Gene

KWMTBOMO10167

Pre Gene Modal

BGIBMGA005630

Annotation

PREDICTED:_sodium/potassium-transporting_ATPase_subunit_alpha-B-like_[Papilio_xuthus]

Location

Bomo_Chr17(-):3410934-3413283      View in EpiBrowser

Full name

Sodium/potassium-transporting ATPase subunit alpha      

Alternative Name

Sodium pump subunit alpha

Location in the cell

PlasmaMembrane   Reliability : 4.601

CDS

ATGACTCAAATAGGTAAAATAGCAGGACTTGTGACCGGATTGAAAAAAGAAGAGACACCGATCGCTAAAGAGATAACACATTTTATCAAACTCATCTGCGGAGTTGCGTTTGTCTTTGGTATAATATTTTTTGCGATGGTGTTTTTTACGCAACACCGTTGGATATCAGCTATTCAATACATGTTAGGAATTATACTTGCCAACGTACCAGAAGGCCTGATAGTAACATTGACAGTGTGCATGACTTTGTCGGCCAACCAGCTACAAAAGAAAAACTGTTTGGCCAAAAGCTTGCACGCTGTGGAAACATTGGGCTCCACATCGTGTATTTGCTCGGACAAAACCGGTACTTTGACTGAAAACCAAATGAAGGTTTCTCATTTGTTCTGTAATTTTAAGATTTACGACAGCGACGATTTTAGTCACGTATCTCAATCTACATACAGTGCGTTGTGTTTGGCAGCTTCCCTAAACCTTAAGGCGTTTTTTGGATTTGACTACTACGACGCTCCAATTGCAAAGAGAAAGATTTATGGTGACGCTTCGGAATCTGCGATATTGCGTTACATGGAACTGCATCGTTCAGCGACGTTGACGCGCGAAGATAACCCTAAGGAGGCGGAGATTCCTTTTAGTTCAGCATACAAATACCAAGTCACGATCCATCGAATGCAAGCCTCTCAAAGCTACTATTTGACAATGAAGGGTGCTCCCGAAATTGTACTAGATTATTGCACAACTGTGCACACCGACGAAGGAGAGCAGCCGTTGACTACACAAACGATCAAAGAACTGAAAGCATACTTTGTCAAATTGGCGAATATGGGCGAACGCGTTATTGGGTATTGCGATTTGAAACTACCGACAACTGATTATCCTCTTGGATACCAATTTGACACGCATCAACTTAATTTTCCCATTGAAAATTTACACTTTCTTGGATGTATATCGATGATTGACCCCCCTAGGAAGGATATAGCGAAAAGCATATCGATGTGTAGACAAGCAGGTATCAAAGTGATCATGATAACCGGTGATCATCCTGTAACGGCATTGGCTATTTCTCGTCAGTGCGGTACCATAACACAGCCCACTGTCTACGATTATGCCTTTGAGCATCACATTGAACTGTCCGATGTTCCATCGCACATAAAAAACCAGTTCAAAGCGGCCGTGATTACAGGCGACGAGCTGCGTAAAATGTCCGTCAACGAATTGAAGTCAGCGCTAGCTAAGTACGAGGAAATAACATTCGCAAGAACCAGTCCGCAGCAGAAGCTATTCATTGTGGAGACTTATCAGTCTTTGAAGTATATCGTGGCCGTCACTGGAGACGGCGTGAACGATTCTCCTGCATTAAAGAAAGCTGATATTGGAATAGCTATGGGCATCAACGGTACAGAGGTATCAAAGCAAGCTGCAGACATGATCTTATTGGACGATAATTTTTCGTCTATTGTGTTAGGAGTGCAAGAAGGAAGACGCATTTTCGATAATTTGAAGAAAACTATAGCGTATACGCTTACCTCGAACACTCCTGAAATGCTGCCTTTCGTTATGTACGCTTGTGTCGGAATGCCTTTACCGTTAACGTTGATGTTGATTTTGGTAATCAACGTTGGAACCGACTTGTTACCAGCCATGAGTTTGGCCTACGAGGATTCCGAAGAGGACATCATGTCGATCCCTCCCAGAAAACAGACCGATCATCTCGTTAACAAAGTTCTCCTTTTCATGGCCTATTTCCAAATAGGATTAATTCAATTTTTCGCTGGAATGTATGCGTACTTTGTAGTTTTCGCCAGAGAAGGATTCTTTCCGTCTAGTTTATTGTTCGTGCGTGATGATTGGGAATCTGATACTAAAGTAATCAGAGATTCAATTGGACGGTTATATTTTTATTCGGAGCGAAAACGAATCGAAAGGAAAGCGCAGACAGCCTACTTTGTGGCTATTTGCTTAACCCAAATATCTGACGTTTTAATATGTAAGACGAGGCGGATTTCGCTCTTCAAAAAAGGCATGAAGAACCAAGTTTTGAATGCTAGTATAGTTATTGATATATTTGCAGCAGTGACTGTCACTTATTTGCCATTGTGCAACGAAATTTTCGGCACGGAGCCCATCGATTGGTATTTATTTTTCCTTGCGGTACCGTTCATGGCGCTTATGATAATTGCGGACGAGATTAGGAGGTATTTAATTAGGAATAATATTTCCAAGTGGCTTGAAAAAGAAACGTATTACTGA

Protein

MTQIGKIAGLVTGLKKEETPIAKEITHFIKLICGVAFVFGIIFFAMVFFTQHRWISAIQYMLGIILANVPEGLIVTLTVCMTLSANQLQKKNCLAKSLHAVETLGSTSCICSDKTGTLTENQMKVSHLFCNFKIYDSDDFSHVSQSTYSALCLAASLNLKAFFGFDYYDAPIAKRKIYGDASESAILRYMELHRSATLTREDNPKEAEIPFSSAYKYQVTIHRMQASQSYYLTMKGAPEIVLDYCTTVHTDEGEQPLTTQTIKELKAYFVKLANMGERVIGYCDLKLPTTDYPLGYQFDTHQLNFPIENLHFLGCISMIDPPRKDIAKSISMCRQAGIKVIMITGDHPVTALAISRQCGTITQPTVYDYAFEHHIELSDVPSHIKNQFKAAVITGDELRKMSVNELKSALAKYEEITFARTSPQQKLFIVETYQSLKYIVAVTGDGVNDSPALKKADIGIAMGINGTEVSKQAADMILLDDNFSSIVLGVQEGRRIFDNLKKTIAYTLTSNTPEMLPFVMYACVGMPLPLTLMLILVINVGTDLLPAMSLAYEDSEEDIMSIPPRKQTDHLVNKVLLFMAYFQIGLIQFFAGMYAYFVVFAREGFFPSSLLFVRDDWESDTKVIRDSIGRLYFYSERKRIERKAQTAYFVAICLTQISDVLICKTRRISLFKKGMKNQVLNASIVIDIFAAVTVTYLPLCNEIFGTEPIDWYLFFLAVPFMALMIIADEIRRYLIRNNISKWLEKETYY

Description

This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium ions, providing the energy for active transport of various nutrients.

Catalytic Activity

ATP + H2O + K(+)(out) + Na(+)(in) = ADP + H(+) + K(+)(in) + Na(+)(out) + phosphate

Subunit

The sodium/potassium-transporting ATPase is composed of a catalytic alpha subunit, an auxiliary non-catalytic beta subunit and an additional regulatory subunit.

Miscellaneous

Ouabain-sensitive electrogenic ion pump.

Similarity

Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family.
Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIC subfamily.

Keywords

Alternative splicing   ATP-binding   Cell membrane   Complete proteome   Ion transport   Membrane   Nucleotide-binding   Phosphoprotein   Potassium   Potassium transport   Reference proteome   RNA editing   Sodium   Sodium transport   Translocase   Transmembrane   Transmembrane helix   Transport  

Feature

chain  Sodium/potassium-transporting ATPase subunit alpha
splice variant  In isoform 2, isoform 3, isoform 6 and isoform 7.

Uniprot

H9J7Y8   A0A2A4JSG0   A0A194QRY7   A0A0L7LF26   A0A212EST2   A0A194QB43   + More
A0A2H1V918   A0A0P4ZDD7   A0A0P4XXA4   A0A0P4WSQ6   A0A0P6ED19   A0A0P5NDR6   A0A0P5MBV3   A0A0P5CQB2   A0A0N8A1P7   A0A0P6HW02   A0A0P5AVV6   A0A0P6FP55   A0A0P5WBW4   A0A0P5EZ23   T1KYM5   A0A0P5UV53   A0A2I9LP96   A0A0K8TRD8   A0A0R3UN08   A0A0P4ZD62   A0A0P6GTA8   T1E1A9   Q3S346   A0A0P5TZH5   Q3S347   A0A0P8YLJ0   A0A0P9C8B9   Q9GPG2   A0A2M4CUE1   B3M359   A0A131XLE6   A0A0A1WY87   K0GEX7   B3P304   A0A0A1X4H1   A0A034W2I4   A0A0D8Y0G3   A0A1I8PAR7   A0A0P5K067   A0A0K8W6J7   A0A034W3G9   B4PQ93   A0A2R5LB15   K0GEX4   A0A0K8UY58   R4VGQ9   A0A0N8P1E9   A0A034W1V5   A0A0R1E5P2   A0A2W1BK20   A0A224YZK0   K0GLY2   A0A1I8MBT1   T1PH35   K0G7C4   I7J4E4   A0A0P8XYP1   A0A0P5UVZ1   E9HAW7   A0A1I8MBT2   A9XTM7   A0A0R1E150   A0A2M4CIP8   B4JRY9   R9QXZ9   E0VNM0   P13607-4   P13607-2   A0A368H1T3   A0A1I8MBT8   A0A131YL94   A0A1I8PAR6   B4IKN2   A0A1Z5LG80   A0A0B4KGG8   A0A2A4JV07   H9ZJM5   A0A0R1E441   A0A0R1E1E2   A0A0R1E113   A0A1I8PAT4   A0A0P8YE28   A0A0N4Y050   E0VPN3   P13607   A0A1W4VZ81   A0A1I8MBT4   A0A2A4JVC3   A0A2A4JUC5   K0GM01   A0A1I8PAW2   A0A0P5CJZ8   A0A0P5C8E2   A0A0P5C931  

EC Number

7.2.2.13

Pubmed

19121390    26354079    26227816    22118469    29248469    26369729    + More
17562880    17994087    18057021    11807118    28049606    25830018    23019645    25348373    26856411    17550304    28756777    28797301    25315136    21292972    20566863    2540956    9648860    10731132    12537572    12537569    12598616    9680312    2557235    17018572    26830274    28528879    12537568    12537573    12537574    16110336    17569856    17569867    26109357    26109356   

EMBL

BABH01020168    NWSH01000703    PCG74706.1    KQ461155    KPJ08283.1    JTDY01001365    + More
KOB74067.1    AGBW02012723    OWR44555.1    KQ459232    KPJ02649.1    ODYU01001126    SOQ36902.1    GDIP01218167    JAJ05235.1    GDIP01235472    JAI87929.1    GDIP01253205    JAI70196.1    GDIQ01078678    JAN16059.1    GDIQ01146812    JAL04914.1    GDIQ01162208    JAK89517.1    GDIP01168268    JAJ55134.1    GDIP01191161    JAJ32241.1    GDIQ01029055    JAN65682.1    GDIP01197974    JAJ25428.1    GDIQ01047502    JAN47235.1    GDIP01088280    JAM15435.1    GDIP01153779    JAJ69623.1    CAEY01000714    GDIP01109684    JAL94030.1    GFWZ01000215    MBW20205.1    GDAI01000902    JAI16701.1    UXSR01005651    VDD83150.1    GDIP01216015    JAJ07387.1    GDIQ01029056    JAN65681.1    GAKT01000064    JAA92998.1    DQ173925    ABA02167.1    GDIP01122237    JAL81477.1    DQ173924    ABA02166.1    CH902617    KPU79731.1    KPU79733.1    AF327439    AAG47843.1    GGFL01004280    MBW68458.1    EDV42459.1    GEFH01000672    JAP67909.1    GBXI01010944    JAD03348.1    JQ771508    AFU25677.1    CH954181    EDV48318.1    GBXI01008719    JAD05573.1    GAKP01010637    JAC48315.1    KN716280    KJH48096.1    GDIQ01191685    JAK60040.1    GDHF01005799    JAI46515.1    GAKP01010639    JAC48313.1    CM000160    EDW96202.2    GGLE01002529    MBY06655.1    JQ771506    AFU25675.1    GDHF01020773    JAI31541.1    KC691291    AGM39710.1    KPU79732.1    GAKP01010640    GAKP01010638    JAC48312.1    KRK02980.1    KZ150095    PZC73617.1    GFPF01011902    MAA23048.1    JQ771505    AFU25674.1    KA647445    AFP62074.1    JQ771507    AFU25676.1    HE962487    CCJ09645.1    KPU79736.1    GDIP01107486    JAL96228.1    GL732613    EFX71104.1    EF672699    ABV65906.1    KRK02982.1    GGFL01001054    MBW65232.1    CH916373    EDV94529.1    JX173959    AGF90965.1    AAZO01003918    DS235340    EEB14976.1    X14476    AF044974    AE014297    AY069184    AY174097    AY174098    U55767    X17471    JOJR01000021    RCN50576.1    GEDV01008478    JAP80079.1    CH480853    EDW51636.1    GFJQ02000574    JAW06396.1    AGB96170.1    NWSH01000562    PCG75639.1    BT133381    AFH36366.1    KRK02979.1    KRK02985.1    KRK02987.1    KPU79735.1    UYSL01020061    VDL72459.1    AAZO01004204    DS235366    EEB15339.1    PCG75638.1    PCG75637.1    JQ771525    AFU25694.1    GDIP01174410    JAJ48992.1    GDIP01174412    JAJ48990.1    GDIP01174411    JAJ48991.1   

Proteomes

UP000005204    UP000218220    UP000053240    UP000037510    UP000007151    UP000053268    + More
UP000015104    UP000046399    UP000267029    UP000007801    UP000008711    UP000053766    UP000095300    UP000002282    UP000095301    UP000000305    UP000001070    UP000009046    UP000000803    UP000252519    UP000001292    UP000038043    UP000271162    UP000192221   

PRIDE

H9J7Y8    I7J4E4    B4JRY9    P13607    H9ZJM5    E0VPN3    + More

Pfam

PF00689   Cation_ATPase_C        + More
PF00690   Cation_ATPase_N
PF00379   Chitin_bind_4

Interpro

IPR004014   ATPase_P-typ_cation-transptr_N        + More
IPR008250   ATPase_P-typ_transduc_dom_A_sf       
IPR006068   ATPase_P-typ_cation-transptr_C       
IPR023298   ATPase_P-typ_TM_dom_sf       
IPR001757   P_typ_ATPase       
IPR023299   ATPase_P-typ_cyto_dom_N       
IPR036412   HAD-like_sf       
IPR023214   HAD_sf       
IPR005775   P-type_ATPase_IIC       
IPR018303   ATPase_P-typ_P_site       
IPR031311   CHIT_BIND_RR_consensus       
IPR000618   Insect_cuticle       

SUPFAM

SSF81653   SSF81653        + More
SSF56784   SSF56784       
SSF81665   SSF81665       
SSF81660   SSF81660       

Gene 3D

3.40.1110.10     3.40.50.1000    

CDD

cd02608  P-type_ATPase_Na-K_like

ProteinModelPortal

H9J7Y8   A0A2A4JSG0   A0A194QRY7   A0A0L7LF26   A0A212EST2   A0A194QB43   + More
A0A2H1V918   A0A0P4ZDD7   A0A0P4XXA4   A0A0P4WSQ6   A0A0P6ED19   A0A0P5NDR6   A0A0P5MBV3   A0A0P5CQB2   A0A0N8A1P7   A0A0P6HW02   A0A0P5AVV6   A0A0P6FP55   A0A0P5WBW4   A0A0P5EZ23   T1KYM5   A0A0P5UV53   A0A2I9LP96   A0A0K8TRD8   A0A0R3UN08   A0A0P4ZD62   A0A0P6GTA8   T1E1A9   Q3S346   A0A0P5TZH5   Q3S347   A0A0P8YLJ0   A0A0P9C8B9   Q9GPG2   A0A2M4CUE1   B3M359   A0A131XLE6   A0A0A1WY87   K0GEX7   B3P304   A0A0A1X4H1   A0A034W2I4   A0A0D8Y0G3   A0A1I8PAR7   A0A0P5K067   A0A0K8W6J7   A0A034W3G9   B4PQ93   A0A2R5LB15   K0GEX4   A0A0K8UY58   R4VGQ9   A0A0N8P1E9   A0A034W1V5   A0A0R1E5P2   A0A2W1BK20   A0A224YZK0   K0GLY2   A0A1I8MBT1   T1PH35   K0G7C4   I7J4E4   A0A0P8XYP1   A0A0P5UVZ1   E9HAW7   A0A1I8MBT2   A9XTM7   A0A0R1E150   A0A2M4CIP8   B4JRY9   R9QXZ9   E0VNM0   P13607-4   P13607-2   A0A368H1T3   A0A1I8MBT8   A0A131YL94   A0A1I8PAR6   B4IKN2   A0A1Z5LG80   A0A0B4KGG8   A0A2A4JV07   H9ZJM5   A0A0R1E441   A0A0R1E1E2   A0A0R1E113   A0A1I8PAT4   A0A0P8YE28   A0A0N4Y050   E0VPN3   P13607   A0A1W4VZ81   A0A1I8MBT4   A0A2A4JVC3   A0A2A4JUC5   K0GM01   A0A1I8PAW2   A0A0P5CJZ8   A0A0P5C8E2   A0A0P5C931  

PDB

3WGV     E-value=0,     Score=1850

KEGG

NA   

GO

GO:0005524   GO:0016021   GO:0008556   GO:0046872   GO:0042302   GO:0009612   GO:0050905   GO:0019991   GO:0008340   GO:0035158   GO:0009266   GO:0007605   GO:0005634   GO:0051124   GO:0001894   GO:0007268   GO:0016323   GO:0060439   GO:0005391   GO:0005918   GO:0007630   GO:0006883   GO:0030007   GO:0005623   GO:0015991   GO:0036376   GO:1990573   GO:0005890   GO:0008344   GO:0006812   GO:0005737   GO:0007626   GO:0035159   GO:0005886   GO:0000166   GO:0008270   GO:0042773   GO:0016651   GO:0006402   GO:0003824  

Subcellular location

Membrane  
Cell membrane  

Length:

749

Number of predicted TMHs:

6

Exp number of AAs in TMHs:

134.31717

Exp number, first 60 AAs:

23.51722

Total prob of N-in:

0.87923

POSSIBLE N-term signal

sequence

inside

1  -  27

TMhelix

28  -  50

outside

51  -  59

TMhelix

60  -  82

inside

83  -  515

TMhelix

516  -  538

outside

539  -  577

TMhelix

578  -  600

inside

601  -  678

TMhelix

679  -  698

outside

699  -  707

TMhelix

708  -  727

inside

728  -  749

 

 

Pi

229.310996

Theta

192.441454

Tajima's D

0.456993

CLR

0.056902

CSRT

0.500174991250438

Interpretation

Uncertain