SGID Silkworm Genome Informatics Database
Gene
KWMTBOMO10169  Validated by peptides from experiments
Pre Gene Modal
BGIBMGA005628
Annotation
uridine_5'-monophosphate_synthase_[Bombyx_mori]
Full name
Uridine 5'-monophosphate synthase      
Alternative Name
Rudimentary-like protein
Location in the cell
Cytoplasmic   Reliability : 2.734
 

Sequence

CDS
ATGGGTTTAGATAAACTAGAAGATCTAGCTTTAAAACTATTTTCTATTGATGCCGTGAAATTTGGAGATTTTACTACTAAGACCGGCATCAAAACACCGGCCTATTTTGATTTGAGGGTTATTGTTAGTTATCCCGACATCATGGAGCTTACCTCGAATATGTTGTACGATTTAGCCGTAAAAGACAGCCAATTTGATCATTTGTGTGGAGTTCCATATACTGCCTTGCCCATTGCTACACTACTAAGTATACAAGCGAAAAAACCTATGTTGATGAGAAGGAAAGAAACAAAATCTTATGGAACCAAAAAAAGCATTGAAGGTCATTTTAAAAAAGATGACACATGTCTCATCATCGAGGACGTCATAACATCTGGCTCAAGCATACTGGAAACAGTCAAAGATTTGAAAAATGAAGGGCTCGTAACTACAGAAGCTGCCATTATTTTAGACCGGGAGCAAGGTGGTAGGGAGAACTTAGCTAAAAATGGCATCCATGTAAAATCATTGTTCACAATGAGAACATTGATTGAAATACTTAAAAAACACAAGAAAATAACAGATGAAATTGTAGTTACAGTAAAAAATTACTTGAATGAAACAAAGGCTCCTGTTATAGAAAAACTTATGGAACGTGTTATACTACCATATGAAAAAAGAATAGATTTTGCAACAAATCTTGTAGCCAGGCAACTATTCAACATTATGGCCACAAAGAAAACTAATTTATGTCTCTCAGCAGACCTCACCATGACTACTGGTATTTTAGATCTGCTAGAAAAAGTTGGAGAACACATTTGTATGGTCAAAACACATATAGACATAATTGATGATTTTAGAGATGACTTTGTTGTGAGGCTGAAACAGCTTGCTGACAGGTTTAATTTCCTTATACTTGAAGATAGGAAGTATGCTGACATCGGACACACTGTGTCATTGCAGTATTCAAAAGGACTGTACAAAATAGGTGAATGGGCAGACTGTGTTACAGTTCATTCTTTACCCGGTGAAGGCATATTGAAGGCACTGAATGGTTCAATGAATTGCATCACTAAGGGAGTGTTCTTGCTTGCTGAAATGAGTAGTGAGGGAAATCTTATAACACAACAATATAAACAGGAAACAGTCAGTATGGCATCCAAATATGCAAACATCATAACCGGATTTGTTTGTCAAAACAAGGACACCTTCCAAAACCCTGGCCTGATTCAATTAACTCCAGGAGTACAACTTGAATGCTCAAAAGACGATTTTGGCCAGATTTATAAAACACCTGAAAAAGTTGTGGTGGAAAATGGTGCCGACGTAATTGTTGTCGGAAGAGGTATCACAGCAGCAAAGAATCCAGAAGTTCAAGCTGTAGCTTATAAGGATGCGTTATGGAAATGTTATATTAAAAGAATATCTGGTAAATTAGAATGA
Protein
MGLDKLEDLALKLFSIDAVKFGDFTTKTGIKTPAYFDLRVIVSYPDIMELTSNMLYDLAVKDSQFDHLCGVPYTALPIATLLSIQAKKPMLMRRKETKSYGTKKSIEGHFKKDDTCLIIEDVITSGSSILETVKDLKNEGLVTTEAAIILDREQGGRENLAKNGIHVKSLFTMRTLIEILKKHKKITDEIVVTVKNYLNETKAPVIEKLMERVILPYEKRIDFATNLVARQLFNIMATKKTNLCLSADLTMTTGILDLLEKVGEHICMVKTHIDIIDDFRDDFVVRLKQLADRFNFLILEDRKYADIGHTVSLQYSKGLYKIGEWADCVTVHSLPGEGILKALNGSMNCITKGVFLLAEMSSEGNLITQQYKQETVSMASKYANIITGFVCQNKDTFQNPGLIQLTPGVQLECSKDDFGQIYKTPEKVVVENGADVIVVGRGITAAKNPEVQAVAYKDALWKCYIKRISGKLE

Summary

Catalytic Activity
diphosphate + orotidine 5'-phosphate = 5-phospho-alpha-D-ribose 1-diphosphate + orotate
H(+) + orotidine 5'-phosphate = CO2 + UMP
Similarity
In the N-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family.
In the C-terminal section; belongs to the OMP decarboxylase family.
Keywords
Complete proteome   Decarboxylase   Glycosyltransferase   Lyase   Multifunctional enzyme   Pyrimidine biosynthesis   Reference proteome   Transferase  
Feature
chain  Uridine 5'-monophosphate synthase
EMBL
BABH01020166    DQ311230    ABD36175.1    NWSH01000703    PCG74689.1    ODYU01000778    + More
SOQ36083.1    FP102341    CBH09304.1    JTDY01001365    KOB74068.1    AGBW02014579    OWR41391.1    RSAL01000090    RVE48080.1    KQ459232    KPJ02651.1    KQ461155    KPJ08281.1    GGFJ01004639    MBW53780.1    ADMH02000361    ETN66833.1    GGFJ01004638    MBW53779.1    GAMD01002719    JAA98871.1    GGFK01006452    MBW39773.1    GGFM01002107    MBW22858.1    CAQQ02123440    CH477750    EAT36623.1    AXCN02000121    CH916373    EDV94864.1    APGK01057391    KB741280    KB631604    ENN70894.1    ERL84613.1    AXCM01003761    GFDL01013586    JAV21459.1    DS231830    EDS30739.1    JXUM01032039    JXUM01032040    KQ560942    KXJ80255.1    KQ971338    EFA01834.2    CH902617    EDV43499.1    CP012526    ALC46689.1    GANO01001613    JAB58258.1    CM000070    EAL29213.1    CH954181    EDV48303.1    CH480853    EDW51621.1    CH479185    EDW38580.1    AAAB01008880    EAA08525.3    CH940652    EDW59669.1    CM000364    EDX12140.1    L00968    AE014297    AY058714    X54230    CH964272    EDW84545.1    CVRI01000052    CRK99704.1    GDAI01002303    JAI15300.1    KK852421    KDR24287.1    OUUW01000007    SPP83397.1    CH933806    EDW16037.1    JRES01000211    KNC33256.1    UFQS01000645    UFQT01000410    UFQT01000645    SSX05697.1    SSX24054.1    GFDG01002333    JAV16466.1    KA645885    AFP60514.1    KQ435010    KZC13745.1    GL440811    EFN65415.1    GBYB01011813    JAG81580.1    AAZX01000583    NEVH01024423    PNF17281.1    GFDF01002899    JAV11185.1    KZ288313    PBC28347.1    NNAY01000465    OXU28182.1    ATLV01011254    KE524659    KFB35970.1    AJWK01010631    GBXI01000879    JAD13413.1    CCAG010021081    GDHF01013682    JAI38632.1    APCN01002549    GL764255    EFZ18097.1    GAKP01014301    GAKP01014298    JAC44651.1    GEZM01075079    JAV64295.1    DS235761    EEB16626.1    GL888493    EGI60148.1    ADTU01015566    KQ976973    KYN06707.1    GAMC01006868    JAB99687.1    GECZ01029408    JAS40361.1    GECZ01012037    JAS57732.1    GL767586    EFZ13419.1    KQ976698    KYM77470.1    KQ435837    KOX71473.1    KQ982294    KYQ58387.1    GEBQ01023656    JAT16321.1    KI392503    ERN15444.1    CM010631    RID65258.1   
Pfam
PF00156   Pribosyltran        + More
PF00215   OMPdecase
PF02138   Beach
PF00400   WD40
PF01728   FtsJ
PF00096   zf-C2H2
PF06479   Ribonuc_2-5A
PF00069   Pkinase
Interpro
IPR013785   Aldolase_TIM        + More
IPR004467   Or_phspho_trans_dom       
IPR023031   OPRT       
IPR014732   OMPdecase       
IPR011060   RibuloseP-bd_barrel       
IPR000836   PRibTrfase_dom       
IPR018089   OMPdecase_AS       
IPR001754   OMPdeCOase_dom       
IPR029057   PRTase-like       
IPR036372   BEACH_dom_sf       
IPR015943   WD40/YVTN_repeat-like_dom_sf       
IPR001680   WD40_repeat       
IPR017986   WD40_repeat_dom       
IPR036322   WD40_repeat_dom_sf       
IPR000409   BEACH_dom       
IPR002877   rRNA_MeTrfase_FtsJ_dom       
IPR015507   rRNA-MeTfrase_E       
IPR029063   SAM-dependent_MTases       
IPR036236   Znf_C2H2_sf       
IPR013087   Znf_C2H2_type       
IPR033523   IRE2       
IPR011009   Kinase-like_dom_sf       
IPR008271   Ser/Thr_kinase_AS       
IPR010513   KEN_dom       
IPR018997   PUB_domain       
IPR018391   PQQ_beta_propeller_repeat       
IPR038357   KEN_sf       
IPR011047   Quinoprotein_ADH-like_supfam       
IPR000719   Prot_kinase_dom       
SUPFAM
SSF53271   SSF53271        + More
SSF51366   SSF51366       
SSF50978   SSF50978       
SSF81837   SSF81837       
SSF53335   SSF53335       
SSF57667   SSF57667       
SSF56112   SSF56112       
SSF50998   SSF50998       
PDB
4HKP     E-value=1.32872e-51,     Score=514

Ontologies

Topology

Length:
473
Number of predicted TMHs:
0
Exp number of AAs in TMHs:
0.19717
Exp number, first 60 AAs:
0.00297
Total prob of N-in:
0.00590
outside
1  -  473
 
 

Population Genetic Test Statistics

Pi
150.864632
Theta
179.732431
Tajima's D
1.469414
CLR
0.518849
CSRT
0.779611019449028
Interpretation
Uncertain

Multiple alignment of Orthologues

 
 

Gene Tree

 
 
Peptides ×
Source Sequence Identity Evalue
25044914 YANFVVDIMAK 100.00 0.002
28556443 FNFLILEDR 100.00 0.009
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