Gene

KWMTBOMO10422

Pre Gene Modal

BGIBMGA007020

Annotation

putative_leucine-rich_protein?_partial_[Operophtera_brumata]

Location

Bomo_Chr17(-):10680532-10682173      View in EpiBrowser

Full name

Protein chibby homolog 1      

Alternative Name

Cytosolic leucine-rich protein
PIGEA-14
PKD2 interactor, Golgi and endoplasmic reticulum-associated 1

Location in the cell

Cytoplasmic   Reliability : 1.303 Mitochondrial   Reliability : 1.777 Nuclear   Reliability : 1.228

CDS

ATGCCACTATTTAGCAGTAAATTCAATCCGAAAACAATTCCGGTCAGAAGACAAGATACATCGGTCTTGAAAAACGAACTCGGCAGTGATTATGCCTCAAAGGAACTGTCACTAGATATTGGTCCGTTAAAGATAAAATTGGGAGATTTTGAAGTATCTTTTGAAGAAGGGCAGTGGATTCCTGCTTCAGGAAGAGCGGGTGCAGCTCATAAGGAGAATTTGCGATTGAAAAACGAACTAGACAGGCTCGAAGAAGAAAACAACATGCTAAGATTGAAATTCGAAATACTGTTGGACATGATGACTGACAAAACAGTTGAAGCGGAACAAGCTGAACTTCAGCGTTCTCAAAGTTTGTCAAGTTTAAAACAGAAGAGTAAAAAGTCGAAATGGTGA

Protein

MPLFSSKFNPKTIPVRRQDTSVLKNELGSDYASKELSLDIGPLKIKLGDFEVSFEEGQWIPASGRAGAAHKENLRLKNELDRLEEENNMLRLKFEILLDMMTDKTVEAEQAELQRSQSLSSLKQKSKKSKW

Description

Inhibits the Wnt/Wingless pathway by binding to CTNNB1/beta-catenin and inhibiting beta-catenin-mediated transcriptional activation through competition with TCF/LEF transcription factors. Has also been shown to play a role in regulating the intracellular trafficking of polycystin-2/PKD2 and possibly of other intracellular proteins. Promotes adipocyte and cardiomyocyte differentiation.

Subunit

Homodimer. Interacts with polycystin-2/PKD2 and GM130. Interacts with the C-terminal region of CTNNB1. Interacts (C-terminus) with TCIM (C-terminus), TCIM competes with CTNNB1 for the interaction with CBY1. Interacts with FAM92A; this interaction facilites targeting of FAM92A to cilium basal body.

Miscellaneous

'Chibby' is Japanese for 'small'; the gene was so named for the RNAi phenotype seen in flies.

Similarity

Belongs to the chibby family.

Keywords

Cell projection   Coiled coil   Complete proteome   Cytoplasm   Cytoskeleton   Differentiation   Golgi apparatus   Nucleus   Phosphoprotein   Reference proteome  

Feature

chain  Protein chibby homolog 1

Uniprot

A0A0L7K3V8   A0A1E1WV30   A0A194QUX8   A0A0N1IIF4   A0A2A4J0G5   A0A212EV21   + More
A0A194PPH3   A0A3S2LZJ1   E2A6W5   A0A087ZS65   A0A2A3EN47   A0A3L8DRG3   A0A2J7PKP7   A0A026VYI5   A0A0L7RCM4   E9IAV5   A0A0M9A849   E2BS25   A0A310SKJ6   A0A151I8X4   A0A158NK44   A0A151WTA4   A0A195BU58   A0A154PKV5   C3YF67   A0A1B6LQV2   A0A067R8X9   A0A195EKA1   A0A195F4N1   A0A0L8FRD4   D6WYH3   A0A210QNX3   A0A1B6K0A5   A0A195EJ59   A0A1B6F3Q0   A0A1U7S283   A0A3Q3BIM9   A0A151NHM8   A0A1S3JDV7   A0A2I4CV20   A0A3P8QID7   G3VBS6   A0A3P8QGW5   A0A3P9CVG4   A0A3Q2UYI4   A0A3B3ZLE4   A0A3B3RDW2   H2V2U9   I3KUI0   A0A3Q1FLQ3   A0A3Q1B124   A0A3P8S0I8   H3D5X4   Q4S4C9   A0A3Q1GVB7   K7F950   A0A3Q2G7S7   F6QTX3   A0A3Q2G7R9   A0A3Q4GS94   A0A3Q3E7M2   A0A3B5QIM1   A0A315VG43   A0A3B5PZE7   A0A3B3V353   A0A3B3Y9N0   M4ADI7   A0A087XKG7   F6T9Z9   A0A1A8GUU7   A0A0S7M1P2   A0A1W2WFF2   A0A2G9RY06   A0A3P8WWJ5   A0A3P8WVU4   A0A147A9V5   A0A0S7M2H4   A0A087V792   A0A0E9WRP1   A0A091I8A2   A0A1A6GU36   A0A1W5AUV6   M7AVG4   Q8JI29   A0A1W5ATN9   Q6INT5   B7ZVK9   B3DL58   Q6NRI7   A0A3B3DAX2   F6XC41   H3AHI9   A0A3Q2YUH4   A0A2J8UWM6   Q9D1C2   Q8K4I6   G5AYT4   A0A2I0USL6   A0A0A0ACG8  

Pubmed

26227816    26354079    22118469    20798317    30249741    24508170    + More
21282665    21347285    18563158    24845553    18362917    19820115    28812685    22293439    21709235    25186727    25463417    29240929    21551351    15496914    17381049    17495919    23542700    29703783    18464734    24487278    25613341    23624526    23594743    20431018    29451363    9215903    16141072    15489334    17261658    17403895    21183079    22673903    21993625   

EMBL

JTDY01013309    KOB52157.1    GDQN01000155    JAT90899.1    KQ461137    KPJ08785.1    + More
KQ459850    KPJ19697.1    NWSH01004560    PCG64930.1    AGBW02012273    OWR45304.1    KQ459603    KPI93035.1    RSAL01000097    RVE47676.1    GL437203    EFN70831.1    KZ288204    PBC33185.1    QOIP01000005    RLU23024.1    NEVH01024535    PNF16889.1    KK107570    EZA48832.1    KQ414615    KOC68742.1    GL762073    EFZ22302.1    KQ435714    KOX79195.1    GL450107    EFN81541.1    KQ760382    OAD60714.1    KQ978331    KYM95077.1    ADTU01002051    KQ982757    KYQ51120.1    KQ976403    KYM92144.1    KQ434931    KZC11860.1    GG666508    EEN61069.1    GEBQ01014008    JAT25969.1    KK852663    KDR19058.1    KQ978801    KYN28289.1    KQ981805    KYN35540.1    KQ427511    KOF66985.1    KQ971362    EFA07876.1    NEDP02002607    OWF50433.1    GECU01007912    GECU01003220    GECU01002824    JAS99794.1    JAT04487.1    JAT04883.1    KYN28288.1    GECZ01024929    JAS44840.1    AKHW03002956    KYO36321.1    AEFK01191040    AERX01002206    CAAE01014738    CAG04503.1    AGCU01057944    AGCU01057945    NHOQ01001879    PWA21884.1    AYCK01020405    HAEB01012966    HAEC01006694    SBQ74832.1    GBYX01126290    JAO95714.1    KV928571    PIO32790.1    GCES01011007    JAR75316.1    GBYX01126289    JAO95715.1    KL482540    KFO08484.1    GBXM01015641    JAH92936.1    KL217503    KFO95970.1    LZPO01068922    OBS69444.1    KB574221    EMP27020.1    AF393213    AAM73681.1    BC072188    AAH72188.1    BX000473    BX323878    BC171621    AAI71621.1    AAMC01026211    BC167320    BC170579    BC170581    AAI67320.1    AAI70579.1    BC070763    AAH70763.1    AFYH01055794    NDHI03003442    PNJ49656.1    PNJ49657.1    AF331040    AK003719    BC005733    AF393211    JH167581    EHB02204.1    KZ505643    PKU49029.1    KL871143    KGL90700.1   

Proteomes

UP000037510    UP000053240    UP000218220    UP000007151    UP000053268    UP000283053    + More
UP000000311    UP000005203    UP000242457    UP000279307    UP000235965    UP000053097    UP000053825    UP000053105    UP000008237    UP000078542    UP000005205    UP000075809    UP000078540    UP000076502    UP000001554    UP000027135    UP000078492    UP000078541    UP000053454    UP000007266    UP000242188    UP000189705    UP000264800    UP000050525    UP000085678    UP000192220    UP000265100    UP000007648    UP000265160    UP000264840    UP000261520    UP000261540    UP000005226    UP000005207    UP000257200    UP000257160    UP000265080    UP000007303    UP000007267    UP000265020    UP000002280    UP000261580    UP000261660    UP000002852    UP000261500    UP000261480    UP000028760    UP000002279    UP000265120    UP000265000    UP000054308    UP000092124    UP000192224    UP000031443    UP000000437    UP000008143    UP000261560    UP000008672    UP000264820    UP000000589    UP000002494    UP000006813    UP000053858   

PRIDE

Q9D1C2    Q8K4I6   

Pfam

PF14645   Chibby

Interpro

IPR028118   Chibby_fam       

CDD

cd07429  Cby_like

ProteinModelPortal

A0A0L7K3V8   A0A1E1WV30   A0A194QUX8   A0A0N1IIF4   A0A2A4J0G5   A0A212EV21   + More
A0A194PPH3   A0A3S2LZJ1   E2A6W5   A0A087ZS65   A0A2A3EN47   A0A3L8DRG3   A0A2J7PKP7   A0A026VYI5   A0A0L7RCM4   E9IAV5   A0A0M9A849   E2BS25   A0A310SKJ6   A0A151I8X4   A0A158NK44   A0A151WTA4   A0A195BU58   A0A154PKV5   C3YF67   A0A1B6LQV2   A0A067R8X9   A0A195EKA1   A0A195F4N1   A0A0L8FRD4   D6WYH3   A0A210QNX3   A0A1B6K0A5   A0A195EJ59   A0A1B6F3Q0   A0A1U7S283   A0A3Q3BIM9   A0A151NHM8   A0A1S3JDV7   A0A2I4CV20   A0A3P8QID7   G3VBS6   A0A3P8QGW5   A0A3P9CVG4   A0A3Q2UYI4   A0A3B3ZLE4   A0A3B3RDW2   H2V2U9   I3KUI0   A0A3Q1FLQ3   A0A3Q1B124   A0A3P8S0I8   H3D5X4   Q4S4C9   A0A3Q1GVB7   K7F950   A0A3Q2G7S7   F6QTX3   A0A3Q2G7R9   A0A3Q4GS94   A0A3Q3E7M2   A0A3B5QIM1   A0A315VG43   A0A3B5PZE7   A0A3B3V353   A0A3B3Y9N0   M4ADI7   A0A087XKG7   F6T9Z9   A0A1A8GUU7   A0A0S7M1P2   A0A1W2WFF2   A0A2G9RY06   A0A3P8WWJ5   A0A3P8WVU4   A0A147A9V5   A0A0S7M2H4   A0A087V792   A0A0E9WRP1   A0A091I8A2   A0A1A6GU36   A0A1W5AUV6   M7AVG4   Q8JI29   A0A1W5ATN9   Q6INT5   B7ZVK9   B3DL58   Q6NRI7   A0A3B3DAX2   F6XC41   H3AHI9   A0A3Q2YUH4   A0A2J8UWM6   Q9D1C2   Q8K4I6   G5AYT4   A0A2I0USL6   A0A0A0ACG8  

KEGG

101741986    no KO assigned | (RefSeq) major facilitator superfamily domain-containing protein 10-like

GO

GO:1905349   GO:0030178   GO:0060271   GO:0036064   GO:0055007   GO:0045444   GO:0090090   GO:0008104   GO:0008013   GO:0005814   GO:0005634   GO:0045892   GO:0042803   GO:0042802   GO:0005802   GO:0016607   GO:0051289   GO:0005794  

Subcellular location

Nucleus speckle  
Cytoplasm  
Cytoskeleton  
Cilium basal body  
Microtubule organizing center  
Centrosome  
Centriole  
Golgi apparatus  
trans-Golgi network  

Length:

131

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0

Exp number, first 60 AAs:

0

Total prob of N-in:

0.04757

outside

1  -  131

 

 

Pi

151.579091

Theta

130.193824

Tajima's D

-0.456524

CLR

0.299725

CSRT

0.255437228138593

Interpretation

Uncertain