Gene

KWMTBOMO10420

Pre Gene Modal

BGIBMGA007021

Annotation

hypothetical_protein_KGM_19075_[Danaus_plexippus]

Location

Bomo_Chr17(-):10656362-10661143      View in EpiBrowser

Full name

Serine hydroxymethyltransferase      

Location in the cell

Nuclear   Reliability : 2.652

CDS

ATGACGATGTTTCCTGCTTCTGGATCTGCTGCGGTGCCGCAGCAAACAATAAATGGGCAAGTAGTGCAAAACGGCAGCACGACTTTGCCTCGCTCCCATCACCAGAGAACAGGGCGACCACCGGCAGCTCCTAAATCATATGATTACCTTTTAAAAGTGCTACTAGTTGGTGATTCTGATGTTGGAAAACAAGAGATCCTTCAAGATTTAGAGGATGGCTCTGCAGATTCACCCTTTTGCAGCGGTAGTGGATACAAGACCACGACAATACTTTTGGACGGAAAGAGAGTTAAGCTTCAGCTATGGGATACCTCAGGACAGGGAAGGTTTTGTACTATAATTCGGTCATACTCACGTGGGGCCCAAGGTATTCTGCTAGTATATGACATCACAAATAAGTGGTCTTTTGATAGTATTGACAGGTGGCTTGAAGAAGTTGAAAAGCATGCACCCGGTGTCCCAAAAGTTCTGGTCGGGAATAGGTTACACCTCGCTTTCAAACGGCAAGTACAAGAACGGGATGCTGAAATGTATGCTGCAAAGAATCACATGGCTTTCTTCGAAGTGAGTCCGTTGTGCGACTTCAACATCAGGGAAAGTTTTTGTGAACTCTCACGGATGGCCCTTCACAGAAACGGCATGGAGAGACTCTGGAGGAGCAATAAAGTACTCAGTCTACAAGAGCTGTGCTGTCGTGCAATAGTAGCGCGGACATCCGTGTACGGTCTCGAAAGGCTTCCATTACCGAGCGCCCTGAAGTCCCATCTCAAGTCGTACGCGATATCGGCCGCTCCGAGCCGGCACCGAGCCCGCACGACCAAACACACGCATCATACAAGACTCAACTGCACCGGTCGTAACTCATGTACGATTGCCTGA

Protein

MTMFPASGSAAVPQQTINGQVVQNGSTTLPRSHHQRTGRPPAAPKSYDYLLKVLLVGDSDVGKQEILQDLEDGSADSPFCSGSGYKTTTILLDGKRVKLQLWDTSGQGRFCTIIRSYSRGAQGILLVYDITNKWSFDSIDRWLEEVEKHAPGVPKVLVGNRLHLAFKRQVQERDAEMYAAKNHMAFFEVSPLCDFNIRESFCELSRMALHRNGMERLWRSNKVLSLQELCCRAIVARTSVYGLERLPLPSALKSHLKSYAISAAPSRHRARTTKHTHHTRLNCTGRNSCTIA

Description

Interconversion of serine and glycine.

Catalytic Activity

(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O = (6S)-5,6,7,8-tetrahydrofolate + L-serine

Cofactor

pyridoxal 5'-phosphate

Similarity

Belongs to the SHMT family.

Uniprot

A0A3S2LIX9   A0A194PHY6   A0A212FB49   E2GHU1   A0A194QYV9   H9JBX6   + More
A0A212FDL8   A0A2J7REW5   A0A067RFT5   K7J5L0   A0A310S9F8   A0A2A3E109   A0A088AQW8   A0A0J7L2Q8   E1ZW03   A0A195DJQ1   A0A3L8DUB0   A0A195C9H2   F4WXC0   A0A158NU09   A0A154P0H1   A0A0C9PX33   A0A0M9AC19   A0A0A9YKY4   T1I6E5   A0A0K8TF99   A0A2P8YVP2   A0A0T6AWT5   A0A0L7R4W6   A0A151I4N5   A0A224XTD0   A0A023F5T0   A0A069DS17   E2BKI8   A0A1B6CV49   A0A1Y1M859   A0A195FJ48   N6TPL1   A0A2H1WNR7   D6WYZ4   A0A1W4X0U1   A0A1S3CZW3   A0A1B6L016   V5G8Z0   A0A0K8TNN2   D3TNL9   A0A1B0AMY0   A0A1B6M3C0   U5ETY4   A0A1A9WFW2   A0A1B6FCS8   A0A1B6IF75   A0A1I8NUS3   U4U098   A0A1B0CJM8   A0A0P4VHD7   A0A0V0GE20   Q171G7   B4N2F7   A0A2S2PX09   A0A182G7W9   A0A2H8TJR0   B4NTP8   B4IGF9   J9JV74   B4Q1M5   A0A0Q5TJA8   A0A1W4V2W8   A0A1Q3EYS6   B0XDP4   A0A0P8ZSG9   A0A182PWD1   A0A1L8DV32   A0A182K5D5   Q95RQ2   E0VST9   A0A182XXW4   Q9VYM8   A0A182N056   A0A182JLU6   A0A182QXV3   Q7Q4W5   A0A182HMN9   A0A182RMU7   A0A182SH89   A0A182LYF8   A0A182LDE9   A0A182W5E9   A0A2M3Z9N1   A0A2M4BX07   W5JID7   A0A1B0D222   A0A182FMN5   A0A2M4ATH9   A0A0A1XLC6   A0A0A1WR71   A0A0P4WIA7   A0A0A0PV43   A0A0K8W499  

EC Number

2.1.2.1

Pubmed

26354079    22118469    19121390    24845553    20075255    20798317    + More
30249741    21719571    21347285    25401762    26823975    29403074    25474469    26334808    28004739    23537049    18362917    19820115    26369729    20353571    27129103    17510324    17994087    26483478    17550304    20566863    25244985    10731132    12537568    12537572    12537573    12537574    16110336    17569856    17569867    26109357    26109356    12364791    14747013    17210077    20966253    20920257    23761445    25830018   

EMBL

RSAL01000097    RVE47672.1    KQ459603    KPI93031.1    AGBW02009379    OWR50961.1    + More
HM355929    ADN84947.1    KQ461137    KPJ08781.1    BABH01014822    AGBW02009020    OWR51846.1    NEVH01004429    PNF39378.1    KK852663    KDR19055.1    KQ762903    OAD55280.1    KZ288467    PBC25387.1    LBMM01001085    KMQ96953.1    GL434710    EFN74635.1    KQ980794    KYN13047.1    QOIP01000004    RLU24027.1    KQ978143    KYM96763.1    GL888423    EGI61169.1    ADTU01026236    KQ434782    KZC04640.1    GBYB01000996    GBYB01006063    JAG70763.1    JAG75830.1    KQ435698    KOX80756.1    GBHO01011841    GDHC01015806    GDHC01011772    JAG31763.1    JAQ02823.1    JAQ06857.1    ACPB03001813    GBRD01001549    JAG64272.1    PYGN01000334    PSN48322.1    LJIG01022721    KRT79063.1    KQ414657    KOC65859.1    KQ976445    KYM86066.1    GFTR01005063    JAW11363.1    GBBI01002177    JAC16535.1    GBGD01002154    JAC86735.1    GL448810    EFN83775.1    GEDC01019932    JAS17366.1    GEZM01038173    JAV81741.1    KQ981522    KYN40685.1    APGK01056846    KB741277    ENN71165.1    ODYU01009952    SOQ54713.1    KQ971363    EFA09306.2    GEBQ01022924    JAT17053.1    GALX01001861    JAB66605.1    GDAI01001872    JAI15731.1    EZ423021    ADD19297.1    JXJN01000640    GEBQ01009593    JAT30384.1    GANO01001711    JAB58160.1    GECZ01021757    JAS48012.1    GECU01022156    JAS85550.1    KB630186    KB632028    KB632155    ERL83460.1    ERL88124.1    ERL89222.1    AJWK01014755    GDKW01003559    JAI53036.1    GECL01000503    JAP05621.1    CH477456    EAT40624.1    CH963925    EDW78546.1    GGMS01000701    MBY69904.1    JXUM01046914    KQ561496    KXJ78387.1    GFXV01002474    MBW14279.1    CH983255    EDX16317.1    CH480836    EDW48909.1    ABLF02034859    CM000162    EDX01466.2    CH954180    KQS30443.1    GFDL01014657    JAV20388.1    DS232771    EDS45552.1    CH902630    KPU77439.1    GFDF01003798    JAV10286.1    AY061218    AAL28766.1    DS235756    EEB16445.1    AE014298    AAF48164.2    AHN59623.1    AXCN02001441    AAAB01008963    EAA12147.5    APCN01004851    AXCM01000689    GGFM01004482    MBW25233.1    GGFJ01008466    MBW57607.1    ADMH02001082    ETN64152.1    AJVK01002598    AJVK01002599    GGFK01010567    MBW43888.1    GBXI01002954    JAD11338.1    GBXI01013364    JAD00928.1    GDRN01035223    JAI67411.1    KF859983    AHJ90466.1    GDHF01006393    JAI45921.1   

Proteomes

UP000283053    UP000053268    UP000007151    UP000053240    UP000005204    UP000235965    + More
UP000027135    UP000002358    UP000242457    UP000005203    UP000036403    UP000000311    UP000078492    UP000279307    UP000078542    UP000007755    UP000005205    UP000076502    UP000053105    UP000015103    UP000245037    UP000053825    UP000078540    UP000008237    UP000078541    UP000019118    UP000007266    UP000192223    UP000079169    UP000092460    UP000091820    UP000095300    UP000030742    UP000092461    UP000008820    UP000007798    UP000069940    UP000249989    UP000000304    UP000001292    UP000007819    UP000002282    UP000008711    UP000192221    UP000002320    UP000007801    UP000075885    UP000075881    UP000009046    UP000076408    UP000000803    UP000075884    UP000075880    UP000075886    UP000007062    UP000075840    UP000075900    UP000075901    UP000075883    UP000075882    UP000075920    UP000000673    UP000092462    UP000069272   

PRIDE

H9JBX6    Q95RQ2    Q9VYM8   

Pfam

PF07525   SOCS_box        + More
PF00071   Ras
PF00464   SHMT
PF00400   WD40

Interpro

IPR036036   SOCS_box-like_dom_sf        + More
IPR001806   Small_GTPase       
IPR027417   P-loop_NTPase       
IPR001496   SOCS_box       
IPR005225   Small_GTP-bd_dom       
IPR015424   PyrdxlP-dep_Trfase       
IPR015421   PyrdxlP-dep_Trfase_major       
IPR015422   PyrdxlP-dep_Trfase_dom1       
IPR039429   SHMT-like_dom       
IPR019798   Ser_HO-MeTrfase_PLP_BS       
IPR001085   Ser_HO-MeTrfase       
IPR036322   WD40_repeat_dom_sf       
IPR017986   WD40_repeat_dom       
IPR001680   WD40_repeat       
IPR015943   WD40/YVTN_repeat-like_dom_sf       

SUPFAM

SSF158235   SSF158235        + More
SSF52540   SSF52540       
SSF53383   SSF53383       
SSF50978   SSF50978       

Gene 3D

3.40.640.10     3.90.1150.10     2.130.10.10    

CDD

cd00378  SHMT

ProteinModelPortal

A0A3S2LIX9   A0A194PHY6   A0A212FB49   E2GHU1   A0A194QYV9   H9JBX6   + More
A0A212FDL8   A0A2J7REW5   A0A067RFT5   K7J5L0   A0A310S9F8   A0A2A3E109   A0A088AQW8   A0A0J7L2Q8   E1ZW03   A0A195DJQ1   A0A3L8DUB0   A0A195C9H2   F4WXC0   A0A158NU09   A0A154P0H1   A0A0C9PX33   A0A0M9AC19   A0A0A9YKY4   T1I6E5   A0A0K8TF99   A0A2P8YVP2   A0A0T6AWT5   A0A0L7R4W6   A0A151I4N5   A0A224XTD0   A0A023F5T0   A0A069DS17   E2BKI8   A0A1B6CV49   A0A1Y1M859   A0A195FJ48   N6TPL1   A0A2H1WNR7   D6WYZ4   A0A1W4X0U1   A0A1S3CZW3   A0A1B6L016   V5G8Z0   A0A0K8TNN2   D3TNL9   A0A1B0AMY0   A0A1B6M3C0   U5ETY4   A0A1A9WFW2   A0A1B6FCS8   A0A1B6IF75   A0A1I8NUS3   U4U098   A0A1B0CJM8   A0A0P4VHD7   A0A0V0GE20   Q171G7   B4N2F7   A0A2S2PX09   A0A182G7W9   A0A2H8TJR0   B4NTP8   B4IGF9   J9JV74   B4Q1M5   A0A0Q5TJA8   A0A1W4V2W8   A0A1Q3EYS6   B0XDP4   A0A0P8ZSG9   A0A182PWD1   A0A1L8DV32   A0A182K5D5   Q95RQ2   E0VST9   A0A182XXW4   Q9VYM8   A0A182N056   A0A182JLU6   A0A182QXV3   Q7Q4W5   A0A182HMN9   A0A182RMU7   A0A182SH89   A0A182LYF8   A0A182LDE9   A0A182W5E9   A0A2M3Z9N1   A0A2M4BX07   W5JID7   A0A1B0D222   A0A182FMN5   A0A2M4ATH9   A0A0A1XLC6   A0A0A1WR71   A0A0P4WIA7   A0A0A0PV43   A0A0K8W499  

PDB

2FU5     E-value=4.74791e-36,     Score=377

KEGG

101741690    K07928 Ras-related protein Rab-40 | (RefSeq) ras-related protein Rab-40C

GO

GO:0035556   GO:0003924   GO:0005525   GO:0004372   GO:0035999   GO:0030170   GO:0008168   GO:0019264   GO:0006886   GO:0000139   GO:0032482   GO:0031982   GO:0016192   GO:0007264   GO:0032259   GO:0006563   GO:0016740   GO:0006418   GO:0003723   GO:0046872   GO:0003824  

PANTHER

PTHR11680  

Length:

292

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.00013

Exp number, first 60 AAs:

0

Total prob of N-in:

0.01059

outside

1  -  292

 

 

Pi

150.573365

Theta

205.997734

Tajima's D

-1.29499

CLR

0.542773

CSRT

0.0905954702264887

Interpretation

Possibly Positive selection