Gene

KWMTBOMO10330  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA007233

Annotation

DID_protein_[Bombyx_mori]

Location

Bomo_Chr17(-):7770093-7771622      View in EpiBrowser

Full name

Elongator complex protein 6      

Alternative Name

Protein TMEM103

Location in the cell

Nuclear   Reliability : 1.806

CDS

ATGTCTGACATTATAACATCATGTCTACAATTGCAGAAAAATATATCTACCAACAGGATTGTGGTTAAAGAAATAAATGGTTGTGATGGTTCATTCATTGTCAATTGTGTTATCAGTTACTGTATTAAGCAAAACAGCCCTCTTTTGATAGTATCCTCACATAACTCAATAACTCATTACCACAATGTTGGTTTAAGAATGAACCATAATCTGTTTAAAAGTTGTGAGGCTGGGGTGATAGATTATTTTGATTTTGGTGACGCAACATTAACAAATATAATGGAGTATGCTGAATCTGATCAATTGCTCATAGATGTGCTGAAAAAAATAGAAGAAATGCAGCGTAATCATGACACAGTTAACATTATTTTTGATGGAATCACACATTTACTAGATCTTCAGTATACATTACAAGAAGTGAATAAGTTTTGTTCTGAAATTATAGAAATTGCTGCTAAATCAAAAAATCCTTTTGTAATATTTCATTGCAATGATGTGATGGAAGATGATGCTAACCACTGTTTGGCAAATTTGCTATCGCACAAAGCACAAACTGTGGTTGAAGTGGAAAACCTTTCTTCAGGATTGAGTTCAGATGTCTCAGGTCATTTGACAATAAAATATCCAGGAAACAAATTCAATGAAGAACACATACATACAGTGGATATGAAGCCAAAAAAATATCTTTATAAATTGTTTGACAGAGGAGTAAAATTGCTTGCACCTGGTACTGTTTAA

Protein

MSDIITSCLQLQKNISTNRIVVKEINGCDGSFIVNCVISYCIKQNSPLLIVSSHNSITHYHNVGLRMNHNLFKSCEAGVIDYFDFGDATLTNIMEYAESDQLLIDVLKKIEEMQRNHDTVNIIFDGITHLLDLQYTLQEVNKFCSEIIEIAAKSKNPFVIFHCNDVMEDDANHCLANLLSHKAQTVVEVENLSSGLSSDVSGHLTIKYPGNKFNEEHIHTVDMKPKKYLYKLFDRGVKLLAPGTV

Description

Acts as subunit of the RNA polymerase II elongator complex, which is a histone acetyltransferase component of the RNA polymerase II (Pol II) holoenzyme and is involved in transcriptional elongation. Elongator may play a role in chromatin remodeling and is involved in acetylation of histones H3 and probably H4. Involved in cell migration (By similarity).
Acts as subunit of the RNA polymerase II elongator complex, which is a histone acetyltransferase component of the RNA polymerase II (Pol II) holoenzyme and is involved in transcriptional elongation. Elongator may play a role in chromatin remodeling and is involved in acetylation of histones H3 and probably H4. Involved in cell migration.

Subunit

Component of the RNA polymerase II elongator complex (Elongator), which consists of ELP1, STIP1/ELP2, ELP3, ELP4, ELP5 and ELP6.

Similarity

Belongs to the ELP6 family.

Keywords

Complete proteome   Reference proteome   Transcription   Transcription regulation   Alternative splicing  

Feature

chain  Elongator complex protein 6
splice variant  In isoform 2.

Uniprot

Q2F5I8   H9JCI8   A0A0L7LQH1   A0A194QB34   A0A194QS90   S4PWR9   + More
A0A212EZY7   A0A067RHR5   A0A2J7QAD4   A0A2J7QAD5   E2AF91   A0A2P8ZCB7   B4HFU5   E9J5N6   B3P155   A0A0J7NFY5   A0A0L7RHW7   A0A026WGI4   A0A3L8DDH9   Q9NH01   B4PQ00   A0A195FTS6   E2B905   F4WS73   A0A0C9QP75   Q9VFW4   Q6NP11   B4R1A7   A0A1W4UK74   B3LX71   B4KA86   A0A151JNR3   A0A146LT93   Q29A19   B4G3M0   A0A0N0BCP5   A0A0P5IWI9   A0A1B0CKS0   A0A158NB78   A0A3B0K0P3   A0A154P888   A0A151I3I7   A0A0P5PYF1   A0A0P5JVP9   A0A0P6AZ51   A0A151I8E5   A0A0P6CZP9   A0A0M3QXP5   B4M6C2   D6WX79   B4NKC5   A0A1Q3G172   A0A1S4FX14   Q16LJ7   A0A232EWW8   B4JI64   A0A0P5IPS2   A0A0K8TL94   A0A0K8W1S0   A0A034W450   A0A2R7WK45   J3JWS7   A0A182GZY7   U5EX87   A0A023EYN2   A0A0A1WQD1   E9FTH6   W8CAI6   B3SA08   A0A1B6JGU2   A0A369S0F6   T1PAT2   A0A1I8PJU9   A0A1B6CDG3   A0A1Y3MVQ6   A0A2C9KGW8   A0A0K2V0A4   T2MDD9   A0A0K2V071   G3VV31   A0A1B6GCC5   A0A2I3HYW0   A0A1B6MU84   A0A1Y2ALX6   A0A1B6MI81   A0A2S2P358   A0A1J1HN44   A0A1Y1X978   A0A1Y1KF09   B2RYG8   A0A3L7HPD0   A0A0H2UH13   Q8BK75   G3R5Z3   Q8BK75-2   A0A2D0PRN0   U3FDE0   U3BAM8   A0A2K5DZJ5  

Pubmed

19121390    26227816    26354079    23622113    22118469    24845553    + More
20798317    29403074    17994087    21282665    24508170    30249741    17550304    21719571    10731132    12537568    12537572    12537573    12537574    16110336    17569856    17569867    26109357    26109356    18057021    26823975    15632085    23185243    21347285    18362917    19820115    17510324    28648823    26369729    25348373    22516182    23537049    26483478    25474469    25830018    21292972    24495485    18719581    30042472    25315136    15562597    24065732    21709235    28004739    15489334    29704459    12040188    19468303    16141072    22854966    22398555    25243066   

EMBL

DQ311435    ABD36379.1    BABH01039061    BABH01039062    JTDY01000329    KOB77675.1    + More
KQ459232    KPJ02753.1    KQ461155    KPJ08184.1    GAIX01006308    JAA86252.1    AGBW02011226    OWR47011.1    KK852498    KDR22573.1    NEVH01016331    PNF25544.1    PNF25543.1    GL439067    EFN67895.1    PYGN01000107    PSN54131.1    CH480815    EDW42330.1    GL768171    EFZ11867.1    CH954181    EDV49244.1    LBMM01005479    KMQ91480.1    KQ414588    KOC70450.1    KK107231    EZA55078.1    QOIP01000009    RLU18444.1    RLU18792.1    AF234629    AAF40432.1    CM000160    EDW97227.1    KRK03597.1    KQ981272    KYN43831.1    GL446405    EFN87839.1    GL888305    EGI62948.1    GBYB01005364    JAG75131.1    AE014297    BT081367    AAF54931.1    ACO34925.1    ADV37306.1    BT011120    AAR82787.1    CM000364    EDX13084.1    CH902617    EDV41671.1    KPU79287.1    CH933806    EDW14573.1    KRG01083.1    KQ978820    KYN28150.1    GDHC01007665    JAQ10964.1    CM000070    EAL27532.1    KRT00091.1    CH479179    EDW25028.1    KQ435908    KOX68998.1    GDIQ01209575    JAK42150.1    AJWK01016575    ADTU01010487    OUUW01000013    SPP87875.1    KQ434823    KZC07330.1    KQ976487    KYM83652.1    GDIQ01121701    GDIP01066823    LRGB01001937    JAL30025.1    JAM36892.1    KZS09907.1    GDIQ01193376    JAK58349.1    GDIP01028908    JAM74807.1    KQ978366    KYM94596.1    GDIQ01085167    JAN09570.1    CP012526    ALC46229.1    CH940652    EDW59198.1    KRF78749.1    KQ971361    EFA08802.1    CH964272    EDW84055.1    KRF99954.1    GFDL01001503    JAV33542.1    CH477903    EAT35193.1    NNAY01001816    OXU22836.1    CH916369    EDV92945.1    GDIQ01212473    JAK39252.1    GDAI01002650    JAI14953.1    GDHF01031003    GDHF01026311    GDHF01007544    JAI21311.1    JAI26003.1    JAI44770.1    GAKP01010052    GAKP01010051    GAKP01010050    JAC48900.1    KK854968    PTY20013.1    APGK01039001    BT127695    KB740966    KB632186    AEE62657.1    ENN76936.1    ERL89706.1    JXUM01022077    KQ560620    KXJ81575.1    GANO01002653    JAB57218.1    GBBI01005003    JAC13709.1    GBXI01013654    JAD00638.1    GL732524    EFX89633.1    GAMC01005721    JAC00835.1    DS985260    EDV20429.1    GECU01009256    GECU01001814    JAS98450.1    JAT05893.1    NOWV01000131    RDD39533.1    KA645260    AFP59889.1    GEDC01025816    GEDC01022200    JAS11482.1    JAS15098.1    KZ151083    OUM59698.1    HACA01026543    CDW43904.1    HAAD01004066    CDG70298.1    HACA01026542    CDW43903.1    AEFK01082368    AEFK01082369    GECZ01009693    JAS60076.1    ADFV01172851    ADFV01172852    ADFV01172853    ADFV01172854    GEBQ01000509    JAT39468.1    MCOG01000233    ORY23492.1    GEBQ01004354    JAT35623.1    GGMR01011163    MBY23782.1    CVRI01000010    CRK88812.1    MCFG01000098    ORX82297.1    GEZM01088406    GEZM01088405    GEZM01088404    JAV58215.1    CH473954    BC166773    RAZU01000165    RLQ67756.1    AC160104    CH466621    EDL09021.1    AK011270    AK075986    BC048732    CABD030021132    GAMS01009892    GAMR01007607    GAMQ01007601    GAMP01008930    JAB13244.1    JAB26325.1    JAB34250.1    JAB43825.1    GAMT01009207    JAB02654.1   

Proteomes

UP000005204    UP000037510    UP000053268    UP000053240    UP000007151    UP000027135    + More
UP000235965    UP000000311    UP000245037    UP000001292    UP000008711    UP000036403    UP000053825    UP000053097    UP000279307    UP000002282    UP000078541    UP000008237    UP000007755    UP000000803    UP000000304    UP000192221    UP000007801    UP000009192    UP000078492    UP000001819    UP000008744    UP000053105    UP000092461    UP000005205    UP000268350    UP000076502    UP000078540    UP000076858    UP000078542    UP000092553    UP000008792    UP000007266    UP000007798    UP000008820    UP000215335    UP000001070    UP000019118    UP000030742    UP000069940    UP000249989    UP000000305    UP000009022    UP000253843    UP000095301    UP000095300    UP000195826    UP000076420    UP000007648    UP000001073    UP000193920    UP000183832    UP000193944    UP000002494    UP000273346    UP000000589    UP000001519    UP000221080    UP000008225    UP000233020   

PRIDE

Q2F5I8    H9JCI8    Q9NH01    Q9VFW4    Q6NP11    B2RYG8    + More
Q8BK75   

Pfam

PF09807   ELP6        + More
PF02037   SAP
PF18386   ROQ_II
PF00642   zf-CCCH
PF13445   zf-RING_UBOX

Interpro

IPR018627   ELP6        + More
IPR007527   Znf_SWIM       
IPR036361   SAP_dom_sf       
IPR003034   SAP_dom       
IPR001841   Znf_RING       
IPR036855   Znf_CCCH_sf       
IPR027370   Znf-RING_LisH       
IPR041523   ROQ_II       
IPR013083   Znf_RING/FYVE/PHD       
IPR017907   Znf_RING_CS       
IPR000571   Znf_CCCH       
IPR000014   PAS       
IPR027417   P-loop_NTPase       

SUPFAM

SSF68906   SSF68906        + More
SSF90229   SSF90229       
SSF52540   SSF52540       

Gene 3D

1.10.720.30     3.30.40.10    

ProteinModelPortal

Q2F5I8   H9JCI8   A0A0L7LQH1   A0A194QB34   A0A194QS90   S4PWR9   + More
A0A212EZY7   A0A067RHR5   A0A2J7QAD4   A0A2J7QAD5   E2AF91   A0A2P8ZCB7   B4HFU5   E9J5N6   B3P155   A0A0J7NFY5   A0A0L7RHW7   A0A026WGI4   A0A3L8DDH9   Q9NH01   B4PQ00   A0A195FTS6   E2B905   F4WS73   A0A0C9QP75   Q9VFW4   Q6NP11   B4R1A7   A0A1W4UK74   B3LX71   B4KA86   A0A151JNR3   A0A146LT93   Q29A19   B4G3M0   A0A0N0BCP5   A0A0P5IWI9   A0A1B0CKS0   A0A158NB78   A0A3B0K0P3   A0A154P888   A0A151I3I7   A0A0P5PYF1   A0A0P5JVP9   A0A0P6AZ51   A0A151I8E5   A0A0P6CZP9   A0A0M3QXP5   B4M6C2   D6WX79   B4NKC5   A0A1Q3G172   A0A1S4FX14   Q16LJ7   A0A232EWW8   B4JI64   A0A0P5IPS2   A0A0K8TL94   A0A0K8W1S0   A0A034W450   A0A2R7WK45   J3JWS7   A0A182GZY7   U5EX87   A0A023EYN2   A0A0A1WQD1   E9FTH6   W8CAI6   B3SA08   A0A1B6JGU2   A0A369S0F6   T1PAT2   A0A1I8PJU9   A0A1B6CDG3   A0A1Y3MVQ6   A0A2C9KGW8   A0A0K2V0A4   T2MDD9   A0A0K2V071   G3VV31   A0A1B6GCC5   A0A2I3HYW0   A0A1B6MU84   A0A1Y2ALX6   A0A1B6MI81   A0A2S2P358   A0A1J1HN44   A0A1Y1X978   A0A1Y1KF09   B2RYG8   A0A3L7HPD0   A0A0H2UH13   Q8BK75   G3R5Z3   Q8BK75-2   A0A2D0PRN0   U3FDE0   U3BAM8   A0A2K5DZJ5  

KEGG

692989    no KO assigned | (RefSeq) DID protein

GO

GO:0033588   GO:0002098   GO:0008270   GO:0008103   GO:0005158   GO:0035011   GO:0046628   GO:0046872   GO:0005634   GO:0005829   GO:0030335   GO:0005524   GO:0007018   GO:0008017   GO:0006811   GO:0016021   GO:0006418   GO:0003723   GO:0003824  

PANTHER

PTHR16184  

Length:

245

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.06722

Exp number, first 60 AAs:

0.06639

Total prob of N-in:

0.05148

outside

1  -  245

 

 

Pi

198.802758

Theta

189.988777

Tajima's D

0.132909

CLR

0

CSRT

0.4006799660017

Interpretation

Uncertain