Gene

KWMTBOMO10169  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA005628

Annotation

uridine_5'-monophosphate_synthase_[Bombyx_mori]

Location

Bomo_Chr17(-):3445600-3449443      View in EpiBrowser

Full name

Uridine 5'-monophosphate synthase      

Alternative Name

Rudimentary-like protein

Location in the cell

Cytoplasmic   Reliability : 2.734

CDS

ATGGGTTTAGATAAACTAGAAGATCTAGCTTTAAAACTATTTTCTATTGATGCCGTGAAATTTGGAGATTTTACTACTAAGACCGGCATCAAAACACCGGCCTATTTTGATTTGAGGGTTATTGTTAGTTATCCCGACATCATGGAGCTTACCTCGAATATGTTGTACGATTTAGCCGTAAAAGACAGCCAATTTGATCATTTGTGTGGAGTTCCATATACTGCCTTGCCCATTGCTACACTACTAAGTATACAAGCGAAAAAACCTATGTTGATGAGAAGGAAAGAAACAAAATCTTATGGAACCAAAAAAAGCATTGAAGGTCATTTTAAAAAAGATGACACATGTCTCATCATCGAGGACGTCATAACATCTGGCTCAAGCATACTGGAAACAGTCAAAGATTTGAAAAATGAAGGGCTCGTAACTACAGAAGCTGCCATTATTTTAGACCGGGAGCAAGGTGGTAGGGAGAACTTAGCTAAAAATGGCATCCATGTAAAATCATTGTTCACAATGAGAACATTGATTGAAATACTTAAAAAACACAAGAAAATAACAGATGAAATTGTAGTTACAGTAAAAAATTACTTGAATGAAACAAAGGCTCCTGTTATAGAAAAACTTATGGAACGTGTTATACTACCATATGAAAAAAGAATAGATTTTGCAACAAATCTTGTAGCCAGGCAACTATTCAACATTATGGCCACAAAGAAAACTAATTTATGTCTCTCAGCAGACCTCACCATGACTACTGGTATTTTAGATCTGCTAGAAAAAGTTGGAGAACACATTTGTATGGTCAAAACACATATAGACATAATTGATGATTTTAGAGATGACTTTGTTGTGAGGCTGAAACAGCTTGCTGACAGGTTTAATTTCCTTATACTTGAAGATAGGAAGTATGCTGACATCGGACACACTGTGTCATTGCAGTATTCAAAAGGACTGTACAAAATAGGTGAATGGGCAGACTGTGTTACAGTTCATTCTTTACCCGGTGAAGGCATATTGAAGGCACTGAATGGTTCAATGAATTGCATCACTAAGGGAGTGTTCTTGCTTGCTGAAATGAGTAGTGAGGGAAATCTTATAACACAACAATATAAACAGGAAACAGTCAGTATGGCATCCAAATATGCAAACATCATAACCGGATTTGTTTGTCAAAACAAGGACACCTTCCAAAACCCTGGCCTGATTCAATTAACTCCAGGAGTACAACTTGAATGCTCAAAAGACGATTTTGGCCAGATTTATAAAACACCTGAAAAAGTTGTGGTGGAAAATGGTGCCGACGTAATTGTTGTCGGAAGAGGTATCACAGCAGCAAAGAATCCAGAAGTTCAAGCTGTAGCTTATAAGGATGCGTTATGGAAATGTTATATTAAAAGAATATCTGGTAAATTAGAATGA

Protein

MGLDKLEDLALKLFSIDAVKFGDFTTKTGIKTPAYFDLRVIVSYPDIMELTSNMLYDLAVKDSQFDHLCGVPYTALPIATLLSIQAKKPMLMRRKETKSYGTKKSIEGHFKKDDTCLIIEDVITSGSSILETVKDLKNEGLVTTEAAIILDREQGGRENLAKNGIHVKSLFTMRTLIEILKKHKKITDEIVVTVKNYLNETKAPVIEKLMERVILPYEKRIDFATNLVARQLFNIMATKKTNLCLSADLTMTTGILDLLEKVGEHICMVKTHIDIIDDFRDDFVVRLKQLADRFNFLILEDRKYADIGHTVSLQYSKGLYKIGEWADCVTVHSLPGEGILKALNGSMNCITKGVFLLAEMSSEGNLITQQYKQETVSMASKYANIITGFVCQNKDTFQNPGLIQLTPGVQLECSKDDFGQIYKTPEKVVVENGADVIVVGRGITAAKNPEVQAVAYKDALWKCYIKRISGKLE

Catalytic Activity

diphosphate + orotidine 5'-phosphate = 5-phospho-alpha-D-ribose 1-diphosphate + orotate
H(+) + orotidine 5'-phosphate = CO2 + UMP

Similarity

In the N-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family.
In the C-terminal section; belongs to the OMP decarboxylase family.

Keywords

Complete proteome   Decarboxylase   Glycosyltransferase   Lyase   Multifunctional enzyme   Pyrimidine biosynthesis   Reference proteome   Transferase  

Feature

chain  Uridine 5'-monophosphate synthase

Uniprot

H9J7Y6   Q2F642   A0A2A4JS88   A0A2H1V5H1   D0ABA9   A0A0L7LET4   + More
A0A212EIU5   A0A3S2M065   A0A194QGS7   A0A194QXI0   A0A2M4BL31   W5JU62   A0A2M4BL32   T1DQ66   A0A2M4AG61   A0A2M3Z341   T1GJV6   A0A182IR66   Q16QF3   A0A182QCX4   B4JSX4   A0A182YGP3   A0A1S4FSU7   N6ST75   A0A340TBA6   A0A182LTP8   A0A1Q3F1P9   B0W331   A0A182HBI2   D1ZZL8   B3M2W9   A0A0M3QXY6   U5EU74   Q293K2   B3P2Y9   B4IKL7   A0A182UWE0   B4GM06   Q7QB57   B4M4V8   B4R153   A0A182U319   A0A1W4VZ99   Q01637   B4NH48   A0A1I8QBG3   A0A1J1IHM2   A0A0K8TMZ9   A0A067RKE1   A0A3B0JMA6   B4KE16   A0A0L0CLW6   A0A1I8ND48   A0A336KMV5   A0A1L8ECV2   T1PCL7   A0A154PPC3   E2AMC4   A0A0C9QBM4   K7IX88   A0A2J7PLS7   A0A182FSD4   A0A1L8DY49   A0A2A3E9E0   A0A232FC27   A0A182P6S0   A0A182NLC8   A0A182JTD1   A0A1A9YAD0   A0A182RYP4   A0A0B4J2P4   A0A084VDC6   A0A1B0A7K6   A0A1B0CG08   A0A0A1XS98   A0A1B0FG80   A0A0K8VID5   A0A1A9V6T5   A0A182I7R6   E9IMV3   A0A182XJ45   A0A182L7A8   A0A034VMW4   A0A1Y1KX77   E0VTC0   F4X083   A0A158NHC2   A0A195D1G3   W8BLK2   A0A1B6EQX9   A0A1B6G5N9   E9J1A5   A0A1W4WG07   A0A195AZK8   A0A0M8ZX99   A0A151XDF2   A0A1B6KY40   U5CZ43   A0A397ZJR9  

Pubmed

19121390    26227816    22118469    26354079    20920257    23761445    + More
17510324    17994087    25244985    23537049    26483478    18362917    19820115    15632085    12364791    14747013    17210077    8444350    10731132    12537572    12537569    2122228    26369729    24845553    26108605    25315136    20798317    20075255    28648823    24438588    25830018    21282665    20966253    25348373    28004739    20566863    21719571    21347285    24495485    24357323   

EMBL

BABH01020166    DQ311230    ABD36175.1    NWSH01000703    PCG74689.1    ODYU01000778    + More
SOQ36083.1    FP102341    CBH09304.1    JTDY01001365    KOB74068.1    AGBW02014579    OWR41391.1    RSAL01000090    RVE48080.1    KQ459232    KPJ02651.1    KQ461155    KPJ08281.1    GGFJ01004639    MBW53780.1    ADMH02000361    ETN66833.1    GGFJ01004638    MBW53779.1    GAMD01002719    JAA98871.1    GGFK01006452    MBW39773.1    GGFM01002107    MBW22858.1    CAQQ02123440    CH477750    EAT36623.1    AXCN02000121    CH916373    EDV94864.1    APGK01057391    KB741280    KB631604    ENN70894.1    ERL84613.1    AXCM01003761    GFDL01013586    JAV21459.1    DS231830    EDS30739.1    JXUM01032039    JXUM01032040    KQ560942    KXJ80255.1    KQ971338    EFA01834.2    CH902617    EDV43499.1    CP012526    ALC46689.1    GANO01001613    JAB58258.1    CM000070    EAL29213.1    CH954181    EDV48303.1    CH480853    EDW51621.1    CH479185    EDW38580.1    AAAB01008880    EAA08525.3    CH940652    EDW59669.1    CM000364    EDX12140.1    L00968    AE014297    AY058714    X54230    CH964272    EDW84545.1    CVRI01000052    CRK99704.1    GDAI01002303    JAI15300.1    KK852421    KDR24287.1    OUUW01000007    SPP83397.1    CH933806    EDW16037.1    JRES01000211    KNC33256.1    UFQS01000645    UFQT01000410    UFQT01000645    SSX05697.1    SSX24054.1    GFDG01002333    JAV16466.1    KA645885    AFP60514.1    KQ435010    KZC13745.1    GL440811    EFN65415.1    GBYB01011813    JAG81580.1    AAZX01000583    NEVH01024423    PNF17281.1    GFDF01002899    JAV11185.1    KZ288313    PBC28347.1    NNAY01000465    OXU28182.1    ATLV01011254    KE524659    KFB35970.1    AJWK01010631    GBXI01000879    JAD13413.1    CCAG010021081    GDHF01013682    JAI38632.1    APCN01002549    GL764255    EFZ18097.1    GAKP01014301    GAKP01014298    JAC44651.1    GEZM01075079    JAV64295.1    DS235761    EEB16626.1    GL888493    EGI60148.1    ADTU01015566    KQ976973    KYN06707.1    GAMC01006868    JAB99687.1    GECZ01029408    JAS40361.1    GECZ01012037    JAS57732.1    GL767586    EFZ13419.1    KQ976698    KYM77470.1    KQ435837    KOX71473.1    KQ982294    KYQ58387.1    GEBQ01023656    JAT16321.1    KI392503    ERN15444.1    CM010631    RID65258.1   

Proteomes

UP000005204    UP000218220    UP000037510    UP000007151    UP000283053    UP000053268    + More
UP000053240    UP000000673    UP000015102    UP000075880    UP000008820    UP000075886    UP000001070    UP000076408    UP000019118    UP000030742    UP000075920    UP000075883    UP000002320    UP000069940    UP000249989    UP000007266    UP000007801    UP000092553    UP000001819    UP000008711    UP000001292    UP000075903    UP000008744    UP000007062    UP000008792    UP000000304    UP000075902    UP000192221    UP000000803    UP000007798    UP000095300    UP000183832    UP000027135    UP000268350    UP000009192    UP000037069    UP000095301    UP000076502    UP000000311    UP000002358    UP000235965    UP000069272    UP000242457    UP000215335    UP000075885    UP000075884    UP000075881    UP000092443    UP000075900    UP000005203    UP000030765    UP000092445    UP000092461    UP000092444    UP000078200    UP000075840    UP000076407    UP000075882    UP000009046    UP000007755    UP000005205    UP000078542    UP000192223    UP000078540    UP000053105    UP000075809    UP000017836   

PRIDE

H9J7Y6    Q2F642    Q01637   

Pfam

PF00156   Pribosyltran        + More
PF00215   OMPdecase
PF02138   Beach
PF00400   WD40
PF01728   FtsJ
PF00096   zf-C2H2
PF06479   Ribonuc_2-5A
PF00069   Pkinase

Interpro

IPR013785   Aldolase_TIM        + More
IPR004467   Or_phspho_trans_dom       
IPR023031   OPRT       
IPR014732   OMPdecase       
IPR011060   RibuloseP-bd_barrel       
IPR000836   PRibTrfase_dom       
IPR018089   OMPdecase_AS       
IPR001754   OMPdeCOase_dom       
IPR029057   PRTase-like       
IPR036372   BEACH_dom_sf       
IPR015943   WD40/YVTN_repeat-like_dom_sf       
IPR001680   WD40_repeat       
IPR017986   WD40_repeat_dom       
IPR036322   WD40_repeat_dom_sf       
IPR000409   BEACH_dom       
IPR002877   rRNA_MeTrfase_FtsJ_dom       
IPR015507   rRNA-MeTfrase_E       
IPR029063   SAM-dependent_MTases       
IPR036236   Znf_C2H2_sf       
IPR013087   Znf_C2H2_type       
IPR033523   IRE2       
IPR011009   Kinase-like_dom_sf       
IPR008271   Ser/Thr_kinase_AS       
IPR010513   KEN_dom       
IPR018997   PUB_domain       
IPR018391   PQQ_beta_propeller_repeat       
IPR038357   KEN_sf       
IPR011047   Quinoprotein_ADH-like_supfam       
IPR000719   Prot_kinase_dom       

SUPFAM

SSF53271   SSF53271        + More
SSF51366   SSF51366       
SSF50978   SSF50978       
SSF81837   SSF81837       
SSF53335   SSF53335       
SSF57667   SSF57667       
SSF56112   SSF56112       
SSF50998   SSF50998       

Gene 3D

3.20.20.70     1.10.1540.10     2.130.10.10     1.20.1440.180    

CDD

cd06223  PRTases_typeI

ProteinModelPortal

H9J7Y6   Q2F642   A0A2A4JS88   A0A2H1V5H1   D0ABA9   A0A0L7LET4   + More
A0A212EIU5   A0A3S2M065   A0A194QGS7   A0A194QXI0   A0A2M4BL31   W5JU62   A0A2M4BL32   T1DQ66   A0A2M4AG61   A0A2M3Z341   T1GJV6   A0A182IR66   Q16QF3   A0A182QCX4   B4JSX4   A0A182YGP3   A0A1S4FSU7   N6ST75   A0A340TBA6   A0A182LTP8   A0A1Q3F1P9   B0W331   A0A182HBI2   D1ZZL8   B3M2W9   A0A0M3QXY6   U5EU74   Q293K2   B3P2Y9   B4IKL7   A0A182UWE0   B4GM06   Q7QB57   B4M4V8   B4R153   A0A182U319   A0A1W4VZ99   Q01637   B4NH48   A0A1I8QBG3   A0A1J1IHM2   A0A0K8TMZ9   A0A067RKE1   A0A3B0JMA6   B4KE16   A0A0L0CLW6   A0A1I8ND48   A0A336KMV5   A0A1L8ECV2   T1PCL7   A0A154PPC3   E2AMC4   A0A0C9QBM4   K7IX88   A0A2J7PLS7   A0A182FSD4   A0A1L8DY49   A0A2A3E9E0   A0A232FC27   A0A182P6S0   A0A182NLC8   A0A182JTD1   A0A1A9YAD0   A0A182RYP4   A0A0B4J2P4   A0A084VDC6   A0A1B0A7K6   A0A1B0CG08   A0A0A1XS98   A0A1B0FG80   A0A0K8VID5   A0A1A9V6T5   A0A182I7R6   E9IMV3   A0A182XJ45   A0A182L7A8   A0A034VMW4   A0A1Y1KX77   E0VTC0   F4X083   A0A158NHC2   A0A195D1G3   W8BLK2   A0A1B6EQX9   A0A1B6G5N9   E9J1A5   A0A1W4WG07   A0A195AZK8   A0A0M8ZX99   A0A151XDF2   A0A1B6KY40   U5CZ43   A0A397ZJR9  

PDB

4HKP     E-value=1.32872e-51,     Score=514

KEGG

692850    K13421 uridine monophosphate synthetase [EC:2.4.2.10 4.1.1.23] | (RefSeq) uridine 5'-monophosphate s

GO

GO:0004590   GO:0009116   GO:0006207   GO:0044205   GO:0004588   GO:0008168   GO:0001510   GO:0006222   GO:0019856   GO:0003676   GO:0005524   GO:0004540   GO:0006397   GO:0004672   GO:0016021   GO:0016036   GO:0005829   GO:0046686   GO:0003824   GO:0008152   GO:0006221   GO:0006402   GO:0046872  

PANTHER

PTHR13954:SF15  

Length:

473

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.19717

Exp number, first 60 AAs:

0.00297

Total prob of N-in:

0.00590

outside

1  -  473

 

 

Pi

150.864632

Theta

179.732431

Tajima's D

1.469414

CLR

0.518849

CSRT

0.779611019449028

Interpretation

Uncertain