Gene

KWMTBOMO10342

Pre Gene Modal

BGIBMGA007228

Annotation

potassium_coupled_amino_acid_transporter_[Manduca_sexta]

Location

Bomo_Chr17(-):7920322-7934292      View in EpiBrowser

Full name

Transporter       + More
Sodium-dependent nutrient amino acid transporter 1      

Location in the cell

PlasmaMembrane   Reliability : 4.949

CDS

ATGAGTCAAACACATGTGAACAATGGGTTCGACATGTCCTCGGAGAATCCTCCGACGGACAGGGACCCGTCATTGAATCGTCCAGGATCACCCAAGCCGAAGCGATCCACAAAACCTGATCTACCTCCTCCGGCACTGAAGGTTCCAGTCAATGAAAAGAAGGCTTTCGAAGATATAGAAGGTGCTCCTGAACGTATGATGTGGTCTAATCAAATTGAATTCCTCATGTCGTGCATCGCTACATCAGTGGGCTTAGGCAACGTATGGCGGTTTCCATTCGTTGCATATCAAAATGGCGGCGGGGCCTTCCTTATACCCTATATCATAGTGTTGTTTTTAGTCGGCAAACCCATGTACTACCTCGAATGTGTTTTGGGACAGTTTAGTTCGAGAAATTCTGTCAAAGTTTGGTCTTTATCACCAGCAATGAAAGGAACCGGCTATGCTCAAGCTTTGGGTTGCGGATACATCCTATCTTACTACGTAGTAATTGTTGGTCTATGCCTGTATTATTTGTCAATGAGTTTCCAGTCTACACTGCCATGGGCTGTTTGTGAACCTGGTTGGGAAAACTGCGTGCCTTCGGATCCTAACAGTGCCCCAGTTGGAACCGTAGTCAACGGCACCAGTAGCGCGGAGCTTTACTTCTTGAGAACAGTTCTTCAGCAAAGCGATGGTATCGAAGGCGGACTCGGCGCTCCTATATGGTACCTGACCTTATGTTTGCTCGCAACGTGGGTGATTATTTTTGTCATCGTCGCACAAGGCGTGAAGAGTTCTGGCAAGGCTGCATACTTCCTAGCTTTGTTCCCCTATGTCGTTATGATCATATTGTTCATAACGACTGTAATTTTACCCGGAGCTGGTACGGGAATCCTCTTCTTCATAACGCCTCAATGGAGTAAACTATTAGAGTTAGACGTATGGTATGCTGCAGTAACGCAAGTATTCTTCTCGTTAACAGTTTGCACTGGAGCTATCATCATGTTCTCATCCTATAATGGTTTCAAACAAAATGTCTACAGAGATGCAATGATTGTTACAACTTTGGACACCCTCACAAGTTTGCTATCCGGCTTTACTATTTTCGGTATCCTCGGTAACTTGGCTAATGAACTAAATTCTCGAGTAGAAGATGTGGTCGGCTCTGGAGGAACCGGACTAGCTTTCATCTCGTACCCTGACGCCATTGCAAAAACGTTCATGCCACAGTTGTTCTCAGTTCTGTTCTTCCTGATGATGGCTGTGCTGGGTGTGGGTTCATCTGTGGCTCTTTTGTCGACCATCAACACTGTAGTGATGGACGCTTTCCCCAACGTTCCCACAGTGTTCATGTCGGCTCTCTGCTGTACCGTTGGATTTTTAGTGGGACTTGTTTACGTCACACCTGGTGGACAATATATATTGGAGCTTGTCGATTACTACGGTGGAACGTTTTTAGTATTATTCTGCGCCATTGCTGAAATTATTGGTGTATTCTGGATATACGGCTTAGAGAATCTGTGCCTCGACATCGAATACATGTTGGATATAAAGACGTCTCCTTACTGGCGCATGTGTTGGGGTCTGATCACGCCAGCCATGATGATTATTGTATTCCTGTACGCACTGATTTCATACGAAGCATTGCTCTTCGGAGGAATGGCCGGATATGTGGCTGGTTACCTGTTGTTGATCGTGGGTATTTTGTTGGTACCGATTTCCATCTGCCTTACATTGTACAAGTACAGGACTGGAAACTTCATTGAGACTCTAAAGCTTTCTTTCCGCTCCAAGGAATCTTGGGGTCCAAGATCAGCTGGCGAACGCAGAACCTGGCTTTCATTTAAAGAAGACGCGAAAGTATTACGAGAAAAACTTAATCCCTCACGAATCACGCATGTCTGGTATAGTTTAATAGGAAGCTACAGACGACGAATCTAA

Protein

MSQTHVNNGFDMSSENPPTDRDPSLNRPGSPKPKRSTKPDLPPPALKVPVNEKKAFEDIEGAPERMMWSNQIEFLMSCIATSVGLGNVWRFPFVAYQNGGGAFLIPYIIVLFLVGKPMYYLECVLGQFSSRNSVKVWSLSPAMKGTGYAQALGCGYILSYYVVIVGLCLYYLSMSFQSTLPWAVCEPGWENCVPSDPNSAPVGTVVNGTSSAELYFLRTVLQQSDGIEGGLGAPIWYLTLCLLATWVIIFVIVAQGVKSSGKAAYFLALFPYVVMIILFITTVILPGAGTGILFFITPQWSKLLELDVWYAAVTQVFFSLTVCTGAIIMFSSYNGFKQNVYRDAMIVTTLDTLTSLLSGFTIFGILGNLANELNSRVEDVVGSGGTGLAFISYPDAIAKTFMPQLFSVLFFLMMAVLGVGSSVALLSTINTVVMDAFPNVPTVFMSALCCTVGFLVGLVYVTPGGQYILELVDYYGGTFLVLFCAIAEIIGVFWIYGLENLCLDIEYMLDIKTSPYWRMCWGLITPAMMIIVFLYALISYEALLFGGMAGYVAGYLLLIVGILLVPISICLTLYKYRTGNFIETLKLSFRSKESWGPRSAGERRTWLSFKEDAKVLREKLNPSRITHVWYSLIGSYRRRI

Description

Unusual broad substrate spectrum amino acid:sodium cotransporter that promotes absorption of the D isomers of essential amino acids. Neutral amino acids are the preferred substrates, especially methionine and phenylalanine (By similarity).
Unusual broad substrate spectrum amino acid:sodium cotransporter that promotes absorption of the D isomers of essential amino acids. Neutral amino acids are the preferred substrates, especially methionine and phenylalanine.

Similarity

Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.

Keywords

Amino-acid transport   Complete proteome   Glycoprotein   Ion transport   Membrane   Sodium   Sodium transport   Symport   Transmembrane   Transmembrane helix   Transport   Reference proteome  

Feature

chain  Sodium-dependent nutrient amino acid transporter 1

Uniprot

H9JCI3   O76188   Q9U5A9   A0A194QSZ7   A0A194QH91   A0A2H1VRW7   + More
A0A2A4JUB4   A0A2A4JNI2   A0A1E1VZ02   B2ZXL8   A0A3S2M4K9   A0A2A4JN91   A0A2A4JPM7   A0A2A4JQ43   A0A2A4JQ17   A0A2H1VSW1   A0A212EKM3   A0A1E1WV88   A0A1E1W207   A0A212EKP1   A0A2J7PKX9   A0A1I8Q6E3   A0A2J7PKT0   A0A088AJX5   A0A0L7RF06   A0A310SK53   A0A1Q3G5A3   A0A232F021   Q6VS78   E0VLW4   B3NV41   Q16YU3   A0A1B0B655   J9HFX8   Q8IST0   A0A1A9XLV3   A0A1A9WAV7   A0A067RFW9   A0A0K8TP80   U5EJQ1   A0A195DL34   A0A1I8MYH7   A0A1J1HQJ1   B4NDL8   B4GVM9   B4L7U0   D6WWF3   A0A310S8Y0   A0A3L8DNA2   B4PZQ4   B4R4T6   A0A088AJW4   A0A0L0BU43   B4MEG2   A0A3B0JYF6   A0A2A3ECG5   A0A088AJX6   Q29GB8   C7LA87   A0A2A3EB77   A0A0A1XSM6   Q9W4C5   A0A1W4V6M6   A0A336LX44   A0A1B0AE48   A0A3L8DT63   A0A1A9UT47   E2AWU5   E2BSN7   A0A158NLY9   A0A1B0B654   A0A0K8V9C6   A0A336KAS2   A0A0P6GKY2   A0A1L8DK96   A0A1L8DJX3   A0A182GFI3   A0A0P5G743   A0A336KF85   A0A1B0DCW8   A0A151XF32   A0A0P6HGT0   A0A1L8DJX4   A0A0N8A3A2   B5DZG7   A0A0M9ABU2   A0A0R3NLF5   A0A0M4E615   A0A3B0J223   A0A0P5RG87   E9G979   A0A034WJ71   A0A182GIY5   A0A0A1XHG2   A0A3B0JVN4   B4GDP4   A0A0M4EX99   A0A158NLY7  

Pubmed

19121390    9560287    10829035    26354079    18495929    22118469    + More
28648823    20566863    17994087    17510324    24845553    26369729    25315136    18362917    19820115    30249741    26108605    15632085    25830018    18718864    10731132    12537572    12537569    17893096    20798317    21347285    26483478    21292972    25348373   

EMBL

BABH01039076    BABH01039077    BABH01039078    BABH01039079    AF006063    AAC24190.1    + More
AF013963    AAF18560.1    KQ461155    KPJ08125.1    KQ459232    KPJ02811.1    ODYU01004070    SOQ43560.1    NWSH01000569    PCG75591.1    NWSH01000921    PCG73531.1    GDQN01011140    JAT79914.1    AB365597    BAG39453.1    RSAL01000036    RVE51256.1    PCG73535.1    PCG73534.1    PCG73532.1    PCG73533.1    SOQ43562.1    AGBW02014242    OWR42034.1    GDQN01004191    GDQN01000328    JAT86863.1    JAT90726.1    GDQN01010095    JAT80959.1    OWR42035.1    NEVH01024531    PNF16994.1    PNF16938.1    KQ414608    KOC69394.1    KQ763581    OAD54951.1    GFDL01000068    JAV34977.1    NNAY01001443    OXU23962.1    AY330296    AAR08269.1    DS235282    EEB14370.1    CH954180    EDV45889.1    CH477509    EAT39788.1    JXJN01008983    EJY57747.1    AF543193    AAN40410.1    KK852489    KDR22766.1    GDAI01001449    JAI16154.1    GANO01002161    JAB57710.1    KQ980762    KYN13552.1    CVRI01000017    CRK90243.1    CH964239    EDW81840.1    CH479193    EDW26724.1    CH933814    EDW05515.1    KQ971361    EFA08708.1    OAD54950.1    QOIP01000006    RLU21298.1    CM000162    EDX01121.1    CM000366    EDX17133.1    JRES01001335    KNC23567.1    CH940664    EDW62937.1    OUUW01000003    SPP78406.1    KZ288308    PBC28721.1    CH379064    EAL32192.1    BT099637    ACU68946.1    PBC28724.1    GBXI01000417    JAD13875.1    DQ073009    AE014298    AY121662    AAF46031.2    AAM51989.1    UFQS01000248    UFQT01000248    SSX01993.1    SSX22370.1    QOIP01000004    RLU23635.1    GL443425    EFN62065.1    GL450241    EFN81283.1    ADTU01020082    ADTU01020083    ADTU01020084    ADTU01020085    ADTU01020086    ADTU01020087    ADTU01020088    ADTU01020089    ADTU01020090    ADTU01020091    JXJN01008984    GDHF01016852    JAI35462.1    SSX01994.1    SSX22371.1    GDIQ01033961    JAN60776.1    GFDF01007320    JAV06764.1    GFDF01007322    JAV06762.1    JXUM01010513    KQ560310    KXJ83117.1    GDIQ01245340    JAK06385.1    SSX01995.1    SSX22372.1    AJVK01014254    KQ982205    KYQ59002.1    GDIQ01028602    JAN66135.1    GFDF01007321    JAV06763.1    GDIP01186721    LRGB01001348    JAJ36681.1    KZS12914.1    CM000071    EDY68808.1    KQ435689    KOX81270.1    KRT01700.1    CP012524    ALC41841.1    OUUW01000001    SPP75127.1    GDIQ01101096    JAL50630.1    GL732535    EFX84094.1    GAKP01004550    JAC54402.1    JXUM01067031    JXUM01067032    JXUM01067033    JXUM01067034    JXUM01067035    JXUM01067036    KQ562429    KXJ75930.1    GBXI01003895    JAD10397.1    SPP75128.1    CH479181    EDW31701.1    CP012528    ALC48305.1    ADTU01019952    ADTU01019953    ADTU01019954    ADTU01019955    ADTU01019956    ADTU01019957    ADTU01019958    ADTU01019959    ADTU01019960    ADTU01019961   

Proteomes

UP000005204    UP000053240    UP000053268    UP000218220    UP000283053    UP000007151    + More
UP000235965    UP000095300    UP000005203    UP000053825    UP000215335    UP000009046    UP000008711    UP000008820    UP000092460    UP000092443    UP000091820    UP000027135    UP000078492    UP000095301    UP000183832    UP000007798    UP000008744    UP000009192    UP000007266    UP000279307    UP000002282    UP000000304    UP000037069    UP000008792    UP000268350    UP000242457    UP000001819    UP000000803    UP000192221    UP000092445    UP000078200    UP000000311    UP000008237    UP000005205    UP000069940    UP000249989    UP000092462    UP000075809    UP000076858    UP000053105    UP000092553    UP000000305   

PRIDE

H9JCI3    B2ZXL8    B4GVM9    B4L7U0    B4MEG2    Q29GB8    + More
C7LA87    Q9W4C5   

Pfam

PF00209   SNF        + More
PF00246   Peptidase_M14

Interpro

IPR000175   Na/ntran_symport        + More
IPR037272   SNS_sf       
IPR000834   Peptidase_M14       

SUPFAM

SSF161070   SSF161070       

ProteinModelPortal

H9JCI3   O76188   Q9U5A9   A0A194QSZ7   A0A194QH91   A0A2H1VRW7   + More
A0A2A4JUB4   A0A2A4JNI2   A0A1E1VZ02   B2ZXL8   A0A3S2M4K9   A0A2A4JN91   A0A2A4JPM7   A0A2A4JQ43   A0A2A4JQ17   A0A2H1VSW1   A0A212EKM3   A0A1E1WV88   A0A1E1W207   A0A212EKP1   A0A2J7PKX9   A0A1I8Q6E3   A0A2J7PKT0   A0A088AJX5   A0A0L7RF06   A0A310SK53   A0A1Q3G5A3   A0A232F021   Q6VS78   E0VLW4   B3NV41   Q16YU3   A0A1B0B655   J9HFX8   Q8IST0   A0A1A9XLV3   A0A1A9WAV7   A0A067RFW9   A0A0K8TP80   U5EJQ1   A0A195DL34   A0A1I8MYH7   A0A1J1HQJ1   B4NDL8   B4GVM9   B4L7U0   D6WWF3   A0A310S8Y0   A0A3L8DNA2   B4PZQ4   B4R4T6   A0A088AJW4   A0A0L0BU43   B4MEG2   A0A3B0JYF6   A0A2A3ECG5   A0A088AJX6   Q29GB8   C7LA87   A0A2A3EB77   A0A0A1XSM6   Q9W4C5   A0A1W4V6M6   A0A336LX44   A0A1B0AE48   A0A3L8DT63   A0A1A9UT47   E2AWU5   E2BSN7   A0A158NLY9   A0A1B0B654   A0A0K8V9C6   A0A336KAS2   A0A0P6GKY2   A0A1L8DK96   A0A1L8DJX3   A0A182GFI3   A0A0P5G743   A0A336KF85   A0A1B0DCW8   A0A151XF32   A0A0P6HGT0   A0A1L8DJX4   A0A0N8A3A2   B5DZG7   A0A0M9ABU2   A0A0R3NLF5   A0A0M4E615   A0A3B0J223   A0A0P5RG87   E9G979   A0A034WJ71   A0A182GIY5   A0A0A1XHG2   A0A3B0JVN4   B4GDP4   A0A0M4EX99   A0A158NLY7  

PDB

4XPT     E-value=2.46203e-90,     Score=849

KEGG

101746144    K05038 solute carrier family 6 (neurotransmitter transporter, glycine) member 5/9 | (RefSeq) sodium-

GO

GO:0005328   GO:0016021   GO:0004181   GO:0008270   GO:0015293   GO:0005283   GO:0015175   GO:0015804   GO:0042943   GO:0015179   GO:0042940   GO:0005887   GO:0006814   GO:0005886   GO:0006836   GO:0005326   GO:0015807   GO:0003333   GO:0005416   GO:0005515   GO:0006415   GO:0006418   GO:0003723   GO:0046872   GO:0003824  

PANTHER

PTHR11616  

Subcellular location

Membrane  

Length:

640

Number of predicted TMHs:

12

Exp number of AAs in TMHs:

266.98648

Exp number, first 60 AAs:

0

Total prob of N-in:

0.68319

inside

1  -  73

TMhelix

74  -  93

outside

94  -  102

TMhelix

103  -  125

inside

126  -  151

TMhelix

152  -  174

outside

175  -  234

TMhelix

235  -  257

inside

258  -  263

TMhelix

264  -  296

outside

297  -  310

TMhelix

311  -  333

inside

334  -  344

TMhelix

345  -  367

outside

368  -  403

TMhelix

404  -  426

inside

427  -  438

TMhelix

439  -  461

outside

462  -  475

TMhelix

476  -  498

inside

499  -  518

TMhelix

519  -  541

outside

542  -  550

TMhelix

551  -  573

inside

574  -  640

 

 

Pi

208.413179

Theta

174.320169

Tajima's D

0.689516

CLR

0.073049

CSRT

0.565871706414679

Interpretation

Uncertain