Gene

KWMTBOMO10326

Pre Gene Modal

BGIBMGA007238

Annotation

putative_dual_specificity_mitogen-activated_protein_kinase_kinase_4_MAPKK4_[Danaus_plexippus]

Location

Bomo_Chr17(+):7672993-7677340      View in EpiBrowser

Location in the cell

Nuclear   Reliability : 2.597

CDS

ATGTCCAAAAACGGAGAACTATCATCAAACCAAGGTCCTAGTCGACCAAGCCTACCAAGACCCGAGCTGAATTTATTTGGTACAGAAAAACGTAAAATTTTAGATCTCCCATTGAGTGGCCCGTCGAGCGATGTCGCTTTTGTACCATTTTCATCGACAACTGCACAAATGCAAAAGCCAAAAATTCCTTCACGTACTATTAGAGATGTACTGCCAGAAAATGCGAGAGATAGATGTCGAATATATCCATCAATGCAGTCATCTGGGAAACTACAGCTATCTGCTACTGAAGTATATGATTTCACTGCAGATGACTTGCAAGATCTGGGAGAGATTGGCAGGGGAGCATTTGGAGCTGTAAATAAAATGGTTTATAGAAAGACAAGTCGTGTAATGGCTGTAAAAAGGATTCGCTCAACAGTTGATGAGAAAGAACAAAAGCAGTTGTTAATGGATCTAGAAGTTGTGATGAAGAGTAATGATTGTCTTTATATAGTGGAATTTTATGGAGCACTCTTCAAAGAGGGTGATTGTTGGATCTGTATGGAATTAATGGACACATCACTAGACAAATTTTACAAATTTATATGTGAAAGAATGCAAACTCGAATACCAGAAAATATAATGGCAAAAATTACACTGGCTACAGTTAAGGCTTTAAATTATTTAAAAGAAAAATTGAAAATTATCCATAGGGATGTGAAACCATCTAATATACTGCTAGATAGAAGAGGAAATATAAAACTGTGTGATTTTGGTATATCTGGGAAGCTAGTAGATTCAATAGCTCGGACAAGAGATGCTGGATGTAGACCATACATGGCACCGGAAAGAATTGATCCAGGCCGTGCAAGAGGTTATGATGTACGCTCAGATGTTTGGTCTTTAGGTATTACTTTGATGGAAGTGGCTACTGGTGCATTTCCGTACCCAAGATGGGGATCTGTATTTGAACAGCTACAGCAAGTGGTTCAAGGGGACCCGCCACGTCTTTCATCCAATAACAACATGTTTTCAAACAGCTTCGTTAACTTCGTTAATACTTGCCTTATAAAAGAAGAAACACAGAGACCTAAGTATAACAGGTTACTGGAACACCCATTCATCAAAGGAATAGACCAAAGTCGATCAGATGTTGCTGCATATGTTTGCGAGATCTTAGAATCAATGGAACGGAATGGAGTGAGTCCTTTCACAACAGACCAGCCTGCTCAAGCCTGGGTAGATTAA

Protein

MSKNGELSSNQGPSRPSLPRPELNLFGTEKRKILDLPLSGPSSDVAFVPFSSTTAQMQKPKIPSRTIRDVLPENARDRCRIYPSMQSSGKLQLSATEVYDFTADDLQDLGEIGRGAFGAVNKMVYRKTSRVMAVKRIRSTVDEKEQKQLLMDLEVVMKSNDCLYIVEFYGALFKEGDCWICMELMDTSLDKFYKFICERMQTRIPENIMAKITLATVKALNYLKEKLKIIHRDVKPSNILLDRRGNIKLCDFGISGKLVDSIARTRDAGCRPYMAPERIDPGRARGYDVRSDVWSLGITLMEVATGAFPYPRWGSVFEQLQQVVQGDPPRLSSNNNMFSNSFVNFVNTCLIKEETQRPKYNRLLEHPFIKGIDQSRSDVAAYVCEILESMERNGVSPFTTDQPAQAWVD

Similarity

Belongs to the protein kinase superfamily.

Uniprot

A0A212EZX7   A0A2A4JDV2   S4PY91   A0A194QRN7   A0A2H1VME8   A0A194QBF2   + More
H9JCJ3   A0A2A4JD40   A0A195DFM2   A0A195C4A3   A0A195BP81   A0A158P2U6   A0A151XHS8   F4W5W3   A0A195EYS9   K7J4T5   E2A6Y4   A0A026W3X7   E2BS01   A0A232FC87   U5ESZ6   A0A1L8DLS1   A0A2J7RDN4   A0A1B0CCH5   A0A2J7RDK6   E9IPG7   A0A336MH04   V9IIX5   A0A088AFM6   A0A1W5HRV8   A0A067QRR1   A0A336MIG0   A0A0J7L6L7   A0A2H8TGQ0   A0A2S2NGA6   A0A1Y1MJ85   A0A0K8TKN2   A0A1B6CQT0   J9JQ17   A0A1B6F5D9   E0VH09   A0A1B6LAD8   A0A1Y1MDV6   B0WUY2   A0A1B6D556   A0A1B6HY94   A0A182GJC6   A0A1Q3F2Y7   Q17GI1   A0A1B6K9H3   Q7Q999   A0A182UH55   A0A154P800   A0A1S4GHR2   A0A182HJN1   A0A084WT36   A0A182T376   A0A182K6N8   A0A182R0R8   A0A182IU61   A0A1W4WJ49   A0A182UT57   A0A1A9VSL2   A0A1B0GDM6   A0A1A9Z4Y4   S4SCR9   A0A1A9YAE4   A0A182LYI8   A0A2M3ZHY1   A0A2M4ALE3   A0A2M4BQQ5   W5J358   B4KCQ0   A0A182KWU5   B4M509   A0A139WCN4   A0A1W4WJ58   T1PH36   A0A1I8Q3B0   B4JSS6   A0A1B0ATY0   A0A0L0CI11   D6WXT4   A0A0M3QX59   A0A1W4VQU7   B3P4V8   B4PT77   B4NLB2   B3LWW8   A0A3B0JLG9   B4QY07   Q7KPX5   B4HLI1   Q297N4   Q7KPK6   A0A2P2I7X2   A0A0N7A6Y0   O61444   T1ITH1   A0A0P4W4F6  

Pubmed

22118469    23622113    26354079    19121390    21347285    21719571    + More
20075255    20798317    24508170    30249741    28648823    21282665    24845553    28004739    26369729    20566863    26483478    17510324    12364791    24438588    25039995    20920257    23761445    17994087    20966253    18362917    19820115    25315136    26108605    17550304    9584193    15632085    10731132    12537568    12537572    12537573    12537574    16110336    17569856    17569867    26109357    26109356   

EMBL

AGBW02011226    OWR47007.1    NWSH01001944    PCG69610.1    GAIX01003698    JAA88862.1    + More
KQ461155    KPJ08178.1    ODYU01003098    SOQ41424.1    KQ459232    KPJ02759.1    BABH01039048    PCG69608.1    KQ980903    KYN11642.1    KQ978344    KYM94998.1    KQ976432    KYM87451.1    ADTU01007483    KQ982130    KYQ59770.1    GL887695    EGI70439.1    KQ981905    KYN33378.1    AAZX01012987    GL437203    EFN70850.1    KK107462    QOIP01000013    EZA50311.1    RLU15198.1    GL450107    EFN81517.1    NNAY01000460    OXU28232.1    GANO01002993    JAB56878.1    GFDF01006678    JAV07406.1    NEVH01005288    PNF38928.1    AJWK01006752    AJWK01006753    AJWK01006754    PNF38926.1    GL764503    EFZ17567.1    UFQT01001167    SSX29230.1    JR049599    AEY61015.1    KF017207    KF017208    KZ288301    AGX26047.1    PBC28855.1    KK853039    KDR12188.1    SSX29231.1    LBMM01000452    KMQ98306.1    GFXV01001414    MBW13219.1    GGMR01003550    MBY16169.1    GEZM01034096    GEZM01034095    JAV83936.1    GDAI01002729    JAI14874.1    GEDC01021715    GEDC01009835    JAS15583.1    JAS27463.1    ABLF02037354    GECZ01024384    GECZ01012447    JAS45385.1    JAS57322.1    AAZO01002282    DS235156    EEB12665.1    GEBQ01019308    JAT20669.1    GEZM01034099    GEZM01034098    GEZM01034097    JAV83924.1    DS232112    EDS35300.1    GEDC01016593    JAS20705.1    GECU01028072    GECU01021799    GECU01013877    GECU01011500    JAS79634.1    JAS85907.1    JAS93829.1    JAS96206.1    JXUM01012924    JXUM01012925    GFDL01013187    JAV21858.1    CH477259    EAT45744.1    GEBQ01031884    JAT08093.1    AAAB01008904    EAA09660.5    KQ434823    KZC07328.1    APCN01002192    ATLV01026819    KE525419    KFB53380.1    AXCN02000300    CCAG010011968    JQ269699    AFN26000.1    AXCM01000984    GGFM01007405    MBW28156.1    GGFK01008280    MBW41601.1    GGFJ01006276    MBW55417.1    ADMH02002120    ETN58782.1    CH933806    EDW15899.1    CH940652    EDW59720.1    KQ971362    KYB25728.1    KA647984    AFP62613.1    CH916373    EDV94816.1    JXJN01003468    JXJN01003469    JRES01000344    KNC32048.1    EFA07934.2    CP012526    ALC45363.1    CH954181    EDV49902.1    CM000160    EDW96538.1    CH964272    EDW84315.1    CH902617    EDV43807.1    OUUW01000007    SPP83117.1    CM000364    EDX13744.1    AF035552    AAC39036.1    CH480815    EDW43008.1    CM000070    EAL28171.1    AF061255    AAF35430.1    IACF01004548    LAB70137.1    KJ023198    AIY23114.1    AF035551    AE014297    AY070600    AAC39035.1    AAF54258.1    AAL48071.1    ACZ94848.1    AGB95757.1    AFFK01019182    GDRN01092958    JAI59998.1   

Proteomes

UP000007151    UP000218220    UP000053240    UP000053268    UP000005204    UP000078492    + More
UP000078542    UP000078540    UP000005205    UP000075809    UP000007755    UP000078541    UP000002358    UP000000311    UP000053097    UP000279307    UP000008237    UP000215335    UP000235965    UP000092461    UP000005203    UP000242457    UP000027135    UP000036403    UP000007819    UP000009046    UP000002320    UP000069940    UP000008820    UP000007062    UP000075902    UP000076502    UP000075840    UP000030765    UP000075901    UP000075881    UP000075886    UP000075880    UP000192223    UP000075903    UP000078200    UP000092444    UP000092445    UP000092443    UP000075883    UP000000673    UP000009192    UP000075882    UP000008792    UP000007266    UP000095301    UP000095300    UP000001070    UP000092460    UP000037069    UP000092553    UP000192221    UP000008711    UP000002282    UP000007798    UP000007801    UP000268350    UP000000304    UP000001292    UP000001819    UP000000803   

PRIDE

H9JCJ3    Q7KPX5    Q7KPK6    O61444   

Pfam

PF00069   Pkinase

Interpro

IPR000719   Prot_kinase_dom        + More
IPR017441   Protein_kinase_ATP_BS       
IPR011009   Kinase-like_dom_sf       
IPR008271   Ser/Thr_kinase_AS       

SUPFAM

SSF56112   SSF56112       

ProteinModelPortal

A0A212EZX7   A0A2A4JDV2   S4PY91   A0A194QRN7   A0A2H1VME8   A0A194QBF2   + More
H9JCJ3   A0A2A4JD40   A0A195DFM2   A0A195C4A3   A0A195BP81   A0A158P2U6   A0A151XHS8   F4W5W3   A0A195EYS9   K7J4T5   E2A6Y4   A0A026W3X7   E2BS01   A0A232FC87   U5ESZ6   A0A1L8DLS1   A0A2J7RDN4   A0A1B0CCH5   A0A2J7RDK6   E9IPG7   A0A336MH04   V9IIX5   A0A088AFM6   A0A1W5HRV8   A0A067QRR1   A0A336MIG0   A0A0J7L6L7   A0A2H8TGQ0   A0A2S2NGA6   A0A1Y1MJ85   A0A0K8TKN2   A0A1B6CQT0   J9JQ17   A0A1B6F5D9   E0VH09   A0A1B6LAD8   A0A1Y1MDV6   B0WUY2   A0A1B6D556   A0A1B6HY94   A0A182GJC6   A0A1Q3F2Y7   Q17GI1   A0A1B6K9H3   Q7Q999   A0A182UH55   A0A154P800   A0A1S4GHR2   A0A182HJN1   A0A084WT36   A0A182T376   A0A182K6N8   A0A182R0R8   A0A182IU61   A0A1W4WJ49   A0A182UT57   A0A1A9VSL2   A0A1B0GDM6   A0A1A9Z4Y4   S4SCR9   A0A1A9YAE4   A0A182LYI8   A0A2M3ZHY1   A0A2M4ALE3   A0A2M4BQQ5   W5J358   B4KCQ0   A0A182KWU5   B4M509   A0A139WCN4   A0A1W4WJ58   T1PH36   A0A1I8Q3B0   B4JSS6   A0A1B0ATY0   A0A0L0CI11   D6WXT4   A0A0M3QX59   A0A1W4VQU7   B3P4V8   B4PT77   B4NLB2   B3LWW8   A0A3B0JLG9   B4QY07   Q7KPX5   B4HLI1   Q297N4   Q7KPK6   A0A2P2I7X2   A0A0N7A6Y0   O61444   T1ITH1   A0A0P4W4F6  

PDB

3VUT     E-value=1.36622e-124,     Score=1143

KEGG

101735877    K04430 mitogen-activated protein kinase kinase 4 [EC:2.7.12.2] | (RefSeq) dual specificity mitogen-a

PATHWAY

04013    MAPK signaling pathway - fly - Bombyx mori (domestic silkworm)

GO

GO:0004674   GO:0005524   GO:0004672   GO:0005737   GO:0004708   GO:0000187   GO:0007257   GO:0008545   GO:0023014   GO:0032147   GO:0031098   GO:0030424   GO:0048082   GO:0048666   GO:0007254   GO:0006468   GO:0004697   GO:0016021   GO:0015935   GO:0004812   GO:0006418   GO:0003723   GO:0046872   GO:0003824  

Length:

409

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.02967

Exp number, first 60 AAs:

0.00125

Total prob of N-in:

0.00703

outside

1  -  409

 

 

Pi

119.479404

Theta

140.512741

Tajima's D

-0.721788

CLR

1.01375

CSRT

0.193190340482976

Interpretation

Uncertain