Gene

KWMTBOMO10208  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA005592

Annotation

eukaryotic_translation_initiation_factor_3_subunit_D_[Bombyx_mori]

Location

Bomo_Chr17(+):5005638-5013552      View in EpiBrowser

Full name

Eukaryotic translation initiation factor 3 subunit D       + More
Eukaryotic translation initiation factor 3 subunit D-1      

Alternative Name

Eukaryotic translation initiation factor 3 subunit 7
Eukaryotic translation initiation factor 3 subunit 7-1
Eukaryotic translation initiation factor 3 subunit p66

Location in the cell

Nuclear   Reliability : 2.502

CDS

ATGTCGGAACACGTACTGCCGGCCGAAGGGCCGATGAGGTTTATTTCACCCATAATACAGGATAATCCAACCGGTTGGGGACCTTACGAGATGCCAGACCAATTTAGGGACATGCCCTATCAGCCATTCAGCAAAGGCGATCGATTAGGCAAGATAAGTGATTGGACAATGGTGCAAGACAAGAAGTACCAGAACAAGTATGCATCACAGTTCGGCGCTGGTTCGTCTTATGCATACTTCCATGATGAAGATGAAAGCACCTTTCACCTGGTGGACACTACTCGAGTACAAAAGCCGTACCAGTCATATCAGCGTGGGCGGGCTCGAGGACAGCGTGGTCGTGGTGCCAGGGGTGCACGTACTCCTGGTGGTATGACAACATTGAACAAGCCACGTGAACGCAAGCTTGGTAAGAGGTGGGGTCAACGTGGTGCGCCTATGAAGATTCGTGATGCATCTGTAACTGTAAGGCCAACATGGGTCACGATTGAAGATATGGACTTCCCACGTCTTGCCAAACTATCATTACCTGGTATTAAAGAAGGTGAAGATATTGTCAGTTGCGGTACTTTAGAGTACTACGACAAGGCGTACGACCGCGTCAATGTGAAGCACGAGAAGCCCCTGCAGCGTATAGATCGTATCTTCCATACGGTGACAACAACTGACGATCCTGTGATCCGTCGTCTCAGTAAAACAGCTGGTACTGTTTATGCAACTGATGCTATACTGGCGACGATTATGTGCTGCACTCGGTCTAACTACTCATGGGACATTGTTATCGAGAAAATAGGTGACAAATTGTTCCTGGACAAGCGTGATAATACCGAGTTCGACTTGTTGACCGTTAATGAGACCTCTGTCGAACCTCCAGCTGATGATGGAAATTCTATCAATTCTCCAAGAAACCTGGCACTGGAAGCCACCTTTATCAACCATAACTTCAGTCAACAGGTGCTGAAATCAGGTCCAACGGAGCCTAAGTACAAGTTCCAAGAACCAAACCCGTTCGTCTCTGAAGAGGAAGATGGTGAAGTTGCCTCAGTGGGCTATCGCTATCGTAAATGGATCCTTAACAATGGTGTTGTTTTGATAGCACGCTGCGAGCACGACGCGGTAATGCAGGGCCCCCAGGGCGAGACGCAGTTCCTTACCATCAAGGCGCTCAACGAGTGGGACTCGAAGCTCGCTAACGGCGTCGAGTGGCGACAGAAGCTGGACACGCAGCGCGGCGCCGTGCTCGCCAACGAGCTGCGGAACAACTCCTGCAAGCTCGCCAAGTGGACCGTGCAGGCATTACTGGCGGGCTCGGACCAGATCAAGTTCGGTTACGTGTCCCGCGCGCAGGTGCGAGACAACTCGCGCCACGTCATCCTCGGCACGCAGCAGTTCAAGCCGCACGAGTTCGCCGCCCAGATCAACCTGTCCATGGACAACGCCTGGGGCATCCTGCGGTGCATCATCGACATATGCATGAAGCAGAAGGACGGTAAATACTTGATCATGAAAGACCCGAACAAGCCCCTGATCCGCCTGTACGACATCCCGGACAACACGTTCGAGTCGGACGCGTCCGAGGAGAGCGGCGACGAGCAAGCCGACACGCCCTTCGCGCCGCTCTACTCCTACGGAAACAGCAAACGGGTCTAG

Protein

MSEHVLPAEGPMRFISPIIQDNPTGWGPYEMPDQFRDMPYQPFSKGDRLGKISDWTMVQDKKYQNKYASQFGAGSSYAYFHDEDESTFHLVDTTRVQKPYQSYQRGRARGQRGRGARGARTPGGMTTLNKPRERKLGKRWGQRGAPMKIRDASVTVRPTWVTIEDMDFPRLAKLSLPGIKEGEDIVSCGTLEYYDKAYDRVNVKHEKPLQRIDRIFHTVTTTDDPVIRRLSKTAGTVYATDAILATIMCCTRSNYSWDIVIEKIGDKLFLDKRDNTEFDLLTVNETSVEPPADDGNSINSPRNLALEATFINHNFSQQVLKSGPTEPKYKFQEPNPFVSEEEDGEVASVGYRYRKWILNNGVVLIARCEHDAVMQGPQGETQFLTIKALNEWDSKLANGVEWRQKLDTQRGAVLANELRNNSCKLAKWTVQALLAGSDQIKFGYVSRAQVRDNSRHVILGTQQFKPHEFAAQINLSMDNAWGILRCIIDICMKQKDGKYLIMKDPNKPLIRLYDIPDNTFESDASEESGDEQADTPFAPLYSYGNSKRV

Description

mRNA cap-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation. In the eIF-3 complex, eif3d specifically recognizes and binds the 7-methylguanosine cap of a subset of mRNAs.

Subunit

Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.
Component of the eukaryotic translation initiation factor 3 (eIF-3) complex. The eIF-3 complex interacts with pix.

Similarity

Belongs to the eIF-3 subunit D family.

Keywords

Complete proteome   Cytoplasm   Initiation factor   Protein biosynthesis   Reference proteome   RNA-binding   3D-structure   Phosphoprotein  

Feature

chain  Eukaryotic translation initiation factor 3 subunit D

Uniprot

H9J7V0   Q0ZB77   A0A194QCI3   A0A1E1WTI6   S4PA21   A0A2H1VFC7   + More
A0A2A4JS59   A0A194QRX1   A0A2J7QWQ1   A0A1W4W4E2   A0A067QLI6   D6WX00   A0A0T6B589   U5EU19   A0A1Y1NK83   E2AAA3   A0A195BKL9   A0A1B0CA39   A0A2A3EC42   V9IEV1   A0A088AEQ4   E9IXS1   A0A0M9ABF6   F4X1G9   A0A158NA74   A0A0J7L3A0   A0A195DLX2   A0A3L8D5Y5   A0A151X7H8   A0A195CB89   A0A195FQW8   A0A182FR84   A0A2M4BI56   A0A154PNF9   A0A2M3YZE2   A0A026WQ83   A0A232EYQ7   A0A182TZB3   Q7QBW3   A0A0L7RHJ6   A0A182LFH8   A0A182XEI4   A0A182HTD0   W5JBM2   K7IM66   T1DFE9   A0A182UX05   A0A2M4A1K0   A0A1L8DSG9   A0A2M4A222   A0A0C9RJ85   E2B8B4   A0A336L2X7   A0A026WQB2   J3JX14   A0A182PTH2   A0A182K5M5   A0A0K8TNQ1   N6TPQ0   A0A1Q3F2T9   B0X6P7   A0A1L8DS15   A0A182Q3E2   A0A182J5X1   N6TSB8   A0A182Y7B2   Q16UF8   A0A182N4L5   A0A023EXB8   A0A084VE17   A0A182RNL5   A0A182MMK0   E0VST5   A0A1J1HQI6   A0A182VQ80   A0A0A1XJE6   A0A2P8YLX9   A0A161MJ01   A0A224XAG6   W8BZ53   A0A0V0G2Y1   A0A0P4VP88   R4FLD0   A0A0A9Z2P9   A0A069DVH3   A0A1B6HX44   A0A034WI55   A0A023FAQ3   A0A0A9YWT8   T1PEM6   A0A1A9WYR1   B4K892   B4JTN0   A0A1A9UVG9   A0A1I8PMQ4   A0A0L0CSS3   A0A1B0B3F1   D3TM00   B4LYI3   A0A2R7W249  

Pubmed

19121390    26354079    23622113    24845553    18362917    19820115    + More
28004739    20798317    21282665    21719571    21347285    30249741    24508170    28648823    12364791    20966253    20920257    23761445    20075255    27462815    22516182    26369729    23537049    25244985    17510324    24945155    26483478    24438588    20566863    25830018    29403074    24495485    27129103    25401762    26823975    26334808    25348373    25474469    25315136    17994087    26108605    20353571   

EMBL

BABH01020034    DQ645459    KQ459232    KPJ02695.1    GDQN01000705    JAT90349.1    + More
GAIX01003449    JAA89111.1    ODYU01002251    SOQ39486.1    NWSH01000679    PCG74841.1    KQ461155    KPJ08237.1    NEVH01009422    PNF33012.1    KK853286    KDR08942.1    KQ971361    EFA08069.1    LJIG01009693    KRT82570.1    GANO01002530    JAB57341.1    GEZM01005540    JAV96107.1    GL438057    EFN69629.1    KQ976455    KYM85155.1    AJWK01003260    KZ288301    PBC28862.1    JR042231    AEY59580.1    GL766762    EFZ14688.1    KQ435710    KOX79833.1    GL888529    EGI59697.1    ADTU01010056    LBMM01000967    KMQ97136.1    KQ980734    KYN13841.1    QOIP01000012    RLU15882.1    KQ982446    KYQ56326.1    KQ978009    KYM98129.1    KQ981305    KYN42980.1    GGFJ01003553    MBW52694.1    KQ435007    KZC13411.1    GGFM01000889    MBW21640.1    KK107131    EZA58202.1    NNAY01001594    OXU23485.1    AAAB01008859    KQ414588    KOC70452.1    APCN01000459    ADMH02001603    ETN61872.1    GAMD01003161    JAA98429.1    GGFK01001346    MBW34667.1    GFDF01004819    JAV09265.1    GGFK01001488    MBW34809.1    GBYB01013292    JAG83059.1    GL446286    EFN88116.1    UFQS01001369    UFQT01001369    SSX10541.1    SSX30227.1    EZA58205.1    RLU15890.1    BT127782    AEE62744.1    GDAI01001609    JAI15994.1    APGK01056936    APGK01056937    KB741277    KB632155    ENN71215.1    ERL89177.1    GFDL01013169    JAV21876.1    DS232420    GFDF01004818    JAV09266.1    AXCN02000047    ENN71216.1    ERL89176.1    CH477622    JXUM01160349    GAPW01000544    KQ573664    JAC13054.1    KXJ67915.1    ATLV01012142    KE524764    KFB36211.1    AXCM01003145    DS235756    EEB16441.1    CVRI01000008    CRK88473.1    GBXI01003277    JAD11015.1    PYGN01000503    PSN45214.1    GEMB01001350    JAS01806.1    GFTR01007060    JAW09366.1    GAMC01004617    JAC01939.1    GECL01003630    JAP02494.1    GDKW01001774    JAI54821.1    GAHY01001463    JAA76047.1    GBHO01007524    GDHC01017696    JAG36080.1    JAQ00933.1    GBGD01001078    JAC87811.1    GECU01028458    GECU01014609    JAS79248.1    JAS93097.1    GAKP01005132    JAC53820.1    GBBI01000724    JAC17988.1    GBHO01007523    GDHC01015070    JAG36081.1    JAQ03559.1    KA647237    AFP61866.1    CH933806    CH916374    JRES01000065    KNC34444.1    JXJN01007813    CCAG010018120    EZ422452    ADD18728.1    CH940650    KK854246    PTY13659.1   

Proteomes

UP000005204    UP000053268    UP000218220    UP000053240    UP000235965    UP000192223    + More
UP000027135    UP000007266    UP000000311    UP000078540    UP000092461    UP000242457    UP000005203    UP000053105    UP000007755    UP000005205    UP000036403    UP000078492    UP000279307    UP000075809    UP000078542    UP000078541    UP000069272    UP000076502    UP000053097    UP000215335    UP000075902    UP000007062    UP000053825    UP000075882    UP000076407    UP000075840    UP000000673    UP000002358    UP000075903    UP000008237    UP000075885    UP000075881    UP000019118    UP000030742    UP000002320    UP000075886    UP000075880    UP000076408    UP000008820    UP000075884    UP000069940    UP000249989    UP000030765    UP000075900    UP000075883    UP000009046    UP000183832    UP000075920    UP000245037    UP000095301    UP000091820    UP000009192    UP000001070    UP000078200    UP000095300    UP000037069    UP000092460    UP000092444    UP000008792   

PRIDE

H9J7V0    Q0ZB77    K7IM66    B4K892    B4JTN0    B4LYI3    + More

Pfam

PF05091   eIF-3_zeta        + More
PF01428   zf-AN1
PF01369   Sec7
PF00169   PH
PF15911   WD40_3

Interpro

IPR007783   eIF3d        + More
IPR035896   AN1-like_Znf       
IPR000058   Znf_AN1       
IPR003903   UIM_dom       
IPR000904   Sec7_dom       
IPR011993   PH-like_dom_sf       
IPR023394   Sec7_C_sf       
IPR035999   Sec7_dom_sf       
IPR001849   PH_domain       
IPR036322   WD40_repeat_dom_sf       
IPR039468   WDR19_WD40_rpt       
IPR040379   WDR19/dyf-2       
IPR001680   WD40_repeat       
IPR011990   TPR-like_helical_dom_sf       
IPR015943   WD40/YVTN_repeat-like_dom_sf       

SUPFAM

SSF118310   SSF118310        + More
SSF48425   SSF48425       
SSF48452   SSF48452       
SSF50978   SSF50978       

Gene 3D

4.10.1110.10     1.10.1000.11     2.30.29.30     1.25.40.10     2.130.10.10    

CDD

cd00171  Sec7

ProteinModelPortal

H9J7V0   Q0ZB77   A0A194QCI3   A0A1E1WTI6   S4PA21   A0A2H1VFC7   + More
A0A2A4JS59   A0A194QRX1   A0A2J7QWQ1   A0A1W4W4E2   A0A067QLI6   D6WX00   A0A0T6B589   U5EU19   A0A1Y1NK83   E2AAA3   A0A195BKL9   A0A1B0CA39   A0A2A3EC42   V9IEV1   A0A088AEQ4   E9IXS1   A0A0M9ABF6   F4X1G9   A0A158NA74   A0A0J7L3A0   A0A195DLX2   A0A3L8D5Y5   A0A151X7H8   A0A195CB89   A0A195FQW8   A0A182FR84   A0A2M4BI56   A0A154PNF9   A0A2M3YZE2   A0A026WQ83   A0A232EYQ7   A0A182TZB3   Q7QBW3   A0A0L7RHJ6   A0A182LFH8   A0A182XEI4   A0A182HTD0   W5JBM2   K7IM66   T1DFE9   A0A182UX05   A0A2M4A1K0   A0A1L8DSG9   A0A2M4A222   A0A0C9RJ85   E2B8B4   A0A336L2X7   A0A026WQB2   J3JX14   A0A182PTH2   A0A182K5M5   A0A0K8TNQ1   N6TPQ0   A0A1Q3F2T9   B0X6P7   A0A1L8DS15   A0A182Q3E2   A0A182J5X1   N6TSB8   A0A182Y7B2   Q16UF8   A0A182N4L5   A0A023EXB8   A0A084VE17   A0A182RNL5   A0A182MMK0   E0VST5   A0A1J1HQI6   A0A182VQ80   A0A0A1XJE6   A0A2P8YLX9   A0A161MJ01   A0A224XAG6   W8BZ53   A0A0V0G2Y1   A0A0P4VP88   R4FLD0   A0A0A9Z2P9   A0A069DVH3   A0A1B6HX44   A0A034WI55   A0A023FAQ3   A0A0A9YWT8   T1PEM6   A0A1A9WYR1   B4K892   B4JTN0   A0A1A9UVG9   A0A1I8PMQ4   A0A0L0CSS3   A0A1B0B3F1   D3TM00   B4LYI3   A0A2R7W249  

PDB

6FEC     E-value=0,     Score=1759

KEGG

733085    K03251 translation initiation factor 3 subunit D | (RefSeq) eIF3-S7, eIF3d; eukaryotic translation i

PATHWAY

03013    RNA transport - Bombyx mori (domestic silkworm)

GO

GO:0002191   GO:0016282   GO:0001732   GO:0005852   GO:0003743   GO:0033290   GO:0098808   GO:0006413   GO:0008270   GO:0032012   GO:0005086   GO:0035721   GO:0005929   GO:0005634   GO:0006446   GO:0016021   GO:0005737   GO:0003824   GO:0008152   GO:0004588   GO:0006221   GO:0006402   GO:0046872  

PANTHER

PTHR12399   PTHR14920  

Subcellular location

Cytoplasm  

Length:

549

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.00771000000000001

Exp number, first 60 AAs:

0

Total prob of N-in:

0.00034

outside

1  -  549

 

 

Pi

210.092688

Theta

188.424469

Tajima's D

0.179451

CLR

0.659847

CSRT

0.422078896055197

Interpretation

Uncertain