Gene

KWMTBOMO10266

Pre Gene Modal

BGIBMGA007274

Annotation

PREDICTED:_protein_I'm_not_dead_yet-like_[Plutella_xylostella]

Location

Bomo_Chr17(-):6291876-6292527      View in EpiBrowser

Full name

Protein I'm not dead yet       + More
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit      

Alternative Name

INDY transporter protein
drIndy

Location in the cell

PlasmaMembrane   Reliability : 2.743

CDS

ATGTTACTTATGGAGTTAGCTATGTATTTTTATTTGATTATCGTGTACTTCGGATTTTTAAGACCCAATAGCCAAGCTGCTAAAGATTCTGTGATCACCCCAGAAAGTATCGAAGCAGCAAAAAAGACCGTTGATAAAGATTGGGTAAATTTGGGAAAAGTAACATTTTGGGAATATATGGTAATCATATTATTTGGTGGAGCAATGGTATTATTCTTTGCAAGATCCCCTCAAATTTTTCAAGGTTGGGGCGATAAAACCATCAGTTATTTCGGGATTAAAAATAACAAATTGTAA

Protein

MLLMELAMYFYLIIVYFGFLRPNSQAAKDSVITPESIEAAKKTVDKDWVNLGKVTFWEYMVIILFGGAMVLFFARSPQIFQGWGDKTISYFGIKNNKL

Description

Cation-independent electroneutral transporter (not associated with membrane depolarization) of a variety of tricarboxylic and dicarboxylic acid-cycle intermediates. There is also small, but detectable, transport of monocarboxylics. Transport is through the epithelium of the gut and across the plasma membranes of organs involved in intermediary metabolism and storage. Affinity for substrates is citrate > succinate > pyruvate. Fumarate, a-ketoglutarate, and glutarate are also transported, but not lactate. Transport mechanism that is not coupled to Na(+), K(+), or Cl(-). Function is shown in Xenopus oocytes and human retinal pigment epithelial (HRPE) cell lines.
Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER).

Subunit

Component of the oligosaccharyltransferase (OST) complex.

Miscellaneous

The life-extending effect of mutations is likely caused by an alteration in energy balance caused by a decrease in transport function.

Similarity

Belongs to the SLC13A/DASS transporter (TC 2.A.47) family. NADC subfamily.
Belongs to the DDOST 48 kDa subunit family.

Keywords

Alternative splicing   Cell membrane   Complete proteome   Membrane   Reference proteome   Transmembrane   Transmembrane helix   Transport  

Feature

chain  Protein I'm not dead yet
splice variant  In isoform B.

Uniprot

A0A3S2NWJ4   A0A212FAN4   A0A194QRQ2   A0A2A4J2F5   A0A3S2NFT2   A0A2A4JSL5   + More
A0A194QH25   A0A2H1VD01   T1GDJ2   A0A182GSH0   W5J711   A0A2M3ZG83   A0A1L8DEL7   A0A1L8DES5   A0A1L8DE76   A0A1L8DE04   A0A182GSH2   A0A182FER4   A0A1B0GFN7   A0A1B0A737   A0A336KEI2   A0A1A9V5X8   A0A336KWG5   A0A336KDB7   A0A182SQS9   Q16UM1   A0A1L8ECM3   A0A1L8E9V4   A0A0P6JNM3   A0A1S4FNK3   Q16UM2   A0A182NZ46   A0A182WWT0   Q7QIT2   A0A182VBY4   A0A182L392   A0A182UAV5   A0A182HWF9   B4J1T3   A0A182GSH1   A0A1A9XD94   A0A1B0C4D6   A0A182WL11   A0A182JX44   A0A182Y266   A0A1A9W3H3   A0A0P8XVW7   B3M868   A0A2M4BIC4   A0A2M4BIG4   A0A182Q6Q6   A0A0L0C679   A0A182JDR1   A0A0C9RKM7   A0A1I8QD75   E9IWV9   A0A182PTK9   A0A1W4WEQ3   B3NHN6   A0A0Q5UJB0   Q9VVT2-2   A0A0J9RXY5   E1JI19   B4IFW0   D0IQJ2   Q9VVT2   A0A0J9RXQ8   A0A0C9QGV0   A0A0R1DXX2   B4QPW6   A0A195CS08   B4PIY5   A0A151WJU9   A0A195E354   B4N4U3   A0A0R3P3N0   A0A182RMY3   B5DPF3   U5EXM5   A0A0Q9XRT0   B4KXS1   A0A154PRT9   A0A084WJU3   Q16UM0   T1PEL6   A0A0M4ETS4   A0A1S4FNY7   A0A1Q3FP35   A0A182J1X2   A0A1Q3FNV3   K7IW72   K7J4H9   A0A1I8M3N9   A0A0Q9WVC4   B4LFX1   A0A0Q9WUJ9   A0A0M4EI95   A0A1J1IEA9  

Pubmed

22118469    26354079    26483478    20920257    23761445    17510324    + More
12364791    14747013    17210077    20966253    17994087    25244985    26108605    21282665    12186628    10731132    12537572    12537569    10581279    11118146    12391301    22936249    12537568    12537573    12537574    16110336    17569856    17569867    17550304    15632085    24438588    20075255    25315136   

EMBL

RSAL01000130    RVE46445.1    AGBW02009440    OWR50804.1    KQ461155    KPJ08193.1    + More
NWSH01003418    PCG66337.1    RVE46444.1    NWSH01000682    PCG74819.1    KQ459232    KPJ02746.1    ODYU01001889    SOQ38729.1    CAQQ02394832    CAQQ02394833    JXUM01002644    KQ560143    KXJ84194.1    ADMH02002049    ETN59761.1    GGFM01006709    MBW27460.1    GFDF01009206    JAV04878.1    GFDF01009207    JAV04877.1    GFDF01009399    JAV04685.1    GFDF01009398    JAV04686.1    JXUM01002648    KXJ84196.1    CCAG010022811    UFQS01000322    UFQT01000322    SSX02867.1    SSX23234.1    UFQS01001198    UFQT01001198    SSX09649.1    SSX29445.1    SSX02866.1    SSX23233.1    CH477618    EAT38222.1    GFDG01002319    JAV16480.1    GFDG01003239    JAV15560.1    GDIQ01002285    JAN92452.1    EAT38221.1    AAAB01008807    EAA03999.4    APCN01001489    CH916366    EDV98013.1    JXUM01002647    KXJ84195.1    JXJN01025422    CH902618    KPU78880.1    EDV41007.1    GGFJ01003664    MBW52805.1    GGFJ01003663    MBW52804.1    AXCN02000497    JRES01000836    KNC27883.1    GBYB01013822    JAG83589.1    GL766616    EFZ14935.1    CH954178    EDV51831.1    KQS43994.1    AF509505    AE014296    AY102686    AF217399    AAF73384.1    AAM27515.1    CM002912    KMZ00448.1    ACZ94736.1    CH480834    EDW46547.1    BT100230    ACY56898.1    KMZ00449.1    GBYB01013823    JAG83590.1    CM000159    KRK01936.1    CM000363    EDX10994.1    KQ977329    KYN03523.1    EDW94576.1    KQ983028    KYQ48153.1    KQ979701    KYN19511.1    CH964101    EDW79382.1    CH379069    KRT07809.1    EDY73532.1    GANO01002475    JAB57396.1    CH933809    KRG06824.1    EDW19778.1    KQ435090    KZC14611.1    ATLV01024071    ATLV01024072    KE525348    KFB50487.1    EAT38223.1    KA647227    AFP61856.1    CP012526    ALC46330.1    GFDL01005799    JAV29246.1    GFDL01005766    JAV29279.1    CH940647    KRF84878.1    EDW70370.1    KRF84879.1    CP012525    ALC44427.1    CVRI01000047    CRK98547.1   

Proteomes

UP000283053    UP000007151    UP000053240    UP000218220    UP000053268    UP000015102    + More
UP000069940    UP000249989    UP000000673    UP000069272    UP000092444    UP000092445    UP000078200    UP000075901    UP000008820    UP000075884    UP000076407    UP000007062    UP000075903    UP000075882    UP000075902    UP000075840    UP000001070    UP000092443    UP000092460    UP000075920    UP000075881    UP000076408    UP000091820    UP000007801    UP000075886    UP000037069    UP000075880    UP000095300    UP000075885    UP000192223    UP000008711    UP000000803    UP000001292    UP000002282    UP000000304    UP000078542    UP000075809    UP000078492    UP000007798    UP000001819    UP000075900    UP000009192    UP000076502    UP000030765    UP000092553    UP000002358    UP000095301    UP000008792    UP000183832   

PRIDE

Q9VVT2    D0IQJ2   

Pfam

PF00939   Na_sulph_symp        + More
PF13903   Claudin_2
PF00086   Thyroglobulin_1
PF04139   Rad9
PF03345   DDOST_48kD
PF15277   Sec3-PIP2_bind
PF09763   Sec3_C

Interpro

IPR004031   PMP22/EMP/MP20/Claudin        + More
IPR031312   Na/sul_symport_CS       
IPR001898   SLC13A/DASS       
IPR000716   Thyroglobulin_1       
IPR036857   Thyroglobulin_1_sf       
IPR007268   Rad9/Ddc1       
IPR005013   DDOST_48_kDa_subunit       
IPR028258   Sec3-PIP2_bind       
IPR019160   Sec3_C       

SUPFAM

SSF57610   SSF57610       

Gene 3D

4.10.800.10    

CDD

cd00191  TY

ProteinModelPortal

A0A3S2NWJ4   A0A212FAN4   A0A194QRQ2   A0A2A4J2F5   A0A3S2NFT2   A0A2A4JSL5   + More
A0A194QH25   A0A2H1VD01   T1GDJ2   A0A182GSH0   W5J711   A0A2M3ZG83   A0A1L8DEL7   A0A1L8DES5   A0A1L8DE76   A0A1L8DE04   A0A182GSH2   A0A182FER4   A0A1B0GFN7   A0A1B0A737   A0A336KEI2   A0A1A9V5X8   A0A336KWG5   A0A336KDB7   A0A182SQS9   Q16UM1   A0A1L8ECM3   A0A1L8E9V4   A0A0P6JNM3   A0A1S4FNK3   Q16UM2   A0A182NZ46   A0A182WWT0   Q7QIT2   A0A182VBY4   A0A182L392   A0A182UAV5   A0A182HWF9   B4J1T3   A0A182GSH1   A0A1A9XD94   A0A1B0C4D6   A0A182WL11   A0A182JX44   A0A182Y266   A0A1A9W3H3   A0A0P8XVW7   B3M868   A0A2M4BIC4   A0A2M4BIG4   A0A182Q6Q6   A0A0L0C679   A0A182JDR1   A0A0C9RKM7   A0A1I8QD75   E9IWV9   A0A182PTK9   A0A1W4WEQ3   B3NHN6   A0A0Q5UJB0   Q9VVT2-2   A0A0J9RXY5   E1JI19   B4IFW0   D0IQJ2   Q9VVT2   A0A0J9RXQ8   A0A0C9QGV0   A0A0R1DXX2   B4QPW6   A0A195CS08   B4PIY5   A0A151WJU9   A0A195E354   B4N4U3   A0A0R3P3N0   A0A182RMY3   B5DPF3   U5EXM5   A0A0Q9XRT0   B4KXS1   A0A154PRT9   A0A084WJU3   Q16UM0   T1PEL6   A0A0M4ETS4   A0A1S4FNY7   A0A1Q3FP35   A0A182J1X2   A0A1Q3FNV3   K7IW72   K7J4H9   A0A1I8M3N9   A0A0Q9WVC4   B4LFX1   A0A0Q9WUJ9   A0A0M4EI95   A0A1J1IEA9  

KEGG

101744933    K14445 solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 2/3/5 | (RefSeq

GO

GO:0016021   GO:0005215   GO:0006814   GO:0055085   GO:0016020   GO:0015746   GO:0015137   GO:0015141   GO:0050833   GO:0005887   GO:0008340   GO:0010889   GO:0016323   GO:0006848   GO:0005886   GO:0015744   GO:0000077   GO:0030896   GO:0016740   GO:0018279   GO:0005789   GO:0000145   GO:0006887  

PANTHER

PTHR10830  

Subcellular location

Basolateral cell membrane  
Endoplasmic reticulum membrane  

Length:

98

Number of predicted TMHs:

2

Exp number of AAs in TMHs:

38.20867

Exp number, first 60 AAs:

23.88767

Total prob of N-in:

0.81067

POSSIBLE N-term signal

sequence

inside

1  -  1

TMhelix

2  -  20

outside

21  -  54

TMhelix

55  -  74

inside

75  -  98

 

 

Pi

107.675009

Theta

117.662467

Tajima's D

-0.301801

CLR

0.286059

CSRT

0.292235388230588

Interpretation

Uncertain