Gene

KWMTBOMO10401

Pre Gene Modal

BGIBMGA007073

Annotation

PREDICTED:_ubiquitin_carboxyl-terminal_hydrolase_nonstop_[Papilio_machaon]

Location

Bomo_Chr17(+):10225859-10230385      View in EpiBrowser

Full name

Ubiquitinyl hydrolase 1       + More
Ubiquitin carboxyl-terminal hydrolase nonstop      

Alternative Name

Deubiquitinating enzyme nonstop
Ubiquitin thioesterase nonstop
Ubiquitin-specific-processing protease nonstop

Location in the cell

Extracellular   Reliability : 1.224 PlasmaMembrane   Reliability : 1.623

CDS

ATGAATGACAATGGTTGCATACACCTAAATAATTTTAAGGCTGCTAAAGGCACTAACCCATATAAAATCGTACATGCATTTTTTGTTTCCTGTACGTCGTATGAAGCACGGAGATACAAGGCAACATCCTGTCTCTGCTTTGCTTGTGGCCAGCCTGGACCTCGTATGCATTCATGTCTCCACTGTATCTACTTTGCATGCTATGCTGGTCATATTCAAGAACACTCCAAATCTAAGAAACACTTCCTGTATGTTGACCTTAGCTATGGAAATGTCTTCTGTGCTCAATGCCAAGACTACATTTATGATAGGGAGCTTACTGAGATCGCTGCAATACATAAGGCAAAGGAGGCTAAGTCCCTTGGTATAAGCATACCTTTTATGCCATGGTTACCAAACCATAATGAAGCAATGGCTCTTCGTCGCCTACGTAAACGGCGCCTTATCAGTCCTCATACTACAATAGGTTTACGGGGCTTACAGAACCTAGGATCAACATGCTTCATGAACTGCATTGTTCAGACACTAATTCACACTCCACTCCTGAGAGATTATTTCTTAGCAGAAAAACACAAATGTAAGTCGCAAAGTTCTAGCAAATGCTTGGTGTGTGAAGTTTCCAAACTATTTCAGGAGTTTTACTCTGGAGCAAAAACACCGCTGACTTTGCATCGTCTATTACACTTAATATGGACTCACGCCCGTCACTTGGCTGGATATGAACAACAGGATGCTCATGAATTCTTCATTGCCACTCTTGATGTGCTGCATAGACATTGCATGAATGGAGTAGAAGATACAGAAAAAAAGGAAAATGGGCGTTGTAATTGCATTATCGATCAGATATTCACCGGCGGATTACAAAGCGACGTCGTGTGCACCTCCTGCTCTGGAGTCTCCACTACCATCGATCCGTTCTGGGACATCAGTCTTGACGTGGCCGGGCCGGGTTCCCTGCAAGCTTGCTTGGAACGTTTCACCAGAGCCGAACACCTGGGCTCGGCGGCGAAAATAAAATGCTCCAACTGTCGCGCCTACCGTGAATCCACCAAGCAGCTGACTTTAGAGACTTTGCCGATCGTAGCGAGCTTCCACCTCAAACGTTTCGAGCATTCGTCTCAGATCGATCGGAAGATATCCGCCTTCGTATCGTTCCCGGCTGAGTTAGACATGACTCCGTTTATGTCGTCGCATCGTCGTGCCGTCGACGTGGGCGCGGCCGAGAACAATAACACCCCGGAAGGAATGTTCGAGGACAACCGCTACTCTCTGTTCGCGGTGGTCAATCACTTGGGTTCGCTGGACGCAGGGCACTACACCGCATACGTCAGGCAAATGAAAGGAAGCTGGTTCAAATGCGACGACCACATGATTACTAGGGCGTCACTTCGAGAGGTTTTAGATAGCGAAGGATATCTTCTGTTTTATCACAAGACTGTGTTGGAGTATGAATGCGACGTTTCTTAA

Protein

MNDNGCIHLNNFKAAKGTNPYKIVHAFFVSCTSYEARRYKATSCLCFACGQPGPRMHSCLHCIYFACYAGHIQEHSKSKKHFLYVDLSYGNVFCAQCQDYIYDRELTEIAAIHKAKEAKSLGISIPFMPWLPNHNEAMALRRLRKRRLISPHTTIGLRGLQNLGSTCFMNCIVQTLIHTPLLRDYFLAEKHKCKSQSSSKCLVCEVSKLFQEFYSGAKTPLTLHRLLHLIWTHARHLAGYEQQDAHEFFIATLDVLHRHCMNGVEDTEKKENGRCNCIIDQIFTGGLQSDVVCTSCSGVSTTIDPFWDISLDVAGPGSLQACLERFTRAEHLGSAAKIKCSNCRAYRESTKQLTLETLPIVASFHLKRFEHSSQIDRKISAFVSFPAELDMTPFMSSHRRAVDVGAAENNNTPEGMFEDNRYSLFAVVNHLGSLDAGHYTAYVRQMKGSWFKCDDHMITRASLREVLDSEGYLLFYHKTVLEYECDVS

Description

Histone deubiquitinating component of the transcription regulatory histone acetylation (HAT) complex SAGA. Catalyzes the deubiquitination of histone H2B, thereby acting as a coactivator in a large subset of genes. Required to counteract heterochromatin silencing. Controls the development of neuronal connectivity in visual system by being required for accurate axon targeting in the optic lobe. Required for expression of ecdysone-induced genes such as br/broad.

Catalytic Activity

Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

Subunit

Component of the SAGA transcription coactivator-HAT complex, at least composed of Ada2b, not/nonstop, Pcaf/Gcn5, Sgf11 and Spt3.

Similarity

Belongs to the peptidase C19 family.
Belongs to the peptidase C19 family. UBP8 subfamily.

Keywords

Activator   Chromatin regulator   Complete proteome   Hydrolase   Metal-binding   Nucleus   Protease   Reference proteome   Thiol protease   Transcription   Transcription regulation   Ubl conjugation pathway   Zinc   Zinc-finger  

Feature

chain  Ubiquitinyl hydrolase 1

Uniprot

A0A3S2LD34   A0A1E1WUC5   A0A194R534   A0A212FG94   A0A194PHX1   A0A2H1V7A7   + More
H9JC28   A0A2A4IT90   A0A0L7REW9   A0A154P1K6   E2BHH1   A0A2A3EBC8   A0A088AMI7   A0A0C9QS82   A0A0N0U567   E9FWK2   A0A1B6KA10   A0A1B6JZA4   A0A0N8CFR9   A0A026X152   E2APY7   A0A0N8ASS7   A0A0P4YBV7   K7IYF3   A0A195DUN1   F4W884   A0A151HYV6   A0A158NSQ6   A0A151X0D1   A0A195CB19   A0A0N8D386   A0A0P4X4U1   A0A164VLS5   A0A0P5AIY8   A0A195EWI6   A0A1I8M5Q4   A0A1A9ZMV3   A0A1B0BKB3   A0A1I8M5Q9   A0A0L0CGW0   A0A1I8NM89   A0A1A9W3D5   A0A1A9Y9T6   A0A1B6C3K7   V5IEC6   B4L0D4   A0A182GN74   B3M888   B4LID4   A0A1W4W4G0   A0A293LWW2   A0A0J9UNT1   B3NHQ9   A0A3B0JAI2   Q2LYY5   B4N443   Q9VVR1   A0A1B0CL75   B4QPU1   B4PJ09   V4B961   A0A1E1XFK5   A0A224ZB43   A0A1E1XSM8   A0A131Z031   A0A0P5E6G4   A0A3P9B216   A0A3P9HMA2   A0A2R2MQJ5   A0A0N8AND0   M4AS42   A0A1B0F9K9   A0A1A9VMN7   A0A3B4FDH4   A0A3Q1GAW8   A0A3Q3C6N4   A0A3Q4HQ24   A0A3B3V445   A0A3P8QP70   K9IL10   A0A3B3XQC2   A0A087YJ29   A0A3Q1BMH9   H3CPM5   A0A3P8TSC6   A0A286ZK36   A0A2K6F1P9   A0A1A8FNJ7   A0A3P9QD20   A0A2K6F1Q1   H2V462   A0A1A8MCS6   A0A1A8RD98   A0A1A8KRA3   A0A1A8CYS4   A0A1A8U6K3   H3A8J7   A0A0A1XSX4   F7BCG1   M3W0I5  

EC Number

3.4.19.12

Pubmed

26354079    22118469    19121390    20798317    21292972    24508170    + More
30249741    20075255    21719571    21347285    25315136    26108605    25765539    17994087    26483478    22936249    15632085    11182084    10731132    12537572    12537569    18188155    18206972    17550304    23254933    28503490    28797301    29209593    26830274    25186727    17554307    26383154    23542700    15496914    21551351    9215903    25830018    17495919    17975172   

EMBL

RSAL01000218    RVE44093.1    GDQN01000663    JAT90391.1    KQ460685    KPJ12792.1    + More
AGBW02008703    OWR52747.1    KQ459603    KPI93016.1    ODYU01000807    SOQ36144.1    BABH01014789    BABH01014790    NWSH01008640    PCG62464.1    KQ414608    KOC69375.1    KQ434796    KZC05723.1    GL448301    EFN84824.1    KZ288313    PBC28361.1    GBYB01003512    JAG73279.1    KQ435791    KOX74394.1    GL732526    EFX88419.1    GEBQ01031688    GEBQ01029188    JAT08289.1    JAT10789.1    GECU01003177    JAT04530.1    GDIP01136095    GDIQ01085601    JAL67619.1    JAN09136.1    KK107046    QOIP01000004    EZA61731.1    RLU24206.1    GL441643    EFN64504.1    GDIQ01246443    JAK05282.1    GDIP01233339    JAI90062.1    KQ980322    KYN16583.1    GL887898    EGI69579.1    KQ976723    KYM76672.1    ADTU01025108    KQ982624    KYQ53690.1    KQ978023    KYM98002.1    GDIQ01092455    GDIP01073159    JAL59271.1    JAM30556.1    GDIP01246356    JAI77045.1    LRGB01001361    KZS12448.1    GDIP01198344    JAJ25058.1    KQ981948    KYN32640.1    JXJN01015869    JRES01000413    KNC31476.1    GEDC01029324    JAS07974.1    GANP01010422    JAB74046.1    CH933809    EDW19103.2    JXUM01014567    KQ560407    KXJ82566.1    CH902618    EDV41027.2    CH940647    EDW70721.2    GFWV01007709    MAA32439.1    CM002912    KMZ00416.1    CH954178    EDV51854.1    OUUW01000002    SPP77002.1    CH379069    EAL29724.3    CH964095    EDW78917.2    AF179590    AE014296    AY058707    AJWK01017007    AJWK01017008    AJWK01017009    AJWK01017010    CM000363    EDX10969.1    CM000159    EDW94600.2    KB199905    ESP03856.1    GFAC01001166    JAT98022.1    GFPF01013058    MAA24204.1    GFAA01001112    JAU02323.1    GEDV01003764    JAP84793.1    GDIP01145900    JAJ77502.1    GDIQ01258819    JAJ92905.1    CCAG010015211    GABZ01005510    JAA48015.1    AYCK01000799    AEMK02000083    HAEB01013906    SBQ60433.1    HAEF01012985    SBR54144.1    HAEH01015641    HAEI01014619    SBS03249.1    HAED01006291    HAEE01014867    SBR34917.1    HADZ01021021    HAEA01000576    SBP84962.1    HADY01022142    HAEJ01003487    SBS43944.1    AFYH01177354    AFYH01177355    AFYH01177356    AFYH01177357    AFYH01177358    AFYH01177359    AFYH01177360    AFYH01177361    AFYH01177362    AFYH01177363    GBXI01000277    JAD14015.1    AANG04000740   

Proteomes

UP000283053    UP000053240    UP000007151    UP000053268    UP000005204    UP000218220    + More
UP000053825    UP000076502    UP000008237    UP000242457    UP000005203    UP000053105    UP000000305    UP000053097    UP000279307    UP000000311    UP000002358    UP000078492    UP000007755    UP000078540    UP000005205    UP000075809    UP000078542    UP000076858    UP000078541    UP000095301    UP000092445    UP000092460    UP000037069    UP000095300    UP000091820    UP000092443    UP000009192    UP000069940    UP000249989    UP000007801    UP000008792    UP000192221    UP000008711    UP000268350    UP000001819    UP000007798    UP000000803    UP000092461    UP000000304    UP000002282    UP000030746    UP000265160    UP000265200    UP000085678    UP000002852    UP000092444    UP000078200    UP000261460    UP000257200    UP000264840    UP000261580    UP000261500    UP000265100    UP000261480    UP000028760    UP000257160    UP000007303    UP000265080    UP000008227    UP000233160    UP000242638    UP000005226    UP000008672    UP000002280    UP000011712   

PRIDE

H9JC28    Q9VVR1   

Pfam

PF02148   zf-UBP        + More
PF00443   UCH
PF02170   PAZ
PF02171   Piwi

Interpro

IPR013083   Znf_RING/FYVE/PHD        + More
IPR028889   USP_dom       
IPR001394   Peptidase_C19_UCH       
IPR001607   Znf_UBP       
IPR018200   USP_CS       
IPR038765   Papain-like_cys_pep_sf       
IPR003165   Piwi       
IPR003100   PAZ_dom       
IPR036397   RNaseH_sf       
IPR036085   PAZ_dom_sf       
IPR012337   RNaseH-like_sf       
IPR011031   Multihaem_cyt       

SUPFAM

SSF54001   SSF54001        + More
SSF53098   SSF53098       
SSF101690   SSF101690       

Gene 3D

3.30.40.10     3.30.420.10    

ProteinModelPortal

A0A3S2LD34   A0A1E1WUC5   A0A194R534   A0A212FG94   A0A194PHX1   A0A2H1V7A7   + More
H9JC28   A0A2A4IT90   A0A0L7REW9   A0A154P1K6   E2BHH1   A0A2A3EBC8   A0A088AMI7   A0A0C9QS82   A0A0N0U567   E9FWK2   A0A1B6KA10   A0A1B6JZA4   A0A0N8CFR9   A0A026X152   E2APY7   A0A0N8ASS7   A0A0P4YBV7   K7IYF3   A0A195DUN1   F4W884   A0A151HYV6   A0A158NSQ6   A0A151X0D1   A0A195CB19   A0A0N8D386   A0A0P4X4U1   A0A164VLS5   A0A0P5AIY8   A0A195EWI6   A0A1I8M5Q4   A0A1A9ZMV3   A0A1B0BKB3   A0A1I8M5Q9   A0A0L0CGW0   A0A1I8NM89   A0A1A9W3D5   A0A1A9Y9T6   A0A1B6C3K7   V5IEC6   B4L0D4   A0A182GN74   B3M888   B4LID4   A0A1W4W4G0   A0A293LWW2   A0A0J9UNT1   B3NHQ9   A0A3B0JAI2   Q2LYY5   B4N443   Q9VVR1   A0A1B0CL75   B4QPU1   B4PJ09   V4B961   A0A1E1XFK5   A0A224ZB43   A0A1E1XSM8   A0A131Z031   A0A0P5E6G4   A0A3P9B216   A0A3P9HMA2   A0A2R2MQJ5   A0A0N8AND0   M4AS42   A0A1B0F9K9   A0A1A9VMN7   A0A3B4FDH4   A0A3Q1GAW8   A0A3Q3C6N4   A0A3Q4HQ24   A0A3B3V445   A0A3P8QP70   K9IL10   A0A3B3XQC2   A0A087YJ29   A0A3Q1BMH9   H3CPM5   A0A3P8TSC6   A0A286ZK36   A0A2K6F1P9   A0A1A8FNJ7   A0A3P9QD20   A0A2K6F1Q1   H2V462   A0A1A8MCS6   A0A1A8RD98   A0A1A8KRA3   A0A1A8CYS4   A0A1A8U6K3   H3A8J7   A0A0A1XSX4   F7BCG1   M3W0I5  

PDB

3M99     E-value=1.31635e-51,     Score=514

KEGG

101739561    K11366 ubiquitin carboxyl-terminal hydrolase 22/27/51 [EC:3.4.19.12] | (RefSeq) ubiquitin carboxyl-t

GO

GO:0046872   GO:0036459   GO:0006511   GO:0008270   GO:0016579   GO:0016021   GO:0004843   GO:0016578   GO:0045893   GO:0008347   GO:0021782   GO:0007411   GO:0000124   GO:0071819   GO:0007412   GO:0005634   GO:0006355   GO:0006325   GO:0003676   GO:0031047   GO:0016607   GO:0019899   GO:0010485   GO:0016574   GO:0045931   GO:0030374   GO:0004674   GO:0006415   GO:0006418   GO:0003723   GO:0003824  

Subcellular location

Nucleus  

Length:

488

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.22044

Exp number, first 60 AAs:

0.01273

Total prob of N-in:

0.01225

outside

1  -  488

 

 

Pi

187.350924

Theta

154.195552

Tajima's D

0.920101

CLR

0

CSRT

0.63916804159792

Interpretation

Uncertain