Gene

KWMTBOMO10301  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA007299

Annotation

PREDICTED:_Golgi_to_ER_traffic_protein_4_homolog_[Amyelois_transitella]

Location

Bomo_Chr17(+):7255410-7260244      View in EpiBrowser

Full name

Golgi to ER traffic protein 4 homolog      

Alternative Name

Conserved edge expressed protein

Location in the cell

Cytoplasmic   Reliability : 1.156 PlasmaMembrane   Reliability : 1.299

CDS

ATGGCCACGCGTGGAGAAAGAGGAGTTGTTAGGGTATTAGATAAGTTAGAAGCTTCAATTAATTCTGGCCAGTATTATGAAGCACATCAAATGTACAGAACTCTTTATTTTAGATACCTAACTCAGAAAAAATATCCAGAATTGTTAACTTTATTGTACAAAGGGTCTACACTTCTTTTGGAACGCGATCAACAAGGAAGTGGAGCTGATCTCGCCATACTCTTCGTAGAAGTTTTAACAAAATCGGAAACCAAACCTAATGAAGAATGGGTCTCGAAATTGGCAAAATTATTTGAATTAATCAGCTCCAGTGTCCCAGAGCGAGAAACCTTTCTAACAAATTCAATAAAATGGTCAATGGATAACAACAAAAAAGGTGACCCACTCCTACACAAGAAAATAGCAGAAGTATTTTGGAAGGAAAAAAAGTACACAGCTGCTCATAGACACTTTTTACACTCATCGGATGGTTCAGCATATGCTAACATGCTTATAGAGTTACACACAACTAAAGGTCTCAAATCAGAAATAGATTTGTTCATAGCACAAGCTGTGTTGCAAATACTTTGTTTGAGAAATGTAAGAATGGCAACTGAAACATTTTTGAGGTATACAGAAACACATCCCAAAATTAAGAATAGCAAAGGACCTCCATATATATTCCCACTATTGAATTTTTTGTGGTTCTTGCTGAGAGCTGTCGAACAGAGACATGTACGACAGTTTATGGTACTAAAGAATTGGTATGCAATTAGCATTAAAAGGGATCCAAACTACTCCATTTTTTTAGACAATATAGGCCGCATTTGGTTTGGAATAGAAATACCTTCGGAAAATAGAAATCCAAACTCTATGTTCGGAGGTCTAATAAAATCTATTATTGGTGATATAGATAGTTCTGATGATGATGGTGAAAGCAAGACGTCGGCCACAGCTCCTGATTTGGACTAA

Protein

MATRGERGVVRVLDKLEASINSGQYYEAHQMYRTLYFRYLTQKKYPELLTLLYKGSTLLLERDQQGSGADLAILFVEVLTKSETKPNEEWVSKLAKLFELISSSVPERETFLTNSIKWSMDNNKKGDPLLHKKIAEVFWKEKKYTAAHRHFLHSSDGSAYANMLIELHTTKGLKSEIDLFIAQAVLQILCLRNVRMATETFLRYTETHPKIKNSKGPPYIFPLLNFLWFLLRAVEQRHVRQFMVLKNWYAISIKRDPNYSIFLDNIGRIWFGIEIPSENRNPNSMFGGLIKSIIGDIDSSDDDGESKTSATAPDLD

Description

As part of a cytosolic protein quality control complex, the bag6/bat3 complex, maintains misfolded and hydrophobic patches-containing proteins in a soluble state and participates to their proper delivery to the endoplasmic reticulum or alternatively can promote their sorting to the proteasome where they undergo degradation. The bag6/bat3 complex is involved in the post-translational delivery of tail-anchored/type II transmembrane proteins to the endoplasmic reticulum membrane. Similarly, the bag6/bat3 complex also functions as a sorting platform for proteins of the secretory pathway that are mislocalized to the cytosol either delivering them to the proteasome for degradation or to the endoplasmic reticulum. The bag6/bat3 complex also plays a role in the endoplasmic reticulum-associated degradation (ERAD), a quality control mechanism that eliminates unwanted proteins of the endoplasmic reticulum through their retrotranslocation to the cytosol and their targeting to the proteasome. It maintains these retrotranslocated proteins in an unfolded yet soluble state condition in the cytosol to ensure their proper delivery to the proteasome.

Subunit

Component of the bag6/bat3 complex.

Similarity

Belongs to the GET4 family.

Keywords

Complete proteome   Cytoplasm   Reference proteome   Transport  

Feature

chain  Golgi to ER traffic protein 4 homolog

Uniprot

H9JCQ2   A0A3S2M8X6   A0A1E1WNR8   A0A2A4JL93   A0A2H1WR60   A0A212FA41   + More
S4PPR3   A0A194QRP1   A0A0L7KZL7   A0A1W4WIC0   A0A224XFM0   A0A069DRS9   A0A1B6C9S1   A0A2J7PLV0   A0A0V0G5B3   D6WYB6   A0A0N7Z8W5   V5GRX4   A0A1Y1KLU4   A0A067RMM6   A0A1B6GIM5   J3JZ83   A0A1B6MMB8   A0A0A9XXR2   A0A0T6B1V3   A0A2R5LL13   A0A023GKP0   E0VFK7   A0A023FUM9   A0A3B4X9H1   A0A3B4TVK6   A0A146WB57   A0A2I4CSJ7   A0A0F8AEY0   A0A3B3TJV2   A0A3B3WIU1   A0A3Q2QTI7   A0A3Q2C901   A0A3Q0T5K8   A0A147A2R7   A0A087YH40   E6ZGL2   A0A315VYD5   A0A3Q3JIB5   G3NMJ4   A0A023EQ78   A0A182GL78   A0A3Q1HNU9   A0A1E1XBY1   A0A3Q3KWN9   A0A3Q3QJ17   A0A3P9QAK0   A0A3P9J0P2   M4A5E0   A0A0S7G0A1   A0A3Q1GHZ0   A0A3B5BJY7   A0A3P9M0C1   H2N1E0   A0A3Q2XS96   A0A3Q1AKD7   A0A1A7YBN2   A0A1A7XI13   A0A0S7FSZ8   A0A3Q2W7R7   A0A182H6W4   A0A3R7LYG1   A0A3B4F2U3   A0A3Q2X8N8   A0A3Q4GEU8   I3KUM4   E2B1Q9   A0A1A8CAF3   A0A154PPY3   A0A3P8WYI3   A4QNE0   A0A0N8K2W0   A0A226NJT4   A0A226PTK4   G1K3K2   A0A1A8DKN6   A0A1A8JXI0   A0A1A8MFQ4   A0A1A8NLH0   A0A1A8RKJ7   A0A1A8IX59   E2BIS1   A0A3P8TYM2   Q16KN0   G3NMK3   A1Z3X3   A0A1A8PN16   A0A287AWN6   A0A1A8UBT3   A0A1A7ZXW2   A0A2Y9RVL8   A0A3B3BSQ4   H2V3I3   A0A0P4WP96  

Pubmed

19121390    22118469    23622113    26354079    26227816    26334808    + More
18362917    19820115    27129103    28004739    24845553    22516182    25401762    26823975    20566863    25835551    29703783    24945155    26483478    28503490    17554307    23542700    25186727    20798317    24487278    24621616    20431018    17510324    18249086    30723633    29451363    21551351   

EMBL

BABH01034704    RSAL01000006    RVE54193.1    GDQN01002456    JAT88598.1    NWSH01001074    + More
PCG72741.1    ODYU01010378    SOQ55452.1    AGBW02009515    OWR50615.1    GAIX01000077    JAA92483.1    KQ461155    KPJ08157.1    JTDY01004024    KOB68698.1    GFTR01005149    JAW11277.1    GBGD01002111    JAC86778.1    GEDC01027097    JAS10201.1    NEVH01024423    PNF17303.1    GECL01002876    JAP03248.1    KQ971356    EFA09129.1    GDKW01002211    JAI54384.1    GALX01005493    JAB62973.1    GEZM01079835    JAV62373.1    KK852421    KDR24283.1    GECZ01007485    JAS62284.1    BT128564    AEE63521.1    GEBQ01002915    JAT37062.1    GBHO01019966    GDHC01004584    JAG23638.1    JAQ14045.1    LJIG01016292    KRT81038.1    GGLE01005881    MBY10007.1    GBBM01001740    JAC33678.1    DS235115    EEB12163.1    GBBK01000102    JAC24380.1    GCES01059015    JAR27308.1    KQ042663    KKF12255.1    GCES01013838    JAR72485.1    AYCK01000769    FQ310507    CBN81196.1    NHOQ01000843    PWA28360.1    GAPW01002365    JAC11233.1    JXUM01071389    KQ562662    KXJ75372.1    GFAC01002421    JAT96767.1    GBYX01461421    JAO20147.1    HADX01005685    SBP27917.1    HADW01016243    SBP17643.1    GBYX01461433    JAO20135.1    JXUM01114983    KQ565837    KXJ70615.1    QCYY01002914    ROT66639.1    AERX01002224    GL444953    EFN60415.1    HADZ01011820    SBP75761.1    KQ435012    KZC13777.1    BC135489    JARO02000366    KPP78833.1    MCFN01000035    OXB67598.1    AWGT02000022    OXB82727.1    AAMC01119009    HAEA01005346    SBQ33826.1    HAEE01004627    SBR24647.1    HAEF01014045    SBR55204.1    HAEG01003732    SBR69841.1    HAEI01009027    SBS06635.1    HAED01015504    SBR01949.1    GL448530    EFN84411.1    CH477950    CH477244    EAT34855.1    EAT46261.1    EF177382    HAEH01007639    SBR82407.1    AEMK02000013    DQIR01215747    DQIR01225601    DQIR01307325    HDB71224.1    HDC62803.1    HAEJ01004126    SBS44583.1    HADY01008626    SBP47111.1    GDRN01074368    JAI63254.1   

Proteomes

UP000005204    UP000283053    UP000218220    UP000007151    UP000053240    UP000037510    + More
UP000192223    UP000235965    UP000007266    UP000027135    UP000009046    UP000261360    UP000261420    UP000192220    UP000261500    UP000261480    UP000265000    UP000265020    UP000261340    UP000028760    UP000261600    UP000007635    UP000069940    UP000249989    UP000265040    UP000261660    UP000242638    UP000265200    UP000002852    UP000257200    UP000261400    UP000265180    UP000001038    UP000264820    UP000257160    UP000264840    UP000283509    UP000261460    UP000261580    UP000005207    UP000000311    UP000076502    UP000265120    UP000008143    UP000034805    UP000192224    UP000198323    UP000198419    UP000008237    UP000265080    UP000008820    UP000008227    UP000248480    UP000261560    UP000005226   

PRIDE

H9JCQ2   

Pfam

PF04190   DUF410

Interpro

IPR007317   GET4        + More
IPR011990   TPR-like_helical_dom_sf       

SUPFAM

SSF48452   SSF48452       

Gene 3D

1.25.40.10    

ProteinModelPortal

H9JCQ2   A0A3S2M8X6   A0A1E1WNR8   A0A2A4JL93   A0A2H1WR60   A0A212FA41   + More
S4PPR3   A0A194QRP1   A0A0L7KZL7   A0A1W4WIC0   A0A224XFM0   A0A069DRS9   A0A1B6C9S1   A0A2J7PLV0   A0A0V0G5B3   D6WYB6   A0A0N7Z8W5   V5GRX4   A0A1Y1KLU4   A0A067RMM6   A0A1B6GIM5   J3JZ83   A0A1B6MMB8   A0A0A9XXR2   A0A0T6B1V3   A0A2R5LL13   A0A023GKP0   E0VFK7   A0A023FUM9   A0A3B4X9H1   A0A3B4TVK6   A0A146WB57   A0A2I4CSJ7   A0A0F8AEY0   A0A3B3TJV2   A0A3B3WIU1   A0A3Q2QTI7   A0A3Q2C901   A0A3Q0T5K8   A0A147A2R7   A0A087YH40   E6ZGL2   A0A315VYD5   A0A3Q3JIB5   G3NMJ4   A0A023EQ78   A0A182GL78   A0A3Q1HNU9   A0A1E1XBY1   A0A3Q3KWN9   A0A3Q3QJ17   A0A3P9QAK0   A0A3P9J0P2   M4A5E0   A0A0S7G0A1   A0A3Q1GHZ0   A0A3B5BJY7   A0A3P9M0C1   H2N1E0   A0A3Q2XS96   A0A3Q1AKD7   A0A1A7YBN2   A0A1A7XI13   A0A0S7FSZ8   A0A3Q2W7R7   A0A182H6W4   A0A3R7LYG1   A0A3B4F2U3   A0A3Q2X8N8   A0A3Q4GEU8   I3KUM4   E2B1Q9   A0A1A8CAF3   A0A154PPY3   A0A3P8WYI3   A4QNE0   A0A0N8K2W0   A0A226NJT4   A0A226PTK4   G1K3K2   A0A1A8DKN6   A0A1A8JXI0   A0A1A8MFQ4   A0A1A8NLH0   A0A1A8RKJ7   A0A1A8IX59   E2BIS1   A0A3P8TYM2   Q16KN0   G3NMK3   A1Z3X3   A0A1A8PN16   A0A287AWN6   A0A1A8UBT3   A0A1A7ZXW2   A0A2Y9RVL8   A0A3B3BSQ4   H2V3I3   A0A0P4WP96  

PDB

6AU8     E-value=8.10771e-67,     Score=643

KEGG

101736319    K23387 golgi to ER traffic protein 4 | (RefSeq) Golgi to ER traffic protein 4 homolog

GO

GO:0071818   GO:0045048   GO:0005829   GO:0071816   GO:0005654   GO:1904378   GO:0051087   GO:0005730   GO:0051220  

PANTHER

PTHR12875  

Subcellular location

  

Length:

316

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.648810000000001

Exp number, first 60 AAs:

0.00077

Total prob of N-in:

0.04501

outside

1  -  316

 

 

Pi

219.207903

Theta

160.181601

Tajima's D

0.739619

CLR

0.430069

CSRT

0.587170641467927

Interpretation

Uncertain