Gene

KWMTBOMO10376  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA007061

Annotation

cathepsin_B_precursor_[Bombyx_mori]

Location

Bomo_Chr17(+):9222680-9223987      View in EpiBrowser

Location in the cell

Extracellular   Reliability : 1.585 Lysosomal   Reliability : 2.234

CDS

ATGTTTATTTCGCGTGCGGCGTATGTTACGCTGGTGTGCGTTCTTGCAGCGGCCAAAGACTTACCGCATCCACTCTCCGATGAATTCATCAACACGATTAACCTAAAGCAAAATAGTTGGAAGGCGGGACGTAATTTTCCGCGCGACACATCGTTCGCGCATCTTAAGAAAATAATGGGAGTTATCGAGGATGAACATTTTGCGACCCTGCCAATAAAGACTCATAAAATCGATTTAATCGCCAGTCTGCCGGAAAACTTCGATCCCAGAGACAAATGGCCTGACTGTCCAACGTTGAATGAAGTCAGAGATCAAGGGTCTTGTGGCAGTTGTTGGGCTTTCGGTGCCGTCGAAGCTATGACAGACAGAGTATGTACCTATTCTAACGGAACTAAACATTTTCATTTTTCTGCCGAGGATTTGCTTAGTTGCTGCCCTATTTGTGGACTGGGATGCAGCGGAGGAATGCCGAGACTAGCTTGGGAATATTGGAAGCACTTCGGTCTAGTATCAGGAGGTAGTTACAATTCCAGTCAAGGTTGCAGACCTTACGAGATCCCTCCGTGTGAACATCACGTACCCGGCAACAGGATGCCCTGTAGCGGTGACACGAAGACTCCAAAATGCACAAAAAAATGCGAATCTGGATACGACGTTAATTACAAACAAGACAAACAATACGGAAAACATGTATATACTGTGTCCGGAGACGAAGACCACATCCGCGCGGAATTGTTCAAGAATGGTCCCGTCGAAGGTGCTTTCACAGTATATTCAGATTTGCTGTCGTACAAGAGTGGTGTATACAAACACACACAAGGGGACGCTCTCGGCGGGCACGCCGTCAAGATATTAGGCTGGGGTGTCGAAAATGATAACAAATATTGGCTTATTGCAAACTCGTGGAACTCAGATTGGGGAGACAATGGCTTCTTCAAAATTTTGCGCGGCGAGGATCACTGCGGTATTGAGAGCTCCATTGTTACGGGTGAACCGTTCTTAGATGAACACTAG

Protein

MFISRAAYVTLVCVLAAAKDLPHPLSDEFINTINLKQNSWKAGRNFPRDTSFAHLKKIMGVIEDEHFATLPIKTHKIDLIASLPENFDPRDKWPDCPTLNEVRDQGSCGSCWAFGAVEAMTDRVCTYSNGTKHFHFSAEDLLSCCPICGLGCSGGMPRLAWEYWKHFGLVSGGSYNSSQGCRPYEIPPCEHHVPGNRMPCSGDTKTPKCTKKCESGYDVNYKQDKQYGKHVYTVSGDEDHIRAELFKNGPVEGAFTVYSDLLSYKSGVYKHTQGDALGGHAVKILGWGVENDNKYWLIANSWNSDWGDNGFFKILRGEDHCGIESSIVTGEPFLDEH

Similarity

Belongs to the peptidase C1 family.

Uniprot

H9JC16   Q9BLI9   A1Z075   A0A194PJT4   A0A2A4J570   A0A0N1PH85   + More
I4DIZ0   A1DYI5   A0A2H1WG36   I4DML4   E2J8A7   C7BWY6   Q5MGE8   Q9NHF5   A0A1E1VXU2   A0A0L7KTX3   S4NSX4   A0A212FP81   B2KSD9   B2KSE0   A0A2A4J768   A0A1V1FNM0   A0A0L7LR24   A0A1B0CXA8   A0A0T6B0A3   A0A336KB83   A0A1L8DPK1   A0A2A4J6I6   A0A1B0F0N2   B0W0V3   D6WGZ1   A0A0B5J1X8   A0A1J1IT42   U5EX33   A0A2H1W408   A0A2M3YZ69   A0A182SM11   Q70EX1   A0A1W4WLT1   A0A067RI52   A0A2P8XZP0   A0A1B6C2V6   A0A2M3YZ91   A0A1B6FMB6   W5JAL5   A0A182Y8P5   A0A182RE09   A0A2M4CFZ3   A0A2M4A1F2   A0A1B6CNK2   A0A1B6FGW4   A0A1B6G399   A0A1S4FMW6   A0A2J7Q2D7   A0A182QDS9   A0A2M3YZA5   A0A023EQ55   B4M3R5   Q1EGF0   A0A2J7Q2C6   A0A2M3YWH4   A0A2M4CGI0   A0A023EQ36   A0A1Y1LLE3   A0A084WTW2   A0A2M4A1I2   T1PA26   A0A182N9W5   A0A182JR86   A0A1Q3FN80   A0A2M4AIF0   A0A2M4A8M1   A0A2M4AGT9   T1DPY6   B4L388   A0A182F914   A0A0L7L6Z0   Q7Q9Y3   A0A182UK87   A0A182HYS5   A0A182W3J4   A0A2R7X282   A0A182XIF3   A0A2P2HVK2   A0A2H8TIP6   A0A182V7N7   A0A182JAJ1   A0A1I9WL58   A0A2M4BU45   A0A2M4BTS9   V9ISF8   A0A2K8JLG4   A0A2M4BT97   A0A2M4BTC9   A0A2M4BTM9   A0A1B6K5R8   A0A182M059   A9JSF8   A0A182GJJ7  

Pubmed

19121390    11567902    26354079    22651552    19361282    16023793    + More
12421414    26227816    23622113    22118469    20854480    28410430    18362917    19820115    15041015    24845553    29403074    20920257    23761445    25244985    24945155    17994087    17510324    28004739    24438588    25315136    12364791    14747013    17210077    27538518    17934209    26483478   

EMBL

BABH01014707    KM027254    AB045595    AIU94623.1    BAB40804.1    EF154237    + More
ABM05925.1    KQ459603    KPI92989.1    NWSH01002924    PCG67287.1    KQ460328    KPJ15645.1    AK401258    BAM17880.1    EF068255    ABK90823.1    ODYU01008433    SOQ52039.1    AK402532    BAM19154.1    HQ110064    ADN19566.1    FM957999    CAX16634.1    AY829838    AAV91452.1    AF222788    AAF35867.2    GDQN01011563    JAT79491.1    JTDY01005708    KOB66713.1    GAIX01013867    JAA78693.1    AGBW02003464    OWR55554.1    EU126818    ACC66065.1    EU126819    ACC66066.1    PCG67290.1    FX985417    BAX07430.1    JTDY01000293    KOB77859.1    AJWK01033486    LJIG01022451    KRT80525.1    UFQS01000234    UFQT01000234    SSX01751.1    SSX22129.1    GFDF01005780    JAV08304.1    PCG67288.1    AJVK01019293    DS231819    EDS42770.1    KQ971321    EFA01289.1    KP303290    AJF94889.1    CVRI01000059    CRL03411.1    GANO01001145    JAB58726.1    ODYU01006189    SOQ47825.1    GGFM01000757    MBW21508.1    AJ583509    CAE47498.1    KK852667    KDR18937.1    PYGN01001112    PSN37482.1    GEDC01029441    JAS07857.1    GGFM01000824    MBW21575.1    GECZ01018424    JAS51345.1    ADMH02001667    ETN61492.1    GGFL01000084    MBW64262.1    GGFK01001260    MBW34581.1    GEDC01022407    JAS14891.1    GECZ01020323    JAS49446.1    GECZ01012865    JAS56904.1    NEVH01019371    PNF22739.1    AXCN02001202    GGFM01000858    MBW21609.1    GAPW01002413    JAC11185.1    CH940651    EDW65440.1    AY626233    CH477599    AAV31917.1    EAT38474.1    PNF22740.1    GGFF01000145    MBW20612.1    GGFL01000083    MBW64261.1    GAPW01002443    JAC11155.1    GEZM01054344    JAV73751.1    ATLV01026924    KE525420    KFB53656.1    GGFK01001177    MBW34498.1    KA645631    AFP60260.1    GFDL01006099    JAV28946.1    GGFK01007239    MBW40560.1    GGFK01003833    MBW37154.1    GGFK01006679    MBW40000.1    GAMD01001550    JAB00041.1    CH933810    EDW07016.1    JTDY01002528    KOB71237.1    AAAB01008898    EAA09183.5    APCN01005404    KK856497    PTY25904.1    IACF01000029    LAB65845.1    GFXV01002190    MBW13995.1    KU932242    APA33878.1    GGFJ01007137    MBW56278.1    GGFJ01007210    MBW56351.1    JQ780374    AFM82475.1    MF683380    ATU82521.1    GGFJ01007138    MBW56279.1    GGFJ01007205    MBW56346.1    GGFJ01007211    MBW56352.1    GECU01000917    JAT06790.1    AXCM01000198    ABLF02021036    ABLF02021045    ABLF02038382    ABLF02038385    ABLF02038399    BK006309    DAA06097.1    JXUM01001677    KQ560126    KXJ84332.1   

Proteomes

UP000005204    UP000053268    UP000218220    UP000053240    UP000037510    UP000007151    + More
UP000092461    UP000092462    UP000002320    UP000007266    UP000183832    UP000075901    UP000192223    UP000027135    UP000245037    UP000000673    UP000076408    UP000075900    UP000235965    UP000075886    UP000008792    UP000008820    UP000030765    UP000095301    UP000075884    UP000075881    UP000009192    UP000069272    UP000007062    UP000075902    UP000075840    UP000075920    UP000076407    UP000075903    UP000075880    UP000075883    UP000007819    UP000069940    UP000249989   

PRIDE

H9JC16    Q9BLI9   

Pfam

PF00112   Peptidase_C1        + More
PF08127   Propeptide_C1
PF00106   adh_short

Interpro

IPR012599   Propeptide_C1A        + More
IPR025661   Pept_asp_AS       
IPR000169   Pept_cys_AS       
IPR000668   Peptidase_C1A_C       
IPR038765   Papain-like_cys_pep_sf       
IPR025660   Pept_his_AS       
IPR036291   NAD(P)-bd_dom_sf       
IPR002347   SDR_fam       

SUPFAM

SSF54001   SSF54001        + More
SSF51735   SSF51735       

ProteinModelPortal

H9JC16   Q9BLI9   A1Z075   A0A194PJT4   A0A2A4J570   A0A0N1PH85   + More
I4DIZ0   A1DYI5   A0A2H1WG36   I4DML4   E2J8A7   C7BWY6   Q5MGE8   Q9NHF5   A0A1E1VXU2   A0A0L7KTX3   S4NSX4   A0A212FP81   B2KSD9   B2KSE0   A0A2A4J768   A0A1V1FNM0   A0A0L7LR24   A0A1B0CXA8   A0A0T6B0A3   A0A336KB83   A0A1L8DPK1   A0A2A4J6I6   A0A1B0F0N2   B0W0V3   D6WGZ1   A0A0B5J1X8   A0A1J1IT42   U5EX33   A0A2H1W408   A0A2M3YZ69   A0A182SM11   Q70EX1   A0A1W4WLT1   A0A067RI52   A0A2P8XZP0   A0A1B6C2V6   A0A2M3YZ91   A0A1B6FMB6   W5JAL5   A0A182Y8P5   A0A182RE09   A0A2M4CFZ3   A0A2M4A1F2   A0A1B6CNK2   A0A1B6FGW4   A0A1B6G399   A0A1S4FMW6   A0A2J7Q2D7   A0A182QDS9   A0A2M3YZA5   A0A023EQ55   B4M3R5   Q1EGF0   A0A2J7Q2C6   A0A2M3YWH4   A0A2M4CGI0   A0A023EQ36   A0A1Y1LLE3   A0A084WTW2   A0A2M4A1I2   T1PA26   A0A182N9W5   A0A182JR86   A0A1Q3FN80   A0A2M4AIF0   A0A2M4A8M1   A0A2M4AGT9   T1DPY6   B4L388   A0A182F914   A0A0L7L6Z0   Q7Q9Y3   A0A182UK87   A0A182HYS5   A0A182W3J4   A0A2R7X282   A0A182XIF3   A0A2P2HVK2   A0A2H8TIP6   A0A182V7N7   A0A182JAJ1   A0A1I9WL58   A0A2M4BU45   A0A2M4BTS9   V9ISF8   A0A2K8JLG4   A0A2M4BT97   A0A2M4BTC9   A0A2M4BTM9   A0A1B6K5R8   A0A182M059   A9JSF8   A0A182GJJ7  

PDB

1MIR     E-value=8.35977e-110,     Score=1014

KEGG

692390    K01363 cathepsin B [EC:3.4.22.1] | (RefSeq) cathepsin B

PATHWAY

04140    Autophagy - animal - Bombyx mori (domestic silkworm)
04142    Lysosome - Bombyx mori (domestic silkworm)

GO

GO:0050790   GO:0004197   GO:0008234   GO:0005615   GO:0005764   GO:0051603   GO:0016021   GO:0006508   GO:0006415   GO:0006418   GO:0003723   GO:0046872   GO:0003824  

SignalP

Position:   1 - 18,         Likelihood:  0.862393

 

 

Length:

337

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.06424

Exp number, first 60 AAs:

0.05739

Total prob of N-in:

0.02718

outside

1  -  337

 

 

Pi

294.864459

Theta

206.735075

Tajima's D

1.333716

CLR

0

CSRT

0.747312634368282

Interpretation

Uncertain