Gene

KWMTBOMO10263

Pre Gene Modal

BGIBMGA007283

Annotation

PREDICTED:_protein_I'm_not_dead_yet-like_[Papilio_polytes]

Location

Bomo_Chr17(+):6271348-6276120      View in EpiBrowser

Full name

Protein I'm not dead yet      

Alternative Name

INDY transporter protein
drIndy

Location in the cell

PlasmaMembrane   Reliability : 4.755

CDS

ATGTTTGATACAAATGCTGAAGGTGAAAAAGTAGCAAGTGACCTAACAACGTGCTATTTTTGTGCTGCTACCTTTTCAGCTACGATAGGAGGTATCGGCACTTTGGTGGGCACAGCTACTAATTTGGTTTTCAAAGGACTATTTATGACGCCAAATAGTGCTGCGGCTAAGGCTGCTCAAATTACGGAAAAAGCCAAGGAGGCTGCAAGAAATGCTATCGAGGAAGATTGCAAGAGAATTGGGACTATCACGTTTTGGGAAATCATGGTTGTGCTATTATTTGGAGGTGCCATGATATGTTTCTTCTGTCGATCTCCGCAAGTATTTCCCGGATGGGGTGATAAGATTGCAGCACATTTTGGCGTGGAGAGCAAATTTGTTCGAGACTCAGCCCTAGCTATGCTTGTTACATTCCTTATGTTTCTACTTCCATCAACGCTCACTTTCTTTCAAAATTGGAAAGCAAAATTTCACGAGGATCTTCCAAAGTCTCGAGTTTCTTCAGTACTTGATTGGCCAGAACTAAGGGCTCACATGCCGTTTAGCTACATGTTCCTCTTGGGTGGCGGCTTTGCTCTTTCCATGGCAGCAAAATCATCGGGCTTGAACGAGAAAATTGGAAACTATCTTCAGGGGCTGAAAGTGCTGCCGAATTTCATAAATTTGCTTTTGATTATTATAGTTGTAGTTTTCGTCACGAACTTTGCATCTAACGTGGCCGTTTGTAATGTTTTCGCTCCTATTGCTATGCAACTGGCTAAAGAAATAAACCAGAATCCATTGTGGTACGACATAGCGGCAGGCTTCGCGGCTTCGTACTGTTTCATGATCCCAGTTGGCACACCTGGTAATTTAATTGTGCAAAGTGCTGTGAATATGCCTATGCAGAAAATGATAAAAGCAGGTTTCGGTCCCACTGTATCGACGGTCATCATATCTTGGTTGTGCATTTATTTCTGGGGTCCTGTTATTTGGCCGGACTTACATCAGATGCCAAAATGGATTAAAGATGCAAAACCTTAA

Protein

MFDTNAEGEKVASDLTTCYFCAATFSATIGGIGTLVGTATNLVFKGLFMTPNSAAAKAAQITEKAKEAARNAIEEDCKRIGTITFWEIMVVLLFGGAMICFFCRSPQVFPGWGDKIAAHFGVESKFVRDSALAMLVTFLMFLLPSTLTFFQNWKAKFHEDLPKSRVSSVLDWPELRAHMPFSYMFLLGGGFALSMAAKSSGLNEKIGNYLQGLKVLPNFINLLLIIIVVVFVTNFASNVAVCNVFAPIAMQLAKEINQNPLWYDIAAGFAASYCFMIPVGTPGNLIVQSAVNMPMQKMIKAGFGPTVSTVIISWLCIYFWGPVIWPDLHQMPKWIKDAKP

Description

Cation-independent electroneutral transporter (not associated with membrane depolarization) of a variety of tricarboxylic and dicarboxylic acid-cycle intermediates. There is also small, but detectable, transport of monocarboxylics. Transport is through the epithelium of the gut and across the plasma membranes of organs involved in intermediary metabolism and storage. Affinity for substrates is citrate > succinate > pyruvate. Fumarate, a-ketoglutarate, and glutarate are also transported, but not lactate. Transport mechanism that is not coupled to Na(+), K(+), or Cl(-). Function is shown in Xenopus oocytes and human retinal pigment epithelial (HRPE) cell lines.

Miscellaneous

The life-extending effect of mutations is likely caused by an alteration in energy balance caused by a decrease in transport function.

Similarity

Belongs to the SLC13A/DASS transporter (TC 2.A.47) family. NADC subfamily.

Keywords

Alternative splicing   Cell membrane   Complete proteome   Membrane   Reference proteome   Transmembrane   Transmembrane helix   Transport  

Feature

chain  Protein I'm not dead yet
splice variant  In isoform B.

Uniprot

A0A2H1VD01   A0A3S2NFT2   A0A3S2NWJ4   A0A194QH25   A0A2A4J2F5   A0A212FAN4   + More
A0A194QRS7   A0A0L0C679   T1PEL6   A0A1I8M3N9   A0A1A9W3H3   A0A1L8DE04   A0A182GSH1   A0A0P8XVW7   A0A1L8DEL7   B3M868   A0A1B0GFN7   A0A1L8DE76   A0A1B0A737   Q16UM0   A0A1A9V5X8   A0A1L8DES5   A0A1S4FNY7   A0A1A9XD94   A0A1B0C4D6   Q16UM1   Q16UM3   A0A1I8QD75   A0A1Q3FKR1   A0A1Q3FKP1   A0A023EVA1   A0A034WH82   A0A1W4WEQ3   U5EXM5   A0A0A1WUW7   A0A182NZ46   A0A182RMY3   A0A2M4BIG4   A0A1L8E9V4   B4IFW0   A0A182WWT0   A0A2M4BIC4   A0A1L8ECM3   B4PIY5   B3NHN6   A0A0Q5UJB0   D0IQJ2   Q9VVT2   A0A182VBY4   A0A182L392   A0A182UAV5   A0A182HWF9   A0A0J9RXQ8   Q9VVT2-2   E1JI19   Q7QIT2   A0A0J9RXY5   A0A0R1DXX2   A0A182JDR1   A0A182GSH2   W5J711   A0A182Q6Q6   A0A182PTK9   A0A336KEI2   A0A139WGV7   A0A2M3ZG83   D2A4Q5   V5GVC6   A0A336KDB7   A0A336KWG5   B4J1T3   A0A1Q3FP35   A0A0K8W2J2   B4QPW6   B0WCP1   A0A182Y266   A0A1Q3FNV3   A0A182JX44   A0A182FER4   B4N4U3   A0A1J1IEA9   A0A1B0CAN5   A0A084WJU3   W8BH49   T1GDJ2   A0A0K8WEA4   A0A182MHP0   A0A1W4UPB0   A0A182J1X2   A0A2M4A652   A0A1W4UP31   A0A2M4A522   A0A182T3Y2   A0A182L390   A0A182PF37   A0A182HWF8   A0A182UXA5  

Pubmed

26354079    22118469    26108605    25315136    26483478    17994087    + More
17510324    24945155    25348373    25830018    17550304    12186628    10731132    12537572    12537569    10581279    11118146    12391301    20966253    22936249    12537568    12537573    12537574    16110336    17569856    17569867    12364791    14747013    17210077    20920257    23761445    18362917    19820115    25244985    24438588    24495485   

EMBL

ODYU01001889    SOQ38729.1    RSAL01000130    RVE46444.1    RVE46445.1    KQ459232    + More
KPJ02746.1    NWSH01003418    PCG66337.1    AGBW02009440    OWR50804.1    KQ461155    KPJ08192.1    JRES01000836    KNC27883.1    KA647227    AFP61856.1    GFDF01009398    JAV04686.1    JXUM01002647    KQ560143    KXJ84195.1    CH902618    KPU78880.1    GFDF01009206    JAV04878.1    EDV41007.1    CCAG010022811    GFDF01009399    JAV04685.1    CH477618    EAT38223.1    GFDF01009207    JAV04877.1    JXJN01025422    EAT38222.1    EAT38219.1    EAT38220.1    GFDL01006979    JAV28066.1    GFDL01006917    JAV28128.1    JXUM01002643    GAPW01000677    JAC12921.1    KXJ84193.1    GAKP01005451    GAKP01005450    GAKP01005449    GAKP01005447    JAC53505.1    GANO01002475    JAB57396.1    GBXI01012064    JAD02228.1    GGFJ01003663    MBW52804.1    GFDG01003239    JAV15560.1    CH480834    EDW46547.1    GGFJ01003664    MBW52805.1    GFDG01002319    JAV16480.1    CM000159    EDW94576.1    CH954178    EDV51831.1    KQS43994.1    BT100230    ACY56898.1    AF509505    AE014296    AY102686    AF217399    AAF73384.1    AAM27515.1    APCN01001489    CM002912    KMZ00449.1    ACZ94736.1    AAAB01008807    EAA03999.4    KMZ00448.1    KRK01936.1    JXUM01002648    KXJ84196.1    ADMH02002049    ETN59761.1    AXCN02000497    UFQS01000322    UFQT01000322    SSX02867.1    SSX23234.1    KQ971344    KYB27114.1    GGFM01006709    MBW27460.1    EFA05192.1    GALX01004278    JAB64188.1    SSX02866.1    SSX23233.1    UFQS01001198    UFQT01001198    SSX09649.1    SSX29445.1    CH916366    EDV98013.1    GFDL01005799    JAV29246.1    GDHF01006972    JAI45342.1    CM000363    EDX10994.1    DS231889    EDS43692.1    GFDL01005766    JAV29279.1    CH964101    EDW79382.1    CVRI01000047    CRK98547.1    AJWK01004128    AJWK01004129    ATLV01024071    ATLV01024072    KE525348    KFB50487.1    GAMC01008483    JAB98072.1    CAQQ02394832    CAQQ02394833    GDHF01015246    GDHF01009568    GDHF01002892    GDHF01001470    JAI37068.1    JAI42746.1    JAI49422.1    JAI50844.1    AXCM01009055    GGFK01002787    MBW36108.1    GGFK01002576    MBW35897.1   

Proteomes

UP000283053    UP000053268    UP000218220    UP000007151    UP000053240    UP000037069    + More
UP000095301    UP000091820    UP000069940    UP000249989    UP000007801    UP000092444    UP000092445    UP000008820    UP000078200    UP000092443    UP000092460    UP000095300    UP000192223    UP000075884    UP000075900    UP000001292    UP000076407    UP000002282    UP000008711    UP000000803    UP000075903    UP000075882    UP000075902    UP000075840    UP000007062    UP000075880    UP000000673    UP000075886    UP000075885    UP000007266    UP000001070    UP000000304    UP000002320    UP000076408    UP000075881    UP000069272    UP000007798    UP000183832    UP000092461    UP000030765    UP000015102    UP000075883    UP000192221    UP000075901   

PRIDE

D0IQJ2    Q9VVT2   

Pfam

PF00939   Na_sulph_symp        + More
PF13903   Claudin_2
PF00086   Thyroglobulin_1
PF04139   Rad9
PF15277   Sec3-PIP2_bind
PF09763   Sec3_C

Interpro

IPR001898   SLC13A/DASS        + More
IPR004031   PMP22/EMP/MP20/Claudin       
IPR031312   Na/sul_symport_CS       
IPR000716   Thyroglobulin_1       
IPR036857   Thyroglobulin_1_sf       
IPR007268   Rad9/Ddc1       
IPR028258   Sec3-PIP2_bind       
IPR019160   Sec3_C       

SUPFAM

SSF57610   SSF57610       

Gene 3D

4.10.800.10    

CDD

cd00191  TY

ProteinModelPortal

A0A2H1VD01   A0A3S2NFT2   A0A3S2NWJ4   A0A194QH25   A0A2A4J2F5   A0A212FAN4   + More
A0A194QRS7   A0A0L0C679   T1PEL6   A0A1I8M3N9   A0A1A9W3H3   A0A1L8DE04   A0A182GSH1   A0A0P8XVW7   A0A1L8DEL7   B3M868   A0A1B0GFN7   A0A1L8DE76   A0A1B0A737   Q16UM0   A0A1A9V5X8   A0A1L8DES5   A0A1S4FNY7   A0A1A9XD94   A0A1B0C4D6   Q16UM1   Q16UM3   A0A1I8QD75   A0A1Q3FKR1   A0A1Q3FKP1   A0A023EVA1   A0A034WH82   A0A1W4WEQ3   U5EXM5   A0A0A1WUW7   A0A182NZ46   A0A182RMY3   A0A2M4BIG4   A0A1L8E9V4   B4IFW0   A0A182WWT0   A0A2M4BIC4   A0A1L8ECM3   B4PIY5   B3NHN6   A0A0Q5UJB0   D0IQJ2   Q9VVT2   A0A182VBY4   A0A182L392   A0A182UAV5   A0A182HWF9   A0A0J9RXQ8   Q9VVT2-2   E1JI19   Q7QIT2   A0A0J9RXY5   A0A0R1DXX2   A0A182JDR1   A0A182GSH2   W5J711   A0A182Q6Q6   A0A182PTK9   A0A336KEI2   A0A139WGV7   A0A2M3ZG83   D2A4Q5   V5GVC6   A0A336KDB7   A0A336KWG5   B4J1T3   A0A1Q3FP35   A0A0K8W2J2   B4QPW6   B0WCP1   A0A182Y266   A0A1Q3FNV3   A0A182JX44   A0A182FER4   B4N4U3   A0A1J1IEA9   A0A1B0CAN5   A0A084WJU3   W8BH49   T1GDJ2   A0A0K8WEA4   A0A182MHP0   A0A1W4UPB0   A0A182J1X2   A0A2M4A652   A0A1W4UP31   A0A2M4A522   A0A182T3Y2   A0A182L390   A0A182PF37   A0A182HWF8   A0A182UXA5  

PDB

5ULE     E-value=0.000354702,     Score=103

KEGG

101744790    K14445 solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 2/3/5 | (RefSeq

GO

GO:0005215   GO:0016021   GO:0055085   GO:0006814   GO:0050833   GO:0005887   GO:0015141   GO:0015137   GO:0008340   GO:0010889   GO:0015744   GO:0015746   GO:0005886   GO:0006848   GO:0016323   GO:0000077   GO:0030896   GO:0000145   GO:0006887   GO:0016020   GO:0005622   GO:0015935   GO:0004812   GO:0006418   GO:0003723   GO:0046872   GO:0003824  

Subcellular location

Basolateral cell membrane  

Length:

340

Number of predicted TMHs:

7

Exp number of AAs in TMHs:

153.85615

Exp number, first 60 AAs:

22.5484

Total prob of N-in:

0.81117

POSSIBLE N-term signal

sequence

inside

1  -  20

TMhelix

21  -  43

outside

44  -  79

TMhelix

80  -  102

inside

103  -  130

TMhelix

131  -  153

outside

154  -  179

TMhelix

180  -  202

inside

203  -  214

TMhelix

215  -  237

outside

238  -  264

TMhelix

265  -  287

inside

288  -  298

TMhelix

299  -  321

outside

322  -  340

 

 

Pi

24.847561

Theta

20.179306

Tajima's D

0.199245

CLR

0.145713

CSRT

0.433928303584821

Interpretation

Uncertain