Gene

KWMTBOMO10248  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA007311

Annotation

40S_ribosomal_protein_SA_[Bombyx_mori]

Location

Bomo_Chr17(+):5809820-5813560      View in EpiBrowser

Full name

40S ribosomal protein SA      

Alternative Name

37 kDa laminin receptor precursor
37/67 kDa laminin receptor
67 kDa laminin receptor
Laminin receptor 1
Laminin-binding protein precursor p40

Location in the cell

Cytoplasmic   Reliability : 2.911

CDS

ATGTCGGGAGGATTAGACGTGCTCGCCCTCAACGAGGAAGATGTCACCAAAATGCTTGCTGCAACCACCCATCTTGGGGCAGAAAATGTTAACTTCCAGATGGAGACCTATGTCTACAAACGACGTGCTGATGGTACCCATGTGATCAACTTGCGTCGTACCTGGGAAAAACTTGTTCTGGCTGCTCGTGCTGTCGTAGCCATCGAGAACCCCGCTGATGTGTTCGTCATCTCATCACGGCCCTTCGGTCAGCGTGCTGTACTGAAGTTTGCCGCGCACACCGGTGCTACGCCTATTGCGGGACGTTTCACACCAGGTGCTTTTACTAACCAGATCCAAGCTGCATTCCGTGAACCTCGTCTCTTGATTGTATTGGACCCTGCACAAGACCATCAACCCATTACTGAAGCTTCATATGTCAACATTCCTGTGATTGCTTTGTGCAACACAGACTCCCCACTAAGATTTGTGGACATTGCTATCCCATGCAACACCAAGTCTTCCCACTCTATTGGTTTGATGTGGTGGTTGTTGGCACGTGAAGTGCTGAGGCTTCGTGGTGTGCTTCCCCGTGACCAGCGCTGGGATGTTGTGGTTGATTTGTTCTTCTACCGTGACCCTGAAGAAAGTGAAAAGGATGAACAACAAGCCAAGGAACAGGCTGTGGTACCAGCTAAACCAGAAGTAGTTGCTCCTGTCCATGAAGACTGGAATGAAACACTGGAGCCAGTGGCTTCATGGGCTGAAGATACCGCCCCGCCTGCTGCACCCGCTGCAGCTCCTGCTTTTGGAGCACCCCCTGCTCAAGAAGAATGGTCTGCCCAGGTACAAGATGAGTGGAGCACAACTGCCGCCGCACCAGCCGCCGCCACCGCAGCGCCCTCGTGGGGTGGATCCGCTCAAGACTGGAGTGCTGCATAA

Protein

MSGGLDVLALNEEDVTKMLAATTHLGAENVNFQMETYVYKRRADGTHVINLRRTWEKLVLAARAVVAIENPADVFVISSRPFGQRAVLKFAAHTGATPIAGRFTPGAFTNQIQAAFREPRLLIVLDPAQDHQPITEASYVNIPVIALCNTDSPLRFVDIAIPCNTKSSHSIGLMWWLLAREVLRLRGVLPRDQRWDVVVDLFFYRDPEESEKDEQQAKEQAVVPAKPEVVAPVHEDWNETLEPVASWAEDTAPPAAPAAAPAFGAPPAQEEWSAQVQDEWSTTAAAPAAATAAPSWGGSAQDWSAA

Description

Required for the assembly and/or stability of the 40S ribosomal subunit. Required for the processing of the 20S rRNA-precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits.
Required for the assembly and/or stability of the 40S ribosomal subunit. Required for the processing of the 20S rRNA-precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits. Also functions as a cell surface receptor for laminin. Plays a role in cell adhesion to the basement membrane and in the consequent activation of signaling transduction pathways. May play a role in cell fate determination and tissue morphogenesis.

Subunit

Component of the small ribosomal subunit. Mature ribosomes consist of a small (40S) and a large (60S) subunit. The 40S subunit contains about 33 different proteins and 1 molecule of RNA (18S). The 60S subunit contains about 49 different proteins and 3 molecules of RNA (28S, 5.8S and 5S). Interacts with ribosomal protein S21.
Monomer (37LRP) and homodimer (67LR). Component of the small ribosomal subunit. Mature ribosomes consist of a small (40S) and a large (60S) subunit. The 40S subunit contains about 33 different proteins and 1 molecule of RNA (18S). The 60S subunit contains about 49 different proteins and 3 molecules of RNA (28S, 5.8S and 5S). Interacts with RPS21. Interacts with several laminins including at least LAMB1. Interacts with MDK.

Miscellaneous

This protein appears to have acquired a second function as a laminin receptor specifically in the vertebrate lineage.
It is thought that in vertebrates 37/67 kDa laminin receptor acquired a dual function during evolution. It developed from the ribosomal protein SA, playing an essential role in the protein biosynthesis lacking any laminin binding activity, to a cell surface receptor with laminin binding activity.

Similarity

Belongs to the universal ribosomal protein uS2 family.

Keywords

Complete proteome   Cytoplasm   Reference proteome   Ribonucleoprotein   Ribosomal protein   Acetylation   Cell membrane   Membrane   Nucleus   Receptor   Repeat  

Feature

chain  40S ribosomal protein SA

Uniprot

H9JCR4   Q5UAP4   A0A3G1T1D1   A0A194QB13   A0A194QRT7   I4DM16   + More
A0A3S2NXV9   E7DZ30   A0A2H1WG78   A0A2A4JYM1   S4PWY4   I4DNB4   G0ZEE8   A0A212FIS8   A0A0L7LWA1   A0A2J7RGF5   A0A067R227   A0A1W4WZL7   Q0PXX8   A0A1B6CY39   A0A1B6LW65   E0VN22   A0A1J1IRJ4   A0A023F8Y8   A0A161TJI5   A0A0C9PRY9   U5EZJ0   E2BW62   A2I3Z2   E7D1C2   A0A1Y1KZ33   A0A1W2WBX0   H2XTB0   A0A0X7YDQ6   A0A093T4B5   A0A0P4VRM4   R4G8Q1   A0A069DS42   A0A0V0G2J1   A0A091JN11   H2Z279   A0A224XTF0   A0A091HWW7   A0A091HPQ8   A0A099ZLP8   A0A3L8SZB8   A0A093Q9Q3   A0A218UPN6   A0A093GUL4   A0A093C052   A0A0A0A076   A0A091QAI8   A0A091S358   A0A093EMY8   A0A091KW03   A0A094L9N9   A0A091EQM2   A0A093I9Y2   A0A091RCB6   A0A091SMP9   A0A087QH29   R7VPS0   D5XMH1   B5FXT6   G1NGU2   A0A226MJ30   A0A091FRP5   A0A091V0M7   A0A226PU73   R0JZY0   A0A1U7SHM5   P50890   M7B099   A0A3Q0FWN0   A0A091PBH2   K4G2X5   A0A093DK92   U3J7Y9  

Pubmed

19121390    12020843    26354079    22651552    23622113    22118469    + More
26227816    24845553    20566863    25474469    20798317    28004739    12481130    15114417    27129103    26334808    30282656    23371554    17018643    20838655    24621616    8985115    23624526    23056606    23749191   

EMBL

BABH01041208    AB062685    AY769314    MG846933    AXY94785.1    KQ459232    + More
KPJ02733.1    KQ461155    KPJ08202.1    AK402334    BAM18956.1    RSAL01000029    RVE51781.1    HQ424733    ADT80677.1    ODYU01008453    SOQ52078.1    NWSH01000429    PCG76472.1    GAIX01005983    JAA86577.1    AK402822    BAM19404.1    JF265026    AEL28857.1    AGBW02008335    OWR53636.1    JTDY01000012    KOB79436.1    NEVH01003784    PNF39921.1    KK853076    KDR11727.1    DQ673408    GEDC01018941    JAS18357.1    GEBQ01012058    JAT27919.1    DS235332    EEB14788.1    CVRI01000056    CRL01702.1    GBBI01000802    JAC17910.1    GEMB01000119    JAS02992.1    GBYB01004138    JAG73905.1    GANO01000709    JAB59162.1    GL451091    EFN80094.1    EF070495    HQ005870    ADV40166.1    GEZM01069071    JAV66662.1    EAAA01000818    KC507298    AHB12421.1    KL423107    KFW89494.1    GDKW01001528    JAI55067.1    GAHY01000582    JAA76928.1    GBGD01002343    JAC86546.1    GECL01003770    JAP02354.1    KK502279    KFP21952.1    GFTR01004716    JAW11710.1    KL217907    KFP00392.1    KL520075    KFO89308.1    KL894487    KGL81725.1    QUSF01000003    RLW11679.1    KL672330    KFW85678.1    MUZQ01000204    OWK55380.1    KL216618    KFV70752.1    KL236730    KFV09350.1    KL870344    KGL87949.1    KK690823    KFQ16571.1    KK941080    KFQ50699.1    KK373306    KFV44653.1    KK756306    KFP43450.1    KL353928    KFZ60774.1    KK718893    KFO59326.1    KL206987    KFV87932.1    KK812868    KFQ36857.1    KK478086    KFQ59643.1    KL225582    KFM00533.1    KB375329    AKCR02000094    EMC80727.1    PKK20975.1    DP001180    DP001179    ADH10545.1    DQ213582    DQ213584    DQ213585    MCFN01000769    OXB55305.1    KL447288    KFO71809.1    KL410402    KFQ96486.1    AWGT02000015    OXB83238.1    KB742877    EOB03226.1    X94368    KB589327    EMP25493.1    KK847598    KFP88875.1    JX207230    AFM85544.1    KN126788    KFU92660.1    ADON01054041   

Proteomes

UP000005204    UP000053268    UP000053240    UP000283053    UP000218220    UP000007151    + More
UP000037510    UP000235965    UP000027135    UP000192223    UP000079169    UP000009046    UP000183832    UP000008237    UP000008144    UP000053119    UP000007875    UP000054308    UP000053641    UP000276834    UP000053258    UP000197619    UP000053875    UP000053858    UP000052976    UP000053584    UP000053286    UP000053872    UP000007754    UP000001645    UP000198323    UP000053760    UP000053283    UP000198419    UP000189705    UP000000539    UP000031443    UP000016666   

PRIDE

H9JCR4    Q5UAP4    A2I3Z2    B5FXT6    P50890   

Pfam

PF16122   40S_SA_C        + More
PF00318   Ribosomal_S2

Interpro

IPR027498   Ribosomal_S2_euk        + More
IPR005707   Ribosomal_S2_euk/arc       
IPR018130   Ribosomal_S2_CS       
IPR023591   Ribosomal_S2_flav_dom_sf       
IPR001865   Ribosomal_S2       
IPR032281   40S_SA_C       
IPR027504   40S_ribosomal_SA       

SUPFAM

SSF52313   SSF52313       

CDD

cd01425  RPS2

ProteinModelPortal

H9JCR4   Q5UAP4   A0A3G1T1D1   A0A194QB13   A0A194QRT7   I4DM16   + More
A0A3S2NXV9   E7DZ30   A0A2H1WG78   A0A2A4JYM1   S4PWY4   I4DNB4   G0ZEE8   A0A212FIS8   A0A0L7LWA1   A0A2J7RGF5   A0A067R227   A0A1W4WZL7   Q0PXX8   A0A1B6CY39   A0A1B6LW65   E0VN22   A0A1J1IRJ4   A0A023F8Y8   A0A161TJI5   A0A0C9PRY9   U5EZJ0   E2BW62   A2I3Z2   E7D1C2   A0A1Y1KZ33   A0A1W2WBX0   H2XTB0   A0A0X7YDQ6   A0A093T4B5   A0A0P4VRM4   R4G8Q1   A0A069DS42   A0A0V0G2J1   A0A091JN11   H2Z279   A0A224XTF0   A0A091HWW7   A0A091HPQ8   A0A099ZLP8   A0A3L8SZB8   A0A093Q9Q3   A0A218UPN6   A0A093GUL4   A0A093C052   A0A0A0A076   A0A091QAI8   A0A091S358   A0A093EMY8   A0A091KW03   A0A094L9N9   A0A091EQM2   A0A093I9Y2   A0A091RCB6   A0A091SMP9   A0A087QH29   R7VPS0   D5XMH1   B5FXT6   G1NGU2   A0A226MJ30   A0A091FRP5   A0A091V0M7   A0A226PU73   R0JZY0   A0A1U7SHM5   P50890   M7B099   A0A3Q0FWN0   A0A091PBH2   K4G2X5   A0A093DK92   U3J7Y9  

PDB

3BCH     E-value=3.79609e-97,     Score=904

KEGG

692424    K02998 small subunit ribosomal protein SAe | (RefSeq) RpSA, P40; ribosomal protein SA

PATHWAY

03010    Ribosome - Bombyx mori (domestic silkworm)

GO

GO:0022627   GO:0006412   GO:0003735   GO:0000028   GO:0015935   GO:0002181   GO:0005886   GO:0043236   GO:0005634   GO:0005055   GO:0098978   GO:0005840   GO:0005622   GO:0004812   GO:0006418   GO:0003723   GO:0046872   GO:0003824  

PANTHER

PTHR11489  

Subcellular location

Cytoplasm  
Cell membrane   67LR is found at the surface of the plasma membrane, with its C-terminal laminin-binding domain accessible to extracellular ligands. 37LRP is found at the cell surface, in the cytoplasm and in the nucleus.   With evidence from 1 publications.
Nucleus   67LR is found at the surface of the plasma membrane, with its C-terminal laminin-binding domain accessible to extracellular ligands. 37LRP is found at the cell surface, in the cytoplasm and in the nucleus.   With evidence from 1 publications.

Length:

306

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.00974999999999999

Exp number, first 60 AAs:

0.00293

Total prob of N-in:

0.00268

outside

1  -  306

 

 

Pi

220.260037

Theta

184.192878

Tajima's D

0.666065

CLR

0.683246

CSRT

0.55897205139743

Interpretation

Uncertain