Pre Gene Modal
BGIBMGA007266
Annotation
roadblock_domain-containing_protein_3_[Bombyx_mori]
Full name
Ragulator complex protein LAMTOR2 homolog
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Ragulator complex protein LAMTOR2
Ragulator complex protein LAMTOR2
Alternative Name
Late endosomal/lysosomal adaptor and MAPK and MTOR activator 2
Endosomal adaptor protein p14
Late endosomal/lysosomal Mp1-interacting protein
Mitogen-activated protein-binding protein-interacting protein
Roadblock domain-containing protein 3
Endosomal adaptor protein p14
Late endosomal/lysosomal Mp1-interacting protein
Mitogen-activated protein-binding protein-interacting protein
Roadblock domain-containing protein 3
Location in the cell
Extracellular Reliability : 1.836
Sequence
CDS
ATGCTAAAACCGAAAGCATTAACAGAAGTTTTAAGTCAAGCTAATACAGGAGGAGTAGAAAACACTTTGTTGTTGAATCATCAAGGTGCACTTCTAGCTTATTCTGGTTACAATGATAAGGATGCTAGAGTCACTGCTGCAATCGCTAGTAATGTCTGGTCAGCTTATGAAAAACACGGCAGAAATGTTTTTAAAGAAGATGGACTACATTTAATACTAGTAGATTGTTTAAATGGGAAAATTGCAATCACACAAGTTGCCAATTTATTACTGTGTCTTTATGCGAATGAGGCTGTTGGTTTTGGCATTCTGAAAGAAAAAATCAATGCTATTGCTCAGTATCTAGAAGGTCCTTTGAAGCAAGTTGCAAGTTCATAA
Protein
MLKPKALTEVLSQANTGGVENTLLLNHQGALLAYSGYNDKDARVTAAIASNVWSAYEKHGRNVFKEDGLHLILVDCLNGKIAITQVANLLLCLYANEAVGFGILKEKINAIAQYLEGPLKQVASS
Summary
Description
Regulator of the TOR pathway, a signaling cascade that promotes cell growth in response to growth factors, energy levels, and amino acids. As part of the Ragulator complex, may activate the TOR signaling cascade in response to amino acids.
As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V-ATPase, the Ragulator functions as a guanine nucleotide exchange factor activating the small GTPases Rag. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated. Adapter protein that enhances the efficiency of the MAP kinase cascade facilitating the activation of MAPK2.
As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V-ATPase, the Ragulator functions as a guanine nucleotide exchange factor activating the small GTPases Rag. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated. Adapter protein that enhances the efficiency of the MAP kinase cascade facilitating the activation of MAPK2.
Subunit
Part of the Ragulator complex composed of CG5110, CG5189, CG14184, CG14812, and CG14977.
Part of the Ragulator complex composed of LAMTOR1, LAMTOR2, LAMTOR3, LAMTOR4 and LAMTOR5. LAMTOR4 and LAMTOR5 form a heterodimer that interacts, through LAMTOR1, with a LAMTOR2, LAMTOR3 heterodimer. The Ragulator complex interacts with both the mTORC1 complex and heterodimers constituted of the Rag GTPases RRAGA, RRAGB, RRAGC and RRAGD; regulated by amino acid availability (PubMed:15016825, PubMed:15263099, PubMed:15740743, PubMed:19177150). The Ragulator complex interacts with SLC38A9; the probable amino acid sensor (By similarity). Interacts with LAMTOR1 and LAMTOR3; the interaction is direct. Interacts with MAPK1 and MAP2K1 (PubMed:11266467).
Part of the Ragulator complex composed of LAMTOR1, LAMTOR2, LAMTOR3, LAMTOR4 and LAMTOR5. LAMTOR4 and LAMTOR5 form a heterodimer that interacts, through LAMTOR1, with a LAMTOR2, LAMTOR3 heterodimer. The Ragulator complex interacts with both the mTORC1 complex and heterodimers constituted of the Rag GTPases RRAGA, RRAGB, RRAGC and RRAGD; regulated by amino acid availability (PubMed:15016825, PubMed:15263099, PubMed:15740743, PubMed:19177150). The Ragulator complex interacts with SLC38A9; the probable amino acid sensor (By similarity). Interacts with LAMTOR1 and LAMTOR3; the interaction is direct. Interacts with MAPK1 and MAP2K1 (PubMed:11266467).
Similarity
Belongs to the GAMAD family.
Keywords
Complete proteome
Reference proteome
3D-structure
Direct protein sequencing
Endosome
Lysosome
Membrane
Feature
chain Ragulator complex protein LAMTOR2 homolog
Uniprot
Q2F5P9
A0A2A4JL17
A0A2H1W0L2
A0A3S2LVZ8
A0A194QRM3
A0A194QBD6
+ More
S4P9C0 A0A1E1W1R5 A0A2P8YVS6 A0A067R6V5 A0A1W4XIR2 A0A2J7REX2 D6WW26 E2BKI5 E2AKU1 A0A1B6GXF2 A0A1B6JNA9 A0A1W4VR47 B4P4E0 B3NMT3 A0A0N0BKL2 A0A0J7L5Q1 A0A0L7R530 A0A310S9M2 A0A2A3E235 A0A0K8TRE6 A0A195C9C1 A0A195DKM6 F4WXB7 A0A151I4R5 A0A195FJW3 A0A158NU06 A0A151WUL6 B3MDG7 B4J4P4 A0A026X087 B4KM95 B4LNJ2 A0A1B6MJT1 A0A0T6AYT4 B4HNP6 B4QCF7 A0A1B0G1G8 A0A1B2AJR6 Q9V8I2 A0A232EKD2 K7J5N5 A0A0M4EI63 A0A1B6CDN0 A0A1A9UR99 Q28YR8 B4GIY6 A0A1Y1MBU4 C3YWS2 E0VT97 A0A3B0JT00 A0A0L0CMY2 A0A1B0DLU4 A0A1C7CZ89 A0A182V050 A0A182TI74 A0A182XLJ5 Q7QJ23 A0A182I2R0 A0A1A9WYV9 A0A182QH60 A0A182N919 A0A084WER9 A0A182IYL2 A0A182JYP6 D4A465 Q9JHS3 F6V5I1 A0A1S3AIM4 A0A182PYF4 A0A1S3HUH8 A0A1S3F1M4 G3HG98 I3N873 A0A1U7R3C0 A0A250Y9L3 A0A286XEW7 A0A091DQ02 G5ARA4 A0A2K6E9Q1 A0A2K6MVF3 L5JUN2 G3QVA6 A0A2I3GK13 A0A341BNN2 F2Z518 A0A0D9S501 G3U4G5 F6Z4M4 A0A2Y9E8L7 A0A3Q7PFQ4 A0A2R9BQN4 A0A340XFG4 A0A2K5EVR0 A0A2K6RUD0
S4P9C0 A0A1E1W1R5 A0A2P8YVS6 A0A067R6V5 A0A1W4XIR2 A0A2J7REX2 D6WW26 E2BKI5 E2AKU1 A0A1B6GXF2 A0A1B6JNA9 A0A1W4VR47 B4P4E0 B3NMT3 A0A0N0BKL2 A0A0J7L5Q1 A0A0L7R530 A0A310S9M2 A0A2A3E235 A0A0K8TRE6 A0A195C9C1 A0A195DKM6 F4WXB7 A0A151I4R5 A0A195FJW3 A0A158NU06 A0A151WUL6 B3MDG7 B4J4P4 A0A026X087 B4KM95 B4LNJ2 A0A1B6MJT1 A0A0T6AYT4 B4HNP6 B4QCF7 A0A1B0G1G8 A0A1B2AJR6 Q9V8I2 A0A232EKD2 K7J5N5 A0A0M4EI63 A0A1B6CDN0 A0A1A9UR99 Q28YR8 B4GIY6 A0A1Y1MBU4 C3YWS2 E0VT97 A0A3B0JT00 A0A0L0CMY2 A0A1B0DLU4 A0A1C7CZ89 A0A182V050 A0A182TI74 A0A182XLJ5 Q7QJ23 A0A182I2R0 A0A1A9WYV9 A0A182QH60 A0A182N919 A0A084WER9 A0A182IYL2 A0A182JYP6 D4A465 Q9JHS3 F6V5I1 A0A1S3AIM4 A0A182PYF4 A0A1S3HUH8 A0A1S3F1M4 G3HG98 I3N873 A0A1U7R3C0 A0A250Y9L3 A0A286XEW7 A0A091DQ02 G5ARA4 A0A2K6E9Q1 A0A2K6MVF3 L5JUN2 G3QVA6 A0A2I3GK13 A0A341BNN2 F2Z518 A0A0D9S501 G3U4G5 F6Z4M4 A0A2Y9E8L7 A0A3Q7PFQ4 A0A2R9BQN4 A0A340XFG4 A0A2K5EVR0 A0A2K6RUD0
Pubmed
19121390
26354079
23622113
29403074
24845553
18362917
+ More
19820115 20798317 17994087 17550304 26369729 21719571 21347285 24508170 30249741 22936249 10731132 12537572 20381137 28648823 20075255 15632085 28004739 18563158 20566863 26108605 20966253 12364791 14747013 17210077 24438588 15057822 15632090 11266467 16141072 15489334 19177150 21183079 15016825 15263099 15740743 17495919 21804562 28087693 21993624 21993625 23258410 22398555 30723633 19892987 22722832 25362486
19820115 20798317 17994087 17550304 26369729 21719571 21347285 24508170 30249741 22936249 10731132 12537572 20381137 28648823 20075255 15632085 28004739 18563158 20566863 26108605 20966253 12364791 14747013 17210077 24438588 15057822 15632090 11266467 16141072 15489334 19177150 21183079 15016825 15263099 15740743 17495919 21804562 28087693 21993624 21993625 23258410 22398555 30723633 19892987 22722832 25362486
EMBL
BABH01034692
DQ311374
ABD36318.1
NWSH01001074
PCG72747.1
ODYU01005610
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SOQ46630.1 RSAL01000168 RVE45236.1 KQ461155 KPJ08163.1 KQ459232 KPJ02772.1 GAIX01009130 JAA83430.1 GDQN01010114 JAT80940.1 PYGN01000334 PSN48325.1 KK852663 KDR19052.1 NEVH01004429 PNF39367.1 KQ971361 EFA08199.1 GL448810 EFN83772.1 GL440412 EFN65947.1 GECZ01002668 JAS67101.1 GECU01025570 GECU01017335 GECU01006955 JAS82136.1 JAS90371.1 JAT00752.1 CM000158 EDW91626.1 CH954179 EDV55087.1 KQ435698 KOX80754.1 LBMM01000652 KMQ97878.1 KQ414657 KOC65856.1 KQ762903 OAD55283.1 KZ288467 PBC25392.1 GDAI01000659 JAI16944.1 KQ978143 KYM96766.1 KQ980794 KYN13044.1 GL888423 EGI61166.1 KQ976445 KYM86070.1 KQ981522 KYN40688.1 ADTU01026234 KQ982747 KYQ51335.1 CH902619 EDV36415.1 CH916367 EDW02749.1 KK107046 QOIP01000004 EZA61705.1 RLU24275.1 CH933808 EDW08759.1 CH940648 EDW62172.1 GEBQ01003816 JAT36161.1 LJIG01022527 KRT80107.1 CH480816 EDW48465.1 CM000362 CM002911 EDX07681.1 KMY94851.1 CCAG010012985 KX531591 ANY27401.1 AE013599 BT011055 BT030774 BT058093 NNAY01003847 OXU18771.1 CP012524 ALC42410.1 GEDC01025908 JAS11390.1 CM000071 EAL25898.2 CH479183 EDW36404.1 GEZM01035565 JAV83174.1 GG666561 EEN55316.1 DS235760 EEB16603.1 OUUW01000001 SPP75851.1 JRES01000176 KNC33572.1 AJVK01036678 AAAB01008807 EAA04387.1 APCN01000178 AXCN02000540 ATLV01023246 KE525341 KFB48713.1 AXCP01006022 AC117919 CH473976 EDM00701.1 AJ277386 AK019006 BC031816 JH000344 EGW07069.1 AGTP01066576 AGTP01066577 GFFW01004508 JAV40280.1 AAKN02015662 KN123483 KFO24901.1 JH166592 GEBF01006152 EHA99564.1 JAN97480.1 KB031119 ELK02757.1 CABD030006708 ADFV01183717 AEMK02000022 DQIR01093862 DQIR01093865 DQIR01298179 HDA49338.1 HDC53657.1 AQIB01138830 AJFE02072211
SOQ46630.1 RSAL01000168 RVE45236.1 KQ461155 KPJ08163.1 KQ459232 KPJ02772.1 GAIX01009130 JAA83430.1 GDQN01010114 JAT80940.1 PYGN01000334 PSN48325.1 KK852663 KDR19052.1 NEVH01004429 PNF39367.1 KQ971361 EFA08199.1 GL448810 EFN83772.1 GL440412 EFN65947.1 GECZ01002668 JAS67101.1 GECU01025570 GECU01017335 GECU01006955 JAS82136.1 JAS90371.1 JAT00752.1 CM000158 EDW91626.1 CH954179 EDV55087.1 KQ435698 KOX80754.1 LBMM01000652 KMQ97878.1 KQ414657 KOC65856.1 KQ762903 OAD55283.1 KZ288467 PBC25392.1 GDAI01000659 JAI16944.1 KQ978143 KYM96766.1 KQ980794 KYN13044.1 GL888423 EGI61166.1 KQ976445 KYM86070.1 KQ981522 KYN40688.1 ADTU01026234 KQ982747 KYQ51335.1 CH902619 EDV36415.1 CH916367 EDW02749.1 KK107046 QOIP01000004 EZA61705.1 RLU24275.1 CH933808 EDW08759.1 CH940648 EDW62172.1 GEBQ01003816 JAT36161.1 LJIG01022527 KRT80107.1 CH480816 EDW48465.1 CM000362 CM002911 EDX07681.1 KMY94851.1 CCAG010012985 KX531591 ANY27401.1 AE013599 BT011055 BT030774 BT058093 NNAY01003847 OXU18771.1 CP012524 ALC42410.1 GEDC01025908 JAS11390.1 CM000071 EAL25898.2 CH479183 EDW36404.1 GEZM01035565 JAV83174.1 GG666561 EEN55316.1 DS235760 EEB16603.1 OUUW01000001 SPP75851.1 JRES01000176 KNC33572.1 AJVK01036678 AAAB01008807 EAA04387.1 APCN01000178 AXCN02000540 ATLV01023246 KE525341 KFB48713.1 AXCP01006022 AC117919 CH473976 EDM00701.1 AJ277386 AK019006 BC031816 JH000344 EGW07069.1 AGTP01066576 AGTP01066577 GFFW01004508 JAV40280.1 AAKN02015662 KN123483 KFO24901.1 JH166592 GEBF01006152 EHA99564.1 JAN97480.1 KB031119 ELK02757.1 CABD030006708 ADFV01183717 AEMK02000022 DQIR01093862 DQIR01093865 DQIR01298179 HDA49338.1 HDC53657.1 AQIB01138830 AJFE02072211
Proteomes
UP000005204
UP000218220
UP000283053
UP000053240
UP000053268
UP000245037
+ More
UP000027135 UP000192223 UP000235965 UP000007266 UP000008237 UP000000311 UP000192221 UP000002282 UP000008711 UP000053105 UP000036403 UP000053825 UP000242457 UP000078542 UP000078492 UP000007755 UP000078540 UP000078541 UP000005205 UP000075809 UP000007801 UP000001070 UP000053097 UP000279307 UP000009192 UP000008792 UP000001292 UP000000304 UP000092444 UP000000803 UP000215335 UP000002358 UP000092553 UP000078200 UP000001819 UP000008744 UP000001554 UP000009046 UP000268350 UP000037069 UP000092462 UP000075882 UP000075903 UP000075902 UP000076407 UP000007062 UP000075840 UP000091820 UP000075886 UP000075884 UP000030765 UP000075880 UP000075881 UP000002494 UP000000589 UP000002280 UP000079721 UP000075885 UP000085678 UP000081671 UP000001075 UP000005215 UP000189706 UP000005447 UP000028990 UP000006813 UP000233120 UP000233180 UP000010552 UP000001519 UP000001073 UP000252040 UP000008227 UP000029965 UP000007646 UP000002281 UP000248480 UP000286641 UP000240080 UP000265300 UP000233020 UP000233200
UP000027135 UP000192223 UP000235965 UP000007266 UP000008237 UP000000311 UP000192221 UP000002282 UP000008711 UP000053105 UP000036403 UP000053825 UP000242457 UP000078542 UP000078492 UP000007755 UP000078540 UP000078541 UP000005205 UP000075809 UP000007801 UP000001070 UP000053097 UP000279307 UP000009192 UP000008792 UP000001292 UP000000304 UP000092444 UP000000803 UP000215335 UP000002358 UP000092553 UP000078200 UP000001819 UP000008744 UP000001554 UP000009046 UP000268350 UP000037069 UP000092462 UP000075882 UP000075903 UP000075902 UP000076407 UP000007062 UP000075840 UP000091820 UP000075886 UP000075884 UP000030765 UP000075880 UP000075881 UP000002494 UP000000589 UP000002280 UP000079721 UP000075885 UP000085678 UP000081671 UP000001075 UP000005215 UP000189706 UP000005447 UP000028990 UP000006813 UP000233120 UP000233180 UP000010552 UP000001519 UP000001073 UP000252040 UP000008227 UP000029965 UP000007646 UP000002281 UP000248480 UP000286641 UP000240080 UP000265300 UP000233020 UP000233200
Pfam
PF03259 Robl_LC7
ProteinModelPortal
Q2F5P9
A0A2A4JL17
A0A2H1W0L2
A0A3S2LVZ8
A0A194QRM3
A0A194QBD6
+ More
S4P9C0 A0A1E1W1R5 A0A2P8YVS6 A0A067R6V5 A0A1W4XIR2 A0A2J7REX2 D6WW26 E2BKI5 E2AKU1 A0A1B6GXF2 A0A1B6JNA9 A0A1W4VR47 B4P4E0 B3NMT3 A0A0N0BKL2 A0A0J7L5Q1 A0A0L7R530 A0A310S9M2 A0A2A3E235 A0A0K8TRE6 A0A195C9C1 A0A195DKM6 F4WXB7 A0A151I4R5 A0A195FJW3 A0A158NU06 A0A151WUL6 B3MDG7 B4J4P4 A0A026X087 B4KM95 B4LNJ2 A0A1B6MJT1 A0A0T6AYT4 B4HNP6 B4QCF7 A0A1B0G1G8 A0A1B2AJR6 Q9V8I2 A0A232EKD2 K7J5N5 A0A0M4EI63 A0A1B6CDN0 A0A1A9UR99 Q28YR8 B4GIY6 A0A1Y1MBU4 C3YWS2 E0VT97 A0A3B0JT00 A0A0L0CMY2 A0A1B0DLU4 A0A1C7CZ89 A0A182V050 A0A182TI74 A0A182XLJ5 Q7QJ23 A0A182I2R0 A0A1A9WYV9 A0A182QH60 A0A182N919 A0A084WER9 A0A182IYL2 A0A182JYP6 D4A465 Q9JHS3 F6V5I1 A0A1S3AIM4 A0A182PYF4 A0A1S3HUH8 A0A1S3F1M4 G3HG98 I3N873 A0A1U7R3C0 A0A250Y9L3 A0A286XEW7 A0A091DQ02 G5ARA4 A0A2K6E9Q1 A0A2K6MVF3 L5JUN2 G3QVA6 A0A2I3GK13 A0A341BNN2 F2Z518 A0A0D9S501 G3U4G5 F6Z4M4 A0A2Y9E8L7 A0A3Q7PFQ4 A0A2R9BQN4 A0A340XFG4 A0A2K5EVR0 A0A2K6RUD0
S4P9C0 A0A1E1W1R5 A0A2P8YVS6 A0A067R6V5 A0A1W4XIR2 A0A2J7REX2 D6WW26 E2BKI5 E2AKU1 A0A1B6GXF2 A0A1B6JNA9 A0A1W4VR47 B4P4E0 B3NMT3 A0A0N0BKL2 A0A0J7L5Q1 A0A0L7R530 A0A310S9M2 A0A2A3E235 A0A0K8TRE6 A0A195C9C1 A0A195DKM6 F4WXB7 A0A151I4R5 A0A195FJW3 A0A158NU06 A0A151WUL6 B3MDG7 B4J4P4 A0A026X087 B4KM95 B4LNJ2 A0A1B6MJT1 A0A0T6AYT4 B4HNP6 B4QCF7 A0A1B0G1G8 A0A1B2AJR6 Q9V8I2 A0A232EKD2 K7J5N5 A0A0M4EI63 A0A1B6CDN0 A0A1A9UR99 Q28YR8 B4GIY6 A0A1Y1MBU4 C3YWS2 E0VT97 A0A3B0JT00 A0A0L0CMY2 A0A1B0DLU4 A0A1C7CZ89 A0A182V050 A0A182TI74 A0A182XLJ5 Q7QJ23 A0A182I2R0 A0A1A9WYV9 A0A182QH60 A0A182N919 A0A084WER9 A0A182IYL2 A0A182JYP6 D4A465 Q9JHS3 F6V5I1 A0A1S3AIM4 A0A182PYF4 A0A1S3HUH8 A0A1S3F1M4 G3HG98 I3N873 A0A1U7R3C0 A0A250Y9L3 A0A286XEW7 A0A091DQ02 G5ARA4 A0A2K6E9Q1 A0A2K6MVF3 L5JUN2 G3QVA6 A0A2I3GK13 A0A341BNN2 F2Z518 A0A0D9S501 G3U4G5 F6Z4M4 A0A2Y9E8L7 A0A3Q7PFQ4 A0A2R9BQN4 A0A340XFG4 A0A2K5EVR0 A0A2K6RUD0
PDB
1SZV
E-value=2.2145e-44,
Score=444
Ontologies
GO
PANTHER
Topology
Subcellular location
Late endosome membrane
Lysosome membrane
Lysosome membrane
Length:
125
Number of predicted TMHs:
0
Exp number of AAs in TMHs:
2.63564
Exp number, first 60 AAs:
0.00869
Total prob of N-in:
0.12621
outside
1 - 125
Population Genetic Test Statistics
Pi
120.002859
Theta
110.385251
Tajima's D
-0.388017
CLR
17.714476
CSRT
0.270536473176341
Interpretation
Uncertain
