Gene

KWMTBOMO10292

Annotation

KDEL_endoplasmic_reticulum_protein_retention_receptor_2_[Bombyx_mori]

Location

Bomo_Chr17(-):7108858-7111934      View in EpiBrowser

Full name

ER lumen protein-retaining receptor      

Location in the cell

PlasmaMembrane   Reliability : 4.686

CDS

ATGAATATATTCCGTTTGCTTGGTGATCTATCCCACCTGTTAGCTATAATAATATTGTTATTAAAGATTTGGAAATCAAGATCATGTGCAGGGATATCAGGAAAGTCTCAGATTCTGTTTTCAGTGGTATACACGACACGTTATTTGGATCTACTTACAACTCATGTGTCCCCGTATAACACTGTCATGAAGTTGGTGTTCATCTTTACCTCCTATGCAACTATTTATTTGATGTATGTCAAGTTTAAGGCCACCTATGATCACAACCATGACACATTCAGGATTGAATTTCTACTGATCCCCACCTTTATCTTGGCTTTATTGATAAACCATGAGTTTACTGTTTTGGAGGTATTGTGGACTTTTTCCATTTATTTGGAATCTGTCGCTATTCTACCTCAACTGTTCCTGGTTTCAAAAACAAGAGAGGCCGAAAGCATTACCTCTCATTATCTGTTTGCTTTAGGTTCATATAGAGCTCTGTACCTCTTGAACTGGGTTTACCGTTATGTTGTGGAGTCTCACTATGAGTTGATAGCGATTATCTCGGGTGTTGTGCAGACAATTCTGTACTGTGATTTCTTTTACCTTTACATTACGAAAGTGTTGAAGGGAAAGAAACTACAGTTGCCAGCTTAA

Protein

MNIFRLLGDLSHLLAIIILLLKIWKSRSCAGISGKSQILFSVVYTTRYLDLLTTHVSPYNTVMKLVFIFTSYATIYLMYVKFKATYDHNHDTFRIEFLLIPTFILALLINHEFTVLEVLWTFSIYLESVAILPQLFLVSKTREAESITSHYLFALGSYRALYLLNWVYRYVVESHYELIAIISGVVQTILYCDFFYLYITKVLKGKKLQLPA

Description

Required for the retention of luminal endoplasmic reticulum proteins. Determines the specificity of the luminal ER protein retention system. Also required for normal vesicular traffic through the Golgi (By similarity).

Similarity

Belongs to the ERD2 family.

Keywords

Complete proteome   Endoplasmic reticulum   ER-Golgi transport   Membrane   Protein transport   Receptor   Reference proteome   Transmembrane   Transmembrane helix   Transport  

Feature

chain  ER lumen protein-retaining receptor

Uniprot

Q2F604   A0A2H1W1A4   A0A3S2L456   A0A2A4JKY4   A0A1E1WEG7   I4DLJ7   + More
A0A212FDF7   A0A2P8XLI1   S4P9Y5   A0A067QLS7   A0A0L0CGG4   V9II02   A0A0M9A7F8   E9IBL9   B3N9Q0   B4NZP5   E0VNS8   B4KHS0   A0A026WWD6   A0A3B0JLE5   B4HWP4   A0A1W4UFA4   A0A0J9R069   O76767   A0A0T6B8S7   A0A0L7QRU5   B4LVC7   B4JPZ4   B3MJH8   A0A1B6FB24   A0A1B6JPH9   A0A0M4ECD3   Q29NI8   B4G784   B4MUB7   A0A195AWV6   A0A158NHY8   A0A195EH49   A0A151WQZ8   A0A0Q9XHJ0   A0A154PLL3   D6WVB3   A0A1B6D401   A0A1A9V1G1   F4WPW0   K7J2D7   A0A232F0N3   A0A1B0C4T9   A0A195FEX9   A0A1J1IND4   A0A069DQL9   D3TLP8   A0A1Y1LY15   R4G5A6   Q16YU7   A0A023EJP8   A0A182P881   A0A084W5H9   A0A182SCU8   A0A182USJ4   A0A182KDJ5   Q7PDC9   R4WPE2   A0A182MUM5   A0A1Q3FDT4   T1DIQ6   A0A182IPJ7   E2BXG9   A0A0A9W0R4   B0X852   W5JGK3   A0A182FMW1   A0A224XK42   T1EB61   A0A2M3ZES5   A0A2M4ABE7   A0A2M4CHV2   A0A336LXG3   A0A2M4ABD7   A0A182N8R4   A0A1L8DUN0   A0A1L8DUI1   A0A0K8U3D0   A0A195CLH1   A0A0A1XBZ9   A0A1W4WUI8   A0A1W7RAJ1   A0A1I8PY85   A0A2J7PZ93   A0A3R7MD70   A0A1L8EHG8   A0A023GPA8   U5EX25   A0A0N8EDH2   A0A224YYE3   A0A1I8MS60   A0A0P4WES9   E9FXU8   A0A1Z5KVP2   A0A131YZN3  

Pubmed

22651552    26354079    22118469    29403074    23622113    24845553    + More
26108605    21282665    17994087    18057021    17550304    20566863    24508170    30249741    22936249    10731132    12537572    10731138    15632085    21347285    18362917    19820115    21719571    20075255    28648823    26334808    20353571    28004739    17510324    24945155    26483478    24438588    9087549    12364791    14747013    17210077    23691247    24330624    20798317    25401762    26823975    20920257    23761445    25830018    28797301    25315136    21292972    28528879    26830274   

EMBL

DQ311268    ABD36213.1    ODYU01005610    SOQ46632.1    RSAL01000168    RVE45238.1    + More
NWSH01001074    PCG72745.1    GDQN01005662    JAT85392.1    AK402165    KQ459232    BAM18787.1    KPJ02769.1    AGBW02009056    OWR51786.1    PYGN01001777    PSN32855.1    GAIX01003499    JAA89061.1    KK853176    KDR10284.1    JRES01000410    KNC31488.1    JR045993    AEY60111.1    KQ435732    KOX77419.1    GL762111    EFZ22058.1    CH954177    EDV58545.1    CM000157    EDW88829.1    DS235346    EEB15034.1    CH933807    EDW13357.1    KK107078    QOIP01000011    EZA60390.1    RLU17193.1    OUUW01000006    SPP81673.1    CH480818    EDW52439.1    CM002910    KMY89541.1    AF081126    AE014134    AF132559    LJIG01009350    KRT83255.1    KQ414777    KOC61236.1    CH940649    EDW63306.1    KRF81033.1    CH916372    EDV98974.1    CH902620    EDV32346.1    KPU73911.1    GECZ01022438    JAS47331.1    GECU01026976    GECU01006649    JAS80730.1    JAT01058.1    CP012523    ALC39272.1    CH379059    EAL34231.1    CH479180    EDW28338.1    CH963857    EDW76043.1    KQ976725    KYM76537.1    ADTU01016112    KQ978957    KYN27202.1    KQ982813    KYQ50332.1    KRG03713.1    KQ434946    KZC12344.1    KQ971363    EFA07749.1    GEDC01016900    JAS20398.1    GL888255    EGI63789.1    AAZX01007551    NNAY01001391    OXU24140.1    JXJN01025653    KQ981636    KYN38777.1    CVRI01000056    CRL01741.1    GBGD01002903    JAC85986.1    CCAG010013973    EZ422350    ADD18626.1    GEZM01044993    JAV77991.1    ACPB03002212    GAHY01000695    JAA76815.1    CH477509    CH477233    EAT39785.1    EAT46769.1    JXUM01028452    JXUM01043823    GAPW01004318    GAPW01004317    KQ561377    KQ560822    JAC09281.1    KXJ78787.1    KXJ80750.1    ATLV01020648    KE525304    KFB45473.1    AAAB01007222    AAAB01008980    EAA02917.2    EAA13938.2    AK417511    BAN20726.1    AXCM01000430    GFDL01009328    JAV25717.1    GALA01000836    JAA94016.1    GL451254    EFN79617.1    GBHO01045139    GDHC01020610    GDHC01020145    JAF98464.1    JAP98018.1    JAP98483.1    DS232475    EDS42321.1    ADMH02001476    ETN62448.1    GFTR01003570    JAW12856.1    GAMD01000258    JAB01333.1    GGFM01006244    MBW26995.1    GGFK01004794    MBW38115.1    GGFL01000739    MBW64917.1    UFQT01000035    SSX18338.1    GGFK01004749    MBW38070.1    GFDF01003940    JAV10144.1    GFDF01003996    JAV10088.1    GDHF01032123    GDHF01031298    GDHF01026572    JAI20191.1    JAI21016.1    JAI25742.1    KQ977622    KYN01317.1    GBXI01005816    JAD08476.1    GFAH01000220    JAV48169.1    NEVH01020337    PNF21661.1    QCYY01001345    ROT78715.1    GFDG01000668    JAV18131.1    GBBM01000308    JAC35110.1    GANO01001155    JAB58716.1    GDIQ01037492    JAN57245.1    GFPF01007644    MAA18790.1    GDRN01038656    JAI67238.1    GL732526    EFX88165.1    GFJQ02007798    JAV99171.1    GEDV01004612    JAP83945.1   

Proteomes

UP000283053    UP000218220    UP000053268    UP000007151    UP000245037    UP000027135    + More
UP000037069    UP000053105    UP000008711    UP000002282    UP000009046    UP000009192    UP000053097    UP000279307    UP000268350    UP000001292    UP000192221    UP000000803    UP000053825    UP000008792    UP000001070    UP000007801    UP000092553    UP000001819    UP000008744    UP000007798    UP000078540    UP000005205    UP000078492    UP000075809    UP000076502    UP000007266    UP000078200    UP000007755    UP000002358    UP000215335    UP000092460    UP000078541    UP000183832    UP000092444    UP000015103    UP000008820    UP000069940    UP000249989    UP000075885    UP000030765    UP000075901    UP000075903    UP000075881    UP000007062    UP000075883    UP000075880    UP000008237    UP000002320    UP000000673    UP000069272    UP000075884    UP000078542    UP000192223    UP000095300    UP000235965    UP000283509    UP000095301    UP000000305   

PRIDE

Q2F604    O76767   

Pfam

PF00810   ER_lumen_recept

Interpro

IPR000133   ER_ret_rcpt       

ProteinModelPortal

Q2F604   A0A2H1W1A4   A0A3S2L456   A0A2A4JKY4   A0A1E1WEG7   I4DLJ7   + More
A0A212FDF7   A0A2P8XLI1   S4P9Y5   A0A067QLS7   A0A0L0CGG4   V9II02   A0A0M9A7F8   E9IBL9   B3N9Q0   B4NZP5   E0VNS8   B4KHS0   A0A026WWD6   A0A3B0JLE5   B4HWP4   A0A1W4UFA4   A0A0J9R069   O76767   A0A0T6B8S7   A0A0L7QRU5   B4LVC7   B4JPZ4   B3MJH8   A0A1B6FB24   A0A1B6JPH9   A0A0M4ECD3   Q29NI8   B4G784   B4MUB7   A0A195AWV6   A0A158NHY8   A0A195EH49   A0A151WQZ8   A0A0Q9XHJ0   A0A154PLL3   D6WVB3   A0A1B6D401   A0A1A9V1G1   F4WPW0   K7J2D7   A0A232F0N3   A0A1B0C4T9   A0A195FEX9   A0A1J1IND4   A0A069DQL9   D3TLP8   A0A1Y1LY15   R4G5A6   Q16YU7   A0A023EJP8   A0A182P881   A0A084W5H9   A0A182SCU8   A0A182USJ4   A0A182KDJ5   Q7PDC9   R4WPE2   A0A182MUM5   A0A1Q3FDT4   T1DIQ6   A0A182IPJ7   E2BXG9   A0A0A9W0R4   B0X852   W5JGK3   A0A182FMW1   A0A224XK42   T1EB61   A0A2M3ZES5   A0A2M4ABE7   A0A2M4CHV2   A0A336LXG3   A0A2M4ABD7   A0A182N8R4   A0A1L8DUN0   A0A1L8DUI1   A0A0K8U3D0   A0A195CLH1   A0A0A1XBZ9   A0A1W4WUI8   A0A1W7RAJ1   A0A1I8PY85   A0A2J7PZ93   A0A3R7MD70   A0A1L8EHG8   A0A023GPA8   U5EX25   A0A0N8EDH2   A0A224YYE3   A0A1I8MS60   A0A0P4WES9   E9FXU8   A0A1Z5KVP2   A0A131YZN3  

PDB

6I6H     E-value=7.56626e-68,     Score=650

KEGG

692878    K10949 ER lumen protein retaining receptor | (RefSeq) ERD2; KDEL endoplasmic reticulum protein reten

GO

GO:0015031   GO:0046923   GO:0006621   GO:0016021   GO:0005789   GO:0005783   GO:0005046   GO:0016192   GO:0005801   GO:0005794   GO:0006888   GO:0015935   GO:0004812   GO:0006418   GO:0003723   GO:0046872   GO:0003824  

PANTHER

PTHR10585  

Subcellular location

Endoplasmic reticulum membrane  

Length:

212

Number of predicted TMHs:

5

Exp number of AAs in TMHs:

116.61438

Exp number, first 60 AAs:

15.38736

Total prob of N-in:

0.53477

POSSIBLE N-term signal

sequence

outside

1  -  57

TMhelix

58  -  80

inside

81  -  92

TMhelix

93  -  115

outside

116  -  118

TMhelix

119  -  138

inside

139  -  150

TMhelix

151  -  168

outside

169  -  177

TMhelix

178  -  200

inside

201  -  212

 

 

Pi

138.012567

Theta

167.033698

Tajima's D

-0.129022

CLR

0.312463

CSRT

0.333283335833208

Interpretation

Uncertain