Gene

KWMTBOMO10295  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA007298

Annotation

putative_Wdr45l_protein_[Danaus_plexippus]

Location

Bomo_Chr17(+):7120885-7123813      View in EpiBrowser

Full name

WD repeat domain phosphoinositide-interacting protein 3      

Alternative Name

WD repeat-containing protein 45-like
WD repeat-containing protein 45B

Location in the cell

Extracellular   Reliability : 2.029

CDS

ATGAACTTGTCTGAAGAAAATCCATTTGGTAACGGGCTTTTGTACGTGGGCTTTAACCAAGATCAAGGTTGTTTCGCTTGTGGAACGGAAAATGGTTTCCGTGTCTTCAATAGTGACCCCGTACAAGAGAAAGAACGGCAGAACTTTGCTGTTGGCGGTCTTTCGTACGTGGAAATGTTATTCCGGTGTAATTATATGGCTTTGGTGGGAGGTGGTAAAACACCGGTCTATCCTCCGAACAAAGTTATTATTTGGGATGATCTAAAGAAAGATTCCGCCATATCGCTTGACTTCAACAGCCCTGTGAAAGCTGTGAAATTGCGGAGAGACCGTATTGTTGTTGTTCTAGAACAATTGATAAAAGTGTATACTTTTACGGCTCAGCCCCAATTGCTCCATGTGTTTGAAACTTGTCAAAACACAAAAGGGTTGTGCGTAGTATGTCCTAACAGTAATAATGCTCTTCTTGCCTATCCCAGCCGAAAAACTGGTCATGTGCAGTTAGTAGAGTTAAGTAGTCATGCAGGGCCAAGCACAGCCCCAGAAAGTCATCTAATAGCAGCACATGAGGCCCCTCTATGTTGTTTGGCACTTAATGTTGGAGGTACCAGACTAGCCACTGCTTCGACTAAAGGAACCCTAATAAGGGTTTTTGATACATCAACAGGACAGAAATTGGCTGAATTGCGAAGAGGAGCTCATCAGGCAACTATATACTGCATTAATTTTAACCACACAAGTACAAATCTTTGTGTGACCTCAGATCATGGAACTGTTCATGTATTCAGTTTAGAAGATGAGAAACTCAACAAACAGTCCACTTTGGCCACTGTTAACTTTTTGCCTAAATACTTCTCAAGCAATTGGAGTTTTTGCAAATTCACAATACCAAATGGTCCTCCCTGCATTTGTGCGTTTGGTGTTGACAAGAGTTCTATTATTGTGGTTTGTGCTGACGGCTCTTACTACAAATACAAATTCAATGAAAAGGGGGAATGCACCAGAGATGTTTATGATCAGTTTTTGGAGACTTCTGAAGATAGATAA

Protein

MNLSEENPFGNGLLYVGFNQDQGCFACGTENGFRVFNSDPVQEKERQNFAVGGLSYVEMLFRCNYMALVGGGKTPVYPPNKVIIWDDLKKDSAISLDFNSPVKAVKLRRDRIVVVLEQLIKVYTFTAQPQLLHVFETCQNTKGLCVVCPNSNNALLAYPSRKTGHVQLVELSSHAGPSTAPESHLIAAHEAPLCCLALNVGGTRLATASTKGTLIRVFDTSTGQKLAELRRGAHQATIYCINFNHTSTNLCVTSDHGTVHVFSLEDEKLNKQSTLATVNFLPKYFSSNWSFCKFTIPNGPPCICAFGVDKSSIIVVCADGSYYKYKFNEKGECTRDVYDQFLETSEDR

Description

Component of the autophagy machinery that controls the major intracellular degradation process by which cytoplasmic materials are packaged into autophagosomes and delivered to lysosomes for degradation. In the cellular response to starvation, may also function in the inhibition of the mTORC1 signaling pathway.

Similarity

Belongs to the WD repeat SVP1 family.

Keywords

Autophagy   Lysosome   Repeat   WD repeat   Complete proteome   Reference proteome  

Feature

chain  WD repeat domain phosphoinositide-interacting protein 3

Uniprot

H9JCQ1   A0A2A4JM05   A0A2H1W0L9   A0A3S2N9M7   A0A1E1WBQ8   A0A212FDI1   + More
A0A194QS70   A0A194QH51   A0A0L7LLB0   A0A2J7QN31   K7IZI5   A0A1Y1LXH8   A0A067QMA3   A0A3L8E5Q4   E2BQR1   D6WYC7   E2AYD7   F4WD07   A0A195BVW5   A0A158NKN7   A0A1S3J2E5   A0A232FKR4   T1JCL6   A0A154PPM5   A0A1B6CXJ1   V9IH27   A0A088AEF1   A0A2A3E648   A0A0N0U3D8   E0VN38   A0A1L8EN29   Q68F45   V3ZIP6   A0A1S3DM49   A0A1B6IYL7   A0A0P4VMP5   T1I7K3   E9JBZ3   A0A1B6MPL6   A0A1B8Y0G6   Q640T2   A0A023F5H2   K1PZL8   A0A146MGD7   A0A0A9YY90   A0A1B6F4R1   A0A2C9JG06   A0A1A8IMF9   A0A1A8UV92   A0A1A8QUH7   A0A1A8LAX9   A0A1A8DZI0   A0A131Y5B6   A0A224XML6   A0A1Q3FDQ0   A0A1E1XF07   A0A1E1XUN7   A0A023FKV1   A0A3Q3N036   A0A0P7YDW4   A0A3Q3GUL9   K9IIX2   A0A3B3SGR7   A0A151NVT5   B0WR49   A0A2U9CKU7   A0A1A7WQQ0   A0A2L2Y9I4   A0A3B1IXZ5   A0A3B4EK78   A0A091IB64   A0A182GWD0   A0A3Q1EMQ4   A0A3B4FQI9   A0A3B5BHU6   A0A3Q2VXV9   A0A3Q4HFB3   A0A3Q1AJX3   A0A3Q0T7N3   I3KTX2   A0A3P8R4T9   A0A3P9B4D5   A0A3P8TKS9   Q5ZL16   G3PR41   U3DI25   A0A3Q2ZL05   W5UCN0   A0A3B4YMV3   A0A3B3X8X9   A0A3B5PS17   A0A3Q1JUG6   A0A087YMH1   A0A3B4UHP4   A0A3B3VXE6   A8KC31   J3S9X4   A0A0K8TNI9   A0A286X7P3   A0A091DUG4  

Pubmed

19121390    22118469    26354079    26227816    20075255    28004739    + More
24845553    30249741    20798317    18362917    19820115    21719571    21347285    28648823    20566863    27762356    23254933    27129103    21282665    20431018    25474469    22992520    26823975    25401762    15562597    29652888    28503490    29209593    29240929    22293439    26561354    25329095    26483478    25186727    15642098    25243066    23127152    23542700    12477932    23594743    23025625    26369729    21993624   

EMBL

BABH01034693    NWSH01001074    PCG72748.1    ODYU01005610    SOQ46628.1    RSAL01000168    + More
RVE45235.1    GDQN01006679    JAT84375.1    AGBW02009056    OWR51784.1    KQ461155    KPJ08164.1    KQ459232    KPJ02771.1    JTDY01000686    KOB76222.1    NEVH01013201    PNF29994.1    GEZM01048841    JAV76356.1    KK853177    KDR10271.1    QOIP01000001    RLU27178.1    GL449798    EFN81980.1    KQ971356    EFA09113.1    GL443887    EFN61554.1    GL888077    EGI67914.1    KQ976403    KYM92113.1    ADTU01002112    NNAY01000090    OXU31089.1    JH432065    KQ435012    KZC13819.1    GEDC01019124    GEDC01001200    JAS18174.1    JAS36098.1    JR047272    AEY60370.1    KZ288355    PBC27217.1    KQ435908    KOX68971.1    DS235332    EEB14804.1    CM004483    OCT60763.1    BC080000    KB203566    ESO84102.1    GECU01015681    JAS92025.1    GDKW01000761    JAI55834.1    ACPB03000177    ACPB03000178    GL771642    EFZ09638.1    GEBQ01002077    JAT37900.1    KV460620    OCA16386.1    CR762340    BC082507    GBBI01002314    JAC16398.1    JH817657    EKC29662.1    GDHC01000899    JAQ17730.1    GBHO01009072    GBHO01009071    GBHO01009070    GBHO01009069    GBHO01009068    GBHO01009067    GBRD01012034    JAG34532.1    JAG34533.1    JAG34534.1    JAG34535.1    JAG34536.1    JAG34537.1    JAG53790.1    GECZ01024591    JAS45178.1    HAED01012056    SBQ98450.1    HAEJ01010521    SBS50978.1    HAEI01006232    SBR96694.1    HAEF01004134    HAEG01013132    SBR41516.1    HADZ01007717    HAEA01010852    SBQ39332.1    GEFM01002675    GEGO01001600    JAP73121.1    JAR93804.1    GFTR01005358    JAW11068.1    GFDL01009437    JAV25608.1    GFAC01001341    JAT97847.1    GFAA01000675    JAU02760.1    GBBK01002847    JAC21635.1    JARO02006984    KPP64515.1    GABZ01006857    JAA46668.1    AKHW03001857    KYO40843.1    DS232051    EDS33155.1    CP026260    AWP17224.1    HADW01006645    HADX01002953    SBP08045.1    IAAA01009632    IAAA01009633    IAAA01009634    LAA04010.1    KL218461    KFP05447.1    JXUM01004319    JXUM01004320    KQ560172    KXJ84013.1    AERX01002006    AERX01002007    AJ719918    GAMT01008559    GAMS01010125    GAMR01001085    GAMQ01006835    GAMP01005637    JAB03302.1    JAB13011.1    JAB32847.1    JAB35016.1    JAB47118.1    JT406127    AHH37467.1    AYCK01000860    CU611036    BC154337    AAI54338.1    JU176545    GBEX01003994    AFJ52068.1    JAI10566.1    GDAI01001900    JAI15703.1    AAKN02047362    KN121670    KFO35744.1   

Proteomes

UP000005204    UP000218220    UP000283053    UP000007151    UP000053240    UP000053268    + More
UP000037510    UP000235965    UP000002358    UP000027135    UP000279307    UP000008237    UP000007266    UP000000311    UP000007755    UP000078540    UP000005205    UP000085678    UP000215335    UP000076502    UP000005203    UP000242457    UP000053105    UP000009046    UP000186698    UP000030746    UP000079169    UP000015103    UP000008143    UP000005408    UP000076420    UP000261640    UP000034805    UP000192224    UP000261660    UP000261540    UP000050525    UP000002320    UP000246464    UP000018467    UP000261440    UP000054308    UP000069940    UP000249989    UP000257200    UP000261460    UP000261400    UP000264840    UP000261580    UP000257160    UP000261340    UP000005207    UP000265100    UP000265160    UP000265080    UP000000539    UP000007635    UP000008225    UP000264800    UP000221080    UP000261360    UP000261480    UP000002852    UP000265040    UP000028760    UP000261420    UP000261500    UP000000437    UP000005447    UP000028990   

PRIDE

H9JCQ1    Q68F45    Q640T2   

Pfam

PF00400   WD40

Interpro

IPR036322   WD40_repeat_dom_sf        + More
IPR017986   WD40_repeat_dom       
IPR001680   WD40_repeat       
IPR015943   WD40/YVTN_repeat-like_dom_sf       

SUPFAM

SSF50978   SSF50978       

Gene 3D

2.130.10.10    

ProteinModelPortal

H9JCQ1   A0A2A4JM05   A0A2H1W0L9   A0A3S2N9M7   A0A1E1WBQ8   A0A212FDI1   + More
A0A194QS70   A0A194QH51   A0A0L7LLB0   A0A2J7QN31   K7IZI5   A0A1Y1LXH8   A0A067QMA3   A0A3L8E5Q4   E2BQR1   D6WYC7   E2AYD7   F4WD07   A0A195BVW5   A0A158NKN7   A0A1S3J2E5   A0A232FKR4   T1JCL6   A0A154PPM5   A0A1B6CXJ1   V9IH27   A0A088AEF1   A0A2A3E648   A0A0N0U3D8   E0VN38   A0A1L8EN29   Q68F45   V3ZIP6   A0A1S3DM49   A0A1B6IYL7   A0A0P4VMP5   T1I7K3   E9JBZ3   A0A1B6MPL6   A0A1B8Y0G6   Q640T2   A0A023F5H2   K1PZL8   A0A146MGD7   A0A0A9YY90   A0A1B6F4R1   A0A2C9JG06   A0A1A8IMF9   A0A1A8UV92   A0A1A8QUH7   A0A1A8LAX9   A0A1A8DZI0   A0A131Y5B6   A0A224XML6   A0A1Q3FDQ0   A0A1E1XF07   A0A1E1XUN7   A0A023FKV1   A0A3Q3N036   A0A0P7YDW4   A0A3Q3GUL9   K9IIX2   A0A3B3SGR7   A0A151NVT5   B0WR49   A0A2U9CKU7   A0A1A7WQQ0   A0A2L2Y9I4   A0A3B1IXZ5   A0A3B4EK78   A0A091IB64   A0A182GWD0   A0A3Q1EMQ4   A0A3B4FQI9   A0A3B5BHU6   A0A3Q2VXV9   A0A3Q4HFB3   A0A3Q1AJX3   A0A3Q0T7N3   I3KTX2   A0A3P8R4T9   A0A3P9B4D5   A0A3P8TKS9   Q5ZL16   G3PR41   U3DI25   A0A3Q2ZL05   W5UCN0   A0A3B4YMV3   A0A3B3X8X9   A0A3B5PS17   A0A3Q1JUG6   A0A087YMH1   A0A3B4UHP4   A0A3B3VXE6   A8KC31   J3S9X4   A0A0K8TNI9   A0A286X7P3   A0A091DUG4  

PDB

6IYY     E-value=4.15327e-124,     Score=1138

KEGG

101735550    K22991 WD repeat-containing protein 45 | (RefSeq) WD repeat domain phosphoinositide-interacting prot

GO

GO:0032266   GO:0006497   GO:0034045   GO:0000045   GO:0034497   GO:0019898   GO:0080025   GO:0005829   GO:0000422   GO:0009267   GO:0000407   GO:0005764   GO:0062078   GO:0005515   GO:0016021   GO:0046923   GO:0015935   GO:0004812   GO:0006418   GO:0003723   GO:0046872   GO:0003824  

Subcellular location

Preautophagosomal structure  
Lysosome  

Length:

348

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.02349

Exp number, first 60 AAs:

0.00491

Total prob of N-in:

0.00355

outside

1  -  348

 

 

Pi

231.970092

Theta

215.186583

Tajima's D

0.261006

CLR

0

CSRT

0.44272786360682

Interpretation

Uncertain