Gene

KWMTBOMO10388  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA007039

Annotation

BCP_inhibitor_precursor_[Bombyx_mori]

Location

Bomo_Chr17(-):9860906-9862694      View in EpiBrowser

Full name

Viral cathepsin      

Alternative Name

Cysteine proteinase

Location in the cell

Extracellular   Reliability : 2.619

CDS

ATGAATTTCGTCAGTGTGGCGTTGTTAATAGCCACAGTAGTAATGGCGTCCTCGGCGGAGACAGATACTCCGAGACATTATGACCTCAATCAAGCCAAAGAATTGTTCGAAATTTTCGTCAAAGAACATAACAGGGAATACAAGGATGATGCCGACAGAGAGCTGCATTATCAATCATTCAAGAAACACTTGGCAGAGATAAACCAATTGAACGAGAAGAATCCATATACTACGTTTGGCATTAACAAATTTGCTGATTATACTCCTGAGGAACAGCAGAGCAGGTTGGGATTGAGGCTGCCTGCTAAGAAGACATAA

Protein

MNFVSVALLIATVVMASSAETDTPRHYDLNQAKELFEIFVKEHNREYKDDADRELHYQSFKKHLAEINQLNEKNPYTTFGINKFADYTPEEQQSRLGLRLPAKKT

Description

Cysteine protease that plays an essential role in host liquefaction to facilitate horizontal transmission of the virus. May participate in the degradation of foreign protein expressed by the baculovirus system (By similarity).

Catalytic Activity

Endopeptidase of broad specificity, hydrolyzing substrates of both cathepsin L and cathepsin B.

Similarity

Belongs to the peptidase C1 family.

Keywords

Disulfide bond   Hydrolase   Protease   Signal   Thiol protease   Zymogen   Complete proteome   Glycoprotein   Reference proteome  

Feature

propeptide  Activation peptide
chain  Viral cathepsin

Uniprot

Q9XZP6   H9JBZ4   G9F9K2   A0A2A4J449   A0A0L7KR82   A0A2H1W9H6   + More
I4DJB4   A0A0N0PD72   A0A2A4J2W8   A0A194PPD4   A0A220K8K6   A0A212F8Y8   A0A0N1II49   A0A212F8X2   A0A212F8W8   A0A220K8L5   A0A0N0PDH5   A0A212FL79   A0A212F8W7   D9HQA0   A0A212EKJ7   A0A194QV18   A0A212FL76   A0A2H1WA61   A0A0E3URB9   A0A194QPH1   Q287Q3   A0A0N0PD32   A0A2H1V5F8   Q71AH9   Q8QLK1   A0A194QEB8   A0A3G2JTW0   A0A194PI53   Q0IL45   T1QGA4   Q4KT16   A0A2A4JB28   A0A2A4JAL6   Q4PR56   A0A2A4J9U5   Q9PYY5   A0A0A7KR14   A0A3S2N872   A0A212F4R5   Q80LP4   A0A2A4J3Q6   A0A2H4ZKA7   A0A2H2IWF8   C3TWW7   A0A2Z4HHY1   A0A0M3WNJ0   W0UY09   D4N2B1   A0A0B4ZZE9   A0A1C8ZYN4   W5VKI0   Q9YWK4   A0A068LMG5   S5RPP8   D2J4H8   B6D5T7   Q91BH1   A0A1C8ZZ09   I4DL27   A0A2H1WL65   A0A212FQ57   Q462A5   J9HU29   A0A023ESZ5   B6S6T4   A0A1D8QL78   B0FDP0   A0A097P1S9   A0A097P0Y7   Q9J8B9   V9TJU8   A0A2S1XB05   O91466   Q7T5S6   B6S2M4   S5MK26   A0A2P6KGB7   A0A2H1WUN3   A0A346RNS1   A0A2K9VS42   A0A140HRD5  

EC Number

3.4.22.50

Pubmed

19121390    26227816    22651552    26354079    28630352    22118469    + More
20375075    26021909    16055149    16476975    15604435    11886270    17763934    17141348    24158555    15567439    15958686    19243590    10502508    25471493    14599801    29099796    19347664    29895987    27273152    24854001    20167051    24012501    25765042    8345353    9037741    9634101    9820162    9712513    24475121    25838477    23512574    21517121    22879615    11531416    15951000    17510324    24945155    25331863    10567663    24370838    9747739    11562546    8021613    7996162    12124467    14698662    18931089    23852342    30102885    29204787   

EMBL

AJ131752    CAB41937.1    BABH01014760    JN033747    AEW46900.2    NWSH01003476    + More
PCG66220.1    JTDY01006980    KOB65556.1    ODYU01007181    SOQ49731.1    AK401382    BAM18004.1    KQ460328    KPJ15651.1    PCG66219.1    KQ459603    KPI92995.1    MF319706    ASJ26420.1    AGBW02009664    OWR50169.1    LADJ01040910    KPJ21366.1    OWR50171.1    OWR50170.1    MF319705    ASJ26419.1    KPJ15652.1    AGBW02007833    OWR54492.1    OWR50168.1    HM023855    ADJ58588.1    AGBW02014266    OWR42006.1    KQ461185    KPJ07401.1    OWR54494.1    SOQ49732.1    KP752043    AKC91705.1    KPJ07402.1    DQ123841    AAZ38185.1    KPJ15654.1    ODYU01000552    SOQ35504.1    AF539999    AAQ11052.1    U59461    KQ459144    KPJ03764.1    MH370144    AYN44975.1    KPI92997.1    AY394490    AAR28838.1    JX535500    AGC36278.1    AY864330    JX560539    JX560540    JX560541    JX560542    AAY83995.1    AGE61325.1    AGE61624.1    NWSH01002213    PCG68898.1    PCG68899.1    DQ504428    AAY59557.1    PCG68897.1    AF162221    KM102981    AIZ48579.1    RSAL01000218    RVE44085.1    AGBW02010321    OWR48724.1    AP006270    NWSH01003620    PCG66042.1    MF974563    AUF81995.1    FJ227128    ACO53509.1    MH261376    AWW14387.1    KM596836    AKN80580.1    HG425343    HG425344    HG425345    HG425346    HG425347    HG425348    HG425349    CDG72360.1    CDG72497.1    CDG72634.1    CDG72771.1    CDG72923.1    CDG73060.1    CDG73197.1    GQ202541    ADD73783.1    KJ631622    AJD80753.1    KU669289    KU669290    KU669291    KU669292    AOL56499.1    AOL56641.1    AOL56782.1    AOL56924.1    KF611977    KM986882    AHH82613.1    AKN90994.1    AF058929    KM009991    AIE47746.1    JX968491    AGS18775.1    GQ884143    ACZ63497.1    EU839994    ACI28725.1    AF325155    KU669293    KU669294    AOL57066.1    AOL57207.1    AK401995    BAM18617.1    ODYU01009401    SOQ53799.1    AGBW02000036    OWR55819.1    DQ017380    AAZ67431.1    CH478003    EJY58173.1    GAPW01001168    JAC12430.1    EU678671    ACH69415.1    KU752557    AOW41395.1    EU309041    ABY65748.1    KM217573    KM217575    KM217576    KM217577    AIU36660.1    AIU36937.1    AIU37079.1    AIU37221.1    KM217574    AIU36800.1    AF169823    KF695050    KT626571    AHC69579.1    AMO27747.1    MF311096    AWJ76692.1    U53466    AY229987    AAQ21608.1    EU591746    ACF05341.1    KF158713    AGR56811.1    MWRG01012645    PRD25396.1    ODYU01011182    SOQ56763.1    MH394321    AXS67718.1    MF375894    AUV65279.1    KT626572    KX618634    AMO27932.1    AOW42788.1   

Proteomes

UP000005204    UP000218220    UP000037510    UP000053240    UP000053268    UP000007151    + More
UP000201190    UP000204644    UP000235290    UP000201737    UP000202309    UP000214353    UP000202921    UP000202327    UP000283053    UP000232720    UP000005237    UP000203846    UP000204667    UP000069390    UP000069454    UP000069458    UP000069469    UP000069541    UP000069838    UP000069875    UP000203822    UP000203835    UP000214366    UP000203240    UP000202544    UP000204251    UP000202667    UP000207582    UP000008820    UP000203623    UP000232707    UP000203316    UP000009249    UP000203359    UP000203768   

PRIDE

Q9XZP6    H9JBZ4    Q8QLK1    Q9J8B9    O91466   

Pfam

PF08246   Inhibitor_I29        + More
PF00112   Peptidase_C1
PF00031   Cystatin

Interpro

IPR038765   Papain-like_cys_pep_sf        + More
IPR013201   Prot_inhib_I29       
IPR039417   Peptidase_C1A_papain-like       
IPR025660   Pept_his_AS       
IPR025661   Pept_asp_AS       
IPR000668   Peptidase_C1A_C       
IPR000169   Pept_cys_AS       
IPR000010   Cystatin_dom       
IPR018073   Prot_inh_cystat_CS       

SUPFAM

SSF54001   SSF54001       

CDD

cd02248  Peptidase_C1A
cd00042  CY

ProteinModelPortal

Q9XZP6   H9JBZ4   G9F9K2   A0A2A4J449   A0A0L7KR82   A0A2H1W9H6   + More
I4DJB4   A0A0N0PD72   A0A2A4J2W8   A0A194PPD4   A0A220K8K6   A0A212F8Y8   A0A0N1II49   A0A212F8X2   A0A212F8W8   A0A220K8L5   A0A0N0PDH5   A0A212FL79   A0A212F8W7   D9HQA0   A0A212EKJ7   A0A194QV18   A0A212FL76   A0A2H1WA61   A0A0E3URB9   A0A194QPH1   Q287Q3   A0A0N0PD32   A0A2H1V5F8   Q71AH9   Q8QLK1   A0A194QEB8   A0A3G2JTW0   A0A194PI53   Q0IL45   T1QGA4   Q4KT16   A0A2A4JB28   A0A2A4JAL6   Q4PR56   A0A2A4J9U5   Q9PYY5   A0A0A7KR14   A0A3S2N872   A0A212F4R5   Q80LP4   A0A2A4J3Q6   A0A2H4ZKA7   A0A2H2IWF8   C3TWW7   A0A2Z4HHY1   A0A0M3WNJ0   W0UY09   D4N2B1   A0A0B4ZZE9   A0A1C8ZYN4   W5VKI0   Q9YWK4   A0A068LMG5   S5RPP8   D2J4H8   B6D5T7   Q91BH1   A0A1C8ZZ09   I4DL27   A0A2H1WL65   A0A212FQ57   Q462A5   J9HU29   A0A023ESZ5   B6S6T4   A0A1D8QL78   B0FDP0   A0A097P1S9   A0A097P0Y7   Q9J8B9   V9TJU8   A0A2S1XB05   O91466   Q7T5S6   B6S2M4   S5MK26   A0A2P6KGB7   A0A2H1WUN3   A0A346RNS1   A0A2K9VS42   A0A140HRD5  

PDB

4QRX     E-value=0.000158878,     Score=100

KEGG

692611    no KO assigned | (RefSeq) bcpi; BCP inhibitor

GO

GO:0008233   GO:0008234   GO:0016021   GO:0004869  

SignalP

Position:   1 - 19,         Likelihood:  0.993193

 

 

Length:

105

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.64562

Exp number, first 60 AAs:

0.64562

Total prob of N-in:

0.09869

outside

1  -  105

 

 

Pi

204.529003

Theta

163.583977

Tajima's D

0.619012

CLR

0.002938

CSRT

0.543672816359182

Interpretation

Uncertain