Gene

KWMTBOMO10407  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA007025

Annotation

PREDICTED:_probable_isoaspartyl_peptidase/L-asparaginase_GA20639_isoform_X1_[Bombyx_mori]

Location

Bomo_Chr17(-):10408930-10417843      View in EpiBrowser

Full name

Probable isoaspartyl peptidase/L-asparaginase GA20639       + More
Probable isoaspartyl peptidase/L-asparaginase CG7860      

Alternative Name

Beta-aspartyl-peptidase GA20639
Isoaspartyl dipeptidase GA20639
L-asparagine amidohydrolase GA20639
Beta-aspartyl-peptidase CG7860
Isoaspartyl dipeptidase CG7860
L-asparagine amidohydrolase CG7860

Location in the cell

Cytoplasmic   Reliability : 2.811

CDS

ATGAAACCTAAGACCCTCGAAGTCATTGAGAGTGGAGCAATGAAGCCAATTATCATCGTGCATGGAGGGGCTGGTGATATTTCTGAGAGTCGTATTCAAGGAAAGTTTGATGGAGTTAAAGTCGCAGTCAGGGCTGGCTACGAAAAGTTGATGAATGGTGGCAGTGCTTTAGATTCAGTTGAAGCTGCTGTTGTCTCTATGGAATTGGATGAAAATTTTAATGCAGGATATGGTTCTGTATTAAACTTAAATGGCGAAGTAGAAATGGAAGCTAGTATAATGTGGGGTCAAGATCTTATTTCTGGGGCCGTTACGCTAATTAAAGAGTTCCAGCACCCAATAAGTATAGCCCGGAAAGTTTTGACAGATACGCCGCATTCCTTCTTAGGAGGAAACGGAGCTAAGCTGTTCGCACTAGAAAAAGGTTTCCAACAAGTACCACCAGAGTCATTGATAAGCGAAAGCGCTAAAGAGGCACTTAACGATTTCTTGAACAAAGGCGATGACCAGCGAACAGAAATTGGAAGGAAAGATGAGGGTGGTGTGGGAACAGTAGGTGCGGTAGCTATAGACGCTGATGGCCATATAGCTGTTGCTACAAGCACTGGTGGTATAAATGGAAAAATGGTCGGACGTATCGGAGACACGCCACTAATTGGTGGCGGTACTTATGCTGATGACAATGTTGGTGGGATTTCAACAACAGGTCACGGTGAATCAATTTTGAAGTATTGTTTGGCTCATACTATTATCAAACTTATGGAAGGCGGTCTCGATGCAGATACGGCTACTAGGCAAGCTGTAAATGGTATGACAGCACGCTTGAACAACACTGCTGGCGCAATAACATTATCAAAAAACGGTGACGTAGGGATCCACTTCAGTTCTAAAAGAATGGCTTGGGCTTATGTGAAGAACGATAAGGTCTACTACGGAATAGAACACGATCAAACACTTGAAGAACCACTTTAA

Protein

MKPKTLEVIESGAMKPIIIVHGGAGDISESRIQGKFDGVKVAVRAGYEKLMNGGSALDSVEAAVVSMELDENFNAGYGSVLNLNGEVEMEASIMWGQDLISGAVTLIKEFQHPISIARKVLTDTPHSFLGGNGAKLFALEKGFQQVPPESLISESAKEALNDFLNKGDDQRTEIGRKDEGGVGTVGAVAIDADGHIAVATSTGGINGKMVGRIGDTPLIGGGTYADDNVGGISTTGHGESILKYCLAHTIIKLMEGGLDADTATRQAVNGMTARLNNTAGAITLSKNGDVGIHFSSKRMAWAYVKNDKVYYGIEHDQTLEEPL

Description

Has both L-asparaginase and beta-aspartyl peptidase activity. Does not have aspartylglucosaminidase activity and is inactive toward GlcNAc-L-Asn. Likewise, has no activity toward glutamine.

Catalytic Activity

H2O + L-asparagine = L-aspartate + NH4(+)
Cleavage of a beta-linked Asp residue from the N-terminus of a polypeptide.

Subunit

Heterodimer of an alpha and beta chain produced by autocleavage.

Similarity

Belongs to the Ntn-hydrolase family.

Keywords

Autocatalytic cleavage   Complete proteome   Hydrolase   Protease   Reference proteome  

Feature

chain  Probable isoaspartyl peptidase/L-asparaginase GA20639 alpha chain

Uniprot

H9JBY0   A0A2A4IVC9   A0A2H1X4W2   A0A194PHX6   A0A212FG84   A0A194QTC1   + More
D6WUZ1   Q16RI9   N6TJA9   A0A182GK33   U4U5R5   B0W7T7   A0A1Q3FGJ3   A0A182GD97   J3JTW9   A0A1Y1LUX8   A0A1B0CWE4   A0A1S4FS86   A0A1L8E2F5   A0A1B0D2V8   A0A1L8E2N2   A0A1A9X249   A0A0P4VUA4   T1HFP3   A0A1B0GEJ1   A0A2J7Q0N8   R4G4R7   A0A1B0AJ46   T1PCP5   A0A1I8MX18   A0A1B6CCI1   A0A023F7Z9   A0A161MI98   U5EVI6   A0A069DRG3   A0A1A9XGK2   A0A1I8PHJ5   T1HFS9   B3MZ32   A0A0A9W1B9   B4GWG4   A0A3B0J9M9   A0A1W4VH64   A0A0K8SW26   B3NTJ9   A0A1B6GDC8   B4PWP2   B4L3X3   A0A146L5R7   B4F5C6   A0A1B6GVG4   A0A0K8SW86   B4NTP4   A0A1B6IS23   A0A0P6G3X2   Q29I93   B4F5C8   A0A2S2QS08   B4F5C5   Q9VXT7   B4M3L0   B4F5D1   B4F5D2   A0A0L0CLN2   A0A164YZ61   B4F5C7   A0A0P5T3W3   A0A0P5N3F4   B4F5C9   B4JLJ0   C0MLA9   D6WAI9   A0A2H8TMU9   B4MSU1   A0A1L8EGE0   A0A224XTU3   A0A0M4EYW7   A0A1L8EGP2   A0A1L8EGM0   A0A1J1HT65   J9JJ35   A0A1I8MDF4   E9GHZ2   A0A2R7VRK5   W8BM71   A0A1A9UHI4   W8BZQ6   A0A0P6FQS1   A0A0K8UXQ9   A0A1B0AZX1   A0A034WFY1   A0A1I8PQJ3   A0A0P6I6V9   A0A0C9R5D1   A0A1B0GEJ2   A0A034WHH6   A0A1I8PQK4   A0A0K8VA34   A0A0A1XQN1  

Pubmed

19121390    26354079    22118469    18362917    19820115    17510324    + More
23537049    26483478    22516182    28004739    27129103    25315136    25474469    26334808    17994087    25401762    26823975    17550304    18477586    15632085    10731132    12537568    12537572    12537573    12537574    16110336    17569856    17569867    19126864    26109357    26109356    12537569    26108605    21292972    24495485    25348373    25830018   

EMBL

BABH01014801    NWSH01007108    PCG63083.1    ODYU01013035    SOQ59674.1    KQ459603    + More
KPI93021.1    AGBW02008703    OWR52742.1    KQ461137    KPJ08773.1    KQ971357    EFA08343.2    CH477708    EAT37031.1    APGK01035783    KB740928    ENN77958.1    JXUM01013075    KQ560368    KXJ82767.1    KB631763    ERL85941.1    DS231855    EDS38231.1    GFDL01008381    JAV26664.1    JXUM01000019    KQ560100    KXJ84574.1    BT126678    AEE61641.1    GEZM01046190    JAV77442.1    AJWK01032289    AJWK01032290    GFDF01001164    JAV12920.1    AJVK01002878    GFDF01001178    JAV12906.1    GDKW01002190    JAI54405.1    ACPB03003836    CCAG010012287    NEVH01019964    PNF22158.1    GAHY01001120    JAA76390.1    KA646511    AFP61140.1    GEDC01026145    JAS11153.1    GBBI01001363    JAC17349.1    GEMB01001885    JAS01286.1    GANO01001842    JAB58029.1    GBGD01002231    JAC86658.1    CH902632    EDV32876.1    GBHO01041362    JAG02242.1    CH479194    EDW27048.1    OUUW01000003    SPP78635.1    GBRD01015880    GBRD01008382    GBRD01008381    GBRD01008379    GDHC01000391    JAG57439.1    JAQ18238.1    CH954180    EDV47003.1    GECZ01009352    JAS60417.1    CM000162    EDX01788.1    CH933810    EDW07251.1    GDHC01016142    JAQ02487.1    AM999012    CAQ53374.1    GECZ01003341    JAS66428.1    GBRD01015879    GBRD01008380    JAG57441.1    CH983254    EDX16313.1    GECU01017971    JAS89735.1    GDIQ01049832    JAN44905.1    CH379063    AM999014    CAQ53376.1    GGMS01011353    MBY80556.1    AE014298    AM999011    AM999016    AM999019    AM999021    AM999022    FM246129    FM246130    FM246132    FM246133    FM246134    FM246135    FM246136    FM246138    FM246139    AHN59745.1    CAQ53373.1    CAQ53378.1    CAQ53381.1    CAQ53383.1    CAQ53384.1    CAR94055.1    CAR94056.1    CAR94058.1    CAR94059.1    CAR94060.1    CAR94061.1    CAR94062.1    CAR94064.1    CAR94065.1    AY061292    CH940651    EDW65385.1    AM999017    CAQ53379.1    AM999018    AM999020    CAQ53380.1    CAQ53382.1    JRES01000318    KNC32354.1    LRGB01000868    KZS15764.1    AM999013    CAQ53375.1    GDIP01133728    JAL69986.1    GDIQ01147578    JAL04148.1    AM999015    CAQ53377.1    CH916370    EDW00443.1    FM246131    FM246137    CAR94057.1    CAR94063.1    KQ971312    EEZ98638.1    GFXV01003505    MBW15310.1    CH963851    EDW75180.1    GFDG01001019    JAV17780.1    GFTR01004903    JAW11523.1    CP012528    ALC49242.1    GFDG01001013    JAV17786.1    GFDG01001014    JAV17785.1    CVRI01000020    CRK91256.1    ABLF02029627    GL732545    EFX80964.1    KK854017    PTY09461.1    GAMC01004355    GAMC01004354    JAC02201.1    GAMC01004357    GAMC01004356    JAC02199.1    GDIQ01046779    JAN47958.1    GDHF01031186    GDHF01021179    GDHF01014798    JAI21128.1    JAI31135.1    JAI37516.1    JXJN01006483    GAKP01005348    JAC53604.1    GDIQ01034581    JAN60156.1    GBYB01003150    JAG72917.1    GAKP01005347    JAC53605.1    GDHF01016578    JAI35736.1    GBXI01014478    GBXI01001439    JAC99813.1    JAD12853.1   

Proteomes

UP000005204    UP000218220    UP000053268    UP000007151    UP000053240    UP000007266    + More
UP000008820    UP000019118    UP000069940    UP000249989    UP000030742    UP000002320    UP000092461    UP000092462    UP000091820    UP000015103    UP000092444    UP000235965    UP000092445    UP000095301    UP000092443    UP000095300    UP000007801    UP000008744    UP000268350    UP000192221    UP000008711    UP000002282    UP000009192    UP000000304    UP000001819    UP000000803    UP000008792    UP000037069    UP000076858    UP000001070    UP000007798    UP000092553    UP000183832    UP000007819    UP000000305    UP000078200    UP000092460   

PRIDE

H9JBY0    Q9VXT7    B4F5D1    C0MLA9   

Pfam

PF01112   Asparaginase_2

Interpro

IPR000246   Peptidase_T2        + More
IPR033844   ASRGL1_meta       
IPR029055   Ntn_hydrolases_N       

SUPFAM

SSF56235   SSF56235       

CDD

cd04702  ASRGL1_like

ProteinModelPortal

H9JBY0   A0A2A4IVC9   A0A2H1X4W2   A0A194PHX6   A0A212FG84   A0A194QTC1   + More
D6WUZ1   Q16RI9   N6TJA9   A0A182GK33   U4U5R5   B0W7T7   A0A1Q3FGJ3   A0A182GD97   J3JTW9   A0A1Y1LUX8   A0A1B0CWE4   A0A1S4FS86   A0A1L8E2F5   A0A1B0D2V8   A0A1L8E2N2   A0A1A9X249   A0A0P4VUA4   T1HFP3   A0A1B0GEJ1   A0A2J7Q0N8   R4G4R7   A0A1B0AJ46   T1PCP5   A0A1I8MX18   A0A1B6CCI1   A0A023F7Z9   A0A161MI98   U5EVI6   A0A069DRG3   A0A1A9XGK2   A0A1I8PHJ5   T1HFS9   B3MZ32   A0A0A9W1B9   B4GWG4   A0A3B0J9M9   A0A1W4VH64   A0A0K8SW26   B3NTJ9   A0A1B6GDC8   B4PWP2   B4L3X3   A0A146L5R7   B4F5C6   A0A1B6GVG4   A0A0K8SW86   B4NTP4   A0A1B6IS23   A0A0P6G3X2   Q29I93   B4F5C8   A0A2S2QS08   B4F5C5   Q9VXT7   B4M3L0   B4F5D1   B4F5D2   A0A0L0CLN2   A0A164YZ61   B4F5C7   A0A0P5T3W3   A0A0P5N3F4   B4F5C9   B4JLJ0   C0MLA9   D6WAI9   A0A2H8TMU9   B4MSU1   A0A1L8EGE0   A0A224XTU3   A0A0M4EYW7   A0A1L8EGP2   A0A1L8EGM0   A0A1J1HT65   J9JJ35   A0A1I8MDF4   E9GHZ2   A0A2R7VRK5   W8BM71   A0A1A9UHI4   W8BZQ6   A0A0P6FQS1   A0A0K8UXQ9   A0A1B0AZX1   A0A034WFY1   A0A1I8PQJ3   A0A0P6I6V9   A0A0C9R5D1   A0A1B0GEJ2   A0A034WHH6   A0A1I8PQK4   A0A0K8VA34   A0A0A1XQN1  

PDB

4PVS     E-value=2.32132e-63,     Score=613

KEGG

101740385    K13051 L-asparaginase / beta-aspartyl-peptidase [EC:3.5.1.1 3.4.19.5] | (RefSeq) probable isoasparty

PATHWAY

00250    Alanine, aspartate and glutamate metabolism - Bombyx mori (domestic silkworm)
01100    Metabolic pathways - Bombyx mori (domestic silkworm)

GO

GO:0004067   GO:0008798   GO:0005737   GO:0033345   GO:0016787   GO:0016579   GO:0004674   GO:0006415   GO:0016021   GO:0006418   GO:0003723   GO:0046872   GO:0003824  

PANTHER

PTHR10188  

Length:

323

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.01028

Exp number, first 60 AAs:

0.0049

Total prob of N-in:

0.01683

outside

1  -  323

 

 

Pi

177.810379

Theta

196.646301

Tajima's D

-0.888099

CLR

0.060337

CSRT

0.159742012899355

Interpretation

Possibly Positive selection