Gene

KWMTBOMO10196  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA005590

Annotation

deoxyhypusine_hydroxylase/monooxygenase_[Bombyx_mori]

Location

Bomo_Chr17(+):4273543-4277953      View in EpiBrowser

Full name

Deoxyhypusine hydroxylase      

Alternative Name

Deoxyhypusine dioxygenase
Deoxyhypusine monooxygenase

Location in the cell

Cytoplasmic   Reliability : 1.654 Nuclear   Reliability : 1.337

CDS

ATGGCAAACGTGAGTGAGAACGCAGTGAAAAACATCGGGAATGTTCTAAATGATCCCTCCAGGCCAATGAAAGAGCGTTTTCGAGCCCTGTTCACATTAAGAAACATCGGTGGCGAAACTGCCATACAGTGTATTAGCGAATGCTTTAAAGACGAGTCCGTTTTGTTAAAGCATGAGCTTGCTTACTGTTTGGGTCAAATGCAAGACAGAAGAGCCATTCCTATATTGAGGAGCGTGTTAGAGGACCCAAACCATGATCCAATAGTTCGCCATGAAGCCGGAGAAGCCCTTGGGGCAATAGGAGACCCTAATCTCCGAGAGCTGCTCGAAAAGTATCAGCATGATTCAGCAATAGAAGTAGCAGAGACATGCCAGATTGCATTACAAAGGTTAAACTGGGTCGCTAATGACAGTAAAGAAAATGACAATTTGTCTAAAAGTTTATACACTTCAGTGGATCCTGCTCCGCCCAGCATTGAAAATAATTTAGAGGCACTTAAAGATGTATACCTTGATGAGACAAAACCATTGTTTATACGATACAGGGCAATGTTTAGTTTGCGTAATTTAGGAACGACTGAAAGTATCAATGCCTTGGGTGAAGGTCTAAAAGCAAACAGTGCACTGTTCAGACACGAAGTGGCATTTGTTTTCGGTCAAATGCAAGACGAAAGGAGTGTTCCTTTTTTGAAAACAACGCTGGAAGATACAAACGAACATGAAATGGTGAGACACGAGGCCGCTGAAGCATTGGGTTCTATCGCAACTGATGAATGCATCGAAATATTAAAGAGGTACTTGAATGATCCACGTCGTGTCGTCCGAGAAAGCTGCGAAGTGGCCCTCGACATGTCTGAGTACGAAAACAGTCCAGAATTTCAATACGCCAACACATTGCTGACTGTCCAATCTTAG

Protein

MANVSENAVKNIGNVLNDPSRPMKERFRALFTLRNIGGETAIQCISECFKDESVLLKHELAYCLGQMQDRRAIPILRSVLEDPNHDPIVRHEAGEALGAIGDPNLRELLEKYQHDSAIEVAETCQIALQRLNWVANDSKENDNLSKSLYTSVDPAPPSIENNLEALKDVYLDETKPLFIRYRAMFSLRNLGTTESINALGEGLKANSALFRHEVAFVFGQMQDERSVPFLKTTLEDTNEHEMVRHEAAEALGSIATDECIEILKRYLNDPRRVVRESCEVALDMSEYENSPEFQYANTLLTVQS

Description

Catalyzes the hydroxylation of the N(6)-(4-aminobutyl)-L-lysine intermediate to form hypusine, an essential post-translational modification only found in mature eIF-5A factor.
Catalyzes the hydroxylation of the N(6)-(4-aminobutyl)-L-lysine intermediate to form hypusine, an essential post-translational modification only found in mature eIF-5A factor. Essential for organismal viability and plays a role in a wide number of important processes such as cell growth and proliferation, and regulates induction of autophagy and protein synthesis. Has a role in eIF-5A-mediated translational control.

Catalytic Activity

[eIF5A protein]-deoxyhypusine + AH2 + O2 = [eIF5A protein]-hypusine + A + H2O

Cofactor

Fe(2+)

Similarity

Belongs to the deoxyhypusine hydroxylase family.

Feature

chain  Deoxyhypusine hydroxylase

Uniprot

B5TJK7   H9J7U8   A0A1E1WIA6   A0A2H1VTY0   A0A194QCH5   A0A2A4JL03   + More
A0A2A4JK82   A0A194QTB4   S4PCA6   A0A3S2M060   A0A0L7K4H9   A0A212EII1   A0A0J7L905   A0A067QSF3   D6WZ08   A0A232F1L1   K7IN20   A0A2J7R7H0   E9IW39   A0A0C9RWZ7   A0A1L8DAP7   A0A1L8DAU8   N6U7Q2   E2AE55   A0A088A8J8   A0A151K1F0   B0W942   A0A151XGC3   A0A195CML7   A0A1Y1MTP6   A0A195E243   A0A158N9V0   F4X0Y0   A0A154NY01   A0A0M9A7L4   W8CCX1   A0A182JD88   A0A1Q3FED7   A0A2A3E2S4   Q177G8   A0A182TB58   A0A182JUI3   A0A182PNE1   B4JXY7   A0A0K8TR96   A0A023F7K7   B4K9K0   A0A151JV63   A0A034VMG1   B4NL57   A0A182Q7H2   A0A182MGH9   A0A023EP29   A0A0A1WQF0   A0A182VFJ0   A0A182TMD5   A0A182LQV5   Q7PUV4   A0A182HZT4   A0A1I8NXR9   A0A023EQ88   A0A1A9WF60   A0A182XGJ2   A0A0M4ECN3   A0A336K972   A0A182W024   A0A1I8NXR6   A0A1L8EH10   A0A2M4BV03   T1PIX6   A0A182Y467   A0A0K8VHW8   A0A1I8M0P8   B3MSX4   A0A3B5AKM1   A0A182RNV6   A0A0V0G8T0   A0A1L8EH38   A0A224XGL4   B4LVW2   A0A2M3Z9I3   A0A182FRB1   B4PP19   A0A069DRN3   A0A2M4AK53   A0A210QWF1   A0A1B6CET4   A0A2M3Z926   A0A293LGD5   A0A182N681   A0A084VJB0   A0A3Q1BKQ6   W5JH70   B3P510   A0A3B0JJR8   A0A1W4WZ90   A0A2R5L970   I3JLF5   A0A1A9ZUM2   B4QT93  

EC Number

1.14.99.29

Pubmed

19121390    26354079    23622113    26227816    22118469    24845553    + More
18362917    19820115    28648823    20075255    21282665    23537049    20798317    28004739    21347285    21719571    24495485    17510324    17994087    26369729    25474469    25348373    24945155    25830018    20966253    12364791    14747013    17210077    25244985    25315136    17550304    26334808    28812685    24438588    20920257    23761445    25186727   

EMBL

EU978455    ACH73154.1    BABH01020108    BABH01020109    GDQN01004342    JAT86712.1    + More
ODYU01004428    SOQ44287.1    KQ459232    KPJ02685.1    NWSH01001128    PCG72466.1    PCG72467.1    KQ461155    KPJ08245.1    GAIX01005537    JAA87023.1    RSAL01000090    RVE48051.1    JTDY01010463    KOB58193.1    AGBW02014634    OWR41288.1    LBMM01000167    KMR04661.1    KK853008    KDR12555.1    KQ971363    EFA09033.1    NNAY01001310    OXU24400.1    NEVH01006732    PNF36785.1    GL766449    EFZ15236.1    GBYB01012394    GBYB01012396    GBYB01012805    JAG82161.1    JAG82163.1    JAG82572.1    GFDF01010543    JAV03541.1    GFDF01010532    JAV03552.1    APGK01036280    KB740939    KB632061    ENN77700.1    ERL88427.1    GL438827    EFN68288.1    LKEW01001137    KYN45485.1    DS231862    EDS39739.1    KQ982169    KYQ59443.1    KQ977565    KYN01935.1    GEZM01021566    JAV88939.1    KQ979814    KYN18992.1    ADTU01009644    GL888503    EGI59922.1    KQ434782    KZC04555.1    KQ435732    KOX77509.1    GAMC01002956    JAC03600.1    GFDL01009131    JAV25914.1    KZ288419    PBC25998.1    CH477376    EAT42309.1    CH916377    EDV90549.1    GDAI01000952    JAI16651.1    GBBI01001489    JAC17223.1    CH933806    EDW16660.1    KQ981713    KYN37366.1    GAKP01014421    JAC44531.1    CH964272    EDW84260.1    AXCN02000271    AXCM01000193    GAPW01002878    JAC10720.1    GBXI01013018    JAD01274.1    AAAB01008987    EAA00938.4    APCN01002010    GAPW01002879    JAC10719.1    CP012526    ALC45441.1    UFQS01000197    UFQT01000197    SSX01199.1    SSX21579.1    GFDG01000864    JAV17935.1    GGFJ01007691    MBW56832.1    KA648065    AFP62694.1    GDHF01031802    GDHF01023390    GDHF01013862    JAI20512.1    JAI28924.1    JAI38452.1    CH902623    EDV30364.1    GECL01001952    JAP04172.1    GFDG01000863    JAV17936.1    GFTR01004801    JAW11625.1    CH940650    EDW67567.1    GGFM01004445    MBW25196.1    CM000160    EDW99255.1    GBGD01002299    JAC86590.1    GGFK01007677    MBW40998.1    NEDP02001525    OWF53043.1    GEDC01025468    JAS11830.1    GGFM01004239    MBW24990.1    GFWV01002199    MAA26929.1    ATLV01013500    KE524866    KFB38054.1    ADMH02001204    ETN63712.1    CH954182    EDV52924.1    OUUW01000005    SPP81033.1    GGLE01001893    MBY06019.1    AERX01020277    CM000364    EDX15155.1   

Proteomes

UP000005204    UP000053268    UP000218220    UP000053240    UP000283053    UP000037510    + More
UP000007151    UP000036403    UP000027135    UP000007266    UP000215335    UP000002358    UP000235965    UP000019118    UP000030742    UP000000311    UP000005203    UP000078540    UP000002320    UP000075809    UP000078542    UP000078492    UP000005205    UP000007755    UP000076502    UP000053105    UP000075880    UP000242457    UP000008820    UP000075901    UP000075881    UP000075885    UP000001070    UP000009192    UP000078541    UP000007798    UP000075886    UP000075883    UP000075903    UP000075902    UP000075882    UP000007062    UP000075840    UP000095300    UP000091820    UP000076407    UP000092553    UP000075920    UP000076408    UP000095301    UP000007801    UP000261400    UP000075900    UP000008792    UP000069272    UP000002282    UP000242188    UP000075884    UP000030765    UP000257160    UP000000673    UP000008711    UP000268350    UP000192223    UP000005207    UP000092445    UP000000304   

PRIDE

B5TJK7    H9J7U8   

Pfam

PF03130   HEAT_PBS

Interpro

IPR027517   Deoxyhypusine_hydroxylase        + More
IPR011989   ARM-like       
IPR021133   HEAT_type_2       
IPR004155   PBS_lyase_HEAT       
IPR016024   ARM-type_fold       
IPR000225   Armadillo       

SUPFAM

SSF48371   SSF48371       

Gene 3D

1.25.10.10    

ProteinModelPortal

B5TJK7   H9J7U8   A0A1E1WIA6   A0A2H1VTY0   A0A194QCH5   A0A2A4JL03   + More
A0A2A4JK82   A0A194QTB4   S4PCA6   A0A3S2M060   A0A0L7K4H9   A0A212EII1   A0A0J7L905   A0A067QSF3   D6WZ08   A0A232F1L1   K7IN20   A0A2J7R7H0   E9IW39   A0A0C9RWZ7   A0A1L8DAP7   A0A1L8DAU8   N6U7Q2   E2AE55   A0A088A8J8   A0A151K1F0   B0W942   A0A151XGC3   A0A195CML7   A0A1Y1MTP6   A0A195E243   A0A158N9V0   F4X0Y0   A0A154NY01   A0A0M9A7L4   W8CCX1   A0A182JD88   A0A1Q3FED7   A0A2A3E2S4   Q177G8   A0A182TB58   A0A182JUI3   A0A182PNE1   B4JXY7   A0A0K8TR96   A0A023F7K7   B4K9K0   A0A151JV63   A0A034VMG1   B4NL57   A0A182Q7H2   A0A182MGH9   A0A023EP29   A0A0A1WQF0   A0A182VFJ0   A0A182TMD5   A0A182LQV5   Q7PUV4   A0A182HZT4   A0A1I8NXR9   A0A023EQ88   A0A1A9WF60   A0A182XGJ2   A0A0M4ECN3   A0A336K972   A0A182W024   A0A1I8NXR6   A0A1L8EH10   A0A2M4BV03   T1PIX6   A0A182Y467   A0A0K8VHW8   A0A1I8M0P8   B3MSX4   A0A3B5AKM1   A0A182RNV6   A0A0V0G8T0   A0A1L8EH38   A0A224XGL4   B4LVW2   A0A2M3Z9I3   A0A182FRB1   B4PP19   A0A069DRN3   A0A2M4AK53   A0A210QWF1   A0A1B6CET4   A0A2M3Z926   A0A293LGD5   A0A182N681   A0A084VJB0   A0A3Q1BKQ6   W5JH70   B3P510   A0A3B0JJR8   A0A1W4WZ90   A0A2R5L970   I3JLF5   A0A1A9ZUM2   B4QT93  

PDB

4D50     E-value=7.71913e-89,     Score=833

KEGG

100188970    K06072 deoxyhypusine monooxygenase [EC:1.14.99.29] | (RefSeq) Dohh; deoxyhypusine hydroxylase/monoox

GO

GO:0019135   GO:0008612   GO:0046872   GO:0004497   GO:0010508   GO:0042406   GO:0008283   GO:0005488   GO:0003824   GO:0008152   GO:0004588   GO:0006221   GO:0006402  

Subcellular location

Endoplasmic reticulum membrane   In larval imaginal disk and Garland cells.   With evidence from 1 publications.

Length:

304

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.00116

Exp number, first 60 AAs:

0.00078

Total prob of N-in:

0.06020

outside

1  -  304

 

 

Pi

140.385234

Theta

171.420115

Tajima's D

-0.937434

CLR

1690.907414

CSRT

0.151492425378731

Interpretation

Uncertain