
ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]

Cofactor

Mn(2+)

Similarity

Belongs to the FAM20 family.

Keywords

Alternative splicing   ATP-binding   Complete proteome   Disulfide bond   Glycoprotein   Golgi apparatus   Kinase   Manganese   Membrane   Metal-binding   Nucleotide-binding   Reference proteome   Transferase   Transmembrane   Transmembrane helix  

Feature

chain  Extracellular serine/threonine protein CG31145
splice variant  In isoform A.

Uniprot

S4PCV9   A0A1E1W815   A0A1E1WJN6   H9JBW7   A0A194QTF1   A0A194PI05   + More
A0A084VGH1   A0A139WD62   A0A2M4AAY8   A0A2M4AAR3   A0A1Q3FM62   W5JJM7   A0A2M3Z2P8   A0A182F7C9   B0XA37   A0A2M3Z2G5   A0A2M4BJG4   A0A1Y1NDC1   B4JIB4   A0A182JJ67   A0A182XV32   A0A0Q9X2P0   A0A182HFD9   A0A023ETF7   A0A182LTV6   B4M0S4   A0A182RXI1   A0A182P646   A0A0Q9X2M7   B4KA69   A0A1A9UVG6   A0A182VRP2   A0A1I8NDA6   A0A182JYH2   A0A0Q9X9T4   A0A182V348   A0A182LG69   Q7QD21   A0A1B0FQZ4   A0A182HTX0   A0A182XHH6   A0A182ULE1   A0A0K8WGG7   A0A0C9Q499   B3P8G9   A0A1I8PSE8   A0A182QPM4   A0A034V6Z8   A0A1A9ZZA3   A0A1L8DJM9   A0A1L8DJN3   A0A0C9QYK8   A0A1L8DJC4   A0A1L8DJD5   T1P983   A0A182N4U7   A0A1L8DJF0   Q17H62   A4VCL2   A0A1W4V4G0   A0A1W4UQI7   K7IYG8   A0A232EVS4   A0A034V225   A0A0K8W2L7   W8C6P7   A0A1A9YT39   A0A1B0B3E2   A0A0A1XLY5   A0A1W4V3B0   A0A1W4V302   A4VCL2-2   A0A026VVA1   B4PNV0   B4NJL7   A0A3B0JK95   B3LY75   B4HFV6   A0A3L8D655   A0A0M4EFI5   A0A1J1HMK1   V9IGS9   A0A0P8Y1D9   A0A0R1E4I9   A0A0C9PZU9   A0A154P195   A0A146LDF6   A0A0A9Z5R0   B5DY96   I5AN05   A0A1S3D4J6   A0A1B6GGU8   A0A0P4VZ48   A0A0V0GB70   A0A069DUY7   A0A224XF63   B4GP98   A0A1B6KXZ7  

EC Number

2.7.11.1

Pubmed

23622113    19121390    26354079    24438588    18362917    19820115    + More
20920257    23761445    28004739    17994087    25244985    26483478    24945155    18057021    25315136    20966253    12364791    14747013    17210077    25348373    17510324    10731132    12537572    22900076    20075255    28648823    24495485    25830018    24508170    17550304    30249741    26823975    25401762    15632085    27129103    26334808   

EMBL

GAIX01003941    JAA88619.1    GDQN01007960    JAT83094.1    GDQN01003937    JAT87117.1    + More
BABH01014852    BABH01014853    KQ461137    KPJ08803.1    KQ459603    KPI93051.1    ATLV01012922    KE524827    KFB37065.1    KQ971362    KYB25785.1    GGFK01004632    MBW37953.1    GGFK01004544    MBW37865.1    GFDL01006447    JAV28598.1    ADMH02001335    ETN62969.1    GGFM01002051    MBW22802.1    DS232562    EDS43502.1    GGFM01001953    MBW22704.1    GGFJ01004054    MBW53195.1    GEZM01009461    GEZM01009460    JAV94575.1    CH916369    EDV92995.1    CH933806    KRG02284.1    JXUM01036854    KQ561108    KXJ79682.1    JXUM01037191    GAPW01000973    KQ561120    JAC12625.1    KXJ79644.1    AXCM01017555    CH940650    EDW67366.1    KRF83264.1    KRF83265.1    KRG02283.1    EDW16744.2    KRG02282.1    AAAB01008859    EAA08010.4    CCAG010018120    APCN01000587    GDHF01002091    JAI50223.1    GBYB01008878    JAG78645.1    CH954182    EDV53993.1    AXCN02000010    GAKP01021639    JAC37313.1    GFDF01007509    JAV06575.1    GFDF01007507    JAV06577.1    GBYB01008879    JAG78646.1    GFDF01007505    JAV06579.1    GFDF01007506    JAV06578.1    KA645287    AFP59916.1    GFDF01007508    JAV06576.1    CH477253    EAT45951.1    AE014297    BT003468    BT030453    BT081963    ABP87895.1    NNAY01001953    OXU22468.1    GAKP01021641    GAKP01021640    JAC37311.1    GDHF01034068    GDHF01008661    GDHF01006876    JAI18246.1    JAI43653.1    JAI45438.1    GAMC01008411    JAB98144.1    JXJN01007813    GBXI01001978    JAD12314.1    KK107796    EZA47708.1    CM000160    EDW98160.2    CH964272    EDW83941.2    OUUW01000005    SPP81223.1    CH902617    EDV43979.1    CH480815    EDW43349.1    QOIP01000013    RLU15503.1    CP012526    ALC46941.1    CVRI01000010    CRK88754.1    JR041872    AEY59524.1    KPU80568.1    KPU80569.1    KRK04139.1    KRK04140.1    GBYB01007083    JAG76850.1    KQ434796    KZC05709.1    GDHC01012286    JAQ06343.1    GBHO01003017    JAG40587.1    CM000070    EDY67572.2    EIM52340.2    GECZ01015992    GECZ01012895    GECZ01008107    GECZ01007815    JAS53777.1    JAS56874.1    JAS61662.1    JAS61954.1    GDKW01001780    JAI54815.1    GECL01001506    JAP04618.1    GBGD01001139    JAC87750.1    GFTR01006762    JAW09664.1    CH479186    EDW38981.1    GEBQ01023658    JAT16319.1   

Proteomes

UP000005204    UP000053240    UP000053268    UP000030765    UP000007266    UP000000673    + More
UP000069272    UP000002320    UP000001070    UP000075880    UP000076408    UP000009192    UP000069940    UP000249989    UP000075883    UP000008792    UP000075900    UP000075885    UP000078200    UP000075920    UP000095301    UP000075881    UP000075903    UP000075882    UP000007062    UP000092444    UP000075840    UP000076407    UP000075902    UP000008711    UP000095300    UP000075886    UP000092445    UP000075884    UP000008820    UP000000803    UP000192221    UP000002358    UP000215335    UP000092443    UP000092460    UP000053097    UP000002282    UP000007798    UP000268350    UP000007801    UP000001292    UP000279307    UP000092553    UP000183832    UP000076502    UP000001819    UP000079169    UP000008744   

PRIDE

H9JBW7    A4VCL2   

Pfam

PF06702   Fam20C        + More
PF15051   FAM198

Interpro

IPR009581   FAM20_C        + More
IPR029207   FAM198       
IPR024869   FAM20       

ProteinModelPortal

S4PCV9   A0A1E1W815   A0A1E1WJN6   H9JBW7   A0A194QTF1   A0A194PI05   + More
A0A084VGH1   A0A139WD62   A0A2M4AAY8   A0A2M4AAR3   A0A1Q3FM62   W5JJM7   A0A2M3Z2P8   A0A182F7C9   B0XA37   A0A2M3Z2G5   A0A2M4BJG4   A0A1Y1NDC1   B4JIB4   A0A182JJ67   A0A182XV32   A0A0Q9X2P0   A0A182HFD9   A0A023ETF7   A0A182LTV6   B4M0S4   A0A182RXI1   A0A182P646   A0A0Q9X2M7   B4KA69   A0A1A9UVG6   A0A182VRP2   A0A1I8NDA6   A0A182JYH2   A0A0Q9X9T4   A0A182V348   A0A182LG69   Q7QD21   A0A1B0FQZ4   A0A182HTX0   A0A182XHH6   A0A182ULE1   A0A0K8WGG7   A0A0C9Q499   B3P8G9   A0A1I8PSE8   A0A182QPM4   A0A034V6Z8   A0A1A9ZZA3   A0A1L8DJM9   A0A1L8DJN3   A0A0C9QYK8   A0A1L8DJC4   A0A1L8DJD5   T1P983   A0A182N4U7   A0A1L8DJF0   Q17H62   A4VCL2   A0A1W4V4G0   A0A1W4UQI7   K7IYG8   A0A232EVS4   A0A034V225   A0A0K8W2L7   W8C6P7   A0A1A9YT39   A0A1B0B3E2   A0A0A1XLY5   A0A1W4V3B0   A0A1W4V302   A4VCL2-2   A0A026VVA1   B4PNV0   B4NJL7   A0A3B0JK95   B3LY75   B4HFV6   A0A3L8D655   A0A0M4EFI5   A0A1J1HMK1   V9IGS9   A0A0P8Y1D9   A0A0R1E4I9   A0A0C9PZU9   A0A154P195   A0A146LDF6   A0A0A9Z5R0   B5DY96   I5AN05   A0A1S3D4J6   A0A1B6GGU8   A0A0P4VZ48   A0A0V0GB70   A0A069DUY7   A0A224XF63   B4GP98   A0A1B6KXZ7  

PDB

5YH3     E-value=3.6054e-120,     Score=1106

KEGG

101743856    K21958 extracellular serine/threonine protein kinase FAM20C [EC:2.7.11.1] | (RefSeq) extracellular s

GO

GO:0016021   GO:0004674   GO:0016773   GO:0006468   GO:0005794   GO:0005576   GO:0046872   GO:0004672   GO:0000139   GO:0005524  

PANTHER

PTHR12450  

Subcellular location

Golgi apparatus membrane  

Length:

550

Number of predicted TMHs:

1

Exp number of AAs in TMHs:

18.97528

Exp number, first 60 AAs:

18.96829

Total prob of N-in:

0.91649

POSSIBLE N-term signal

sequence

inside

1  -  11

TMhelix

12  -  34

outside

35  -  550

 

 

Pi

215.651322

Theta

180.197234

Tajima's D

0.072847

CLR

11.184896

CSRT

0.397930103494825

Interpretation

Uncertain