Gene

KWMTBOMO10247  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA007310

Annotation

DRK_protein_[Bombyx_mori]

Location

Bomo_Chr17(-):5785531-5807979      View in EpiBrowser

Full name

Protein E(sev)2B       + More
Protein enhancer of sevenless 2B      

Alternative Name

Downstream of receptor kinase
Protein enhancer of sevenless 2B
SH2-SH3 adapter protein drk

Location in the cell

Cytoplasmic   Reliability : 2.653

CDS

ATGGAGGCTCTAGCAAAACACGATTTTACTGCAACCGCAGATGATGAGCTCAGTTTTAGAAAAAATCAAGTATTAAAAATTCTAAACATGGAGGACGATATGAACTGGTACAGAGCTGAATTAGACGGGAAAGAAGGGCTCATTCCTAGTAATTACATACAAATGAAAAATCACAGTTGGTATTATGGGCGTATTACAAGAGCAGATGCAGAAAAACTCTTAGCAAACAAACCTGAAGGTGGCTTCTTGATAAGGATCAGCGAATCAAGCCCTGGCGACTTCTCCTTATCAGTCAAATGTCCGGACGGTGTCCAGCACTTCAAAGTATTAAGAGACGCCTCGAGCAAGTTCTTCCTTTGGGTCGTCAAGTTCAATTCGCTCAACGAACTAGTTGATTATCATCGTACCGCGTCTGTCAGTCGCCTTCAAGACGTTAAACTGCGCGACGTCGTCCCCGAAGAAATGTTGGTGCAGGCTCTATACGACTTCACCCCACAAGAGGCTGGCGAGTTGGAGTTTAGACGCGGTGACGTCATAACCGTGACAGATCGCTCCGACCAGCACTGGTGGCAGGTAAAGTGA

Protein

MEALAKHDFTATADDELSFRKNQVLKILNMEDDMNWYRAELDGKEGLIPSNYIQMKNHSWYYGRITRADAEKLLANKPEGGFLIRISESSPGDFSLSVKCPDGVQHFKVLRDASSKFFLWVVKFNSLNELVDYHRTASVSRLQDVKLRDVVPEEMLVQALYDFTPQEAGELEFRRGDVITVTDRSDQHWWQVK

Description

Required for proper signaling by sevenless. May act to stimulate the ability of Sos to catalyze Ras1 activation by linking sevenless and Sos in a signaling complex (By similarity).
Required for proper signaling by sevenless. May act to stimulate the ability of Sos to catalyze Ras1 activation by linking sevenless and Sos in a signaling complex.

Subunit

Interacts with autophosphorylated sev via SH2 domain and Sos and Dab via SH3 domains. Binds to tyrosine phosphorylated Dab via the SH2 domain (By similarity).
Interacts with autophosphorylated sev via SH2 domain and Sos, Dos and Dab via SH3 domains. Binds to tyrosine phosphorylated Dab via the SH2 domain.

Similarity

Belongs to the GRB2/sem-5/DRK family.

Keywords

Membrane   Repeat   SH2 domain   SH3 domain   Transducer   3D-structure   Complete proteome   Reference proteome  

Feature

chain  Protein E(sev)2B

Uniprot

F2XHI6   A0A194QRR0   A0A194QB94   S4PH84   A0A2H1WG69   A0A1E1WLK8   + More
A0A0L7LVH6   A0A212FIT9   A0A0K8TSK2   A0A2P8ZGQ7   A0A1B6E815   A0A1I8M7H0   A0A1S3D1F1   D3TPP1   A0A0L0C544   A0A146M7N5   A0A0A9XP81   B4MCL9   B4MIT0   B4JVQ1   A0A0J9RBW6   B4P4G9   Q6YKA8   Q08012   A0A3B0IZX0   B3NRK3   A0A224XWK1   A0A0P4VL81   A0A0V0GB86   A0A069DQL3   U5EXG7   A0A023F5F1   T1DNU8   A0A2M4CT90   A0A2M3Z8F8   A0A2M4AJ52   Q7PV64   A0A1I8PIL0   B3MGZ3   B4HQJ5   A0A1S3D1J4   A0A1W4VHZ6   D6WXI3   Q28ZT1   B4GGT9   T1E300   A0A1Q3EU64   A0A1L8DMA8   A0A1B6FSE9   A0A1B6LQ14   A0A0C9RMZ5   B4KMK9   K7IXW9   T1DIQ9   A0A067QZD3   A0A023EIK5   A0A232EQB5   A0A026WTT4   W8BBJ7   A0A0K8WEM4   A0A0A1X3H7   A0A034W8P6   A0A195FLT0   A0A158NEL3   A0A0J7LAC2   V9IHL5   A0A1J1J692   A0A0P6FKN8   A0A1W4WNL1   A0A087ZXM2   A0A195EN05   A0A0N0BKX1   V5GM45   A0A164Y7E8   A0A336KB09   A0A195BZU9   A0A151XIS8   A0A2A3EC90   A0A0N8DRV2   A0A2P2IA47   A0A2J7RGH4   A0A0P6IB62   T1IWZ8   E0VST4   A0A0M4MF07   J3JVP3   N6T8R7   A0A1Y1MVF9   A0A182L4P7   A0A195BUS7   T1HSZ9   A0A0P4WHY9   A0A0L7REL4   A0A087UW82   F4WRU7   A0A0P5XPK9   A0A131YIU8   A0A131XI35   L7M546   A0A1E1X7L1  

Pubmed

26354079    23622113    26227816    22118469    26369729    29403074    + More
25315136    20353571    26108605    26823975    25401762    17994087    22936249    17550304    12694293    8462097    8462098    10731132    12537572    12537569    9671493    12128212    18057021    27129103    26334808    25474469    12364791    14747013    17210077    18362917    19820115    15632085    24330624    20075255    24845553    24945155    28648823    24508170    30249741    24495485    25830018    25348373    21347285    20566863    22516182    23537049    28004739    20966253    21719571    26830274    28049606    25576852    28503490   

EMBL

HQ540305    ADZ99023.1    KQ461155    KPJ08203.1    KQ459232    KPJ02732.1    + More
GAIX01000554    JAA92006.1    ODYU01008453    SOQ52079.1    GDQN01003318    JAT87736.1    JTDY01000012    KOB79435.1    AGBW02008335    OWR53635.1    GDAI01000678    JAI16925.1    PYGN01000062    PSN55685.1    GEDC01011967    GEDC01003253    JAS25331.1    JAS34045.1    CCAG010016887    EZ423393    ADD19669.1    JRES01000890    KNC27518.1    GDHC01005523    GDHC01002856    JAQ13106.1    JAQ15773.1    GBHO01021097    GBHO01021067    GBHO01021036    GBHO01004926    JAG22507.1    JAG22537.1    JAG22568.1    JAG38678.1    CH940659    EDW71407.1    CH963719    EDW72019.1    CH916375    EDV98519.1    CM002911    KMY93517.1    KMY93518.1    CM000158    EDW90608.1    KRJ99318.1    KRJ99319.1    AY135137    AY135136    L12446    L13173    AY135053    AY135054    AY135055    AY135056    AY135057    AY135058    AY135059    AY135060    AY135061    AY135062    AY135063    AY135064    AY135065    AY135066    AY135067    AY135068    AY135069    AY135070    AY135071    AY135072    AY135073    AY135074    AE013599    AY061142    OUUW01000001    SPP73757.1    CH954179    EDV56155.1    KQS62728.1    GFTR01003556    JAW12870.1    GDKW01000721    JAI55874.1    GECL01000947    JAP05177.1    GBGD01002913    JAC85976.1    GANO01000963    JAB58908.1    GBBI01002343    JAC16369.1    GAMD01002555    JAA99035.1    GGFL01004213    MBW68391.1    GGFM01004068    MBW24819.1    GGFK01007480    MBW40801.1    AAAB01008986    EAA00404.4    CH902619    EDV37911.1    CH480816    EDW47730.1    KQ971361    EFA08848.1    CM000071    EAL25532.1    CH479183    EDW35709.1    GALA01000830    JAA94022.1    GFDL01016190    JAV18855.1    GFDF01006590    JAV07494.1    GECZ01016675    JAS53094.1    GEBQ01016660    GEBQ01014363    JAT23317.1    JAT25614.1    GBYB01008436    GBYB01008523    JAG78203.1    JAG78290.1    CH933808    EDW10856.1    GALA01000831    JAA94021.1    KK853076    KDR11728.1    GAPW01004335    JAC09263.1    NNAY01002790    OXU20555.1    KK107109    QOIP01000008    EZA59373.1    RLU19532.1    GAMC01012158    GAMC01012157    GAMC01012156    JAB94398.1    GDHF01027396    GDHF01026559    GDHF01025281    GDHF01018103    GDHF01003527    GDHF01002820    GDHF01000145    JAI24918.1    JAI25755.1    JAI27033.1    JAI34211.1    JAI48787.1    JAI49494.1    JAI52169.1    GBXI01011326    GBXI01010505    GBXI01008423    GBXI01002689    JAD02966.1    JAD03787.1    JAD05869.1    JAD11603.1    GAKP01008809    GAKP01008808    GAKP01008807    JAC50143.1    KQ981490    KYN41207.1    ADTU01013490    LBMM01000137    KMR04788.1    JR046105    AEY60137.1    CVRI01000074    CRL07912.1    GDIQ01055981    JAN38756.1    KQ978625    KYN29583.1    KQ435689    KOX81204.1    GALX01003292    JAB65174.1    LRGB01000930    KZS14957.1    UFQS01000117    UFQT01000117    SSW99973.1    SSX20353.1    KQ978501    KYM93451.1    KQ982080    KYQ60312.1    KZ288288    PBC29310.1    GDIP01007031    JAM96684.1    IACF01005313    LAB70899.1    NEVH01003784    PNF39920.1    GDIQ01023523    JAN71214.1    JH431636    DS235756    EEB16440.1    KR075866    ALE20585.1    BT127311    KB632061    AEE62273.1    ERL88402.1    APGK01039590    APGK01039591    APGK01039592    KB740972    ENN76619.1    GEZM01024109    GEZM01024108    JAV87966.1    KQ976401    KYM92374.1    ACPB03014463    GDRN01038395    GDRN01038393    JAI67255.1    KQ414608    KOC69392.1    KK121952    KFM81621.1    GL888292    EGI63104.1    GDIP01069114    JAM34601.1    GEDV01010079    JAP78478.1    GEFH01002549    JAP66032.1    GACK01005894    JAA59140.1    GFAC01003945    JAT95243.1   

Proteomes

UP000053240    UP000053268    UP000037510    UP000007151    UP000245037    UP000095301    + More
UP000079169    UP000092444    UP000037069    UP000008792    UP000007798    UP000001070    UP000002282    UP000000803    UP000268350    UP000008711    UP000007062    UP000095300    UP000007801    UP000001292    UP000192221    UP000007266    UP000001819    UP000008744    UP000009192    UP000002358    UP000027135    UP000215335    UP000053097    UP000279307    UP000078541    UP000005205    UP000036403    UP000183832    UP000192223    UP000005203    UP000078492    UP000053105    UP000076858    UP000078542    UP000075809    UP000242457    UP000235965    UP000009046    UP000030742    UP000019118    UP000075882    UP000078540    UP000015103    UP000053825    UP000054359    UP000007755   

PRIDE

F2XHI6    Q08012   

Pfam

PF00017   SH2        + More
PF14604   SH3_9
PF00018   SH3_1

Interpro

IPR036860   SH2_dom_sf        + More
IPR000980   SH2       
IPR001452   SH3_domain       
IPR036028   SH3-like_dom_sf       
IPR030219   Grb2       

SUPFAM

SSF55550   SSF55550        + More
SSF50044   SSF50044       

Gene 3D

3.30.505.10    

ProteinModelPortal

F2XHI6   A0A194QRR0   A0A194QB94   S4PH84   A0A2H1WG69   A0A1E1WLK8   + More
A0A0L7LVH6   A0A212FIT9   A0A0K8TSK2   A0A2P8ZGQ7   A0A1B6E815   A0A1I8M7H0   A0A1S3D1F1   D3TPP1   A0A0L0C544   A0A146M7N5   A0A0A9XP81   B4MCL9   B4MIT0   B4JVQ1   A0A0J9RBW6   B4P4G9   Q6YKA8   Q08012   A0A3B0IZX0   B3NRK3   A0A224XWK1   A0A0P4VL81   A0A0V0GB86   A0A069DQL3   U5EXG7   A0A023F5F1   T1DNU8   A0A2M4CT90   A0A2M3Z8F8   A0A2M4AJ52   Q7PV64   A0A1I8PIL0   B3MGZ3   B4HQJ5   A0A1S3D1J4   A0A1W4VHZ6   D6WXI3   Q28ZT1   B4GGT9   T1E300   A0A1Q3EU64   A0A1L8DMA8   A0A1B6FSE9   A0A1B6LQ14   A0A0C9RMZ5   B4KMK9   K7IXW9   T1DIQ9   A0A067QZD3   A0A023EIK5   A0A232EQB5   A0A026WTT4   W8BBJ7   A0A0K8WEM4   A0A0A1X3H7   A0A034W8P6   A0A195FLT0   A0A158NEL3   A0A0J7LAC2   V9IHL5   A0A1J1J692   A0A0P6FKN8   A0A1W4WNL1   A0A087ZXM2   A0A195EN05   A0A0N0BKX1   V5GM45   A0A164Y7E8   A0A336KB09   A0A195BZU9   A0A151XIS8   A0A2A3EC90   A0A0N8DRV2   A0A2P2IA47   A0A2J7RGH4   A0A0P6IB62   T1IWZ8   E0VST4   A0A0M4MF07   J3JVP3   N6T8R7   A0A1Y1MVF9   A0A182L4P7   A0A195BUS7   T1HSZ9   A0A0P4WHY9   A0A0L7REL4   A0A087UW82   F4WRU7   A0A0P5XPK9   A0A131YIU8   A0A131XI35   L7M546   A0A1E1X7L1  

PDB

1GRI     E-value=7.50089e-68,     Score=649

KEGG

100862763    K04364 growth factor receptor-binding protein 2 | (RefSeq) DRK; DRK protein

PATHWAY

04013    MAPK signaling pathway - fly - Bombyx mori (domestic silkworm)
04068    FoxO signaling pathway - Bombyx mori (domestic silkworm)
04150    mTOR signaling pathway - Bombyx mori (domestic silkworm)
04320    Dorso-ventral axis formation - Bombyx mori (domestic silkworm)

GO

GO:0007265   GO:0016301   GO:0007614   GO:0070374   GO:0005118   GO:0045500   GO:0032991   GO:0001784   GO:1904263   GO:0008543   GO:0048260   GO:0045793   GO:0007173   GO:0007426   GO:0005154   GO:0008293   GO:0007476   GO:0005070   GO:0030707   GO:0048010   GO:0007427   GO:0005886   GO:0008355   GO:0007465   GO:0008306   GO:0005654   GO:0005737   GO:0005515   GO:0006511   GO:0016579   GO:0006397   GO:0005524   GO:0004812   GO:0006418   GO:0003723   GO:0046872   GO:0003824  

PANTHER

PTHR46037:SF4  

Subcellular location

Membrane  

Length:

193

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.00058

Exp number, first 60 AAs:

0

Total prob of N-in:

0.08698

outside

1  -  193

 

 

Pi

22.846764

Theta

203.64551

Tajima's D

-0.895296

CLR

0.575198

CSRT

0.155942202889855

Interpretation

Uncertain