Gene

KWMTBOMO10341

Pre Gene Modal

BGIBMGA007228

Annotation

putative_amino_acid_transporter_[Bombyx_mori]

Location

Bomo_Chr17(-):7906455-7914632      View in EpiBrowser

Full name

Transporter       + More
Sodium-dependent nutrient amino acid transporter 1      

Location in the cell

PlasmaMembrane   Reliability : 4.861

CDS

ATGGATTCAAATGGGATAAATGAAAAGGGGGATCGGGTGAACGCGGGATTTGATCCATCGCCAGAAAATGTTAATGATTTAAAGGCTATCGACAACGAAGATGGGAAGAAAAGAAACGTGGCTGAGCGCCCAACATGGGACAATCAAATCGAGTTTCTTATGTCTTGCATCGCCACATCGGTTGGTCTCGGAAACGTATGGCGGTTTCCTTTCGTCGCCTACCAAAACGGCGGTGGAGCCTTCCTAATTCCATACATAATAGTACTTTTAGTCATAGGCAAACCTATGTACTTCCTCGAAACAGTACTCGGGCAGTTTAGCAGCGGGAACTGCGTCAAGATCTGGGCATTGTCTCCGGCTATGACCGGTACTGGATACGCACAGACCTTGGGGGCCGTCTACGTGCTTTCGTACTACGTATCAATCATCGCCCTTTGCCTTTACTACTTCGGAGTGAGCTTTAACGCGACCTTACCTTGGACACAATGCCTACCCGAGTGGAGGAACTGTGTGCCTTCAGGACAATCCGCAAATCTTACTGAAATACAAGGTGAAGCCGTCAGTAGCGCCCAACTATACTTCACGGAGACGGTTTTACGTCAATCCGACAGAATAGATGATGGAATCGGAATTCCGATATGGGATCTCACTTTGTGTCTGCTGGTATCGTGGCTTATAATTTTTGTCATCGTGGCCAGAGGTGTGAAGAGTTCTGGCAAGGCTGCTTATTTTCTCGCTCTCTTCCCATACGTAGTTATGTTTATTTTATTGATTAGGGCTGTGACCTTACCAGGTGCCGGTAATGGAATCCTGTTTTTCATTACGCCTCAATGGTCAAAAATCCTTGAAGTCAGGGTAAGAAAATACTTCAAATTTTACACAGACCTTGTTCTTTTAATTGAATTTTTTAATGTTAATCATTTATTTAATCGTTACAACTTAAGGTACAACAAGGAAAGATAG

Protein

MDSNGINEKGDRVNAGFDPSPENVNDLKAIDNEDGKKRNVAERPTWDNQIEFLMSCIATSVGLGNVWRFPFVAYQNGGGAFLIPYIIVLLVIGKPMYFLETVLGQFSSGNCVKIWALSPAMTGTGYAQTLGAVYVLSYYVSIIALCLYYFGVSFNATLPWTQCLPEWRNCVPSGQSANLTEIQGEAVSSAQLYFTETVLRQSDRIDDGIGIPIWDLTLCLLVSWLIIFVIVARGVKSSGKAAYFLALFPYVVMFILLIRAVTLPGAGNGILFFITPQWSKILEVRVRKYFKFYTDLVLLIEFFNVNHLFNRYNLRYNKER

Description

Unusual broad substrate spectrum amino acid:sodium cotransporter that promotes absorption of the D isomers of essential amino acids. Neutral amino acids are the preferred substrates, especially methionine and phenylalanine (By similarity).
Unusual broad substrate spectrum amino acid:sodium cotransporter that promotes absorption of the D isomers of essential amino acids. Neutral amino acids are the preferred substrates, especially methionine and phenylalanine.

Similarity

Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.

Keywords

Amino-acid transport   Complete proteome   Glycoprotein   Ion transport   Membrane   Reference proteome   Sodium   Sodium transport   Symport   Transmembrane   Transmembrane helix   Transport  

Feature

chain  Sodium-dependent nutrient amino acid transporter 1

Uniprot

B2ZXL8   H9JCI3   A0A212EKM3   A0A2A4JN91   A0A2A4JPM7   A0A3S2M4K9   + More
A0A2H1VSW1   A0A194QH91   A0A2A4JQ17   A0A194QSZ7   A0A1E1WBM9   A0A1E1W207   A0A1E1WV88   A0A1E1VZ02   A0A2A4JUB4   A0A2H1VRW7   Q9U5A9   O76188   A0A2A4JQ43   A0A2A4JNI2   A0A1B0D3N9   A0A1A9ZF52   A0A1A9XLV3   A0A1B0B655   A0A310SK53   A0A182GXE6   E0VLW4   A0A1A9UT47   A0A0A1XSM6   A0A2J7PKX9   A0A0L7RF06   A0A164Z6E4   A0A3L8DT63   A0A1A9WAV7   A0A310S8Y0   A0A1B0CRI9   A0A1W4V6M6   A0A0K8V9C6   A0A0N8D7Z5   A0A1I8Q6E3   B4L7U0   A0A232F021   A0A3L8DNA2   A0A2J7PKT0   A0A0P4XUC5   A0A2A3EBQ2   A0A158NLY9   B4NDL8   A0A088AJX5   A0A3B0JYF6   Q6VS78   Q28XZ8   A0A088AJX6   J9HFX8   B4GVM9   A0A1B0G2B5   U5EJQ1   B4GGC9   Q8SYT9   A0A0R3NP58   A0A0P5Q7L1   B4PZQ4   A0A1Q3G5A3   Q29GB8   Q16YU3   B3MRS1   A0A0N8BQ01   A0A0C9S2X2   E2BHK8   B3NV41   C7LA87   Q9W4C5   Q8IST0   A0A0P5G5R9   E2BSN7   B4R4T6   A0A0N8CKC2   A0A1J1J6L0   B4MQK5   A0A1I8N4K6   A0A0P5DXW6   A0A1L8DJU2   A0A0P6FTX1   A0A0P6IQL3   A0A0P4XYZ3   A0A0P5PYZ6   A0A0P5LMR0   A0A1L8DK18   A0A0P5MAD8   A0A067RFW9   E9IKJ8   A0A0P5SH87   A0A0P5XS43   A0A0P5P0Z5   A0A0P5NF57   B0WYH0   A0A1I8MYH7   A0A0P6GLT1   A0A0P5UBD4  

Pubmed

18495929    19121390    22118469    26354079    10829035    9560287    + More
26483478    20566863    25830018    30249741    17994087    28648823    21347285    15632085    17510324    20798317    18718864    10731132    12537572    12537569    17893096    25315136    24845553    21282665   

EMBL

AB365597    BAG39453.1    BABH01039076    BABH01039077    BABH01039078    BABH01039079    + More
AGBW02014242    OWR42034.1    NWSH01000921    PCG73535.1    PCG73534.1    RSAL01000036    RVE51256.1    ODYU01004070    SOQ43562.1    KQ459232    KPJ02811.1    PCG73533.1    KQ461155    KPJ08125.1    GDQN01006688    JAT84366.1    GDQN01010095    JAT80959.1    GDQN01004191    GDQN01000328    JAT86863.1    JAT90726.1    GDQN01011140    JAT79914.1    NWSH01000569    PCG75591.1    SOQ43560.1    AF013963    AAF18560.1    AF006063    AAC24190.1    PCG73532.1    PCG73531.1    AJVK01003076    AJVK01003077    AJVK01003078    JXJN01008983    KQ763581    OAD54951.1    JXUM01095215    JXUM01095216    JXUM01095217    JXUM01095218    KQ564180    KXJ72615.1    DS235282    EEB14370.1    GBXI01000417    JAD13875.1    NEVH01024531    PNF16994.1    KQ414608    KOC69394.1    LRGB01000781    KZS15997.1    QOIP01000004    RLU23635.1    OAD54950.1    AJWK01024833    AJWK01024834    GDHF01016852    JAI35462.1    GDIP01059887    JAM43828.1    CH933814    EDW05515.1    NNAY01001443    OXU23962.1    QOIP01000006    RLU21298.1    PNF16938.1    GDIP01238958    JAI84443.1    KZ288308    PBC28722.1    ADTU01020082    ADTU01020083    ADTU01020084    ADTU01020085    ADTU01020086    ADTU01020087    ADTU01020088    ADTU01020089    ADTU01020090    ADTU01020091    CH964239    EDW81840.1    OUUW01000003    SPP78406.1    AY330296    AAR08269.1    CM000071    EAL26168.3    CH477509    EJY57747.1    CH479193    EDW26724.1    CCAG010020761    GANO01002161    JAB57710.1    CH479183    EDW35549.1    AY071318    AAL48940.1    KRT02897.1    GDIQ01124476    JAL27250.1    CM000162    EDX01121.1    GFDL01000068    JAV34977.1    CH379064    EAL32192.1    EAT39788.1    CH902622    EDV34476.1    GDIQ01156251    JAK95474.1    GBYB01015246    JAG85013.1    GL448301    EFN84817.1    CH954180    EDV45889.1    BT099637    ACU68946.1    DQ073009    AE014298    AY121662    AAF46031.2    AAM51989.1    AF543193    AAN40410.1    GDIQ01253497    JAJ98227.1    GL450241    EFN81283.1    CM000366    EDX17133.1    GDIP01123271    JAL80443.1    CVRI01000070    CRL07420.1    CH963849    EDW74394.1    GDIP01167429    JAJ55973.1    GFDF01007368    JAV06716.1    GDIQ01053859    JAN40878.1    GDIQ01007327    JAN87410.1    GDIP01238678    JAI84723.1    GDIQ01122189    JAL29537.1    GDIQ01168559    JAK83166.1    GFDF01007367    JAV06717.1    GDIQ01170422    JAK81303.1    KK852489    KDR22766.1    GL763991    EFZ18898.1    GDIQ01093536    JAL58190.1    GDIP01068181    JAM35534.1    GDIQ01268049    GDIQ01141708    JAL10018.1    GDIQ01165667    GDIQ01165666    JAK86059.1    DS232189    EDS37047.1    GDIQ01031762    JAN62975.1    GDIP01119086    JAL84628.1   

Proteomes

UP000005204    UP000007151    UP000218220    UP000283053    UP000053268    UP000053240    + More
UP000092462    UP000092445    UP000092443    UP000092460    UP000069940    UP000249989    UP000009046    UP000078200    UP000235965    UP000053825    UP000076858    UP000279307    UP000091820    UP000092461    UP000192221    UP000095300    UP000009192    UP000215335    UP000242457    UP000005205    UP000007798    UP000005203    UP000268350    UP000001819    UP000008820    UP000008744    UP000092444    UP000002282    UP000007801    UP000008237    UP000008711    UP000000803    UP000000304    UP000183832    UP000095301    UP000027135    UP000002320   

PRIDE

B2ZXL8    H9JCI3    B4L7U0    B4GVM9    Q8SYT9    Q29GB8    + More
C7LA87    Q9W4C5   

Pfam

PF00209   SNF        + More
PF00246   Peptidase_M14
PF01423   LSM

Interpro

IPR037272   SNS_sf        + More
IPR000175   Na/ntran_symport       
IPR000834   Peptidase_M14       
IPR010920   LSM_dom_sf       
IPR034100   Sm_F       
IPR001163   LSM_dom_euk/arc       

SUPFAM

SSF161070   SSF161070        + More
SSF50182   SSF50182       

CDD

cd01722  Sm_F

ProteinModelPortal

B2ZXL8   H9JCI3   A0A212EKM3   A0A2A4JN91   A0A2A4JPM7   A0A3S2M4K9   + More
A0A2H1VSW1   A0A194QH91   A0A2A4JQ17   A0A194QSZ7   A0A1E1WBM9   A0A1E1W207   A0A1E1WV88   A0A1E1VZ02   A0A2A4JUB4   A0A2H1VRW7   Q9U5A9   O76188   A0A2A4JQ43   A0A2A4JNI2   A0A1B0D3N9   A0A1A9ZF52   A0A1A9XLV3   A0A1B0B655   A0A310SK53   A0A182GXE6   E0VLW4   A0A1A9UT47   A0A0A1XSM6   A0A2J7PKX9   A0A0L7RF06   A0A164Z6E4   A0A3L8DT63   A0A1A9WAV7   A0A310S8Y0   A0A1B0CRI9   A0A1W4V6M6   A0A0K8V9C6   A0A0N8D7Z5   A0A1I8Q6E3   B4L7U0   A0A232F021   A0A3L8DNA2   A0A2J7PKT0   A0A0P4XUC5   A0A2A3EBQ2   A0A158NLY9   B4NDL8   A0A088AJX5   A0A3B0JYF6   Q6VS78   Q28XZ8   A0A088AJX6   J9HFX8   B4GVM9   A0A1B0G2B5   U5EJQ1   B4GGC9   Q8SYT9   A0A0R3NP58   A0A0P5Q7L1   B4PZQ4   A0A1Q3G5A3   Q29GB8   Q16YU3   B3MRS1   A0A0N8BQ01   A0A0C9S2X2   E2BHK8   B3NV41   C7LA87   Q9W4C5   Q8IST0   A0A0P5G5R9   E2BSN7   B4R4T6   A0A0N8CKC2   A0A1J1J6L0   B4MQK5   A0A1I8N4K6   A0A0P5DXW6   A0A1L8DJU2   A0A0P6FTX1   A0A0P6IQL3   A0A0P4XYZ3   A0A0P5PYZ6   A0A0P5LMR0   A0A1L8DK18   A0A0P5MAD8   A0A067RFW9   E9IKJ8   A0A0P5SH87   A0A0P5XS43   A0A0P5P0Z5   A0A0P5NF57   B0WYH0   A0A1I8MYH7   A0A0P6GLT1   A0A0P5UBD4  

PDB

6DZZ     E-value=8.02488e-53,     Score=522

KEGG

100174816    K05038 solute carrier family 6 (neurotransmitter transporter, glycine) member 5/9 | (RefSeq) +nsd-2,

GO

GO:0016021   GO:0005328   GO:0015293   GO:0004181   GO:0008270   GO:0005283   GO:0015804   GO:0015175   GO:0015179   GO:0042943   GO:0005887   GO:0042940   GO:0006814   GO:0000387   GO:0005681   GO:0003333   GO:0006836   GO:0005326   GO:0005416   GO:0015807   GO:0005515   GO:0006415   GO:0006418   GO:0003723   GO:0046872   GO:0003824  

PANTHER

PTHR11616  

Subcellular location

Membrane  

Length:

320

Number of predicted TMHs:

5

Exp number of AAs in TMHs:

111.20085

Exp number, first 60 AAs:

2.27447

Total prob of N-in:

0.24294

outside

1  -  70

TMhelix

71  -  93

inside

94  -  129

TMhelix

130  -  152

outside

153  -  209

TMhelix

210  -  232

inside

233  -  240

TMhelix

241  -  263

outside

264  -  291

TMhelix

292  -  309

inside

310  -  320

 

 

Pi

191.656933

Theta

162.431584

Tajima's D

0.366903

CLR

100.679869

CSRT

0.470176491175441

Interpretation

Uncertain