Gene

KWMTBOMO10409

Pre Gene Modal

BGIBMGA007076

Annotation

PREDICTED:_E3_ubiquitin-protein_ligase_SMURF2_isoform_X2_[Bombyx_mori]

Location

Bomo_Chr17(+):10428774-10430132      View in EpiBrowser

Full name

E3 ubiquitin-protein ligase      

Location in the cell

Mitochondrial   Reliability : 2.624

CDS

ATGACACCAACCTACCTTCCAAAGTTCACTCGAGGCGCCGAGCGGCAGTGGCTGGCGCTGCAGCGCGGGCTGGCGGACGTGGTGCCGCCGCAGCTGCTGCGGCCGCTGTCGGCGCGCGACCTGCAGCCGCTGCTGGCCGGCCGCGCCGACCTCGACCCCACCGACTGGCGCCGGCACACGCGCCTCAAGCACCTCGCGCCCGACTCCGCGCTCGCCCAGTGGTTCTGGGAGATCGTCGACGAATTCGACCAGGAGATGCGCGCTCGCCTCTTGCAGTTCGTCACCGGATCGCGACGAGTGCCCCTCGCCGGATTCAGGGCTCTACAGGGTTCAACTGGTGTGGCGGCTCCGCGACTGTTCACACTGCACCTGGTTGCGGACGCGACTCCGGATTCTCTGCCGAAAGCACACACGTGCTTCAACCGCCTCGACCTACCTCCCTATCCGACCAAGCAGAAACTGCACGACAAATTGAAGCAAGCTATTCTCGAGACCGCCGGATTCGCTGTCGAATGA

Protein

MTPTYLPKFTRGAERQWLALQRGLADVVPPQLLRPLSARDLQPLLAGRADLDPTDWRRHTRLKHLAPDSALAQWFWEIVDEFDQEMRARLLQFVTGSRRVPLAGFRALQGSTGVAAPRLFTLHLVADATPDSLPKAHTCFNRLDLPPYPTKQKLHDKLKQAILETAGFAVE

Catalytic Activity

S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.

Uniprot

C1K002   A0A2A4IV20   A0A194QTY4   A0A212FG70   A0A194PI81   A0A2H1X2W9   + More
A0A2R4RM56   A0A0L7LHI1   A0A2A4IWS0   A0A1Y1N4K6   A0A0K8UCC2   A0A164TRF7   A0A1B6FFB2   D6WYJ4   B4GIB6   W8BRF4   A0A2D4J5U2   C3Z7U6   G3HY97   A0A2U3YYE4   A0A067R094   G9KQA7   A0A1Y1N4I3   Q8BSC0   A0A1Y1N4L7   A0A0K8W3D5   A0A195BU48   E2BQR5   A0A195EKD6   A0A1B0CN66   A0A158NKS0   A0A2K6LFT5   A0A0K8WJH5   A0A3Q0CGG6   A0A0K8U308   A0A2K5L104   W8BYH0   A0A2P8Z2L4   A0A0A1XN45   F4WXC9   A0A2K5E553   A0A2K6PRR3   A0A093TLT2   A0A2K6G747   A0A0P5QQF7   A0A2I2ZPL7   A0A2R9ARF8   A0A2I3TM51   A0A2K6A334   A0A2I3LWQ6   A0A2K5JJR1   A0A0P5DT95   A0A2K5V9I5   F7HPB2   A0A0P4YG65   A0A2K5SIV0   A0A2R8P278   A0A0P6BFV1   A0A2K6TJV0   A0A034WHS1   A0A0T6B731   A0A0P5EFL8   A0A1S3QSB0   A0A0P5Q1M4   A0A0P5XVV3   A0A0N8E5T4   E9GIQ7   A0A0P6HFJ1   A0A0P5M8W3   A0A0N8CBX3   A0A1L8DT98   A0A0P6G6U7   A0A1L8DTI7   A0A195F4R6   A0A151X854   A0A0P5RFW4   A0A0P5W4I8   A0A0P5VMP5   A0A0C9RB03   E9IQA5   A0A1S3QQD4   A0A195CYH3   A0A088A7D3   W8C5H1   A0A0M9A0C8   A0A0J7L5C5   A0A0N8BJD9   A0A2J7Q3N9   A0A026WH76   A0A1Z5L4N3   T1JG98   A0A3L8DFT2   E2ANQ2   G2HIE5   A0A2A3EBV2   A0A0L7QUM7   A0A0P5J6P9   U4UA05   A0A336MMQ5   A0A1I8PTT7  

EC Number

2.3.2.26

Pubmed

19121390    26354079    22118469    26227816    28004739    18362917    + More
19820115    17994087    24495485    18563158    21804562    24845553    23236062    10349636    11042159    11076861    11217851    12466851    16141073    20798317    21347285    28071753    29403074    25830018    21719571    25362486    22398555    22722832    16136131    17431167    25348373    21292972    21282665    24508170    28528879    30249741    21484476    23537049   

EMBL

BABH01014801    FJ770216    ACN94452.1    NWSH01007230    PCG63032.1    KQ461137    + More
KPJ08774.1    AGBW02008703    OWR52741.1    KQ459603    KPI93022.1    ODYU01013035    SOQ59673.1    MF062247    AVZ23640.1    JTDY01001118    KOB74824.1    NWSH01006024    PCG63734.1    GEZM01013000    JAV92823.1    GDHF01028098    JAI24216.1    LRGB01001751    KZS10685.1    GECZ01020878    JAS48891.1    KQ971362    EFA08997.2    CH479183    EDW36236.1    GAMC01004878    JAC01678.1    IACK01142535    LAA91799.1    GG666591    EEN51451.1    JH000915    EGW00443.1    KK853134    KDR10851.1    JP018488    AES07086.1    GEZM01013002    JAV92821.1    AK034736    BAC28813.1    GEZM01013001    JAV92822.1    GDHF01018812    GDHF01006752    JAI33502.1    JAI45562.1    KQ976403    KYM92107.1    GL449798    EFN81984.1    KQ978801    KYN28324.1    AJWK01019865    AJWK01019866    AJWK01019867    AJWK01019868    AJWK01019869    ADTU01002122    GDHF01001011    JAI51303.1    GDHF01031170    GDHF01000858    JAI21144.1    JAI51456.1    GAMC01004882    JAC01674.1    PYGN01000224    PSN50736.1    GBXI01001861    JAD12431.1    GL888424    EGI61095.1    KL444856    KFW95169.1    GDIQ01110976    JAL40750.1    CABD030053272    AJFE02052573    AJFE02052574    AJFE02052575    AJFE02052576    AACZ04036707    AC188938    AC214551    AHZZ02022033    AHZZ02022034    GDIP01151618    JAJ71784.1    AQIA01045382    AQIA01045383    AQIA01045384    JSUE03029080    JSUE03029081    GDIP01227867    JAI95534.1    GDIP01029897    JAM73818.1    GAKP01003821    GAKP01003820    JAC55131.1    LJIG01009654    KRT82647.1    GDIQ01270303    JAJ81421.1    GDIQ01126978    JAL24748.1    GDIP01066692    JAM37023.1    GDIQ01058996    JAN35741.1    GL732546    EFX80702.1    GDIQ01020521    JAN74216.1    GDIQ01159005    GDIQ01157004    JAK92720.1    GDIQ01162105    GDIQ01094875    JAL56851.1    GFDF01004391    JAV09693.1    GDIQ01056350    JAN38387.1    GFDF01004390    JAV09694.1    KQ981805    KYN35575.1    KQ982431    KYQ56552.1    GDIQ01120674    JAL31052.1    GDIP01091278    JAM12437.1    GDIP01097937    JAM05778.1    GBYB01000497    GBYB01004051    JAG70264.1    JAG73818.1    GL764688    EFZ17234.1    KQ977110    KYN05720.1    GAMC01004881    GAMC01004879    GAMC01004877    JAC01677.1    KQ435800    KOX73303.1    LBMM01000669    KMQ97826.1    GDIQ01171947    JAK79778.1    NEVH01019065    PNF23201.1    KK107231    EZA55021.1    GFJQ02004956    JAW02014.1    JH432197    QOIP01000009    RLU19052.1    GL441295    EFN64938.1    AK306509    BAK63503.1    KZ288296    PBC28954.1    KQ414734    KOC62347.1    GDIQ01229081    JAK22644.1    KB630245    KB630279    KB631948    ERL83496.1    ERL83514.1    ERL87411.1    UFQT01001639    SSX31280.1   

Proteomes

UP000005204    UP000218220    UP000053240    UP000007151    UP000053268    UP000037510    + More
UP000076858    UP000007266    UP000008744    UP000001554    UP000001075    UP000245341    UP000027135    UP000078540    UP000008237    UP000078492    UP000092461    UP000005205    UP000233180    UP000189706    UP000233060    UP000245037    UP000007755    UP000233020    UP000233200    UP000233160    UP000001519    UP000240080    UP000002277    UP000233140    UP000028761    UP000233080    UP000233100    UP000006718    UP000233040    UP000008225    UP000233220    UP000087266    UP000000305    UP000078541    UP000075809    UP000078542    UP000005203    UP000053105    UP000036403    UP000235965    UP000053097    UP000279307    UP000000311    UP000242457    UP000053825    UP000030742    UP000095300   

PRIDE

G3HY97   

Pfam

PF00632   HECT        + More
PF00397   WW
PF00168   C2
PF00400   WD40
PF13844   Glyco_transf_41

Interpro

IPR036020   WW_dom_sf        + More
IPR000008   C2_dom       
IPR001202   WW_dom       
IPR000569   HECT_dom       
IPR024928   E3_ub_ligase_SMURF1       
IPR035983   Hect_E3_ubiquitin_ligase       
IPR035892   C2_domain_sf       
IPR011990   TPR-like_helical_dom_sf       
IPR019734   TPR_repeat       
IPR015943   WD40/YVTN_repeat-like_dom_sf       
IPR001680   WD40_repeat       
IPR037919   OGT       
IPR017986   WD40_repeat_dom       
IPR013026   TPR-contain_dom       
IPR020472   G-protein_beta_WD-40_rep       
IPR029489   OGT/SEC/SPY_C       
IPR036322   WD40_repeat_dom_sf       
IPR019775   WD40_repeat_CS       

SUPFAM

SSF56204   SSF56204        + More
SSF51045   SSF51045       
SSF48452   SSF48452       
SSF50978   SSF50978       

Gene 3D

2.60.40.150     1.25.40.10     2.130.10.10    

CDD

cd00201  WW
cd00078  HECTc

ProteinModelPortal

C1K002   A0A2A4IV20   A0A194QTY4   A0A212FG70   A0A194PI81   A0A2H1X2W9   + More
A0A2R4RM56   A0A0L7LHI1   A0A2A4IWS0   A0A1Y1N4K6   A0A0K8UCC2   A0A164TRF7   A0A1B6FFB2   D6WYJ4   B4GIB6   W8BRF4   A0A2D4J5U2   C3Z7U6   G3HY97   A0A2U3YYE4   A0A067R094   G9KQA7   A0A1Y1N4I3   Q8BSC0   A0A1Y1N4L7   A0A0K8W3D5   A0A195BU48   E2BQR5   A0A195EKD6   A0A1B0CN66   A0A158NKS0   A0A2K6LFT5   A0A0K8WJH5   A0A3Q0CGG6   A0A0K8U308   A0A2K5L104   W8BYH0   A0A2P8Z2L4   A0A0A1XN45   F4WXC9   A0A2K5E553   A0A2K6PRR3   A0A093TLT2   A0A2K6G747   A0A0P5QQF7   A0A2I2ZPL7   A0A2R9ARF8   A0A2I3TM51   A0A2K6A334   A0A2I3LWQ6   A0A2K5JJR1   A0A0P5DT95   A0A2K5V9I5   F7HPB2   A0A0P4YG65   A0A2K5SIV0   A0A2R8P278   A0A0P6BFV1   A0A2K6TJV0   A0A034WHS1   A0A0T6B731   A0A0P5EFL8   A0A1S3QSB0   A0A0P5Q1M4   A0A0P5XVV3   A0A0N8E5T4   E9GIQ7   A0A0P6HFJ1   A0A0P5M8W3   A0A0N8CBX3   A0A1L8DT98   A0A0P6G6U7   A0A1L8DTI7   A0A195F4R6   A0A151X854   A0A0P5RFW4   A0A0P5W4I8   A0A0P5VMP5   A0A0C9RB03   E9IQA5   A0A1S3QQD4   A0A195CYH3   A0A088A7D3   W8C5H1   A0A0M9A0C8   A0A0J7L5C5   A0A0N8BJD9   A0A2J7Q3N9   A0A026WH76   A0A1Z5L4N3   T1JG98   A0A3L8DFT2   E2ANQ2   G2HIE5   A0A2A3EBV2   A0A0L7QUM7   A0A0P5J6P9   U4UA05   A0A336MMQ5   A0A1I8PTT7  

PDB

1ZVD     E-value=5.51211e-51,     Score=503

KEGG

100272227    K04678 E3 ubiquitin ligase SMURF1/2 [EC:2.3.2.26] | (RefSeq) Smurf2; E3 ubiquitin-protein ligase SMU

PATHWAY

04120    Ubiquitin mediated proteolysis - Bombyx mori (domestic silkworm)
04144    Endocytosis - Bombyx mori (domestic silkworm)
04341    Hedgehog signaling pathway - fly - Bombyx mori (domestic silkworm)
04350    TGF-beta signaling pathway - Bombyx mori (domestic silkworm)

GO

GO:0006511   GO:0061630   GO:0016874   GO:0004842   GO:0016567   GO:0030514   GO:0043161   GO:0005737   GO:0000209   GO:0045732   GO:0030579   GO:0016740   GO:0016021   GO:0016757   GO:0006493   GO:0016579   GO:0004674   GO:0006415   GO:0006418   GO:0003723   GO:0046872   GO:0003824  

PANTHER

PTHR44366  

Length:

171

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.01022

Exp number, first 60 AAs:

0

Total prob of N-in:

0.07485

outside

1  -  171

 

 

Pi

214.806242

Theta

187.704881

Tajima's D

0.560545

CLR

0

CSRT

0.528023598820059

Interpretation

Possibly Positive selection