Gene

KWMTBOMO10309

Pre Gene Modal

BGIBMGA007259

Annotation

L-xylulose_reductase_[Bombyx_mori]

Location

Bomo_Chr17(-):7341825-7343709      View in EpiBrowser

Full name

L-xylulose reductase      

Alternative Name

Dicarbonyl/L-xylulose reductase
Sperm antigen P26h

Location in the cell

Cytoplasmic   Reliability : 1.929

CDS

ATGGATAAATATTTTGAAGGAAAAAGAATACTTGTTACTGGTGGTTGTCAAGGGATAGGTCGTGGATTAGTCTTAGAACTTTGGAGACTGGGTGCGAATGTTGTTACTGTTTCAAATAATGCTGAAAACTTAAACAAACTCAAAGAGGAATATCCATCCATTGAAATAGTGTACGTTGATCTTCGAAATTGGAATAAAACAAGAGAAGTCATTGATGCTCTTGGAGTTTTTGATGGCCTTGTCAATAATGCCGGTATTGCTATAATCGAACCTTTTTTGGAATGCAAAAAAGAAAGCCTAAATGAAACCTTTGATGTAAATGTTAATGCCGTTATTAATGTGAGTCAAGTGGTAGCGAAAAAAATGATAGAAAACAAAAGAAAAGGTTCCATCGTAAATATTTCATCGCAAGCTTCTAAGGCAGCTCTAAAGGATCACGTAGCATATTGTGCCTCAAAAGGTGCTCTAGACGCACTAACCAGGGTTATGGCCCTAGAACTGGGACCTTTTGGCATACGAATTAATACAGTTAACCCTACTGTCATTATGACTGAAATGGGTAGAAAAGTTTGGGCGGAACCATCAAAATCAAAGGAAATGTTATCTAAAATACCTCTTGGAAGATTCGGTGAGGTGGAGGAAGTGGTTAATGCGGTAATATTCCTGCTTTGTGACAGTGCTAGTTTAATTTCTGGAGTACAATTACCAATTGACGGAGGGTTTTTGGCAACATAA

Protein

MDKYFEGKRILVTGGCQGIGRGLVLELWRLGANVVTVSNNAENLNKLKEEYPSIEIVYVDLRNWNKTREVIDALGVFDGLVNNAGIAIIEPFLECKKESLNETFDVNVNAVINVSQVVAKKMIENKRKGSIVNISSQASKAALKDHVAYCASKGALDALTRVMALELGPFGIRINTVNPTVIMTEMGRKVWAEPSKSKEMLSKIPLGRFGEVEEVVNAVIFLLCDSASLISGVQLPIDGGFLAT

Catalytic Activity

NADP(+) + xylitol = H(+) + L-xylulose + NADPH

Biophysicochemical Properties

0.11 mM for L-xylulose (at 25 degrees Celsius)

Subunit

Homotetramer.

Similarity

Belongs to the short-chain dehydrogenases/reductases (SDR) family.

Keywords

Acetylation   Carbohydrate metabolism   Complete proteome   Cytoplasmic vesicle   Direct protein sequencing   Glucose metabolism   Membrane   Methylation   NADP   Oxidoreductase   Phosphoprotein   Reference proteome   Xylose metabolism   Cell membrane  

Feature

chain  L-xylulose reductase

Uniprot

H9JCL4   Q1HPW6   A0A194QBJ4   A0A2H1WQM2   A0A2A4JDX1   A0A194QRL3   + More
A0A2H1WQD7   A0A212EMP4   A0A194QCS6   A0A194QT21   A0A212EMJ1   S4NJ55   A0A3S2NR58   A0A194QRN6   A0A2A4JCF4   A0A194QBF1   H9JCL3   A0A0L7LCK1   I4DPS3   A0A212ET48   A0A0B4J2T8   A0A1B6KAD0   A0A1B6KQK9   A0A3L8DFD7   A0A0T6BAL7   A0A1B6CL77   A0A1B6HKU2   A0A0B4J2P7   A0A1B6EM10   A0A0L7QQ52   H3AXF4   A0A3S2MIQ7   A0A067QQF0   A0A1B6E6K6   A0A3P9I215   A0A2J7PLW4   G1KJT4   E9FWF2   A0A3P9L555   A0A3B3HPT7   A0A232F2W7   A0A3B4DUY0   A0A1W4WDN7   A0A3Q2ZWE8   C3KGY6   A0A1A7XQ15   A0A1A7YJ59   Q567K5   A0A060Y4P2   A0A3Q1BGC9   G3GXD0   B5X5V8   A0A1D2MSF7   A0A3Q1JRU4   A0A3P8YKW3   A0A3Q1H4K4   A0A0A9XW67   A0A3B4YYI2   A0A3Q3LTD3   Q6P630   A0A3B3DJP1   F6ZAZ2   A0A1U7Q257   Q91XV4   A0A3Q0R148   A0A287D7E0   A0A3Q3N2A4   A0A3Q4N9X8   A0A287D9C5   A0A3B4XW07   A0A3Q2VTJ7   Q4QR61   A0A3B4GQP7   A0A3B4UVP5   A0A1A8M8Y6   A0A1A8H172   A0A1A8DRS3   A0A1U7SVA7   F4WJ19   A0A286ZQ44   E2B5S7   A0A3P8T7Q8   A0A0B7B8J0   A0A1A8A5C5   A0A1A8U1F4   Q920P0   A0A1A8K3X2   A0A1W5AWA2   Q91X52   A0A1S2ZU09   A0A026WNB0   A0A1A8Q5H3   E2ARD3   A0A1A8FCA1   A0A3Q3J7V8   A0A3P8N8H7   A0A3P9DCU8   A0A3B1IVZ8   M3WFI7   A0A2Y9PQ94  

EC Number

1.1.1.10

Pubmed

19121390    26354079    22118469    23622113    26227816    22651552    + More
20075255    30249741    9215903    24845553    17554307    21292972    28648823    23594743    24755649    21804562    23929341    29704459    20433749    27289101    25069045    25401762    26823975    29451363    19892987    9890754    11306103    11882650    25186727    27762356    21719571    30723633    20798317    12604240    21477590    16141072    15489334    21183079    24508170    25329095    17975172   

EMBL

BABH01034711    DQ443286    ABF51375.1    KQ459232    KPJ02784.1    ODYU01010271    + More
SOQ55262.1    NWSH01001898    PCG69754.1    KQ461155    KPJ08153.1    SOQ55263.1    AGBW02013813    OWR42711.1    KPJ02785.1    KPJ08150.1    OWR42710.1    GAIX01013814    JAA78746.1    RSAL01000006    RVE54201.1    KPJ08152.1    PCG69755.1    KPJ02787.1    BABH01034712    JTDY01001666    KOB73208.1    AK403751    BAM19913.1    AGBW02012635    OWR42712.1    OWR44673.1    GEBQ01031577    GEBQ01023032    JAT08400.1    JAT16945.1    GEBQ01026252    JAT13725.1    QOIP01000009    RLU18873.1    LJIG01003013    KRT83927.1    GEDC01023843    GEDC01023079    GEDC01020713    JAS13455.1    JAS14219.1    JAS16585.1    GECU01036917    GECU01032419    GECU01026666    GECU01001796    JAS70789.1    JAS75287.1    JAS81040.1    JAT05911.1    GECZ01030802    JAS38967.1    KQ414806    KOC60616.1    AFYH01016877    AFYH01016878    AFYH01016879    AFYH01016880    CM012455    RVE60060.1    KK853134    KDR10850.1    GEDC01003718    JAS33580.1    NEVH01024423    PNF17309.1    GL732526    EFX87881.1    NNAY01001163    OXU24932.1    BT082201    ACQ57908.1    HADW01018500    SBP19900.1    HADX01008006    SBP30238.1    BX548040    BC093141    AAH93141.1    FR907432    CDQ86686.1    JH000058    KE682086    RAZU01000244    EGW06279.1    ERE67862.1    RLQ62673.1    BT046427    BT058382    BT059117    BT060083    BT125410    ACI66228.1    ACN10095.1    ACN10830.1    ADM16151.1    LJIJ01000639    ODM95655.1    GBHO01019978    GBHO01019977    GBHO01019976    GBRD01015772    GDHC01019453    JAG23626.1    JAG23627.1    JAG23628.1    JAG50054.1    JAP99175.1    BC062504    CR762052    AAH62504.1    CAJ81504.1    AB045204    AGTP01070806    BC097532    CM004482    AAH97532.1    OCT62589.1    HAEF01011660    HAEG01001859    SBR52769.1    HAEC01009022    SBQ77238.1    HAEA01007778    SBQ36258.1    GL888181    EGI65789.1    AEMK02000080    DQIR01193138    HDB48615.1    GL445887    EFN88896.1    HACG01042778    HACG01042779    CEK89643.1    CEK89644.1    HADY01011393    SBP49878.1    HAEJ01001448    SBS41905.1    AB061719    HAEE01007070    SBR27090.1    D89656    AK004023    AK007627    AK153521    BC012247    KK107148    EZA57458.1    HAEH01010174    SBR89050.1    GL442047    EFN64011.1    HAEB01009909    SBQ56436.1    AANG04004184   

Proteomes

UP000005204    UP000053268    UP000218220    UP000053240    UP000007151    UP000283053    + More
UP000037510    UP000002358    UP000279307    UP000005203    UP000053825    UP000008672    UP000027135    UP000265200    UP000235965    UP000001646    UP000000305    UP000265180    UP000001038    UP000215335    UP000261440    UP000192223    UP000264800    UP000000437    UP000193380    UP000257160    UP000001075    UP000030759    UP000273346    UP000087266    UP000094527    UP000265040    UP000265140    UP000257200    UP000261400    UP000261660    UP000261560    UP000002281    UP000189706    UP000261340    UP000005215    UP000261640    UP000261580    UP000261360    UP000264840    UP000186698    UP000261460    UP000261420    UP000189704    UP000007755    UP000008227    UP000008237    UP000265080    UP000002494    UP000192224    UP000000589    UP000079721    UP000053097    UP000000311    UP000261600    UP000265100    UP000265160    UP000018467    UP000011712    UP000248483   

PRIDE

H9JCL4    Q1HPW6    H9JCL3    A0A0B4J2P7    G3GXD0    Q920P0    + More
Q91X52   

Pfam

PF00106   adh_short        + More
PF01370   Epimerase

Interpro

IPR020904   Sc_DH/Rdtase_CS        + More
IPR002347   SDR_fam       
IPR036291   NAD(P)-bd_dom_sf       
IPR001509   Epimerase_deHydtase       

SUPFAM

SSF51735   SSF51735       

ProteinModelPortal

H9JCL4   Q1HPW6   A0A194QBJ4   A0A2H1WQM2   A0A2A4JDX1   A0A194QRL3   + More
A0A2H1WQD7   A0A212EMP4   A0A194QCS6   A0A194QT21   A0A212EMJ1   S4NJ55   A0A3S2NR58   A0A194QRN6   A0A2A4JCF4   A0A194QBF1   H9JCL3   A0A0L7LCK1   I4DPS3   A0A212ET48   A0A0B4J2T8   A0A1B6KAD0   A0A1B6KQK9   A0A3L8DFD7   A0A0T6BAL7   A0A1B6CL77   A0A1B6HKU2   A0A0B4J2P7   A0A1B6EM10   A0A0L7QQ52   H3AXF4   A0A3S2MIQ7   A0A067QQF0   A0A1B6E6K6   A0A3P9I215   A0A2J7PLW4   G1KJT4   E9FWF2   A0A3P9L555   A0A3B3HPT7   A0A232F2W7   A0A3B4DUY0   A0A1W4WDN7   A0A3Q2ZWE8   C3KGY6   A0A1A7XQ15   A0A1A7YJ59   Q567K5   A0A060Y4P2   A0A3Q1BGC9   G3GXD0   B5X5V8   A0A1D2MSF7   A0A3Q1JRU4   A0A3P8YKW3   A0A3Q1H4K4   A0A0A9XW67   A0A3B4YYI2   A0A3Q3LTD3   Q6P630   A0A3B3DJP1   F6ZAZ2   A0A1U7Q257   Q91XV4   A0A3Q0R148   A0A287D7E0   A0A3Q3N2A4   A0A3Q4N9X8   A0A287D9C5   A0A3B4XW07   A0A3Q2VTJ7   Q4QR61   A0A3B4GQP7   A0A3B4UVP5   A0A1A8M8Y6   A0A1A8H172   A0A1A8DRS3   A0A1U7SVA7   F4WJ19   A0A286ZQ44   E2B5S7   A0A3P8T7Q8   A0A0B7B8J0   A0A1A8A5C5   A0A1A8U1F4   Q920P0   A0A1A8K3X2   A0A1W5AWA2   Q91X52   A0A1S2ZU09   A0A026WNB0   A0A1A8Q5H3   E2ARD3   A0A1A8FCA1   A0A3Q3J7V8   A0A3P8N8H7   A0A3P9DCU8   A0A3B1IVZ8   M3WFI7   A0A2Y9PQ94  

PDB

3D3W     E-value=1.51815e-66,     Score=639

KEGG

732969    K03331 L-xylulose reductase [EC:1.1.1.10] | (RefSeq) dicarbonyl L-xylulose reductase

PATHWAY

00040    Pentose and glucuronate interconversions - Bombyx mori (domestic silkworm)
01100    Metabolic pathways - Bombyx mori (domestic silkworm)

GO

GO:0016491   GO:0050662   GO:0051289   GO:0005881   GO:0042802   GO:0050038   GO:0005997   GO:0006006   GO:0016655   GO:0004090   GO:0005903   GO:0006739   GO:0005902   GO:0044105   GO:0042732   GO:0001669   GO:0016020   GO:0055114   GO:0016324   GO:0016614   GO:0005524   GO:0006468   GO:0016021   GO:0015935   GO:0004812   GO:0006418   GO:0003723   GO:0046872   GO:0003824  

Subcellular location

Membrane  
Cytoplasmic vesicle  
Secretory vesicle  
Acrosome  
Apical cell membrane   Probably recruited to membranes via an interaction with phosphatidylinositol (By similarity). In kidney, it is localized in the brush border membranes of proximal tubular cells.   With evidence from 1 publications.

Length:

244

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.6816

Exp number, first 60 AAs:

0.01839

Total prob of N-in:

0.12672

outside

1  -  244

 

 

Pi

176.510975

Theta

175.108587

Tajima's D

0.212419

CLR

0

CSRT

0.427628618569072

Interpretation

Uncertain