Gene

KWMTBOMO10212  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA005593

Annotation

putative_signal_recognition_particle_68_kDa_protein_[Bombyx_mori]

Location

Bomo_Chr17(+):5028808-5035664      View in EpiBrowser

Full name

Signal recognition particle subunit SRP68      

Alternative Name

Signal recognition particle 68 kDa protein

Location in the cell

Cytoplasmic   Reliability : 2.347

CDS

ATGGTAGGTCAAGAGAGTGAAATTGAAAATGGAAAGGTGACAGCGGTAGAAAATTCTGATAAGAAAAATGAGAAGGCACCCATCCTCCTCAACTTAGAAATATTTCGGATAACAAGAGACAGTCAGCAGCAGCATGGTCTCCGACATGCTGATTATCAGAGATATCGTGGCTATTGTTCGCGCCGCATAAGAAGACTGCGAAAAGTACTCAAAATACCACAGGGAGACAGACGCCATTACCGTCGTCGTGATGTCACAACTACCCACCTTACGGCCAACAATGCCGAGAATAGATTGCTGTACATACCGCTGCTGCAAGCCGAGAGGGCATGGGCTCATGCCATGCAACTGCGTCAGGAAGCTAACACTGAACCGAGAAAAAAGTTTCATCTTGTGTCTCGACTGAAGAAAGCATGTGCACATGGGCAGATGCTTTTGCAGCTTTGTGAGGAAAGCGGCAGGTGCGAAGCGCGTACGGTGCTAGAGGCGGGCGCGTACGCTTCTTGGCTGCGGGGCGTGTTGCTGCTGGAGTTGCAACAATGGCGCGAGGCAGCGGACTCATTGCAACGGGCCAGGATCGTACTCGAACAACTCTGTACAGCCTTGCCGGCGGACGAACGGATTGTTTACGATCAGAAGCTAGAGGAGCTGAAGCCGAGTCTTCGTTATTGTGCTTACAACATCGGTGACGAGTCCGCCGCCGGAGACCTTATGGCCATGCGCGGTCAAGGACTCATGCACAACCTCGATGCGCTGATGGCACAGGCTAAAGAGTCGCGTTCTGGCATTATGCACGAAGTGGAGTGGCGGGGCCGTCGCGTCACTGTCAAACCGGAAAAGGTTCGACTTTTCCTTATTGCTCTACAGGATCTGGACAAATCCGTGTCCAAGGCGGAGACGGCTCAAGCCAAGATCGACATTCTCGAGAACATCCTGATGGACTGCAAGGATGCAATTTCCGCAATCAAGGACGAGATAAAAACCGATCCGAAACTGAAATCCGCACCCGAGATCCAAGCCTCCAGCGTCGGCTACCTGCTCTCGTATTTGATGTACGTGCGACTTGTACGCACTATCGAGCGAAACAATTTGCTCGTCGAACAAGCTGAAGAAGCGCGCAAGAACAACATACAGATCGACGGAAAGAAAGTCCGGCCTCAAGACTTGACCAGGCTCTACGAGATCATTCTGCAGAATTACAATGAACTGCAACAGTTGCCGGGCTTTGAGAACGACGCAGTTTATCAAAAGGAAATCGATACGCAAATGAAGGCGTATCGCGCGTTCCGTTGCTATTACATCGCTCAAGTGCTCACCGGACTGAGACGCTTCAGGGAGGCTTTAGCGATGCTCGAAAGATGCAACACGTATACCGTTGAATCGCTCAAAAGTAAACTGGACAATCAACAACTAAAGGACAAGTTGCAAGTCTTGAAGAAGGACATAGAAAGCTGCAAATTCGAAGTCCACGCTGATTCTGTGCTCGAGGATGATGAAGAAGACGAAGAGAGTAAATACGCTTCGAGCGGCAAATCTTACAAAGACAAGAAGCCTCTGGTGGAGCGCTTGGACGATTACAGAGAAGATTCCCAGGTGCTTACGAAGAACCCGAACATTTATAGAATGCCTCCCCCAATGGAAGCGATTCCTTGTAAGCCACTGTTCTTTGATTTGGCCTGCAATTTCGTTGAGTTCCCGAATTTGGACGATAAAACGGGCGCTACAGATGGCAAGAAGCAAGGTGCAGGACTCACTGGACTCGTTAAAGGATTTTTGGGTTGGGGAAAAAGCGATAAATAG

Protein

MVGQESEIENGKVTAVENSDKKNEKAPILLNLEIFRITRDSQQQHGLRHADYQRYRGYCSRRIRRLRKVLKIPQGDRRHYRRRDVTTTHLTANNAENRLLYIPLLQAERAWAHAMQLRQEANTEPRKKFHLVSRLKKACAHGQMLLQLCEESGRCEARTVLEAGAYASWLRGVLLLELQQWREAADSLQRARIVLEQLCTALPADERIVYDQKLEELKPSLRYCAYNIGDESAAGDLMAMRGQGLMHNLDALMAQAKESRSGIMHEVEWRGRRVTVKPEKVRLFLIALQDLDKSVSKAETAQAKIDILENILMDCKDAISAIKDEIKTDPKLKSAPEIQASSVGYLLSYLMYVRLVRTIERNNLLVEQAEEARKNNIQIDGKKVRPQDLTRLYEIILQNYNELQQLPGFENDAVYQKEIDTQMKAYRAFRCYYIAQVLTGLRRFREALAMLERCNTYTVESLKSKLDNQQLKDKLQVLKKDIESCKFEVHADSVLEDDEEDEESKYASSGKSYKDKKPLVERLDDYREDSQVLTKNPNIYRMPPPMEAIPCKPLFFDLACNFVEFPNLDDKTGATDGKKQGAGLTGLVKGFLGWGKSDK

Description

Signal-recognition-particle assembly has a crucial role in targeting secretory proteins to the rough endoplasmic reticulum membrane.
Signal-recognition-particle assembly has a crucial role in targeting secretory proteins to the rough endoplasmic reticulum membrane. Srp68 binds the 7S RNA, Srp72 binds to this complex subsequently. This ribonucleoprotein complex might interact directly with the docking protein in the ER membrane and possibly participate in the elongation arrest function (By similarity).

Subunit

Signal recognition particle consists of a 7S RNA molecule of 300 nucleotides and six protein subunits: Srp72, Srp68, Srp54, Srp19, Srp14 and Srp9.

Similarity

Belongs to the SRP68 family.

Keywords

Complete proteome   Cytoplasm   Reference proteome   Ribonucleoprotein   RNA-binding   Signal recognition particle  

Feature

chain  Signal recognition particle subunit SRP68

Uniprot

Q0N2R7   H9J7V1   A0A2A4JST9   A0A2H1WXZ3   S4PYH2   A0A212FFF5   + More
A0A194QCI9   A0A194QRW6   A0A0L7KJZ3   A0A1E1VXV0   A0A1J1IBL8   A0A0K8TT17   A0A1B0GN56   A0A336KGJ9   Q16U06   U5EUQ1   A0A182H0I8   A0A182GPN0   A0A1L8DVJ5   A0A1L8DVZ8   B0WMF9   A0A182Q8R5   A0A1Q3FAB6   A0A2J7PLR9   A0A1B6CIN9   A0A023EU35   A0A1A9UJE0   A0A1A9Z2P3   A0A1B0G0V2   T1PBK6   A0A1A9YEN1   A0A1B0B189   A0A1B0CSX8   D3TL53   A0A0L0CKE1   A0A182XWI8   A0A067RMM2   A0A182PD57   A0A084VXE4   W8BUY5   A0A034VAW1   A0A0K8WL07   A0A182K5W3   A0A182RFV1   A0A182LVI5   A0A1A9WTH5   A0A1I8PHA1   A0A182VYD5   A0A182SJZ4   A0A2M4BHC2   A0A2M4BH93   A0A2M3ZHL6   E0VTC5   W5J3V1   A0A182FA82   A0A2M4BI81   A0A182NMV4   B4N6N3   A0A2M4AAH0   A0A0M3QW49   A0A0A1WUL3   Q7QK73   A0A182HZN0   A0A182WZI3   A0A182LQP2   A0A182V143   A0A182U418   Q29F46   B4HKJ1   A0A3B0JY57   A0A0J9RRS5   A0A1W4V0E4   B4PFG3   A0A1B6L3X3   B4J152   B4KVN8   B3NBK9   B4LEV6   B4QMN5   A0A1S4EAW6   A0A2J7PLS8   Q9VSS2   B3M5W5   A0A182J126   B4HAZ5   A0A026X0Y1   E9IQ46   A0A0P4VSP3   A0A2M3ZHZ3   A0A0N0BED1   A0A1L8DVC2   A0A158P1B8   A0A069DW85   A0A088AR84   E2ATX5   A0A0J7KUK6   E2BQK6   A0A2A3E9E5   J9K2B9   T1I0Y0  

Pubmed

19121390    23622113    22118469    26354079    26227816    26369729    + More
17510324    26483478    24945155    25315136    20353571    26108605    25244985    24845553    24438588    24495485    25348373    20566863    20920257    23761445    17994087    25830018    12364791    14747013    17210077    20966253    15632085    22936249    17550304    10731132    12537572    12537569    15901661    24508170    30249741    21282665    27129103    21347285    26334808    20798317   

EMBL

DQ646414    ABH10804.1    BABH01020024    NWSH01000679    PCG74846.1    ODYU01011923    + More
SOQ57943.1    GAIX01003293    JAA89267.1    AGBW02008828    OWR52462.1    KQ459232    KPJ02700.1    KQ461155    KPJ08232.1    JTDY01009611    KOB63224.1    GDQN01011499    JAT79555.1    CVRI01000045    CRK96956.1    GDAI01000322    JAI17281.1    AJVK01004376    UFQS01000446    UFQT01000446    SSX04036.1    SSX24401.1    CH477635    EAT38012.1    GANO01002223    JAB57648.1    JXUM01101401    KQ564645    KXJ71972.1    JXUM01078749    KQ563085    KXJ74508.1    GFDF01003620    JAV10464.1    GFDF01003619    JAV10465.1    DS231997    EDS31016.1    AXCN02001555    GFDL01010597    JAV24448.1    NEVH01024423    PNF17284.1    GEDC01024018    JAS13280.1    GAPW01000688    JAC12910.1    CCAG010000567    KA646054    AFP60683.1    JXJN01007030    AJWK01026757    EZ422153    ADD18348.1    JRES01000364    KNC31924.1    KK852421    KDR24278.1    ATLV01018026    KE525209    KFB42638.1    GAMC01005777    GAMC01005776    JAC00779.1    GAKP01020025    GAKP01020022    JAC38930.1    GDHF01000744    JAI51570.1    AXCM01004735    GGFJ01003283    MBW52424.1    GGFJ01003284    MBW52425.1    GGFM01007167    MBW27918.1    DS235761    EEB16631.1    ADMH02002183    ETN57993.1    GGFJ01003625    MBW52766.1    CH964161    EDW80022.1    GGFK01004465    MBW37786.1    CP012525    ALC43529.1    GBXI01011740    JAD02552.1    AAAB01008799    EAA03741.4    APCN01001987    CH379068    EAL31226.2    CH480815    EDW40794.1    OUUW01000009    SPP85362.1    CM002912    KMY98526.1    CM000159    EDW93089.1    GEBQ01021636    JAT18341.1    CH916366    EDV96907.1    CH933809    EDW19509.1    CH954178    EDV50605.1    CH940647    EDW70213.1    CM000363    EDX09789.1    PNF17286.1    AE014296    AY058698    CH902618    EDV39655.1    CH479246    EDW37789.1    KK107046    QOIP01000004    EZA61738.1    RLU24201.1    GL764659    EFZ17326.1    GDKW01000430    JAI56165.1    GGFM01007297    MBW28048.1    KQ435837    KOX71472.1    GFDF01003708    JAV10376.1    ADTU01006214    GBGD01000957    JAC87932.1    GL442747    EFN63106.1    LBMM01003073    KMQ93998.1    GL449769    EFN82064.1    KZ288313    PBC28348.1    ABLF02013100    ACPB03010572   

Proteomes

UP000005204    UP000218220    UP000007151    UP000053268    UP000053240    UP000037510    + More
UP000183832    UP000092462    UP000008820    UP000069940    UP000249989    UP000002320    UP000075886    UP000235965    UP000078200    UP000092445    UP000092444    UP000095301    UP000092443    UP000092460    UP000092461    UP000037069    UP000076408    UP000027135    UP000075885    UP000030765    UP000075881    UP000075900    UP000075883    UP000091820    UP000095300    UP000075920    UP000075901    UP000009046    UP000000673    UP000069272    UP000075884    UP000007798    UP000092553    UP000007062    UP000075840    UP000076407    UP000075882    UP000075903    UP000075902    UP000001819    UP000001292    UP000268350    UP000192221    UP000002282    UP000001070    UP000009192    UP000008711    UP000008792    UP000000304    UP000079169    UP000000803    UP000007801    UP000075880    UP000008744    UP000053097    UP000279307    UP000053105    UP000005205    UP000005203    UP000000311    UP000036403    UP000008237    UP000242457    UP000007819    UP000015103   

PRIDE

Q0N2R7    H9J7V1    Q9VSS2   

Pfam

PF16969   SRP68

Interpro

IPR026258   SRP68        + More
IPR038253   SRP68_N_sf       
IPR011990   TPR-like_helical_dom_sf       
IPR034652   SRP68-RBD       
IPR015943   WD40/YVTN_repeat-like_dom_sf       

SUPFAM

SSF48452   SSF48452       

Gene 3D

1.10.3450.40     2.130.10.10    

CDD

cd15481  SRP68-RBD

ProteinModelPortal

Q0N2R7   H9J7V1   A0A2A4JST9   A0A2H1WXZ3   S4PYH2   A0A212FFF5   + More
A0A194QCI9   A0A194QRW6   A0A0L7KJZ3   A0A1E1VXV0   A0A1J1IBL8   A0A0K8TT17   A0A1B0GN56   A0A336KGJ9   Q16U06   U5EUQ1   A0A182H0I8   A0A182GPN0   A0A1L8DVJ5   A0A1L8DVZ8   B0WMF9   A0A182Q8R5   A0A1Q3FAB6   A0A2J7PLR9   A0A1B6CIN9   A0A023EU35   A0A1A9UJE0   A0A1A9Z2P3   A0A1B0G0V2   T1PBK6   A0A1A9YEN1   A0A1B0B189   A0A1B0CSX8   D3TL53   A0A0L0CKE1   A0A182XWI8   A0A067RMM2   A0A182PD57   A0A084VXE4   W8BUY5   A0A034VAW1   A0A0K8WL07   A0A182K5W3   A0A182RFV1   A0A182LVI5   A0A1A9WTH5   A0A1I8PHA1   A0A182VYD5   A0A182SJZ4   A0A2M4BHC2   A0A2M4BH93   A0A2M3ZHL6   E0VTC5   W5J3V1   A0A182FA82   A0A2M4BI81   A0A182NMV4   B4N6N3   A0A2M4AAH0   A0A0M3QW49   A0A0A1WUL3   Q7QK73   A0A182HZN0   A0A182WZI3   A0A182LQP2   A0A182V143   A0A182U418   Q29F46   B4HKJ1   A0A3B0JY57   A0A0J9RRS5   A0A1W4V0E4   B4PFG3   A0A1B6L3X3   B4J152   B4KVN8   B3NBK9   B4LEV6   B4QMN5   A0A1S4EAW6   A0A2J7PLS8   Q9VSS2   B3M5W5   A0A182J126   B4HAZ5   A0A026X0Y1   E9IQ46   A0A0P4VSP3   A0A2M3ZHZ3   A0A0N0BED1   A0A1L8DVC2   A0A158P1B8   A0A069DW85   A0A088AR84   E2ATX5   A0A0J7KUK6   E2BQK6   A0A2A3E9E5   J9K2B9   T1I0Y0  

PDB

6FRK     E-value=1.71526e-110,     Score=1023

KEGG

778482    K03107 signal recognition particle subunit SRP68 | (RefSeq) Srp68; signal recognition particle 68 kD

PATHWAY

03060    Protein export - Bombyx mori (domestic silkworm)

GO

GO:0005047   GO:0030942   GO:0008312   GO:0006614   GO:0005786   GO:0016021   GO:0005515   GO:0006221   GO:0006402   GO:0046872   GO:0003824   GO:0003723  

PANTHER

PTHR12860  

Subcellular location

Cytoplasm  

Length:

599

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.02261

Exp number, first 60 AAs:

0

Total prob of N-in:

0.00059

outside

1  -  599

 

 

Pi

157.097266

Theta

169.546876

Tajima's D

-0.84594

CLR

0.208874

CSRT

0.165541722913854

Interpretation

Uncertain