Gene

KWMTBOMO10346  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA007247

Annotation

PREDICTED:_nuclear_distribution_protein_nudE-like_1_isoform_X1_[Bombyx_mori]

Location

Bomo_Chr17(+):7979875-7985044      View in EpiBrowser

Full name

Nuclear distribution protein nudE-like 1-B       + More
Nuclear distribution protein nudE homolog 1      

Location in the cell

Nuclear   Reliability : 3.657

CDS

ATGCAATCTCCGAAACAAGCAGATTGTGACACAGTGGAGTACTGGAAAAATCTAGCAGAATGCTATGAACAGAAAGTGAACGACATTCAGCAAGAATTAGATGAATACACAGAAAATTCGGCTCAGTTGGAAAAGGAATTGGAAGCATCATTAGGGCAAGTTGAAAAGCAGAACAGAGATCTGGAACACCAAAATCAACGCCTTAAAAATGAAATTGAAATGTTAAAAAACAAGCTGGAAAGAAGTCAATATGAGACTAATGCTTTAGAAAATGAACTACAAGCTTTAAAGATAGATAAGGACAAGCAGGCAGCATATGTGAGGGAATTGGAACAAAAGAACGATGATCTGGAAAGAGGTCAAAGAGTCATATCAGAATCCGTATCGTGTATAGAAACAATGTTAAATGAAGCATATGAGAGGAATGCAGTTCTTGAAAATGAAGTTGATGAAATAGAAAATCTTAGGATAAAATTGCAGAGAGCAAATGATGAAGCTAGAGATCTGAAACAAGAATTAAAAGTTGTTGAAAGAATTCCGTCAAGTAAGAAAGAGGAAGATGAAAATGAAACAACATTAACGAACGGACATCTTTCAAATTCAACTCGGAATCAAGTTGAGATTGAGACACAAACATCCATTATGTCACCACAAAAACGGGAAATAAATGGTAACGCAATGACACCATCGGCCAGAGTTTCAGCAATAAATTTAGTTGGTGATCTCCTTAGGAAGGTTGGGGCTTTGGAATCGAAATTAGCATCGTGTCGTGGTACAGTTAGACCTAAAGAGCATTCACCAAACACGACCTCGGAAGTCAATAAGGACTACAGATGTGTACTCAAGAATTAA

Protein

MQSPKQADCDTVEYWKNLAECYEQKVNDIQQELDEYTENSAQLEKELEASLGQVEKQNRDLEHQNQRLKNEIEMLKNKLERSQYETNALENELQALKIDKDKQAAYVRELEQKNDDLERGQRVISESVSCIETMLNEAYERNAVLENEVDEIENLRIKLQRANDEARDLKQELKVVERIPSSKKEEDENETTLTNGHLSNSTRNQVEIETQTSIMSPQKREINGNAMTPSARVSAINLVGDLLRKVGALESKLASCRGTVRPKEHSPNTTSEVNKDYRCVLKN

Description

Required for organization of the cellular microtubule array and microtubule anchoring at the centrosome. Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end (By similarity).
Required for centrosome duplication and formation and function of the mitotic spindle. Essential for the development of the cerebral cortex. May regulate the production of neurons by controlling the orientation of the mitotic spindle during division of cortical neuronal progenitors of the proliferative ventricular zone of the brain. Orientation of the division plane perpendicular to the layers of the cortex gives rise to two proliferative neuronal progenitors whereas parallel orientation of the division plane yields one proliferative neuronal progenitor and a post-mitotic neuron. A premature shift towards a neuronal fate within the progenitor population may result in an overall reduction in the final number of neurons and an increase in the number of neurons in the deeper layers of the cortex.

Subunit

Self-associates. Interacts with CNTRL, LIS1, dynein, SLMAP and TCP1 (By similarity). Interacts with CENPF, dynactin, tubulin gamma, PAFAH1B1, PCM1 and PCNT. Interacts with ZNF365.

Similarity

Belongs to the nudE family.

Keywords

Coiled coil   Complete proteome   Cytoplasm   Cytoskeleton   Microtubule   Phosphoprotein   Reference proteome   Transport   Alternative splicing   Cell cycle   Cell division   Centromere   Chromosome   Developmental protein   Differentiation   Kinetochore   Lipoprotein   Lissencephaly   Mitosis   Neurogenesis   Palmitate  

Feature

chain  Nuclear distribution protein nudE-like 1-B
splice variant  In isoform 2.

Uniprot

H9JCK2   A0A3S2P3A2   A0A2A4JU80   A0A194QCV7   A0A194QX21   A0A212F6H6   + More
A0A2D0Q421   K9III5   A0A3B1K1X6   A0A3Q0RSN3   A0A3B4EG99   A0A3Q3BNM0   A0A3P9D3G5   A0A3P8QYJ8   A0A3B4FPM0   A0A3Q1JNV9   A0A3Q7SEE4   A0A2K6SFX6   A7SPT5   G5AK09   F6X6L7   A0A3Q2HSQ5   L5M6F0   A0A2K6SFU9   A0A2K6SFU7   A0A287BHJ3   S7PS52   A0A3Q7MU00   F6WM97   A0A091QFY1   I3L8G0   U6CS63   A0A3Q7P6W8   A0A287AZB1   A0A2U3XB89   A0A2Y9HX88   G3TE08   A0A3Q2KLE7   F7CL14   A0A2K5PNP9   A0A340Y3L2   A0A341BAY5   A0A2Y9LER2   A0A2U4ATB0   A0A2Y9LLZ9   A0A341BBB3   A0A2Y9LRY1   A0A2Y9KFB8   A0A341BEG3   A0A2Y9LH55   A0A3Q7Y9M5   A0A2U4AT96   H0WN99   A0A341BCW5   A0A2Y9LH50   A0A2Y9LEH7   A0A3Q7WT80   A0A060W9B3   A0A2Y9LEQ7   M3YS77   G1SD04   L9KXL8   A0A2Y9KSQ5   A0A2K5PNL9   A0A093SVZ7   A0A093NBL7   A0A2K5PNL5   B2GRS6   Q803Q2   A0A384BVE7   A0A3Q7WVA5   A0A2K6DJ70   A0A2K5KMY0   A0A1U7SL92   A0A2J8IPJ6   A0A093ICX5   A0A2K6JR18   A0A2K6PFW5   F7AU88   A0A2K5KN04   A0A093C364   A0A2K5KMX3   A0A096NLV7   G3W7T6   A0A250YFD2   A0A2K6DJ87   G7Q0J8   A0A3Q2DNZ5   A0A2K6JR41   A0A2K6PFW8   A0A3Q0EC48   A0A091NI17   Q9NXR1-1   A0A384CJX1   U6CUR5   A0A3Q7SWD1   A0A2U3VTA3   A0A2Y9HF52   A0A3Q7NFV8  

Pubmed

19121390    26354079    22118469    25329095    25186727    17615350    + More
21993625    16341006    19892987    17495919    24755649    21993624    23385571    25362486    21709235    28087693    22002653    14702039    15616553    15489334    12556484    16291865    16682949    17600710    18220336    18669648    19927128    20068231    21529752    21529751    22526350    23186163    24275569    24813606   

EMBL

BABH01039082    RSAL01000036    RVE51262.1    NWSH01000569    PCG75587.1    KQ459232    + More
KPJ02815.1    KQ461155    KPJ08121.1    AGBW02010016    OWR49333.1    GABZ01006835    JAA46690.1    DS469737    EDO34270.1    JH165553    GEBF01003213    EHA97369.1    JAO00420.1    AAEX03004498    KB104461    ELK33288.1    AEMK02000014    KE163235    EPQ11317.1    KK698649    KFQ25925.1    HAAF01001333    CCP73159.1    AAQR03077633    AAQR03077634    AAQR03077635    FR904390    CDQ61814.1    AEYP01027378    AEYP01027379    AEYP01027380    AEYP01027381    AAGW02057154    AAGW02057155    AAGW02057156    KB320604    ELW67680.1    KL672660    KFW86684.1    KL224628    KFW62343.1    BC165239    AAI65239.1    BC044386    NBAG03000658    PNI12438.1    KK591609    KFW00530.1    KL232548    KFV06697.1    AHZZ02018409    AEFK01165078    AEFK01165079    AEFK01165080    AEFK01165081    AEFK01165082    AEFK01165083    AEFK01165084    AEFK01165085    AEFK01165086    AEFK01165087    GFFW01002441    JAV42347.1    CM001295    EHH60186.1    KL383607    KFP89111.1    AK000108    AC026401    AF001548    BC001421    BC033900    HAAF01002390    CCP74216.1   

Proteomes

UP000005204    UP000283053    UP000218220    UP000053268    UP000053240    UP000007151    + More
UP000221080    UP000018467    UP000261340    UP000261440    UP000264840    UP000265160    UP000265100    UP000261460    UP000265040    UP000286640    UP000233220    UP000001593    UP000006813    UP000002254    UP000002281    UP000008227    UP000286641    UP000245341    UP000248481    UP000007646    UP000002280    UP000233040    UP000265300    UP000252040    UP000248483    UP000245320    UP000248482    UP000286642    UP000005225    UP000193380    UP000000715    UP000001811    UP000011518    UP000053258    UP000054081    UP000000437    UP000261680    UP000233120    UP000233060    UP000189705    UP000233180    UP000233200    UP000008225    UP000028761    UP000007648    UP000009130    UP000265020    UP000189704    UP000005640    UP000291021    UP000245340   

PRIDE

H9JCK2    I3L8G0    Q803Q2    Q9NXR1   

Pfam

PF04880   NUDE_C

Interpro

IPR033494   NUDE        + More
IPR006964   NUDE_dom       
IPR033493   NDEL1       

ProteinModelPortal

H9JCK2   A0A3S2P3A2   A0A2A4JU80   A0A194QCV7   A0A194QX21   A0A212F6H6   + More
A0A2D0Q421   K9III5   A0A3B1K1X6   A0A3Q0RSN3   A0A3B4EG99   A0A3Q3BNM0   A0A3P9D3G5   A0A3P8QYJ8   A0A3B4FPM0   A0A3Q1JNV9   A0A3Q7SEE4   A0A2K6SFX6   A7SPT5   G5AK09   F6X6L7   A0A3Q2HSQ5   L5M6F0   A0A2K6SFU9   A0A2K6SFU7   A0A287BHJ3   S7PS52   A0A3Q7MU00   F6WM97   A0A091QFY1   I3L8G0   U6CS63   A0A3Q7P6W8   A0A287AZB1   A0A2U3XB89   A0A2Y9HX88   G3TE08   A0A3Q2KLE7   F7CL14   A0A2K5PNP9   A0A340Y3L2   A0A341BAY5   A0A2Y9LER2   A0A2U4ATB0   A0A2Y9LLZ9   A0A341BBB3   A0A2Y9LRY1   A0A2Y9KFB8   A0A341BEG3   A0A2Y9LH55   A0A3Q7Y9M5   A0A2U4AT96   H0WN99   A0A341BCW5   A0A2Y9LH50   A0A2Y9LEH7   A0A3Q7WT80   A0A060W9B3   A0A2Y9LEQ7   M3YS77   G1SD04   L9KXL8   A0A2Y9KSQ5   A0A2K5PNL9   A0A093SVZ7   A0A093NBL7   A0A2K5PNL5   B2GRS6   Q803Q2   A0A384BVE7   A0A3Q7WVA5   A0A2K6DJ70   A0A2K5KMY0   A0A1U7SL92   A0A2J8IPJ6   A0A093ICX5   A0A2K6JR18   A0A2K6PFW5   F7AU88   A0A2K5KN04   A0A093C364   A0A2K5KMX3   A0A096NLV7   G3W7T6   A0A250YFD2   A0A2K6DJ87   G7Q0J8   A0A3Q2DNZ5   A0A2K6JR41   A0A2K6PFW8   A0A3Q0EC48   A0A091NI17   Q9NXR1-1   A0A384CJX1   U6CUR5   A0A3Q7SWD1   A0A2U3VTA3   A0A2Y9HF52   A0A3Q7NFV8  

PDB

2V71     E-value=2.28806e-22,     Score=259

KEGG

101746567    K16738 nuclear distribution protein NudE | (RefSeq) nuclear distribution protein nudE-like 1-B

GO

GO:2000574   GO:0007399   GO:0060052   GO:0007100   GO:0007020   GO:0045202   GO:0042802   GO:0051298   GO:0008017   GO:0000776   GO:0007405   GO:0047496   GO:0000132   GO:0031616   GO:0001764   GO:0051303   GO:0021987   GO:0051642   GO:0005813   GO:0016477   GO:0005871   GO:0007059   GO:0032418   GO:0090630   GO:0021955   GO:1990138   GO:1900029   GO:0043203   GO:0008090   GO:0021799   GO:0031252   GO:0043014   GO:0048487   GO:0060053   GO:0001833   GO:0010975   GO:0008021   GO:0033157   GO:0008286   GO:1904115   GO:0005874   GO:0005819   GO:0005737   GO:0005875   GO:0010389   GO:0000777   GO:0000086   GO:0005829   GO:0032154   GO:0097711   GO:0019904   GO:0016020   GO:0051301  

PANTHER

PTHR10921   PTHR10921:SF0  

Subcellular location

Cytoplasm   Localizes to the interphase centrosome and the mitotic spindle.   With evidence from 1 publications.
Cytoskeleton   Localizes to the interphase centrosome and the mitotic spindle.   With evidence from 1 publications.
Microtubule organizing center   Localizes to the interphase centrosome and the mitotic spindle.   With evidence from 1 publications.
Centrosome   Localizes to the interphase centrosome and the mitotic spindle.   With evidence from 1 publications.
Spindle   Localizes to the interphase centrosome and the mitotic spindle.   With evidence from 1 publications.
Chromosome  
Centromere  
Kinetochore  
Cleavage furrow  

Length:

283

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.00039

Exp number, first 60 AAs:

0

Total prob of N-in:

0.09708

outside

1  -  283

 

 

Pi

212.731969

Theta

179.927267

Tajima's D

0.463238

CLR

0

CSRT

0.502124893755312

Interpretation

Uncertain