Silkworm Genome Informatics Database

Gene

KWMTBOMO10227 Validated by peptides from experiments

Pre Gene Modal

BGIBMGA000177

Annotation

hypothetical_protein_KGM_07911_[Danaus_plexippus]

Location

Bomo_Chr17(-):5210420-5215577 View in EpiBrowser

Full name

Ubiquitin-related modifier 1 homolog

Location in the cell

Mitochondrial Reliability : 1.47 PlasmaMembrane Reliability : 2.034

CDS

ATGAAATGTCGCACAGCTTGTTGCGGACGGGGCAATAAAAAGGTAGCAGCTTTACAATATGTAGCGTGTGGCTTACAGTGGCGGCATTCGCGGAATGGTTCGTGGTCCCAAATCACTCCTACAATGGTTTTCTCTCATATTTGTCACACATCACTCGGAAAACATTGCTCCTTGGACAGCTGGATAAAAAACATTGTTAAACCAAACAGGTCTAAAAGGAAATATGCCATAAAACTGAAGGAAGAAACACCTATAGGCACAGAAAAAATATATTACGGAACATTAACACCTCAGATAAAGGCCATAAAAATATTCTCTTTATGCACAAGCATAGCAGGTATTGCTATTCAACCTATGTTAATAAGAGAAGCATCAAGCATAGGAAGTACTTCTTTATTGGTAGCCATATGTTCAGTGGTGGGATTCTTCACGTTTGTAACTCCAATACTGCTGCATTTCATCACCAAAAAGTATGTTACCGAAATTTACTACAACGCTGAAACTTCGACATACAAAGCGATTACAATTAATTTCTTTGCAACAAAACGAATTCATGAATTCAAAGTAGAAGATGTATTTGTTCCCGATGTACCAGGAATGTTCACTACTATGCATGCTAATGGCAAGCCGCTGTTCATTGAAGCACGATTCTTCAATAACCCACTGCACTATGCAAAGATCATGGGCTATGATAAGCCAATGGATTTTAAACTAGGAGAAACGCAAGAAAGTAAAAACCAAAAGTGTGTGGCACTGATGACAATGGGTATCAAAACCTATTAA

Protein

MKCRTACCGRGNKKVAALQYVACGLQWRHSRNGSWSQITPTMVFSHICHTSLGKHCSLDSWIKNIVKPNRSKRKYAIKLKEETPIGTEKIYYGTLTPQIKAIKIFSLCTSIAGIAIQPMLIREASSIGSTSLLVAICSVVGFFTFVTPILLHFITKKYVTEIYYNAETSTYKAITINFFATKRIHEFKVEDVFVPDVPGMFTTMHANGKPLFIEARFFNNPLHYAKIMGYDKPMDFKLGETQESKNQKCVALMTMGIKTY

Description

Acts as a sulfur carrier required for 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Serves as sulfur donor in tRNA 2-thiolation reaction by being thiocarboxylated (-COSH) at its C-terminus by the MOCS3/UBA4 homolog. The sulfur is then transferred to tRNA to form 2-thiolation of mcm(5)S(2)U. Also acts as a ubiquitin-like protein (UBL) that is covalently conjugated via an isopeptide bond to lysine residues of target proteins. The thiocarboxylated form serves as substrate for conjugation and oxidative stress specifically induces the formation of UBL-protein conjugates.

Similarity

Belongs to the URM1 family.

Uniprot

S4PII8 A0A2A4J281 B0WIN8 A0A0L7LGU9 B3NFA1 A0A3B0JWX0 + More
A0A0L0CQ63 A0A182PEC0 A0A1B0D8R8 A0A1W4WLC2 A0A1B0BQ38 A0A1A9WY59 A0A336LEI9 A0A336MYS1 A0A151WR41 A0A1D2MMC8 A0A2P2I0G3 J9KA18 C4WXY4

Pubmed

23622113 26227816 17994087 26108605 27289101

EMBL

GAIX01000189 JAA92371.1 NWSH01004089 PCG65502.1 DS231951 EDS28615.1 + More
JTDY01001135 KOB74778.1 CH954178 EDV50443.1 OUUW01000002 SPP77221.1 JRES01000080 KNC34327.1 AJVK01027680 JXJN01018363 UFQS01003052 UFQT01003052 SSX15113.1 SSX34492.1 UFQS01002630 UFQT01002630 SSX14403.1 SSX33813.1 KQ982807 KYQ50369.1 LJIJ01000883 ODM93964.1 IACF01001813 LAB67491.1 ABLF02037941 AK342920 BAH72754.1

Proteomes

UP000218220 UP000002320 UP000037510 UP000008711 UP000268350 UP000037069 + More
UP000075885 UP000092462 UP000192223 UP000092460 UP000091820 UP000075809 UP000094527 UP000007819

Pfam

PF06979 TMEM70 + More
PF09138 Urm1

Interpro

IPR009724   TMEM70        + More
IPR015221   Urm1
IPR016155   Mopterin_synth/thiamin_S_b
IPR012675   Beta-grasp_dom_sf

SUPFAM

SSF54285 SSF54285

Gene 3D

3.10.20.30

CDD

cd01764 Urm1

ProteinModelPortal

S4PII8 A0A2A4J281 B0WIN8 A0A0L7LGU9 B3NFA1 A0A3B0JWX0 + More
A0A0L0CQ63 A0A182PEC0 A0A1B0D8R8 A0A1W4WLC2 A0A1B0BQ38 A0A1A9WY59 A0A336LEI9 A0A336MYS1 A0A151WR41 A0A1D2MMC8 A0A2P2I0G3 J9KA18 C4WXY4

KEGG

101745764 K17966 transmembrane protein 70, mitochondrial | (RefSeq) transmembrane protein 70 homolog, mitochon

GO

GO:0016021 GO:0032447 GO:0002098 GO:0005829 GO:0034227

PANTHER

PTHR13281

Subcellular location

Cytoplasm

Length:

260

Number of predicted TMHs:

2

Exp number of AAs in TMHs:

43.47653

Exp number, first 60 AAs:

0.0011

Total prob of N-in:

0.99754

inside

1 - 98

TMhelix

99 - 121

outside

122 - 130

TMhelix

131 - 153

inside

154 - 260

Pi

186.129209

Theta

179.090969

Tajima's D

0.106756

CLR

11.473592

CSRT

0.401729913504325

Interpretation

Uncertain

Sequence

Summary

Ontologies

Topology

Population Genetic Test Statistics