Gene

KWMTBOMO10138  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA005641

Annotation

putative_mitogen-activated_protein_kinase_(MAPKK)_[Heliconius_melpomene]

Location

Bomo_Chr17(-):3019986-3022699      View in EpiBrowser

Full name

Diacylglycerol kinase      

Location in the cell

Nuclear   Reliability : 2.758

CDS

ATGTCGAGAAGAAAACTGCCGCCCCCGGGCTTTAACTTTAAGACTCAAACGGAACAAGTTGTGACTCCACCAGGGAATTTAGATAAACAAACAACAATTACAGTTGATGACCGAACATTCACTGTACATGCTGATGATTTGGTAAAGATTTGTGATCTTGGCCGAGGAGCATATGGCATTGTTGAGAAGATGCGCCACCTACCTAGCAACACTATTATGGCTGTTAAGAGAATCACAGCCACATTCAACAATCAATCTTTGGAACAAAAACGTTTGTTAATGGATCTTGATGTATCAATGAGAGCAAGGAAGGGATGTTTGGATTTGTATGGAAGTAATGGATATGAGTTTAGACAAATTTTACACAAAAGTCTACAAAATGATCGTACCATACCTGAGAATATTCTTGGAAAGATAGCATTTTCGGTTGTTAGTGCTTTACATTATTTATACTCCAAACTCAGAGTCATACATAGAGATGTGAAACCATCAAATATATTGATCAACAGAAAGGGTGAAGTGAAGATGTGTGACTTTGGCATTTCTGGTCATCTGGTAGATTCTGTTGCAAAAACAATTGATGCTGGCTGTAAACCTTATATGGCACCAGAACGAATTGATCCAACTGGAAATCCTGGGCAATATGACATTCGAAGTGACGTGTGGTCTCTGGGAATATCCATGATTGAATTAGCAACAGGAACTTTCCCATACAACACATGGGGCACACCTTTCGAGCAACTAAAACAAGTTGTTAAAGATGATCCACCAAGGCTTCCAGTGGGAAAATTTTCAAACGAGTTTGAGGATTTAATAGTGCAATGCTTACAGAAAGACTATAGACTCAGACCAAATTACGATGCATTGTTAGTGCATCCATTCTGCCAGGAACACAGTCAAAAGGAAACCGATGTTGCATCTTTTGTTCAGGAAATATTAGATTTAGCAGGCGATGCTTAG

Protein

MSRRKLPPPGFNFKTQTEQVVTPPGNLDKQTTITVDDRTFTVHADDLVKICDLGRGAYGIVEKMRHLPSNTIMAVKRITATFNNQSLEQKRLLMDLDVSMRARKGCLDLYGSNGYEFRQILHKSLQNDRTIPENILGKIAFSVVSALHYLYSKLRVIHRDVKPSNILINRKGEVKMCDFGISGHLVDSVAKTIDAGCKPYMAPERIDPTGNPGQYDIRSDVWSLGISMIELATGTFPYNTWGTPFEQLKQVVKDDPPRLPVGKFSNEFEDLIVQCLQKDYRLRPNYDALLVHPFCQEHSQKETDVASFVQEILDLAGDA

Catalytic Activity

a 1,2-diacyl-sn-glycerol + ATP = a 1,2-diacyl-sn-glycero-3-phosphate + ADP + H(+)

Similarity

Belongs to the protein kinase superfamily.
Belongs to the eukaryotic diacylglycerol kinase family.

Uniprot

H9J7Z9   A0A2A4JEF0   D0AB87   L7WW91   A0A2H1VVK4   A0A212EP69   + More
A0A194QAR5   A0A194QTH5   S4NSS2   A0A0L7LPN6   A0A1Y1JW72   A0A2P8Y5R8   A0A1W4XB76   A0A1B6IB42   A0A1B6GET5   A0A067QN57   A0A1B6L3U1   A9XK84   A0A0T6AYY0   A0A0M9AAQ5   E0VQ74   A0A026WS53   A0A158NNP5   A0A023ER47   E2B907   A0A151HZL0   A0A1L8DM37   E2AZT9   A0A2J7PXF6   Q17KN4   Q67EX4   U5EW25   A0A069DYN1   A0A1L8DMC4   A0A0J7KV34   A0A0K8TSJ2   A0A0C9QM81   A0A224XTF1   A0A0P4VRJ8   R4G3V7   A0A1I8PC03   A0A1I8M2L4   T1PDH9   A0A151X7T9   A0A1Q3F5W1   A0A154P2K1   A0A2A3E1J1   A0A0V0G9F5   A0A151J3E7   A0A0L7QK85   B0W7R1   V5GF02   J9JYM3   A0A336LUS6   D6WX74   K7J2E0   A0A232F0F6   A0A1A9VNI1   A0A1B0AFB7   D3TLE9   A0A1A9WVR0   A0A088AVZ4   A0A0K8UXF9   A0A034WHR3   A0A2H8TDS5   A0A195FS05   A0A0A1XEX4   A0A310SX15   A0A2R7W8R2   B4JLY8   A0A1J1IV25   A0A0L0BUV4   T1IUF7   B4L621   W8B7L0   B4Q205   B3MS42   B4GW95   A0A1W4VK79   A0A3B0KRW6   B4M728   Q29IB7   B3NX72   A0A0M4F9A4   B4NUD3   B4IGM0   O62602   E9H2U1   Q9U983   B4NEN3   A0A0N8CT73   A0A0N8DCF9   A0A0P5L8K9   A0A0N7ZKQ6   A0A0N8AGI5   A0A0P5Y8M6   U4U2E7   A0A0N8DX38   N6UGG3   A0A0P5EKH4  

EC Number

2.7.1.107

Pubmed

19121390    23674305    22118469    26354079    23622113    26227816    + More
28004739    29403074    24845553    17706772    20566863    24508170    30249741    21347285    24945155    26483478    20798317    17510324    14986920    26334808    26369729    27129103    25315136    18362917    19820115    20075255    28648823    20353571    25348373    25830018    17994087    26108605    24495485    17550304    15632085    9584193    10731132    12537568    12537572    12537573    12537574    16110336    17569856    17569867    26109357    26109356    21292972    10364162    23537049   

EMBL

BABH01020201    NWSH01001832    PCG69964.1    FP102340    CBH09282.1    KC469893    + More
AGC92692.1    ODYU01004701    SOQ44860.1    AGBW02013517    OWR43290.1    KQ459232    KPJ02628.1    KQ461155    KPJ08305.1    GAIX01013942    JAA78618.1    JTDY01000391    KOB77400.1    GEZM01099000    JAV53582.1    PYGN01000896    PSN39599.1    GECU01037056    GECU01036185    GECU01035622    GECU01034966    GECU01026631    GECU01023613    GECU01023593    GECU01021463    GECU01018946    GECU01017131    GECU01006000    GECU01005905    GECU01004573    GECU01003580    GECU01003023    GECU01002428    JAS70650.1    JAS71521.1    JAS72084.1    JAS72740.1    JAS81075.1    JAS84093.1    JAS84113.1    JAS86243.1    JAS88760.1    JAS90575.1    JAT01707.1    JAT01802.1    JAT03134.1    JAT04127.1    JAT04684.1    JAT05279.1    GECZ01008848    JAS60921.1    KK853134    KDR10863.1    GEBQ01021620    GEBQ01001690    JAT18357.1    JAT38287.1    EF491249    ABR28347.1    LJIG01022489    KRT80305.1    KQ435711    KOX79423.1    AAZO01004340    DS235392    EEB15530.1    KK107119    QOIP01000009    EZA58783.1    RLU18329.1    ADTU01002755    ADTU01002756    JXUM01007305    JXUM01007306    JXUM01007307    GAPW01002484    KQ560237    JAC11114.1    KXJ83678.1    GL446405    EFN87841.1    KQ976693    KYM77658.1    GFDF01006558    JAV07526.1    GL444277    EFN61068.1    NEVH01020858    PNF21021.1    CH477222    EAT47270.1    AY358075    AAQ68075.1    GANO01003151    JAB56720.1    GBGD01002100    JAC86789.1    GFDF01006559    JAV07525.1    LBMM01002940    KMQ94158.1    GDAI01000688    JAI16915.1    GBYB01001722    JAG71489.1    GFTR01005177    JAW11249.1    GDKW01001556    JAI55039.1    GAHY01001331    JAA76179.1    KA646749    AFP61378.1    KQ982431    KYQ56442.1    GFDL01012090    JAV22955.1    KQ434789    KZC05350.1    KZ288451    PBC25568.1    GECL01001404    JAP04720.1    KQ980284    KYN16962.1    KQ414989    KOC58975.1    DS231855    EDS38205.1    GALX01005912    JAB62554.1    ABLF02040695    UFQS01000212    UFQT01000212    SSX01406.1    SSX21786.1    KQ971361    EFA08029.1    AAZX01007551    NNAY01001391    OXU24141.1    CCAG010006445    EZ422251    ADD18527.1    GDHF01021048    JAI31266.1    GAKP01004758    JAC54194.1    GFXV01000415    MBW12220.1    KQ981285    KYN43211.1    GBXI01010246    GBXI01004816    JAD04046.1    JAD09476.1    KQ759840    OAD62646.1    KK854406    PTY15551.1    CH916371    EDV91749.1    CVRI01000061    CRL04061.1    JRES01001303    KNC23773.1    JH431533    CH933812    EDW05817.1    GAMC01009365    GAMC01009363    JAB97190.1    CM000162    EDX01526.1    CH902622    EDV34597.1    CH479194    EDW26979.1    OUUW01000021    SPP89409.1    CH940653    EDW62595.1    CH379063    EAL32736.2    CH954180    EDV47244.1    CP012528    ALC48757.1    CH983901    EDX16580.1    CH480836    EDW48970.1    AF035549    AF035550    AF041136    AE014298    AY052103    AAC39033.1    AAC39034.1    AAF22365.1    AAF48223.1    AAK93527.1    GL732587    EFX73950.1    AJ238572    CAB45101.1    CH964239    EDW82202.1    GDIP01101263    JAM02452.1    GDIP01047375    JAM56340.1    GDIQ01173279    JAK78446.1    GDIP01235889    JAI87512.1    GDIP01149657    JAJ73745.1    GDIP01062764    JAM40951.1    KB632013    ERL88044.1    GDIQ01083364    JAN11373.1    APGK01036393    KB740939    ENN77747.1    GDIQ01268410    JAJ83314.1   

Proteomes

UP000005204    UP000218220    UP000007151    UP000053268    UP000053240    UP000037510    + More
UP000245037    UP000192223    UP000027135    UP000053105    UP000009046    UP000053097    UP000279307    UP000005205    UP000069940    UP000249989    UP000008237    UP000078540    UP000000311    UP000235965    UP000008820    UP000036403    UP000095300    UP000095301    UP000075809    UP000076502    UP000242457    UP000078492    UP000053825    UP000002320    UP000007819    UP000007266    UP000002358    UP000215335    UP000078200    UP000092445    UP000092444    UP000091820    UP000005203    UP000078541    UP000001070    UP000183832    UP000037069    UP000009192    UP000002282    UP000007801    UP000008744    UP000192221    UP000268350    UP000008792    UP000001819    UP000008711    UP000092553    UP000000304    UP000001292    UP000000803    UP000000305    UP000007798    UP000030742    UP000019118   

PRIDE

H9J7Z9    O62602    Q9U983   

Pfam

PF00069   Pkinase        + More
PF00609   DAGK_acc
PF00781   DAGK_cat

Interpro

IPR008271   Ser/Thr_kinase_AS        + More
IPR011009   Kinase-like_dom_sf       
IPR017441   Protein_kinase_ATP_BS       
IPR000719   Prot_kinase_dom       
IPR001206   Diacylglycerol_kinase_cat_dom       
IPR000756   Diacylglycerol_kin_accessory       
IPR037607   DGK       
IPR002219   PE/DAG-bd       
IPR017438   ATP-NAD_kinase_N       
IPR016064   NAD/diacylglycerol_kinase_sf       
IPR011990   TPR-like_helical_dom_sf       
IPR013026   TPR-contain_dom       

SUPFAM

SSF56112   SSF56112        + More
SSF111331   SSF111331       
SSF48452   SSF48452       

Gene 3D

3.40.50.10330     1.25.40.10    

ProteinModelPortal

H9J7Z9   A0A2A4JEF0   D0AB87   L7WW91   A0A2H1VVK4   A0A212EP69   + More
A0A194QAR5   A0A194QTH5   S4NSS2   A0A0L7LPN6   A0A1Y1JW72   A0A2P8Y5R8   A0A1W4XB76   A0A1B6IB42   A0A1B6GET5   A0A067QN57   A0A1B6L3U1   A9XK84   A0A0T6AYY0   A0A0M9AAQ5   E0VQ74   A0A026WS53   A0A158NNP5   A0A023ER47   E2B907   A0A151HZL0   A0A1L8DM37   E2AZT9   A0A2J7PXF6   Q17KN4   Q67EX4   U5EW25   A0A069DYN1   A0A1L8DMC4   A0A0J7KV34   A0A0K8TSJ2   A0A0C9QM81   A0A224XTF1   A0A0P4VRJ8   R4G3V7   A0A1I8PC03   A0A1I8M2L4   T1PDH9   A0A151X7T9   A0A1Q3F5W1   A0A154P2K1   A0A2A3E1J1   A0A0V0G9F5   A0A151J3E7   A0A0L7QK85   B0W7R1   V5GF02   J9JYM3   A0A336LUS6   D6WX74   K7J2E0   A0A232F0F6   A0A1A9VNI1   A0A1B0AFB7   D3TLE9   A0A1A9WVR0   A0A088AVZ4   A0A0K8UXF9   A0A034WHR3   A0A2H8TDS5   A0A195FS05   A0A0A1XEX4   A0A310SX15   A0A2R7W8R2   B4JLY8   A0A1J1IV25   A0A0L0BUV4   T1IUF7   B4L621   W8B7L0   B4Q205   B3MS42   B4GW95   A0A1W4VK79   A0A3B0KRW6   B4M728   Q29IB7   B3NX72   A0A0M4F9A4   B4NUD3   B4IGM0   O62602   E9H2U1   Q9U983   B4NEN3   A0A0N8CT73   A0A0N8DCF9   A0A0P5L8K9   A0A0N7ZKQ6   A0A0N8AGI5   A0A0P5Y8M6   U4U2E7   A0A0N8DX38   N6UGG3   A0A0P5EKH4  

PDB

3VN9     E-value=5.15126e-98,     Score=912

KEGG

101744017    K04432 mitogen-activated protein kinase kinase 3 [EC:2.7.12.2] | (RefSeq) dual specificity mitogen-a

GO

GO:0005524   GO:0004674   GO:0004672   GO:0000187   GO:0005737   GO:0004708   GO:0023014   GO:0032147   GO:0031098   GO:0035556   GO:0003951   GO:0007205   GO:0004143   GO:0038066   GO:0031435   GO:0040018   GO:0090090   GO:0002385   GO:0048082   GO:0007309   GO:0045793   GO:0001934   GO:0004697   GO:0000165   GO:0007314   GO:0006468   GO:0016021   GO:0004535   GO:0003723   GO:0005634   GO:0006402   GO:0046872   GO:0003824  

PANTHER

PTHR11255  

Length:

319

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.14094

Exp number, first 60 AAs:

0

Total prob of N-in:

0.01173

outside

1  -  319

 

 

Pi

314.532692

Theta

166.358616

Tajima's D

2.451871

CLR

116.550715

CSRT

0.941402929853507

Interpretation

Uncertain