Gene

KWMTBOMO10222

Pre Gene Modal

BGIBMGA014443

Annotation

PREDICTED:_tyrosine--tRNA_ligase?_mitochondrial_[Papilio_machaon]

Location

Bomo_Chr17(+):5143718-5147032      View in EpiBrowser

Full name

Tyrosine--tRNA ligase       + More
Tyrosine--tRNA ligase, mitochondrial      
Alkaline phosphatase      

Alternative Name

Tyrosyl-tRNA synthetase
Mitochondrial tyrosyl-tRNA synthetase

Location in the cell

Mitochondrial   Reliability : 1.779

CDS

ATGTATCAAGATTTGTTCCCGAACACTGCGGGAAAAGAAATATTAAATTTGTTGAACAAAGCCCCACAATGTGTTTATGCTGGTTTTGATCCAACAGCTGATAGCCTTCATGTTGGGAATCTACTGGTAATAATAAATCTACTCCATTGGTACAGAGGAGGACACAAAGTCATTGCATTGTTAGGGGGGGCAACTGGGCATATTGGTGACCCGAGTGGCAGAAACACTGATCGTGCAGCATTACAAAAAGAAGTTATAGAAAAAAATATAAAATGTATCAGGAACAACTTGGAAACTATATTTGAAAATCACAATAAATACATCTCATCCAAAGATGATGGACCACCACAACCACTAAGAATAGTCAATAATGAAGAATGGTATAGAAAAATAGATTCAATACAGTTTGTAAGCGAAATAGGTCGTAATTTTCGGATGGGCACAATGCTGTTGAAACACAGTGTTCAATCTAGAATCAACTCTGAAGTTGGCATGAGTTTCACCGAATTTAGCTATCAGATATTTCAGTCATATGATTGGTTACATTTACTAAAAGAATATGACTGTAGGTTTCAGGTAGGTGGCAGTGATCAGATGGGTAATATCACAGCTGGCCATGAATTAATAAGTAGAACTGCAAAGACAGATGTTTATGGTTTAACATTGCCATTAGTAACAACAGATGAAGGGGATAAGTTTGGAAAGTCTGCAGGAAATGCATTGTGGTTGGATTCAGCAAAAACAAGTCCATTTAGTTTGTATCAATATTTCATTCGAACCAAAGATGCTGATGTAGAGCGACTGTTGAAGCTATTTACTTTCTACAGCTTAGGAGAGATCAGAGATATCATGTATAAACATGAACAGCATCCGGATCAAAGGTATCCACAGCAGTGTCTGGCTGAGCAGCTAACGACTCTGGTGCATGGAAAGGATGGATTAGCCCAAGCACAAAGAGCAACATCTGCTATTTACAGTAAGGATATTAAATCATTAGTCTCGTTGAAGAGTGATGAGTTGGAAAAAGTTTTCGAAGGTGCTCCCGTTACTAGTTTATTATTATCACCTGGAATAACAGTTTTAGAACTTGGAATGAAAGCTAAATGCTTCCCGACTGAGAATGATGCCATGAGAATTATAGAAGCCGGTGGATTCTACATCAATCATCAGAAAATAAAGAAAATTGATGAGGTCATAACACAATCAGCACACATACTACCAAATCTAATATCACTCTTAAGGACTGGGAAACGTAATTATTATATTGTGAAATGGCAAACATAA

Protein

MYQDLFPNTAGKEILNLLNKAPQCVYAGFDPTADSLHVGNLLVIINLLHWYRGGHKVIALLGGATGHIGDPSGRNTDRAALQKEVIEKNIKCIRNNLETIFENHNKYISSKDDGPPQPLRIVNNEEWYRKIDSIQFVSEIGRNFRMGTMLLKHSVQSRINSEVGMSFTEFSYQIFQSYDWLHLLKEYDCRFQVGGSDQMGNITAGHELISRTAKTDVYGLTLPLVTTDEGDKFGKSAGNALWLDSAKTSPFSLYQYFIRTKDADVERLLKLFTFYSLGEIRDIMYKHEQHPDQRYPQQCLAEQLTTLVHGKDGLAQAQRATSAIYSKDIKSLVSLKSDELEKVFEGAPVTSLLLSPGITVLELGMKAKCFPTENDAMRIIEAGGFYINHQKIKKIDEVITQSAHILPNLISLLRTGKRNYYIVKWQT

Description

Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr).

Catalytic Activity

ATP + L-tyrosine + tRNA(Tyr) = AMP + diphosphate + H(+) + L-tyrosyl-tRNA(Tyr)
a phosphate monoester + H2O = an alcohol + phosphate

Subunit

Homodimer.

Similarity

Belongs to the class-I aminoacyl-tRNA synthetase family.
Belongs to the alkaline phosphatase family.

Keywords

Aminoacyl-tRNA synthetase   ATP-binding   Complete proteome   Ligase   Mitochondrion   Nucleotide-binding   Protein biosynthesis   Reference proteome   Transit peptide  

Feature

chain  Tyrosine--tRNA ligase, mitochondrial

Uniprot

H9JY25   A0A2H1VT49   A0A2A4J8Z0   A0A194QGZ0   A0A212FFF8   A0A194QRV7   + More
A0A0L7LS86   A0A195CLP7   A0A2S2N9A3   J9JRX2   A0A023F3D0   F4W6P1   A0A151HZV4   A0A151XAQ3   A0A158P2I1   A0A2J7RIN6   A0A195EQN4   A0A151J8N6   Q16SL3   A0A3B0JTV9   A0A1I8MD56   A0A0K8T3L0   T1HKY5   A0A0A9Y2U1   E2B667   Q28Z21   A0A1B0DBD8   A0A182H500   A0A1Y1M479   B4J4D4   B4KTJ0   B4PBV0   A0A1B6D968   B4LN55   B3MC25   A0A1B6C6N0   A0A0J9RLZ0   B4IH83   B3NQY8   Q9W107   K7ITI4   A0A1W4UZI1   A0A232EI78   A0A0M3QV72   A0A1B0FDZ9   E2AGL3   A0A0K8VEW0   E9J3V7   A0A1A9ZE36   A0A1A9VNJ8   A0A1I8NNG3   B4MP96   D3TL61   A0A0L0CB85   W8C8K7   A0A1B6IT28   A0A034VI70   A0A0A1XNE5   A0A1A9WQR0   E0VHG3   N6U5M8   A0A1B6F2B0   A0A1B6CPM2   A0A336MKG6   A0A336MFZ3   A0A1B6CXB4   A0A0C9QM19   A0A1B0AZK7   B4QCK0   A0A1B0CT28   A0A182PM56   A0A139WDX0   A0A067R4R7   A0A0L7R0G5   E9FWE8   A0A182VVI3   A0A182I9Q2   A0A182X584   A0A0P5XC04   A0A182V3U7   Q7QEJ0   A0A0P5XC23   U5ER20   A0A0P5KB86   A0A0P5CNU8   A0A182R226   A0A1A9YMY8   A0A182UL79   A0A1J1J372   A0A154NXY0   A0A182QLZ4   A0A182N144   A0A2P8XID7   A0A182J403   A0A0J7KLY6   A0A182FIV6   A0A0P6C717   A0A182MGK4   A0A3R7SLX7   A0A2M4AVS9  

EC Number

6.1.1.1
3.1.3.1

Pubmed

19121390    26354079    22118469    26227816    25474469    21719571    + More
21347285    17510324    25315136    25401762    26823975    20798317    15632085    17994087    26483478    28004739    17550304    22936249    18057021    10731132    12537572    12537569    20075255    28648823    21282665    20353571    26108605    24495485    25348373    25830018    20566863    23537049    18362917    19820115    24845553    21292972    12364791    14747013    17210077    29403074   

EMBL

BABH01041812    ODYU01004284    SOQ43989.1    NWSH01002300    PCG68587.1    KQ459232    + More
KPJ02711.1    AGBW02008828    OWR52453.1    KQ461155    KPJ08222.1    JTDY01000251    KOB78061.1    KQ977595    KYN01625.1    GGMR01000707    MBY13326.1    ABLF02012310    GBBI01002924    JAC15788.1    GL887707    EGI70117.1    KQ976675    KYM78226.1    KQ982335    KYQ57446.1    ADTU01006781    NEVH01003493    PNF40699.1    KQ982021    KYN30486.1    KQ979492    KYN21217.1    CH477672    EAT37451.1    OUUW01000001    SPP74518.1    GBRD01005712    JAG60109.1    ACPB03020517    GBHO01017135    GDHC01005149    JAG26469.1    JAQ13480.1    GL445930    EFN88760.1    CM000071    EAL25794.1    AJVK01004854    AJVK01004855    AJVK01004856    JXUM01110506    KQ565419    KXJ71001.1    GEZM01043894    JAV78676.1    CH916367    EDW01616.1    CH933808    EDW08551.1    CM000158    EDW92604.1    GEDC01015057    JAS22241.1    CH940648    EDW60059.1    CH902619    EDV37212.1    GEDC01028234    JAS09064.1    CM002911    KMY96434.1    CH480838    EDW49259.1    CH954179    EDV57071.1    AE013599    AY060975    AY113395    BT030810    AAZX01003331    NNAY01004350    OXU18021.1    CP012524    ALC41909.1    CCAG010004895    GL439322    EFN67433.1    GDHF01029121    GDHF01024460    GDHF01014825    GDHF01006952    JAI23193.1    JAI27854.1    JAI37489.1    JAI45362.1    GL768069    EFZ12549.1    CH963849    EDW73935.1    EZ422161    ADD18356.1    JRES01000655    KNC29516.1    GAMC01002969    JAC03587.1    GECU01017612    JAS90094.1    GAKP01015946    GAKP01015944    JAC43006.1    GBXI01001478    JAD12814.1    DS235170    EEB12819.1    APGK01038980    KB740966    KB631578    ENN76915.1    ERL84399.1    GECZ01025455    JAS44314.1    GEDC01022055    JAS15243.1    UFQT01001201    SSX29479.1    UFQT01001175    SSX29322.1    GEDC01019188    JAS18110.1    GBYB01004584    JAG74351.1    JXJN01006356    CM000362    EDX08616.1    AJWK01026956    AJWK01026957    AJWK01026958    AJWK01026959    KQ971357    KYB26031.1    KK852980    KDR12986.1    KQ414670    KOC64311.1    GL732526    EFX88442.1    APCN01001016    GDIP01074309    JAM29406.1    AAAB01008846    EAA06615.3    GDIP01074308    JAM29407.1    GANO01003006    JAB56865.1    GDIP01233776    GDIP01164578    GDIQ01241443    GDIQ01186812    GDIQ01186811    GDIP01074310    GDIQ01054665    JAI89625.1    JAJ58824.1    JAK64913.1    GDIP01168935    JAJ54467.1    CVRI01000064    CRL05321.1    KQ434781    KZC04473.1    AXCN02002167    PYGN01002030    PSN31760.1    LBMM01005582    KMQ91403.1    GDIP01007922    JAM95793.1    AXCM01000981    QCYY01002955    ROT66341.1    GGFK01011553    MBW44874.1   

Proteomes

UP000005204    UP000218220    UP000053268    UP000007151    UP000053240    UP000037510    + More
UP000078542    UP000007819    UP000007755    UP000078540    UP000075809    UP000005205    UP000235965    UP000078541    UP000078492    UP000008820    UP000268350    UP000095301    UP000015103    UP000008237    UP000001819    UP000092462    UP000069940    UP000249989    UP000001070    UP000009192    UP000002282    UP000008792    UP000007801    UP000001292    UP000008711    UP000000803    UP000002358    UP000192221    UP000215335    UP000092553    UP000092444    UP000000311    UP000092445    UP000078200    UP000095300    UP000007798    UP000037069    UP000091820    UP000009046    UP000019118    UP000030742    UP000092460    UP000000304    UP000092461    UP000075885    UP000007266    UP000027135    UP000053825    UP000000305    UP000075920    UP000075840    UP000076407    UP000075903    UP000007062    UP000075900    UP000092443    UP000075902    UP000183832    UP000076502    UP000075886    UP000075884    UP000245037    UP000075880    UP000036403    UP000069272    UP000075883    UP000283509   

PRIDE

H9JY25    Q9W107   

Pfam

PF00579   tRNA-synt_1b        + More
PF00245   Alk_phosphatase
PF00001   7tm_1
PF04831   Popeye
PF00787   PX

Interpro

IPR036986   S4_RNA-bd_sf        + More
IPR001412   aa-tRNA-synth_I_CS       
IPR014729   Rossmann-like_a/b/a_fold       
IPR024088   Tyr-tRNA-ligase_bac-type       
IPR002307   Tyr-tRNA-ligase       
IPR002305   aa-tRNA-synth_Ic       
IPR024107   Tyr-tRNA-ligase_bac_1       
IPR002942   S4_RNA-bd       
IPR017452   GPCR_Rhodpsn_7TM       
IPR000276   GPCR_Rhodpsn       
IPR018299   Alkaline_phosphatase_AS       
IPR001952   Alkaline_phosphatase       
IPR017850   Alkaline_phosphatase_core_sf       
IPR018490   cNMP-bd-like       
IPR006916   Popeye_prot       
IPR036871   PX_dom_sf       
IPR001683   Phox       

SUPFAM

SSF53649   SSF53649        + More
SSF51206   SSF51206       
SSF64268   SSF64268       

Gene 3D

3.10.290.10     3.40.50.620     3.40.720.10     3.30.1520.10    

CDD

cd00805  TyrRS_core
cd00165  S4
cd16012  ALP

ProteinModelPortal

H9JY25   A0A2H1VT49   A0A2A4J8Z0   A0A194QGZ0   A0A212FFF8   A0A194QRV7   + More
A0A0L7LS86   A0A195CLP7   A0A2S2N9A3   J9JRX2   A0A023F3D0   F4W6P1   A0A151HZV4   A0A151XAQ3   A0A158P2I1   A0A2J7RIN6   A0A195EQN4   A0A151J8N6   Q16SL3   A0A3B0JTV9   A0A1I8MD56   A0A0K8T3L0   T1HKY5   A0A0A9Y2U1   E2B667   Q28Z21   A0A1B0DBD8   A0A182H500   A0A1Y1M479   B4J4D4   B4KTJ0   B4PBV0   A0A1B6D968   B4LN55   B3MC25   A0A1B6C6N0   A0A0J9RLZ0   B4IH83   B3NQY8   Q9W107   K7ITI4   A0A1W4UZI1   A0A232EI78   A0A0M3QV72   A0A1B0FDZ9   E2AGL3   A0A0K8VEW0   E9J3V7   A0A1A9ZE36   A0A1A9VNJ8   A0A1I8NNG3   B4MP96   D3TL61   A0A0L0CB85   W8C8K7   A0A1B6IT28   A0A034VI70   A0A0A1XNE5   A0A1A9WQR0   E0VHG3   N6U5M8   A0A1B6F2B0   A0A1B6CPM2   A0A336MKG6   A0A336MFZ3   A0A1B6CXB4   A0A0C9QM19   A0A1B0AZK7   B4QCK0   A0A1B0CT28   A0A182PM56   A0A139WDX0   A0A067R4R7   A0A0L7R0G5   E9FWE8   A0A182VVI3   A0A182I9Q2   A0A182X584   A0A0P5XC04   A0A182V3U7   Q7QEJ0   A0A0P5XC23   U5ER20   A0A0P5KB86   A0A0P5CNU8   A0A182R226   A0A1A9YMY8   A0A182UL79   A0A1J1J372   A0A154NXY0   A0A182QLZ4   A0A182N144   A0A2P8XID7   A0A182J403   A0A0J7KLY6   A0A182FIV6   A0A0P6C717   A0A182MGK4   A0A3R7SLX7   A0A2M4AVS9  

PDB

3ZXI     E-value=9.5713e-87,     Score=816

KEGG

101737306    K01866 tyrosyl-tRNA synthetase [EC:6.1.1.1] | (RefSeq) tyrosine--tRNA ligase, mitochondrial

PATHWAY

00970    Aminoacyl-tRNA biosynthesis - Bombyx mori (domestic silkworm)

GO

GO:0006437   GO:0005737   GO:0003723   GO:0004831   GO:0005524   GO:0070184   GO:0005739   GO:0005759   GO:0004930   GO:0043039   GO:0016021   GO:0005829   GO:0004035   GO:0035091   GO:0006412   GO:0000166   GO:0004812   GO:0006418   GO:0046872   GO:0003824  

PANTHER

PTHR11766  

Subcellular location

Mitochondrion matrix  

Length:

427

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.11911

Exp number, first 60 AAs:

0.08927

Total prob of N-in:

0.00829

outside

1  -  427

 

 

Pi

16.77067

Theta

15.51283

Tajima's D

0.009047

CLR

2.609893

CSRT

0.373631318434078

Interpretation

Uncertain