Gene

KWMTBOMO10157

Pre Gene Modal

BGIBMGA005633

Annotation

PREDICTED:_thrombospondin_type-1_domain-containing_protein_7A-like_[Bombyx_mori]

Location

Bomo_Chr17(-):3162632-3174783      View in EpiBrowser

Full name

Thrombospondin type-1 domain-containing protein 7A      

Location in the cell

Extracellular   Reliability : 3.318

CDS

ATGCCAACACTCGTCCAACCTTGTGAGGTGCCTTGTCCGCGAGACTGCGAGGTTGGCGAATGGAGTGACTGGAGTGCCTGTCAACCTGTAGACGGCTGCCCTCTATTCCCGGTACAACAACTTACGACAACAGGATACAGCGTCCGTCGTCGCCGCGTAATATCGGCAGCGTCAGGAGGAGGAGCTGCCTGTCCTCCGCTGGAAGAAAAGAGGACTTGTAGCACCCCCCGATGCGCGTCCTGGAAGGCTCTGCCGTGGGGACCGTGTGTACTCAACCAACCACACACGACTTGCGGTCCGGGAAGACGGAATAGAGAACTCAGATGTGTGGGTCACGATGGGCGAGAGGCGGAAAGGGCGTGGTGCGCCGGTACCGGGGCACCAGCGCGCGGAGAGCGTTGTCGCATCGCGTGTCCCGGTGACTGCGTGGTGTCCTCGTGGGGAGCGTGGTCGCGGTGCTCGGCTCCTTGCGCGGCACCATCAAGACCACCACCCCACACCAGTCGCCGGAGACATGTGCTTGCACACGCAGCGCCCGATGGTTGGCCGTGTCCCTCAGAAGATCAGTTAATACAAAACGAGACTTGCAACACCCACGCGTGCGCTACATACTCGTGGCTGGCAACACCGTGGGGACCATGTGAGAGAAGACGCACAGATTTCATCCCTGTTACCAACTACACTGATCTAGTGGATGGAGAAACGTTCAACGAAAGCGACGATGAGGAGCCCTGTATCGAGGAGGGGGAGATGAATCGTGACGTCATGTGCATACAAAACAACGCTGATGTCGTCCGCGAGGCTTTATGTGCTCCTCTACGTCGTCCAGCATCTCGGCGCGCCTGCACCGTACGCTGTAGGAGAGGATGTAGGGTCGAAGCTTGGATGCCCTGGTCTCCCTGTCCCAACACGTGTGATCCTGGTAAGCAAGTCCGCATGCGGGTTGTACACGGCGGGCCCAGCTGTGGCCCTCGACAGGAGACCAGAGACTGTCCTGTGGCCAAAACCTGCAGGTCCAAAGACGCTGTATGGATCGCCGGAGAGTGGAGTACTTGCAAACTGTCTCCCGGTGAGAGGTGCGGCGTTGGACTAAGGATCAGAAGTATCTGGTGCGGTTCAGATTCACATAGAGTAGAAGCCGGTGCCTGTGCTGGACAGTTAATACCTCGCAGCGTGGCCGACTGTCAGGTGCCTTGTGAACACTCCTCGCCTCCCACTTGCGATGTCATCTGCTCTGATCCGTTAAGATACTTGGACGCCTCAGATCCAGACATAATGAGTTGCGTCTGCAAGAATGTTTCCTTAGAGTTGTTGCCGGCCGACTCCGACTGCATCCTTCCTCCAGGATTGGAATGTGGAGAGGGTAGGGCTCTGCGCGCGGCTCGTTGTATGGTGGCTGGACGAGATGTGCCCATGGACGTATGCAAGAAATTTCATCCACTCACAGGACCCAGCAGGGTTCGTGAAGCGACAACCGACGGATACTCGTACGACAATGAGTTCCTGAGTCTGCTCCGTGGGGCGTGCACGGTGCGCTGTGCGCGCGACTGTACCACCGGGGAGTGGGGCGAGTGGGGACCGTGCAATGCAGAGCCCGGCTCGCGGGCCGCCTTTAGATTCAGAACAAGGTAG

Protein

MPTLVQPCEVPCPRDCEVGEWSDWSACQPVDGCPLFPVQQLTTTGYSVRRRRVISAASGGGAACPPLEEKRTCSTPRCASWKALPWGPCVLNQPHTTCGPGRRNRELRCVGHDGREAERAWCAGTGAPARGERCRIACPGDCVVSSWGAWSRCSAPCAAPSRPPPHTSRRRHVLAHAAPDGWPCPSEDQLIQNETCNTHACATYSWLATPWGPCERRRTDFIPVTNYTDLVDGETFNESDDEEPCIEEGEMNRDVMCIQNNADVVREALCAPLRRPASRRACTVRCRRGCRVEAWMPWSPCPNTCDPGKQVRMRVVHGGPSCGPRQETRDCPVAKTCRSKDAVWIAGEWSTCKLSPGERCGVGLRIRSIWCGSDSHRVEAGACAGQLIPRSVADCQVPCEHSSPPTCDVICSDPLRYLDASDPDIMSCVCKNVSLELLPADSDCILPPGLECGEGRALRAARCMVAGRDVPMDVCKKFHPLTGPSRVREATTDGYSYDNEFLSLLRGACTVRCARDCTTGEWGEWGPCNAEPGSRAAFRFRTR

Description

Required for normal sprouting angiogenesis and normal embryonic development of intersegmental vessels (ISV) (PubMed:21520329, PubMed:27484901). Required for normal function of the glomerular filtration barrier (PubMed:28814510). Required for normal axon outgrowth on embryonic motor neurons at the level of the horizontal myoseptum. Required for normal expression of notch1b, suggesting that its functions in angiogenesis and neuron outgrowth are due to decreased expression of notch1b (PubMed:27484901). Plays a role in actin cytoskeleton rearrangement (By similarity).

Keywords

Angiogenesis   Cell membrane   Cell projection   Complete proteome   Differentiation   Disulfide bond   Glycoprotein   Membrane   Reference proteome   Repeat   Signal   Transmembrane   Transmembrane helix  

Feature

chain  Thrombospondin type-1 domain-containing protein 7A

Uniprot

A0A2H1V9E5   A0A2A4K3G2   A0A212EP93   A0A3S2NYX4   L7X3X3   A0A194QAS9   + More
A0A194QSJ5   H9J7Z1   A0A0L7LJ01   A0A067RMA8   A0A2J7RQB6   A0A2J7RQC4   A0A2J7RQC2   A0A3B4DBY8   H2T661   A0A2R7WIU0   G3WCF8   W5LR66   A0A3B1K076   A0A3B4DFQ6   F6U7M2   A0A3Q0JCS4   A0A2U9CZH2   A0A3Q3C0Q9   A0A3Q1FHZ3   A0A3Q0RNP6   H3D264   A0A3Q2P7P6   A0A3Q3EMV6   A0A146VLN0   A0A3Q1GJI1   A0A3Q1CIG4   A0A3Q1FPK7   A0A3B4H4G7   A0A3B5AT27   A0A0R4IT78   A0A3P9CEK6   A0A3P8NYA0   A0A151MQH0   A7MBS7   A0A3B4YKN9   A0A3Q3VW83   A0A3Q4I2S2   A0A3P8UFD4   A0A3P8NY44   A0A3P8NY21   A0A093P8F0   A0A3Q3BUL2   A0A091T5S3   A0A3P8Q4A9   A0A3Q3KUE2   A0A3N0XZI8   A0A3B4UIT3   F6UYV2   A0A091GHH7   A0A218V8C3   A0A3P8Q5R1   A0A091P2W7   H3CL39   A0A1L8FVV5   A0A3Q3BC96   A0A091PRX3   G1KNP5   A0A3Q1HDS2   A0A3B4C5M3   A0A0A0A5E1   A0A3B3BBP5   A0A3Q0H8N5   A0A3Q1IAC1   V8P8A0   A0A3Q3LS20   A0A1U8DBG7   A0A3Q0H7A6   A0A3P9MW48   A0A3Q2P7L0   A0A3Q4HAH9   A0A3Q0HBX9   A0A1L8FR49   A0A3Q0HBV4   A0A3B4B3J5   A0A3B4T2L2   A0A1S3FGH0   A0A3Q2DQT3   A0A091USM2   H0YW06   A0A3Q3JEL5   A0A087XPB8   A0A091S3J7   W5KWY0   A0A3B4XSK1   A0A091VA07   I3L9K6   A0A093R712   A0A286ZT45   A0A3Q3IUS0   A0A2D0S0T5   R0LS98   A0A3B3D060   F1SF66  

Pubmed

22118469    23674305    26354079    19121390    26227816    24845553    + More
21551351    21709235    25329095    17495919    15496914    23594743    25186727    22293439    21520329    27484901    28814510    20431018    27762356    29451363    24297900    25463417    20360741   

EMBL

ODYU01001380    SOQ37470.1    NWSH01000227    PCG78210.1    AGBW02013517    OWR43277.1    + More
RSAL01000090    RVE48087.1    KC469893    AGC92705.2    KQ459232    KPJ02643.1    KQ461155    KPJ08289.1    BABH01020186    BABH01020187    BABH01020188    BABH01020189    JTDY01000925    KOB75410.1    KK852427    KDR24128.1    NEVH01001345    PNF43027.1    PNF43026.1    PNF43028.1    KK854856    PTY19261.1    AEFK01203360    AEFK01203361    AEFK01203362    AEFK01203363    AEFK01203364    AEFK01203365    AEFK01203366    AEFK01203367    AEFK01203368    CP026264    AWP21907.1    GCES01068092    JAR18231.1    CR381594    CR627498    CR735126    AKHW03005461    KYO26723.1    BC151897    HQ267705    AAI51898.1    ADO87037.1    KL225169    KFW68547.1    KK437585    KFQ69190.1    RJVU01057109    ROK35869.1    AAMC01087874    AAMC01087875    AAMC01087876    AAMC01087877    AAMC01087878    KL448119    KFO80644.1    MUZQ01000031    OWK62078.1    KK652013    KFQ02332.1    CM004476    OCT75720.1    KK677455    KFQ10028.1    KL870371    KGL88220.1    AZIM01000592    ETE70211.1    CM004477    OCT74038.1    KL410115    KFQ93979.1    ABQF01013404    ABQF01013405    ABQF01013406    ABQF01013407    ABQF01013408    ABQF01013409    ABQF01013410    AYCK01015430    AYCK01015431    KK939468    KFQ49552.1    KK420951    KFQ86523.1    AEMK02000070    KL432146    KFW91927.1    KB742773    EOB04620.1   

Proteomes

UP000218220    UP000007151    UP000283053    UP000053268    UP000053240    UP000005204    + More
UP000037510    UP000027135    UP000235965    UP000261440    UP000005226    UP000007648    UP000018467    UP000002280    UP000079169    UP000246464    UP000264840    UP000257200    UP000261340    UP000007303    UP000265000    UP000261660    UP000257160    UP000261460    UP000261400    UP000000437    UP000265160    UP000265100    UP000050525    UP000261360    UP000261620    UP000261580    UP000265080    UP000054081    UP000261640    UP000261420    UP000008143    UP000053760    UP000197619    UP000186698    UP000264800    UP000001646    UP000265040    UP000053858    UP000261560    UP000189705    UP000242638    UP000261520    UP000081671    UP000265020    UP000053283    UP000007754    UP000261600    UP000028760    UP000008227    UP000221080   

PRIDE

H9J7Z1    I3L9K6    F1SF66   

Pfam

PF00090   TSP_1

Interpro

IPR000884   TSP1_rpt        + More
IPR036383   TSP1_rpt_sf       

SUPFAM

SSF82895   SSF82895       

Gene 3D

2.20.100.10    

ProteinModelPortal

A0A2H1V9E5   A0A2A4K3G2   A0A212EP93   A0A3S2NYX4   L7X3X3   A0A194QAS9   + More
A0A194QSJ5   H9J7Z1   A0A0L7LJ01   A0A067RMA8   A0A2J7RQB6   A0A2J7RQC4   A0A2J7RQC2   A0A3B4DBY8   H2T661   A0A2R7WIU0   G3WCF8   W5LR66   A0A3B1K076   A0A3B4DFQ6   F6U7M2   A0A3Q0JCS4   A0A2U9CZH2   A0A3Q3C0Q9   A0A3Q1FHZ3   A0A3Q0RNP6   H3D264   A0A3Q2P7P6   A0A3Q3EMV6   A0A146VLN0   A0A3Q1GJI1   A0A3Q1CIG4   A0A3Q1FPK7   A0A3B4H4G7   A0A3B5AT27   A0A0R4IT78   A0A3P9CEK6   A0A3P8NYA0   A0A151MQH0   A7MBS7   A0A3B4YKN9   A0A3Q3VW83   A0A3Q4I2S2   A0A3P8UFD4   A0A3P8NY44   A0A3P8NY21   A0A093P8F0   A0A3Q3BUL2   A0A091T5S3   A0A3P8Q4A9   A0A3Q3KUE2   A0A3N0XZI8   A0A3B4UIT3   F6UYV2   A0A091GHH7   A0A218V8C3   A0A3P8Q5R1   A0A091P2W7   H3CL39   A0A1L8FVV5   A0A3Q3BC96   A0A091PRX3   G1KNP5   A0A3Q1HDS2   A0A3B4C5M3   A0A0A0A5E1   A0A3B3BBP5   A0A3Q0H8N5   A0A3Q1IAC1   V8P8A0   A0A3Q3LS20   A0A1U8DBG7   A0A3Q0H7A6   A0A3P9MW48   A0A3Q2P7L0   A0A3Q4HAH9   A0A3Q0HBX9   A0A1L8FR49   A0A3Q0HBV4   A0A3B4B3J5   A0A3B4T2L2   A0A1S3FGH0   A0A3Q2DQT3   A0A091USM2   H0YW06   A0A3Q3JEL5   A0A087XPB8   A0A091S3J7   W5KWY0   A0A3B4XSK1   A0A091VA07   I3L9K6   A0A093R712   A0A286ZT45   A0A3Q3IUS0   A0A2D0S0T5   R0LS98   A0A3B3D060   F1SF66  

PDB

1W0S     E-value=0.0146621,     Score=91

KEGG

101741472    no KO assigned | (RefSeq) thrombospondin type-1 domain-containing protein 7A-like

GO

GO:0016021   GO:0005886   GO:0031532   GO:0043534   GO:0042995   GO:0032835   GO:0048675   GO:0001525   GO:0008593   GO:0072015   GO:0002040   GO:0003094  

Subcellular location

Cell membrane   Detected on podocyte foot processes.   With evidence from 1 publications.
Cell projection   Detected on podocyte foot processes.   With evidence from 1 publications.

Length:

543

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0

Exp number, first 60 AAs:

0

Total prob of N-in:

0.00134

outside

1  -  543

 

 

Pi

251.248316

Theta

154.662717

Tajima's D

2.36074

CLR

0.460794

CSRT

0.933603319834008

Interpretation

Uncertain